The biogenesis of RNAs and proteins is a threat to the cell. Indeed, the act of transcription and nascent RNAs challenge DNA stability. Both RNAs and nascent proteins can also initiate the formation of toxic aggregates because of their physicochemical properties. In reviewing the literature, I show that co-transcriptional and co-translational biophysical constraints can trigger DNA instability that in turn increases the likelihood that sequences that alleviate the constraints emerge over evolutionary time. These directed genetic variations rely on the biogenesis (...) of small RNAs that are transcribed directly from challenged DNA regions or processed from the transcripts that directly or indirectly generate constraints or aggregates. These small RNAs can then target the genomic regions from which they initially originate and increase the local mutation rate of the targeted loci. This mechanism is based on molecular pathways involved in anti-parasite genome defence systems, and implies that gene expression-related biophysical constraints represent a driving force of genome evolution. Are randomly generated mutations the only source of genetic variation during evolution? This paper describes the molecular mechanisms by which co-transcriptional and co-translational biophysical constraints trigger genetic variations in targeted-genomic sequences in an RNA-depending manner. This directed-mutational process that drives genome evolution is related to antiparasite genome defence systems. (shrink)

Essays appraising the contemporary relevance of am kara for inter-religious dialogue and human rights as well as revised assessments of am kara s understanding of divine grace, the role of the gods, Buddhism, am kara s relation to later Advaita, and the unity of the Self.

From the resurrection of body to eternal recurrence -- The shadow of God -- The guiding thread -- The logic of the body -- The system of identical cases -- From eternal recurrence to the resurrection of body.

The commentary raises political questions about the ways in which data has been constituted as an object vested with certain powers, influence, and rationalities. We place the emergence and transformation of professional practices such as ‘data science’, ‘data journalism’, ‘data brokerage’, ‘data mining’, ‘data storage’, and ‘data analysis’ as part of the reconfiguration of a series of fields of power and knowledge in the public and private accumulation of data. Data politics asks questions about the ways in which data has (...) become such an object of power and explores how to critically intervene in its deployment as an object of knowledge. It is concerned with the conditions of possibility of data that involve things, language, and people that together create new worlds. We define ‘data politics’ as both the articulation of political questions about these worlds and the ways in which they provoke subjects to govern themselves and others by making rights claims. We contend that without understanding these conditions of possibility – of worlds, subjects and rights – it would be difficult to intervene in or shape data politics if by that it is meant the transformation of data subjects into data citizens. (shrink)

We have entered a new era of nature. What remains of the frontiers of modern thought that divided the living from the inert, subjectivity from objectivity, the apparent from the real, value from fact, and the human from the nonhuman? Can the great oppositions that presided over the modern invention of nature still claim any cogency? In _Nature as Event_, Didier Debaise shows how new narratives and cosmologies are necessary to rearticulate that which until now had been separated. Following (...) William James and Alfred North Whitehead, Debaise presents a pluralistic approach to nature. What would happen if we attributed subjectivity and potential to all beings, human and nonhuman? Why should we not consider aesthetics and affect as the fabric that binds all existence? And what if the senses of importance and value were no longer understood to be exclusively limited to the human? (shrink)

According to the (in)famous fourth law of Kuryłowicz (K4), when a morphological doublet arises in a language, the newer form becomes associated with the prototypical, basic meaning, while the old form takes a secondary meaning. This paper takes a first attempt at a more thorough inquiry of K4 to assess whether prototypicality of meaning has an effect on morphological change. Three studies on historical Dutch are taken on: -enversus -splurals, the apocope of schwa and the apocope of -de.The effects of (...) prototypicality are analysed both on a token level (differences in meaning within lemmas) as well as on a type level (differences between lemmas). As proxies for prototypicality of meaning (psycho)linguistic predictors are used, such as concreteness, age of acquisition, chronology of meaning, meaning frequency and metaphor. Results show no clear effect of prototypicality on a token level, but they do suggest an effect on a type level: more concrete meanings tend to show up more often with the newer variant. Yet these results may also be ascribed to iconicity as the newer variants in these cases are the shorter ones and concrete meanings tend to be represented by shorter words than abstract ones. (shrink)

