Post‐translational modifications regulate each step of DNA replication to ensure the faithful transmission of genetic information. In this context, we recently showed that deubiquitination of SUMO2/3 and SUMOylated proteins by USP7 helps to create a SUMO‐rich and ubiquitin‐low environment around replisomes that is necessary to maintain the activity of replication forks and for new origin firing. We propose that a two‐flag system mediates the collective concentration of factors at sites of DNA replication, whereby SUMO and Ubiquitinated‐SUMO would constitute “stay” or (...) “go” signals respectively for replisome and accessory factors. We here discuss the findings that led to this model, which have implications for the potential use of USP7 inhibitors as anticancer agents. (shrink)

Providing the first English translation of Análisis del ser del mexicano, this book features a full biography of Uranga, a detailed overview of the translated text, and discussion of Uranga's relevance to contemporary debates in the phenomenology of culture, the philosophy of liberation, Latin American philosophy and phenomenology itself. Reading Uranga's brilliant words expertly translated and introduced by Carlos Alberto Sánchez finally allows us to understand why this Mexican philosopher is considered one of the most fearless and original thinkers of (...) the 20th century. (shrink)

The parallel distributed processing (PDP) perspective brings forward the important point that all semantic phenomena are based on analog underlying mechanisms, involving the weighted summation of multiple inputs by individual neurons. It falls short of indicating, however, how the essentially discrete nature of semantic processing may emerge at the cognitive level. Bridging this gap probably requires attractor networks.

The act of iudicare hostes (‘declare public enemy’) was a formal pronouncement of the Roman Senate, voted for the first time in 88 BCE following a proposal by L. Cornelius Sulla after his first march on Rome. Legal historians have generally interpreted it as an emergency measure intended to preserve legality in a situation of civil strife and viewed it as a consistently defined institutional framework throughout the final decades of the Republic. Through an analysis of Sulla’s performative political communication, (...) before, during and in the immediate aftermath of the march, this paper argues that the act of judging (iudicare) someone a public enemy (hostis publicus) was first deployed as a political action, void of legal effects. Later instances of iudicare suggest that this act underwent a process of institutionalization after 63 BCE. (shrink)

Stakeholder engagement and dialogue have a central role in defining the relations between organisations and their internal and external interlocutors. Drawing upon the analysis of dialogic motifs, power–conflict dynamics and sociopolitical perspectives, and based on a set of interviews with the stakeholders of a consumer-owned cooperative, the research explores the dialogic potential of stakeholder engagement. The analysis revealed a fragmented picture where the co-design and co-implementation aspects were mainly related to the non-business areas of cooperative life, while business logic dominated (...) the most central aspects. Stakeholder engagement was mainly related to consensus building, while dialogic engagement based on a pluralistic understanding was only partially considered and then neglected. The social capital in the local area, the growing size of the organisation and the related power structure embrace stakeholder engagement, influencing the orientation of the dialogic dynamic. The analysis indicates that a dialogic exchange is a relative concept which depends on the interests involved and the topics discussed. It also reveals that the key factors in the democratisation of stakeholder engagement are a mutual understanding and long-term opportunities. Common sociopolitical aspects are also important, but they do not necessarily guarantee the creation of dialogism paths. The research contributes to the critical dialogic literature in revealing whether and how stakeholder engagement has been implemented in a specific setting. It also shows the limitations of voluntarist stakeholder engagement initiatives. (shrink)

La obra literaria de santa Rosa de Lima se reduce a unos versos registrados en el Primer Proceso Ordinario de la jerarquía peruana y a dos medios pliegos holográficos, conservados en el convento de Santa Rosa de las Madres, de Lima. Basándose en estos datos y ahondando en el testimonio de las conclusiones obtenidas por el Dr. Juan del Castillo, tras el examen de conciencia de 1614 realizado a la Santa, el autor realiza una semblanza de la primera escritora místico-visionaria (...) de la América del virreinato. (shrink)

Cet ouvrage important reflète le dynamisme actuel en Espagne de la recherche en histoire des femmes, tout en vérifiant la diversité théorique, méthodologique et thématique de ce courant historiographique. Afin de faciliter la présentation nous regroupons par thèmes les 24 travaux inclus dans cette vaste publication. En premier lieu, distinguons les contributions orientées vers l’analyse théorique. Mª Isabel del Val Valdivieso dans « A modo de introducción. La historiografía en los albores del...

