Evidence is accumulating that individual and environmental factors in childhood and adolescence should be considered when investigating adult health and aging-related processes. The data required for this is gathered by comprehensive long-term longitudinal studies. This article describes the protocol of the Zurich Longitudinal Studies, a set of three comprehensive cohort studies on child growth, health, and development that are currently expanding into adulthood. Between 1954 and 1961, 445 healthy infants were enrolled in the first ZLS cohort. Their physical, motor, cognitive, (...) and social development and their environment were assessed comprehensively across childhood, adolescence, and into young adulthood. In the 1970s, two further cohorts were added to the ZLS and assessed with largely matched study protocols: Between 1974 and 1979, the second ZLS cohort included 265 infants, and between 1970 and 2002, the third ZLS cohort included 327 children of participants of the first ZLS cohort. Since 2019, the participants of the three ZLS cohorts have been traced and invited to participate in a first wave of assessments in adulthood to investigate their current health and development. This article describes the ZLS study protocol and discusses opportunities, methodological and conceptual challenges, and limitations arising from a long-term longitudinal cohort recruited from a study about development in early life. In the future, the ZLS will provide data to investigate childhood antecedents of adult health outcomes and, ultimately, will help respond to the frequent call of scientists to shift the focus of aging research into the first decades of life and, thus, to take a lifespan perspective on aging. (shrink)

This article casts light on the moral implications of the possibility of human extinction, with a specific focus on extinction caused by an interruption in human reproduction. In the first two paragraphs, I show that moral philosophy has not yet given promising explanations for the wrongness of this kind of extinction. Specifically, the second paragraph contains a detailed rejection of John Leslie’s main claims on the morality of extinction. In the third paragraph, I offer a demonstration of the fact that (...) a moral view which stresses the permissibility of some types of human extinction can be effectively constructed, while in the following paragraph I propose a prima facie defense of a new approach to the topic which is likely to provide us with reasons in favor of the wrongness of a premature departure of humankind. (shrink)

Erratum to: Philosophia 42:1063–1084DOI10.1007/s11406-014-9553-7The original version of this article unfortunately includes some imperfections. The correct details are given below.In the second paragraph of the text, references to Leslie 2002 are actually to Leslie 1996.At note 23, the sentence “even if in so doing I would not make A’s condition overall worse” should be replaced by “even if in so doing I would not make B’s condition overall worse”; in the following period, an “if” should be inserted between “even” and “it”.In (...) the last page of the third paragraph, the sentence “would result in a strong violation of some kind of duty toward already existing people than” is intended substituted by the following one: “would result in a violation of some kind of duty toward already existing people, then,”. (shrink)

Análise dos processos de formação do professor. Situa inicialmente as alternativas de constituição dos agentes do sistema político administrativo da educação do final do período imperial para focalizar as estratégias formativas adotadas pela Escola Complementar, analisando para tanto entrevistas, documentos iconográficos e escritos. A delimitação espacial do estudo é a Província de São Pedro do Rio Grande do Sul, Brasil.

Discute a instrução pública a partir de seus agentes e os processos formativos de seleção, instrução, contratação, especialização e diferenciação que ao longo do tempo constituíram o professor contribuindo para a formação do cidadão e institucionalização da educação no Rio Grande do Sul.

Italian Sounding—i. e., the Italian appearance of a product or service brand irrespective of its country of origin—represents a global market phenomenon affecting a wide range of economic sectors, particularly the agro-food sector. Although its economic impact has been repeatedly stressed from different points of view, systematic scientific knowledge regarding its social–psychological bases is lacking. Three studies carried out in three different countries address this literature gap. Different consumer groups are targeted regarding major product categories pre-selected categories, which are the (...) major Italian food goods within the specific country according to piloting. In each study, the main independent variable has been manipulated by presenting real product images, whose “Italianness” degree is effectively manipulated by the main study variable across three or four levels. Main hypotheses are tested via a survey with the specific product images administered to samples in Italy, China, and the USA. Across the three studies, results show that Made in Italy products, compared to the other ones, are advantaged in terms of the main dependent variables: reputation profile, general reputation, attitude, and willingness to pay. Moreover, Italian Sounding products are endowed with corresponding significant advantages when compared to the Generic Foreign by non-Italian samples. Results reveal the specific social–psychological profile of Italian Sounding products in terms of either weaknesses or strengths when compared to both Made in Italy products and Generic Foreign ones, differently in the eyes of Italian and non-Italian consumers across different countries. Finally, consistently across the three studies, the extent to which a food product is perceived to be Italian increases consumers' WTP for that product, and this effect is consistently mediated by the product's reputation. (shrink)

Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet‐secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding this early (...) step of muscle regeneration exacerbates inflammation at later stages, compromises neo‐angiogenesis and the growth of newly formed myofibers, and reduces post‐injury muscle force production. Platelets also contribute to the recruitment of pro‐regenerative stromal cells from the adipose tissue, and the platelet releasate may also regulate the metabolism and proliferation of muscle satellite cells, which sustain myogenesis. Therefore, harnessing the signaling functions of platelets and the platelet secretome may provide new avenues for promoting skeletal muscle regeneration in health and disease. (shrink)

This paper formalizes an approach to the Internet of Things as a socio-technical system of systems and a part of the infosphere. It introduces a principle-based, human-centered approach to designing Internet of Things artifacts as elements of contextual cross-channel ecosystems. It connects the Internet of Things to the conceptualization of cross-channel ecosystems from current information architecture theory and practice, positing that the Internet of Things is both a formal, objective superset of any given ecosystem and a contextual, subjective subset of (...) specifically instantiated ecosystems. The paper argues for the necessity of a transdisciplinary theoretical framework to promote a human-centered generative understanding of the Internet of Things phenomena and their consequences, in accordance with the Metamodel Methodology. It proposes a phenomenology-grounded information architecture model detailing a set of 16 principles and secondary heuristics grouped according to an architectural perspective, which identifies guidelines that support the design of Internet of Things artifacts considering their objective characteristics; a human perspective, which identifies guidelines that support the design of Internet of Things artifacts considering subject/object relationships and the production of meaning; and a systemic perspective, which identifies guidelines that support the design of Internet of Things artifacts as relational parts of information-based ecosystems. These principles and guidelines are meant to provide the foundations for a practice-based approach to designing the Internet of Things–enabled information ecosystems. (shrink)

This paper formalizes an approach to the Internet of Things as a socio-technical system of systems and a part of the infosphere. It introduces a principle-based, human-centered approach to designing Internet of Things artifacts as elements of contextual cross-channel ecosystems. It connects the Internet of Things to the conceptualization of cross-channel ecosystems from current information architecture theory and practice, positing that the Internet of Things is both a formal, objective superset of any given ecosystem and a contextual, subjective subset of (...) specifically instantiated ecosystems. The paper argues for the necessity of a transdisciplinary theoretical framework to promote a human-centered generative understanding of the Internet of Things phenomena and their consequences, in accordance with the Metamodel Methodology. It proposes a phenomenology-grounded information architecture model detailing a set of 16 principles and secondary heuristics grouped according to an architectural perspective, which identifies guidelines that support the design of Internet of Things artifacts considering their objective characteristics; a human perspective, which identifies guidelines that support the design of Internet of Things artifacts considering subject/object relationships and the production of meaning; and a systemic perspective, which identifies guidelines that support the design of Internet of Things artifacts as relational parts of information-based ecosystems. These principles and guidelines are meant to provide the foundations for a practice-based approach to designing the Internet of Things–enabled information ecosystems. (shrink)

This paper formalizes an approach to the Internet of Things as a socio-technical system of systems and a part of the infosphere. It introduces a principle-based, human-centered approach to designing Internet of Things artifacts as elements of contextual cross-channel ecosystems. It connects the Internet of Things to the conceptualization of cross-channel ecosystems from current information architecture theory and practice, positing that the Internet of Things is both a formal, objective superset of any given ecosystem and a contextual, subjective subset of (...) specifically instantiated ecosystems. The paper argues for the necessity of a transdisciplinary theoretical framework to promote a human-centered generative understanding of the Internet of Things phenomena and their consequences, in accordance with the Metamodel Methodology. It proposes a phenomenology-grounded information architecture model detailing a set of 16 principles and secondary heuristics grouped according to an architectural perspective, which identifies guidelines that support the design of Internet of Things artifacts considering their objective characteristics; a human perspective, which identifies guidelines that support the design of Internet of Things artifacts considering subject/object relationships and the production of meaning; and a systemic perspective, which identifies guidelines that support the design of Internet of Things artifacts as relational parts of information-based ecosystems. These principles and guidelines are meant to provide the foundations for a practice-based approach to designing the Internet of Things–enabled information ecosystems. (shrink)

Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned. Since its discovery in 1985, it has been used by us and by many laboratories around the world as an invaluable marker to study the distribution of synapses in the brain and to uncover the basic features of the life cycle of SVs. Although single gene ablation of Syp does not lead to an overt phenotype, a large body of experimental data both in vitro and in vivo indicate (...) that Syp (alone or in association with homologous proteins) is involved in multiple, important aspects of SV exo‐endocytosis, including regulation of SNARE assembly into the fusion core complex, formation of the fusion pore initiating neurotransmitter release, activation of SV endocytosis and SV biogenesis. In this article, we summarise the main results of the studies on Syp carried out by our and other laboratories, and explain why we believe that Syp plays a major role in SV trafficking. BioEssays 26:445–453, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This paper presents an intuitive explanation about why and how Rawlsian Theory of Justice (Rawls in A theory of justice, Harvard University Press, Harvard, 1971) provides the foundations to a solution for algorithmic bias. The contribution of the paper is to discuss and show why Rawlsian ideas in their original form (e.g. the veil of ignorance, original position, and allowing inequalities that serve the worst-off) are relevant to operationalize fairness for algorithmic decision making. The paper also explains how this leads (...) to a specific MinMaxfairness solution, which addresses the basic challenges of algorithmic justice. We combine substantive elements of Rawlsian perspective with an intuitive explanation in order to provide accessible and practical insights. The goal is to propose and motivate why and how the MinMaxfairness solution derived from Rawlsian principles overcomes some of the current challenges for algorithmic bias and highlight the benefits provided when compared to other approaches. The paper presents and discusses the solution by building a bridge between the qualitative theoretical aspects and the quantitative technical approach. (shrink)

J’espère que tout cela sera le point de départ d’une collaboration efficace dans l’avenir, et que je me permets de souhaiter, en outre, amicale.Louis Rougier à Hans Reichenbach, 24 novembre 1931.

May implicit and explicit collaboration influence text comprehension and spatial recognition interaction? Visuospatial representation implies implicit, visual and spatial processing of actions and concepts at different levels of awareness. Implicit learning is linked to unaware, nonverbal and prototypical processing, especially in the early stages of development when it is prevailing. Spatial processing is studied as knowledge prototypes , conceptual and mind maps . According to the hypothesis that text comprehension and spatial recognition connecting processes may also be implicit, this paper (...) analyzes the possibility to identify and to define implicit non verbal criteria for organizing concepts into spatial representation. The focus of the research question is if prototypical processing (mainly implicit, but also explicit) criteria of conceptual organization may be model based. According to Thinking Prototypes Theory , explicit knowledge could be supported by implicit models of basic processing. On implicit side, conceptual development could be the resultant of the increasing complexity of prototypical implicit models interaction during individual lifespan, as in conceptual change research explicit conceptual development may be dependent on correlation . Unlike Theory Theory in Thinking Prototypes Theory implicit processing may collaborate with explicit knowledge without transforming itself from implicit to explicit. Prototypical implicit processing is considered as an entanglement of basic functions operating synergically in a complex way. Prototypical implicit processing units may be classified as far as they concern different basic thinking operations ( add , chain , each , compare , focus and link ). The experimental design was developed with primary school students in Naples. (shrink)

Reflections on Little Rock is one of Hannah Arendt’s most controversial writings. Read from the perspective of the political philosopher, it appears even more contentious than her famous remarks in Eichmann in Jerusalem. In the last two decades, a number of critical contributions have been published addressing this essay, highlighting how it casts serious doubts on the correctness of Arendt’s dealing with the racial question and, more generally, on the tenability of central elements of her political thought – e.g., her (...) distinction between the political and the social. However, only occasional – and, as I will try to demonstrate, quite imprecise – analyses of the implications of RLR for an understanding of Arendt’s view of judgment have been produced. The aim of the present article is to reread what both Arendt’s position on judgment and its main contemporary reformulation, advanced by Linda Zerilli, imply for the making of political choices in pluralistic societies. Special attention will be... (shrink)

The purpose of this scoping review is to investigate the value of creative arts therapies in healthy older adults. This article aims to shed light on current knowledge concerning the effectiveness of art therapies for the prevention of common age-related conditions using the definition of art therapy provided by the American Art Therapy Association, as well as Cohen’s conceptual framework for the psychological conceptualization of the relationship between the arts and health in later life. The objective is to carefully capture (...) subthreshold situations of distress, which are often not taken into account and primarily involve psychological aspects that are crucial in the multidimensional perspective of healthy aging. Twelve articles were selected and examined following an initial electronic search on 3 databases. A thematic analysis of the results identified four major themes: improving cognitive performance and proprioception; enhancing self-identity and meaningful life; reducing feelings of loneliness and depressive symptoms; and the importance of socialization. All these aspects constitute the basis for preventing psychological distress and enhancing mental well-being for healthy aging. (shrink)