Contemporary political theory (CPT) has approached questions of plurality and diversity by drawing rather implicitly on anthropological accounts of difference. This was the case with the ‘cultural turn’, which significantly shaped theories of multiculturalism. Similarly, the current ‘ontological turn’ is gaining influence and leaving a marked impact on CPT. I examine the recent turn and assess both the possibilities it offers and the challenges it poses for decentering CPT and opening radical, decolonial avenues for thinking difference otherwise. I take Paul (...) Nadasdy's critique of the ontological turn as an invitation to reflect on the methodological precepts that inform how the field frames the scope and limits of comparison. In pursuit of this, I examine the Zapatistas’ notion of a ‘world of many worlds’, which provides a way of approaching difference that captures the generative aspects of the ontological turn while avoiding the pitfalls of relativism and political inertia. I argue that the Zapatistas’ insights offer ethical guidance towards social and ecological thriving. Ultimately, my goal is to move CPT towards a more capacious form of making sense of what is out there in the world, and thus make room for better ways of inhabiting the Earth. (shrink)

Nous sommes entourés de machines dont une composante tire son nom d’une faculté cognitive du vivant. Les ordinateurs possèdent en effet une ou plusieurs « mémoires » : mémoire morte, mémoire vive, registres du processeur, disques durs, cartes mémoire, clefs USB, etc. Quelle est la raison d’être de la mémoire informatique et à quelles conditions est-elle matériellement possible? Nous montrerons dans un premier temps que la notion de mémoire dérive de l’idée même d’un traitement de l’information, et qu’elle joue à (...) ce titre un rôle majeur dans les modèles formels de l’informatique. Nous montrerons ensuite comment sont compensés les éventuels biais induits par une réalisation physique. On verra par là même le lien particulier qu’entretiennent en informatique la forme et la matière : si l’inscription dans une matière est possible, c’est dans un matériau quelconque, dont sont systématiquement neutralisées les particularités physiques. La forme est ainsi dégagée par abstraction de la matière dans laquelle elle s’exprime. (shrink)

Les questions morales pénètrent nos représentations, nos pratiques, nos politiques. Qu'il s'agisse, dans le monde privé, d'interpréter les conduites des autres et de discipliner les siennes propres, ou bien, dans l'espace public, de sanctionner des déviances et de réguler des populations, nos sociétés mobilisent des normes, des valeurs et des affects, qu'illustrent notamment les tensions entre la raison humanitaire et l'ordre sécuritaire. Redonnant toute sa force critique au concept d'économies morales, les auteurs réunis ici par Didier Fassin et Jean-Sébastien (...) Eideliman en explorent les multiples facettes à travers une série d'enquêtes conduites sur quatre continents. Des lieux d'enfermement des étrangers en France aux prisons de haute sécurité aux Etats-Unis, de la stigmatisation des familles roms en Italie à la marginalisation des enfants de migrants en Chine, de la condamnation du tourisme sexuel en Thaïlande à l'évaluation des transactions amoureuses au Mali, des pratiques de charité en Inde aux politiques contre la pauvreté au Chili, les auteurs s'attachent à comprendre comment on gouverne et on juge, comment on assiste et on exclut. Mais ils montrent aussi que les professionnels et leurs publics n'adoptent pas de manière passive et uniforme ces modèles moraux : ils déploient des subjectivités éthiques pour résister ou " faire avec ", autour du handicap et de la toxicomanie, de l'asile et de la naturalisation, de la violence et de la finance. Cet ouvrage nous propose ainsi de penser la vie sociale et politique de la morale. (shrink)

When he died in 1984, Michel Foucault was widely regarded as one of the most powerful minds of this century. Hailed by historians and lionized in America, he continues to provoke lively debate. This meticulously documented narrative debunks the many myths and rumors surrounding the brilliant philosopher to consider that all Foucault's books are "fragments of an autobiography".