To think a Deleuzian politics requires to understand the philosophical markleft in his work by Spinoza. Both philosophers’ paths crisscross in their problems, questions and consequences. In this paper three concepts will be put in relation: critique, right and crowd. The aim is to elucidate how man can open new ways of political experience from the conjunction of two philosophies articulated upon a common ground: immanence and life.

The aim of this text is to develop an epistemological-technique approach which permit analyze the work of Juan Downey, and his use of technical medias and also include the struggle against the State in the political and cultural model of the primitive societies of the Yano- mani, particularly by the work of Pierre Clastres and Jacques Lizot, and also their point of view of the methods of production in the societies of abundance, as theorized the anthropologist Marshall Sahlins, considering these (...) anthropological paradigms as a medium to understand the mediatic interaction and the technique development in the works of Juan Downey. (shrink)

The aim of this text is to develop an epistemological-technique approach which permit analyze the work of Juan Downey, and his use of technical medias and also include the struggle against the State in the political and cultural model of the primitive societies of the Yano- mani, particularly by the work of Pierre Clastres and Jacques Lizot, and also their point of view of the methods of production in the societies of abundance, as theorized the anthropologist Marshall Sahlins, considering these (...) anthropological paradigms as a medium to understand the mediatic interaction and the technique development in the works of Juan Downey. (shrink)

Las exigencias del diálogo entre la fe y la cultura actual han obligado a plantearse seriamente la tarea de "inculturación" del cristianismo, una misión necesaria aunque compleja y delicada. Tras definir los términos principales del tema, se exponen los criterios a seguir y los equilibrios necesarios para su adecuada realización. A continuación se describe el objeto principal de este estudio: la inculturación de la catequesis. En primer lugar, los agentes o personas responsables de la inculturación (la comunidad cristiana, los diferentes (...) servicios o ministerios, el papel de los catequistas), los aspectos o lugares particularmente implicados (pequeñas comunidades cristianas, catequesis locales, catequesis populares, etc.). El estudio termina destacando algunos de los posibles riesgos y dificultades que la tarea de inculturar la catequesis debería intentar superar. (shrink)

The anticipation of the typical under the assumption of the non-occurrence of the atypical is the experiential schema governing the individuation of ordinary enduring objects and their properties. Against this background, a primitive form of “if-and-only-if” consciousness is implicit in our everyday perceptual intentions. The thematization of the fact that perception operates under this proto-tentative structure occurs at the level of reflection and is expressed by defeasible judgments of the form “if p, then q, unless r,” or “if p, then (...) q provided that not-r”. Here I will argue that what is made thematic by judgments containing such restrictive clauses is the structure of unpredictability inherent in what Husserl calls the horizon of latency and, indirectly, the world as background of normality. (shrink)

Includes articles about Origen, Thomas Aquinas, Hegel, Schleiermacher, Blondel, Teilhard de Chardin, Barth, Heidegger, Gadamer, postmodernism.

El artículo presenta y comenta las catequesis de Benedicto XVI en las audiencias públicas de los miércoles. A lo largo de los años los temas tratados son: los salmos y cánticos litúrgicos de laudes y vísperas; la Iglesia, su naturaleza e identidad; los Padres de la Iglesia; San Pablo (en el Año Paulino, 2008). En 2009, Benedicto XVI lanza una serie dedicada al Año Sacerdotal. En los últimos años de pontificado (2009-2011), presenta figuras de la historia de la Iglesia en (...) la Edad Media en los siglos XII y XIII, y a continuación personalidades femeninas de la historia eclesial de la Edad Media, y Moderna. Una última nueva serie está dedicada a los Doctores de la Iglesia. Estas catequesis dirigidas a todos los fieles constituyen un significativo momento de formación. (shrink)

Los últimos diez años –prácticamente la década a caballo del año 2000– han sido muy fecundos en la reflexión y en el magisterio eclesial a propósito especialmente de la evangelización, la iniciación cristiana y la catequesis. Muchos documentos, publicaciones y experiencias quieren relanzar la acción evangelizadora y catequética por nuevos derroteros.