Ethics in research became a central theme regarding globalization of the scientific development, particularly when related to the socioeconomic conditions of the countries involved as partners in research protocols, production of inputs and of knowledge. The objective of this paper is to analyze the sources of information about ethics in research present at Scientific Electronic Library Online. Methodologically, this is an exploratory study was carried out by the systematic analysis of the literature available. The search engines retrieved 885 summaries, from (...) which 170 were analyzed. The first publication was dated from 1996 and it could be identified the mention to international documents about research in humans. Since 2002 there has been an increase of publications related to the gain of legitimacy of the topic in academy. As a conclusion, although the amount is not huge, the manuscripts presented great impact as they stimulated debates and produced scientific knowledge on the topic. It can be observed that ethics in research has outcome the biomedical field, being inserted in other fields of knowledge. (shrink)

This paper explores both some of the concepts John Dewey exposed while in China in the 1920’s and considers why his idea of democracy did not thrive in China. In the lectures Dewey delivered in China he focused on the strength of democracy, from the perspective of political science, social science, philosophy and education. Dewey clarified the democratic way of thinking, doing and living to the Chinese people. Of these topics, he considered the philosophy of education and social and political (...) philosophy to be the most important. Through his speeches, he underlined the importance of reflective thinking and reasoning in constructing human intelligence and lively inquiries. In the early part of the 20th century, both Dewey’s pragmatism and Marx’s communism were honored and speculated. While both Dewey and Marx promoted similar aims for human beings, that is, the creation of a society for the common good, their means were substantially different. For Dewey, such a result could only be obtained by a gradual construction of communicative social relationships; for Marx, a radical revolution was necessary to get expunge the old currently dominant parties. With regards to their relationship to working for the common good, for many Chinese, Dewey’s philosophies and ideas were unclear, overly complicated, and inefficient, while Marx pointed out a concrete destination, a clearly designed and expedient wayto implement an egalitarian society. (shrink)

This paper reconstructs the concept of the «feeling» elaborated by William James in the text The Varieties of Religious Experience: a study in human nature as a mean towards a moral education. The analysis of the feeling expecially the religious one is structurally connected, in this writing of James, not only with thebiographical problem of the conscience and the knowledge of the self, but also with the strategically wider issue, of «a study of the human nature». The analysis of the (...) experience conducted from the pragmatist perspective allows us to specify the pedagogical function of the «spiritual feeling» in the path of consciousness of the subject: the faith, in fact, seen in its operative dynamic, increases the experimental conviction that the world can improve and it prepares in such way to raise and to invigorate the relationship with the life. In such perspective it is underlined the «therapeutic» function of moral emotions for the existence in general, and their specific impact on the process of formation and behavior of the human being. (shrink)

This highly multidisciplinary collection discusses an increasingly important topic among scholars in science and technology studies: objectivity in science. It features eleven essays on scientific objectivity from a variety of perspectives, including philosophy of science, history of science, and feminist philosophy. Topics addressed in the book include the nature and value of scientific objectivity, the history of objectivity, and objectivity in scientific journals and communities. Taken individually, the essays supply new methodological tools for theorizing what is valuable in the pursuit (...) of objective knowledge and for investigating its history. The essays offer many starting points, while suggesting new avenues of research. Taken collectively, the essays exemplify the very virtues of objectivity that they theorize—in reading them together, the reader can sense various anxieties about the dangerously subjective in our age and locate commonalities of concern as well as differences of approach. As a result, the volume offers an expansive vision of a research community seeking a communal understanding of its own methods and its own epistemic anxieties, struggling to enunciate the key problems of knowledge of our time and offer insight into how to overcome them. -/- (Contributors: Alex Csiszar, Scott Edgar, Peter Galison, Ian Hacking, Sandra Harding, Moira Howes, Paolo Savoia, Judy Segal, Joan Steigerwald, and Alison Wylie). (shrink)

J’espère que tout cela sera le point de départ d’une collaboration efficace dans l’avenir, et que je me permets de souhaiter, en outre, amicale.Louis Rougier à Hans Reichenbach, 24 novembre 1931.