The processing of emotional nonlinguistic information in speech is defined as emotional prosody. This auditory nonlinguistic information is essential in the decoding of social interactions and in our capacity to adapt and react adequately by taking into account contextual information. An integrated model is proposed at the functional and brain levels, encompassing 5 main systems that involve cortical and subcortical neural networks relevant for the processing of emotional prosody in its major dimensions, including perception and sound organization; related action tendencies; (...) and associated values that integrate complex social contexts and ambiguous situations. (shrink)

Avant même d'être condamné pour "contestation de crime contre l'humanité" au tournant du siècle, Roger Garaudy était déjà marginalisé dans les champs intellectuel et politique français. Après avoir incarné la résistance au néostalinisme dans le Parti communiste, le philosophe qui fut longtemps l'interlocuteur privilégié de Jean-Paul Sartre au sein du PCF en fut spectaculairement exclu en 1970 pour s'être opposé aux Soviétiques qui venaient d'écraser le Printemps de Prague. Celui que l'historiographie du communisme retient plus volontiers comme le "stalinien modèle", (...) qu'il fut en effet dans l'après-guerre, était pourtant devenu, malgré sa proximité avec Thorez, un critique de plus en plus affirmé du stalinisme après les révélations du XXe Congrès du Parti communiste de l'Union soviétique (PCUS) en 1956 et un acteur majeur de l'aggiornamento du PCF. Son combat pour rénover le communisme français et son goût précoce pour l'écologie et le dialogue des civilisations en firent quelque temps une figure respectée du progressisme français, mais celui qui répétait que le Socialisme était condamné s'il refusait de s'ouvrir à la "transcendance" vit son étoile pâlir après 1970 au point qu'il devint un intellectuel illégitime, celui que l'on condamne sans l'avoir lu. Ce livre explique ce parcours singulier et les raisons de cette "descente aux enfers" de l'ancien philosophe du Bureau politique, avant sa condamnation ultime."--Page 4 of cover. (shrink)

Migrating Minds contributes to the prominent interdisciplinary domain of Cosmopolitan Studies with twenty innovative essays by humanities scholars from all over the world that re-examine theories and practices of cosmopolitanism from a variety of perspectives.

We address the old question whether a logical understanding of Quantum Mechanics requires abandoning some of the principles of classical logic. Against Putnam and others (Among whom we may count or not E. W. Beth, depending on how we interpret some of his statements), our answer is a clear "no". Philosophically, our argument is based on combining a formal semantic approach, in the spirit of E. W. Beth's proposal of applying Tarski's semantical methods to the analysis of physical theories, with (...) an empirical-experimental approach to Logic, as advocated by both Beth and Putnam, but understood by us in the view of the operationalrealistic tradition of Jauch and Piron, i. e. as an investigation of "the logic of yes-no experiments" (or "questions"). Technically, we use the recently-developed setting of Quantum Dynamic Logic (Baltag and Smets 2005, 2008) to make explicit the operational meaning of quantum-mechanical concepts in our formal semantics. Based on our recent results (Baltag and Smets 2005), we show that the correct interpretation of quantum-logical connectives is dynamical, rather than purely propositional. We conclude that there is no contradiction between classical logic and (our dynamic reinterpretation of) quantum logic. Moreover, we argue that the Dynamic-Logical perspective leads to a better and deeper understanding of the "non-classicality" of quantum behavior than any perspective based on static Propositional Logic. (shrink)

We investigate the discrete (finite) case of the Popper–Renyi theory of conditional probability, introducing discrete conditional probabilistic models for knowledge and conditional belief, and comparing them with the more standard plausibility models. We also consider a related notion, that of safe belief, which is a weak (non-negatively introspective) type of “knowledge”. We develop a probabilistic version of this concept (“degree of safety”) and we analyze its role in games. We completely axiomatize the logic of conditional belief, knowledge and safe belief (...) over conditional probabilistic models. We develop a theory of probabilistic dynamic belief revision, introducing probabilistic “action models” and proposing a notion of probabilistic update product, that comes together with appropriate reduction laws. (shrink)

We present a framework for epistemic logic, modeling the logical aspects of System 1 and System 2 cognitive processes, as per dual process theories of reasoning. The framework combines non-normal worlds semantics with the techniques of Dynamic Epistemic Logic. It models non-logically-omniscient, but moderately rational agents: their System 1 makes fast sense of incoming information by integrating it on the basis of their background knowledge and beliefs. Their System 2 allows them to slowly, step-wise unpack some of the logical consequences (...) of such knowledge and beliefs, by paying a cognitive cost. The framework is applied to three instances of limited rationality, widely discussed in cognitive psychology: Stereotypical Thinking, the Framing Effect, and the Anchoring Effect. (shrink)

In this paper we study natural deduction for the intuitionistic and classical (normal) modal logics obtained from the combinations of the axioms T, B, 4 and 5. In this context we introduce a new multi-contextual structure, called T-sequent, that allows to design simple labelfree natural deduction systems for these logics. After proving that they are sound and complete we show that they satisfy the normalization property and consequently the subformula property in the intuitionistic case.