We argue that living systems process information such that functionality emerges in them on a continuous basis. We then provide a framework that can explain and model the normativity of biological functionality. In addition we offer an explanation of the anticipatory nature of functionality within our overall approach. We adopt a Peircean approach to Biosemiotics, and a dynamical approach to Digital-Analog relations and to the interplay between different levels of functionality in autonomous systems, taking an integrative approach. We then apply (...) the underlying biosemiotic logic to a particular biological system, giving a model of the B-Cell Receptor signaling system, in order to demonstrate how biosemiotic concepts can be used to build an account of biological information and functionality. Next we show how this framework can be used to explain and model more complex aspects of biological normativity, for example, how cross-talk between different signaling pathways can be avoided. Overall, we describe an integrated theoretical framework for the emergence of normative functions and, consequently, for the way information is transduced across several interconnected organizational levels in an autonomous system, and we demonstrate how this can be applied in real biological phenomena. Our aim is to open the way towards realistic tools for the modeling of information and normativity in autonomous biological agents. (shrink)

Se trata de una reseña del libro de Fabiana Erazun y Mariana Castillo Merlo (editoras) (2021) _Pensar la política en clave republicana: Debates sobre igualdad y libertad_, Neuquén, Universidad Nacional del Comahue, 180 páginas.

Se trata de una reseña del libro de Jacques Rancière. Disenso. Ensayos sobre estética y política, primera edición en español. México: Fondo de Cultura Económica, 275 páginas.

Se trata de la reseña del libro de Sánchez, Sergio Borges lector de Nietzsche y Carlyle, Córdoba, Editorial de la Universidad Nacional de Córdoba, 110 páginas.

La noción de emergencia acompaña a la Filosofía de la Biología desde finales del siglo XIX, afirmando que las propiedades de los sistemas biológicos no pueden deducirse de las de sus componentes. A lo largo del siglo XX las caracterizaciones de este concepto se han apoyado en cuatro pilares, impredecibilidad, novedad, restricción y causación descendente, pilares ligados a la asunción de una jerarquización de la realidad en niveles de organización. En este trabajo intento demostrar que puede explicarse la naturaleza de (...) las propiedades biológicas sin hacer referencia a la emergencia utilizando como herramienta la noción de cuasi-descomponibilidad propuesta originariamente por Herbert Simon. (shrink)

In this paper we suggest that differing approaches to the science of social cognition mirror the arguments between radical embodied and traditional approaches to cognition. We contrast the use in social cognition of theoretical inference and mental simulation mechanisms with approaches emphasizing a direct perception of others’ mental states. We build from a recent integrative framework unifying these divergent perspectives through the use of dual-process theory and supporting social neuroscience research. Our elaboration considers two complementary notions of direct perception: one (...) primarily stemming from ecological psychology and the other from enactive cognition theory. We use this as the foundation from which to offer an account of the informational basis for social information and assert a set of research propositions to further the science of social cognition. In doing so, we point out how perception of the minds of others can be supported in some cases by lawful information, supporting direct perception of social affordances and perhaps, mental states, and in other cases by cues that support indirect perceptual inference. Our goal is to extend accounts of social cognition by integrating advances across disciplines to provide a multi-level and multi-theoretic description that can advance this field and offer a means through which to reconcile radical embodied and traditional approaches to cognitive neuroscience. (shrink)

La decouverte de plus en plus profonde de la signification du christianisme a transforme la pensee de Fichte. Reciproquement, Fichte s'engage dans la voie d'une transformation du christianisme, au sens d'une metamorphose de la croyance en vision; il saisit la foi comme un stade imparfait de la science et souligne que seule cette derniere est a meme de supprimer l'exteriorite de l'Absolu. Le present ouvrage allie les points de vue genetique et systematique. De ses cinq parties, les quatre premieres exposent, (...) en suivant l'ordre chronologique, l'evolution de la theorie fichteenne du christianisme, depuis les textes prekantiens jusqu'a la Doctrine de l'Etat de 1813. La longue cinquieme partie, structuree thematiquement plutot que chronologiquement, est reservee non seulement a la reprise synthetique, mais aussi a la confrontation critique. Elle examine les differents aspects de la conception fichteenne du christianisme, notamment sa position a l'egard du Nouveau Testament, de la dogmatique, de la morale et de la mystique chretiennes. (shrink)

Bernardino Telesio Dubbed “the first of the new philosophers” by Francis Bacon in 1613, Bernardino Telesio was one of the most eminent thinkers of Renaissance Italy, along with figures such as Pico, Pomponazzi, Cardano, Patrizi, Bruno, Doni, and Campanella. The young Telesio spent the early decades of his life under the guidance of his … Continue reading Telesio, Bernardino →.