Biological sample and data transfer within and out of Africa is steeped in controversy With the H3Africa project now aiming to establish biobanks in Africa, it is essential that there are ethical and legal governance structures in place to oversee the operation of these biobanks. Such governance is essential to ensuring that donors are protected, that cultural perspectives are respected and that researchers have a ready availability of ethically sourced biological samples.

Although scholars continue to debate the influence of social media on body image, increased social media use, especially engaging in appearance-related behaviors may be a potential risk factor for body dissatisfaction in adolescents. Little research has investigated how adolescents process appearance-related content and the potential strategies they use to protect body image perceptions on social media. To investigate coping strategies used by adolescents, four qualitative focus groups were conducted with 29 adolescents aged 15–16 years in mixed-gender Irish secondary schools. Thematic (...) analysis revealed that adolescents employed many different behavioral strategies such as avoiding negative content and selecting positive content. Cognitive processing strategies such as critically evaluating body-related content, psychologically distancing from and positively reframing challenging content were also used, although less frequently. Boys appeared to exhibit greater positive agency over their bodies and social media use and tended to use more active coping styles than girls. Efforts to promote body image on social media such as body positive pages and exposing artificial social media content were considered limited in their effectiveness. (shrink)

Bill D'Alessandro talks to Kenny Easwaran about fractal music, Zoom conferences, being a good referee, teaching in math and philosophy, the rationalist community and its relationship to academia, decision-theoretic pluralism, and the city of Manhattan, Kansas.

Research, innovation, and progress in the life sciences are increasingly contingent on access to large quantities of data. This is one of the key premises behind the “open science” movement and the global calls for fostering the sharing of personal data, datasets, and research results. This paper reports on the outcomes of discussions by the panel “Open science, data sharing and solidarity: who benefits?” held at the 2021 Biennial conference of the International Society for the History, Philosophy, and Social Studies (...) of Biology, and hosted by Cold Spring Harbor Laboratory. (shrink)

Genomic biobanking research is undergoing exponential growth in Africa raising a host of legal, ethical and social issues. Given the scientific complexity associated with genomics, there is a growing recognition globally of the importance of science translation and community engagement for this type of research, as it creates the potential to build relationships, increase trust, improve consent processes and empower local communities. Despite this level of recognition, there is a lack of empirical evidence of the practise and processes for effective (...) CE in genomic biobanking in Africa. To begin to address this vacuum, 17 in-depth face to face interviews were conducted with South African experts in genomic biobanking research and CE to provide insight into the process, benefits and challenges of CE in South Africa. Emerging themes were analysed using a contextualised thematic approach. Several themes emerged concerning the conduct of CE in genomic biobanking research in Africa. Although the literature tends to focus on the local community in CE, respondents in this study described three different layers of stakeholder engagement: community level, peer level and high level. Community level engagement includes potential participants, community advisory boards and field workers; peer level engagement includes researchers, biobankers and scientists, while high level engagement includes government officials, funders and policy makers. Although education of each stakeholder layer is important, education of the community layer can be most challenging, due to the complexity of the research and educational levels of stakeholders in this layer. CE is time-consuming and often requires an interdisciplinary research team approach. However careful planning of the engagement strategy, including an understanding of the differing layers of stakeholder engagement, and the specific educational needs at each layer, can help in the development of a relationship based on trust between the research team and various stakeholder groups. Since the community layer often comprises vulnerable populations in low and middle income countries, co-development of innovative educational tools on genomic biobanking is essential. CE is clearly a component of a broader process best described as stakeholder engagement. (shrink)

ABSTRACTGiven the centrality of corporations in distribution of income and wealth studies, discursive constructions of corporate taxation are essential to understanding the production of inequality. The focus of this study is an interview with Apple’s Chief Executive Tim Cook on the Irish state broadcaster, Raidió Teilifís Éireann’s flagship news programme, Morning Ireland, following the ruling by the European Commission on the corporation tax arrangements between Apple Inc. and Ireland. Drawing on a Critical Discourse Analysis approach, a frame analysis is provided. (...) The significance and extent of the EC’s ruling has potential implications for corporation taxation policy, within and beyond the European Union, which provides a timely reflection in the Brexit era and in the context of rising economic nationalism generally. Thus, the discursive construction of this ruling in the media is of importance in understanding how inequality is produced and reproduced, and journalism’s role therein. (shrink)