Didier Zúñiga | : Le présent article examine la façon dont Charles Taylor a entrepris de poser le problème politique de la sécularisation. Plus spécifiquement, nous voudrions montrer que, si son effort pour articuler une théorie de l’aménagement de la diversité morale et religieuse a certes contribué à critiquer les régimes rigides de la laïcité, Taylor accorde une prééminence incontestable à la liberté de conscience. Or, notre analyse entend démontrer que, selon cette vue, il n’y a pas de place (...) pour l’autonomie religieuse. Notre hypothèse est qu’en présentant les conflits moraux et religieux comme des enjeux de justice, Taylor néglige l’important clivage existant entre, d’une part, les questions de reconnaissance reliées à la différence culturelle et, d’autre part, les revendications d’autorité exprimées par des groupes — et pas simplement des membres individuels — au sein de la sphère publique. | : This paper aims to challenge the assumption that Charles Taylor’s conception of political secularism is pluralist. The article argues that, although Taylor’s work provides the basis for an important critique of the most rigid forms of secularism, his theory places a strong focus on individual conscience. Yet Taylor’s almost exclusive concern for individual conscience excludes the pluralist claim to religious institutional autonomy. In addition, this article argues that Taylor presents moral and religious conflicts as questions of justice, which can be resolved with a correct interpretation of freedom of conscience. Against Taylor’s conception of “laïcité,” the article attempts to show that these problems are best grasped as conflicts between the authority of different groups—not just individuals—and that of the state. (shrink)

Political theory and philosophy need to widen their view of the space in which what matters politically takes place, and I suggest that integrating the conditions of sustainability of all affected—that is, all participants in nature's relations—is a necessary first step in this direction. New materialists and posthumanists have challenged how nature and politics have traditionally been construed. While acknowledging the significance of their contributions, I critically examine the ethical and political implications of their ontological project. I focus particularly on (...) how the decentering of human agency that they advocate for raises a set of concerns that need to be addressed in developing an appropriate ecological ethics. I argue that the latter must be attuned to the vulnerability of living beings who participate in relationships that sustain life on earth. This brings me to conclude that qualitative distinctions between the worlds ofbiosandtechneare necessary. This is because we need to think critically about ways of evaluating types of relationships so that we can assess them and establish which are worth nurturing and protecting and which are not. (shrink)

Facing the flood of contradictory interpretations of Nietzsche’s writings, is it still possible to assert anything positive about the political and intellectual stance of the author of « Zarathoustra »? In his massive study, Domenico Losurdo, Professor of Philosophy at the university of Urbino, argues that Nietzsche’s thoughts, even the most provocative, such as his defence of slavery or eugenics, should not be read as simple metaphors or innocent speculations aiming at the moral improvement of man, but constitute a specific, (...) agressively aristocratic, response to what, according to Nietzsche, is the main threat of his time : the rise of revolutionary ideals, and global democratisation of society. (shrink)

Pratiquer la phénoménologie, c'est reconduire les choses et les concepts aux horizons ou aux situations selon lesquels nous y accédons. Qu'advient-il si cet accès n'est plus seulement le fait du regard objectivant de la conscience ou de la préoccupation de l'existant mais également l'œuvre du corps? A la description des phénomènes se substitue alors l'enchaînement des scènes où ils apparaissent et dont ils sont la concrétisation : une dramatique des phénomènes. Qu'il s'agisse, par exemple, des relations entre le temps et (...) la chair chez Husserl, l'être et le vivant selon Heidegger, la différence ontologique et le corps pour Levinas, les études ici réunies s'attachent à cette dramatique des phénomènes qui atteste que les relations éidétiques ne sont pas des liens désincarnés. (shrink)

Facing the flood of contradictory interpretations of Nietzsche’s writings, is it still possible to assert anything positive about the political and intellectual stance of the author of « Zarathoustra »? In his massive study, Domenico Losurdo, Professor of Philosophy at the university of Urbino, argues that Nietzsche’s thoughts, even the most provocative, such as his defence of slavery or eugenics, should not be read as simple metaphors or innocent speculations aiming at the moral improvement of man, but constitute a specific, (...) agressively aristocratic, response to what, according to Nietzsche, is the main threat of his time : the rise of revolutionary ideals, and global democratisation of society. (shrink)

Manifesto for the recognition of the principle of linguistic and cultural diversity in language research Preamble Over the years, and for several decades now, higher education institutions have been gradually and increasingly urging teacher-researchers to increase their international visibility. It is normal for these teacher-researchers to participate in international debates in their disciplines. This is done during conferences and in the course of article writing, not for advertising purpo...