In recent years, Reichenbach's 1920 conception of the principles of coordination has attracted increased attention after Michael Friedman's attempt to revive Reichenbach's idea of a "relativized a priori". This paper follows the origin and development of this idea in the framework of Reichenbach's distinction between the axioms of coordination and the axioms of connection. It suggests a further differentiation among the coordinating axioms and accordingly proposes a different account of Reichenbach's "relativized a priori".

This dissertation deals with the political uses of anger, focusing on those cases in which anger is mobilized against socially structural forms of injustice (henceforth, “radical anger”). The author provides a philosophical defence of the legitimacy and usefulness of this kind of anger, together with a set of conceptual tools for distinguishing among different instances of anger in the political realm. The text consists of seven chapters, an introduction and a short conclusion. The first chapter offers a genealogy of the (...) pathologization of radical anger, investigating the linguistic and conceptual entanglement of rage and rabies. The following chapter reviews a few cases in which oppressed groups successfully reclaimed radical anger in spite of widespread pathologizing and criminalizing tendencies, drawing mainly from the radical feminist and antiracist traditions. Special attention is also paid to the relationship between anger and violence, as well as to the opportunity for structurally discriminated groups to politically embrace anger. The metaphor of a ballistics of anger is introduced to heuristically distinguish among specific occurrences of political anger. The third chapter outlines the essential features of a political philosophy of radical anger, starting from a re-reading of Michel Foucault’s interpretation of ancient Cynicism which emphasises the angry character of the latter. After asking whether radical anger can be considered philosophically true and reactionary anger defined as untrue, three possible arguments in favour of an affirmative answer are considered. Since the first two arguments, based respectively on the works of Rahel Jaeggi and Giorgio Agamben, prove unsuccessful, a third alternative, relying mainly on the works of Foucault and Hannah Arendt, is proposed by the author. Chapters from 4 to 6 look for contemporary reprises of Cynical anger, proposing a philosophical reading of the lives and works of three figures who angrily confronted several kinds of structural injustice: Valerie Solanas, Malcolm X and Audre Lorde. The dissertation shows that each of them can offer useful additions to the political philosophy of radical anger already sketched. In particular, Solanas can help us thinking the connections between anger, negation, utopia and abolition; X testifies to the importance of the link between radical anger and the notion of care of the self (ἐπιμέλεια ἑαυτοῦ); Lorde allows us to understand the deep implications of the use of radical anger and paves the way for an erotic conception of this feeling. Finally, Chapter 7 presents the international trans-feminist movement Ni Una Menos-Non Una di Meno as an example of the practical and theoretical strengths of radical anger. (shrink)

This paper explores both some of the concepts John Dewey exposed while in China in the 1920’s and considers why his idea of democracy did not thrive in China. In the lectures Dewey delivered in China he focused on the strength of democracy, from the perspective of political science, social science, philosophy and education. Dewey clarified the democratic way of thinking, doing and living to the Chinese people. Of these topics, he considered the philosophy of education and social and political (...) philosophy to be the most important. Through his speeches, he underlined the importance of reflective thinking and reasoning in constructing human intelligence and lively inquiries. In the early part of the 20th century, both Dewey’s pragmatism and Marx’s communism were honored and speculated. While both Dewey and Marx promoted similar aims for human beings, that is, the creation of a society for the common good, their means were substantially different. For Dewey, such a result could only be obtained by a gradual construction of communicative social relationships; for Marx, a radical revolution was necessary to get expunge the old currently dominant parties. With regards to their relationship to working for the common good, for many Chinese, Dewey’s philosophies and ideas were unclear, overly complicated, and inefficient, while Marx pointed out a concrete destination, a clearly designed and expedient wayto implement an egalitarian society. (shrink)

O objetivo do estudo é analisar a série De onde vem? , a qual introduz o conhecimento científico na infância, identificando aspectos que justifiquem o seu emprego como um recurso pedagógico adequado para a introdução de conceitos de Ciência de forma lúdica e dinâmica na infância. Os resultados apresentam aspectos gerais dos episódios da Série, além da descrição estrutural dos episódios de forma generalizada de acordo com as categorias sugeridas por Gomes (2008). A Série introduz conceitos científicos, presentes no cotidiano, (...) por meio de uma linguagem adequada à compreensão infantil, tornando, assim, este material uma importante alternativa de apoio ao professor do Ensino Fundamental para a introdução da ciência na infância. (shrink)