Population biobanks are an increasingly important infrastructure to support research and will be a much-needed resource in the delivery of personalised medicine. Artificial intelligence (AI) systems can process and cross-link very large amounts of data quickly and be used not only for improving research power but also for helping with complex diagnosis and prediction of diseases based on health profiles. AI, therefore, potentially has a critical role to play in personalised medicine, and biobanks can provide a lot of the necessary (...) baseline data related to healthy populations that will enable the development of AI tools. To develop these tools, access to personal data, and in particular, sensitive data, is required. Such data could be accessed from biobanks. Biobanks are a valuable resource for research but accessing and using the data contained within such biobanks raise a host of legal, ethical, and social issues (ELSI). This includes the appropriate consent to manage the collection, storage, use, and sharing of samples and data, and appropriate governance models that provide oversight of secondary use of samples and data. Biobanks have developed new consent models and governance tools to enable access that address some of these ELSI-related issues. In this paper, we consider whether such governance frameworks can enable access to biobank data to develop AI. As Italy has one of the most restrictive regulatory frameworks on the use of genetic data in Europe, we examine the regulatory framework in Italy. We also look at the proposed changes under the European Health Data Space (EHDS). We conclude by arguing that currently, regulatory frameworks are misaligned and unless addressed, accessing data within Italian biobanks to train AI will be severely limited. (shrink)

Internationally, the need to advance science, technology, engineering and mathematics education is recognized as being vital for meeting social and economic challenges and developing a scientifically, mathematically, and technologically literate citizenry. In many countries, however, there are gender differences in the participation and achievement of girls and women in STEM education and STEM careers, usually to the disadvantage of females. This paper aims to identify challenges to female students’ participation in STEM both at post-primary level and beyond in the Irish (...) context. The research questions we aim to address in this paper are: what are student attitudes towards science, technology, engineering and mathematics as measured through interest and perceived ability in STEM, students’ valuing of STEM and students’ commitment to STEM? and what gender differences occur regarding students’ attitudes to science, technology, engineering and mathematics? A survey was completed by 308 post-primary students in Ireland as part of a one-year research project titled “STEMChAT: Women as catalysts for change in STEM education.” Data analysis compiled descriptive statistics, including response frequencies and percentages and median and interquartile range values, and compared gender differences in survey responses using the Kruskal–Wallis H Test. Results indicated that female students had significantly more positive attitudes to science compared to males while in comparison, males had significantly more positive responses to mathematics compared to females. Challenges regarding access to and understanding of STEM in the context of post-primary education are discussed. (shrink)

South Africa has made great progress in the development of HIV/AIDS testing, treatment and prevention campaigns. Yet, it is clear that prevention and treatment campaigns alone are not enough to bring this epidemic under control.

Background:A high prevalence of cognitive impairment and frailty complicates the feasibility of advance care planning in the long-term-care population.Research aim:To identify challenges in implementing the ‘Let Me Decide’ advance care planning programme in long-term-care.Research design:This feasibility study had two phases: (1) staff education on advance care planning and (2) structured advance care planning by staff with residents and families.Participants and research context:long-term-care residents in two nursing homes and one community hospital.Ethical considerations:The local research ethics committee granted ethical approval.Findings:Following implementation, over (...) 50% of all residents had completed some form of end-of-life care plan. Of the 70 residents who died in the post-implementation period, 14% had no care plan, 10% (with capacity) completed an advance care directive and lacking such capacity, 76% had an end-of-life care plan completed for them by the medical team, following discussions with the resident (if able) and family. The considerable logistical challenge of releasing staff for training triggered development of an e-learning programme to facilitate training.Discussion:The challenges encountered were largely concerned with preserving resident’s autonomy, avoiding harm and suboptimal or crisis decision-making, and ensuring residents were treated fairly through optimisation of finite resources.Conclusions:Although it may be too late for many long-term-care residents to complete their own advance care directive, the ‘ Let Me Decide’ programme includes a feasible and acceptable option for structured end-of-life care planning for residents with variable capacity to complete an advance care directive, involving discussion with the resident (to the extent they were able) and their family. While end-of-life care planning was time-consuming to deliver, nursing staff were willing to overcome this and take ownership of the programme, once the benefits in improved communication and enhanced peace of mind among all parties involved became apparent in practice. (shrink)