« La forme est sans doute quelque chose de la réalité, mais quelque chose qui se transmet à la faveur d’une relation causale qui met en rapport l’intelligible et le sensible : le premier est la cause du second, qu’il déter­mine comme tel, au moyen de la forme. ». Jean-François Pradeau : « Platon : les formes intelligibles ». Presses Universitaires de France, 2001. P. 53. Transmission, relation causale et mise en rapport qu'il faudrait compléter par dialogue et participation pour (...) planter le dé... (shrink)

Much work in care ethics and disability studies is concerned with the flourishing of human animals as an independent species. As a result, it focuses on how the built environments and the social structures that produce them restrict and exclude us. This paper addresses this problem and provides tentative first steps towards sketching an account of ethics that is structured around the interdependent nature of human and more than human life. I argue that our embodied existence places us in a (...) shared condition of vulnerability with all forms of life on earth. This allows us to conceive of caring as an essential condition of the sustainability and well-being of social and ecological life systems. To this end, I discuss the notion of anthropocentrism – and the attendant notion of Anthropocene – and argue that the conception of human animality that underwrites it posits a disembodied and homogenous ‘anthropos’ that is equally responsible for and equally affected by unsustainable social systems. Further, I examine the debate that opposes realist and constructivist accounts of nature, and I argue that it is inadequate to look at nature through the lenses of the predatory social systems that are responsible for ecological injustices in the first place. (shrink)

Although it is usually assumed that in Michel Foucault’s work biopolitics is a politics which has life for its object, a closer analysis of the courses he gave at the Collège de France on this topic, as well as of the other seminars and papers of this period, shows that he took a quite different direction, restricting it to the regulation of population. The aim of this article is to return to the origins of the concept and to confront the (...) issue of life as such. This implies four shifts with respect to Foucault’s theory: Politics is not only about the rules of the game of governing, but also about its stakes. More than the power over life, contemporary societies are characterized by the legitimacy they attach to life. Rather than a normalizing process, the intervention in lives is a production of inequalities. The politics of life, then, is not only a question of governmentality and technologies, but also of meaning and values. The discussion is grounded on a series of empirical investigations conducted in France and South Africa on how life and lives are treated in our world. (shrink)

Agency and representation are viewed as preconditions for democratic action. The dominant understanding of agency and representation is defined in terms of certain capacities and abilities that are considered to constitute the basis of personhood. The article will put into question this understanding and the assumptions that underpin it and argue that it rests on a mistaken conception of human animality – one that reduces the self to an autonomous and disembodied rational mind. The article will also suggest that it (...) is problematic because it marginalizes more than human forms of life – as well as those of us who are differently human – and excludes their points of view from the political processes of world making. In contrast, I will put forward an understanding of agency and representation that is attuned to the relational dimensions of all life on earth. By paying attention to the semiotic propensities that all forms of life share – which entails considering nonlinguistic forms of communication – this article responds to the need for more radically democratic ways of listening, giving voice, and caring for the earth’s beings and the relations that form the conditions for life to flourish. (shrink)

A phenomenological approach to questions of the body, ego, temporality and intersubjective relations with the 'other' by a leading French thinker and Husserl scholar.

A radically new philosophy of experience and speculation, based on a reading of Whitehead's Process and Reality. Can experience be thought systematically without transforming the richness of the world as it is lived into reductive philosophical generalities? Can the method of empiricism ever be reconciled with a method of systematic cosmological speculation? Didier Debaise's reading of Whitehead shows clearly what a philosophy that makes this possible looks like, how it works and what is at stake. He focuses in on (...) Whitehead's attempt to construct a metaphysical system of everything in the universe that exists whilst simultaneously claiming that it can account for every element of our experience: everything enjoyed and perceived, willed or thought. (shrink)