Organ transplantation has been central to debates on medical technologies and their complex biopolitical consequences, new forms of medical governance and new opportunities for capital. Attending to transplantation has also opened up new ways of thinking about, acting on and living ‘in’ the body, raising important questions about what it means to be embodied under particular cultural conditions. The specific ways in which a technology like transplantation puts the body parts of some at the disposal of the bodies of others (...) has served to (re)write bodily boundaries, commoditise body parts and reorganise the social relations of exchange, care and responsibility. The controversies that this family of technologies has given rise to are both readable and read as embedded in and expressive of wider forms of conflict and contestation. Putting these controversies and their entanglements centre-stage, this article focuses on the manner in which transplant technologies construct their publics in gendered and socially stratified terms, as they reconstruct the transplanted organ as a new site for the extraction of surplus value. Drawing on data from fieldwork in Mexico, I will examine the catastrophic consequences of transplant medicine for Mexico’s poor, particularly women who bear the burden of care for the country’s predominantly living transplant programme. In carrying the costs (moral, social and economic) their accounts of these processes offer us an important critical vantage point from which to assess the interplay between state, market and the ‘worn’ body in the context of transplantation. (shrink)

Narratives of the experience of pulmonary tuberculosis are relatively rare in the Irish context. A scourge of the early twentieth century, TB was as much a social as a physically debilitating disease that rendered sufferers silent about their experience. Thus, the personal diaries and letters of Irish poet, Seán Ó Ríordáin, are rare. This article presents translations of his personal papers in a historico-medical context to chronicle Ó Ríordáin’s experience of a life marred by respiratory disease. Familiar to generations of (...) schoolchildren are his imaginative poems, whose lively metre punctuated the Irish language curriculum from primary through to secondary schooling; for most they leave an indelible mark. Such buoyant poems however belie the reality of his existence, lived in the shadow of chronic illness, and punctuated with despair over his condition and anxiety about the periods of extended sick leave his illness necessitated. Although despair dominated his diaries and he routinely begged God, Mary, the Saints and the devil for death, they were also the locus where his creativity developed. In his diaries, caricatures of friends and sketches of everyday things nestle among the first lines of some of his most influential poems and quotes from distinguished philosophers and writers. Evocative and tragic, his diaries offer a unique prism to the experience of respiratory disease in Ireland. (shrink)

Previous research has successfully used feature integration theory to operationalise the predictions of Perceptual Load Theory, while simultaneously testing the predictions of both models. Building on this work, we test the extent to which these models hold up in a 3D world. In two experiments, participants responded to a target stimulus within an array of shapes whose apparent depth was manipulated using a combination of monoscopic and stereoscopic cues. The search task was designed to test the predictions of feature integration (...) theory, as the target was identified by a single feature or a conjunction of features and embedded in search arrays of varying size, and perceptual load theory, as the task included congruent and incongruent distractors presented alongside search tasks imposing high or low perceptual load. Findings from both experiments upheld the predictions of feature integration theory, regardless of 2D/3D condition. Longer search times in conditions with a combination of monoscopic and stereoscopic depth cues suggests that binding features into three-dimensional objects requires greater attentional effort. This additional effort should have implications for perceptual load theory, yet our findings did not uphold its predictions; the effect of incongruent distractors did not differ between conjunction search trials and feature search trials. Individual differences in susceptibility to the effects of perceptual load were evident and likely explain the absence of load effects. Overall, our findings suggest that feature integration theory may be useful for predicting attentional performance in a 3D world. (shrink)

We introduce a family of rules for adjusting one's credences in response to learning the credences of others. These rules have a number of desirable features. 1. They yield the posterior credences that would result from updating by standard Bayesian conditionalization on one's peers' reported credences if one's likelihood function takes a particular simple form. 2. In the simplest form, they are symmetric among the agents in the group. 3. They map neatly onto the familiar Condorcet voting results. 4. They (...) preserve shared agreement about independence in a wide range of cases. 5. They commute with conditionalization and with multiple peer updates. Importantly, these rules have a surprising property that we call synergy - peer testimony of credences can provide mutually supporting evidence raising an individual's credence higher than any peer's initial prior report. At first, this may seem to be a strike against them. We argue, however, that synergy is actually a desirable feature and the failure of other updating rules to yield synergy is a strike against them. (shrink)

Smith gives an excellent overview on research in language evolution, in which he discusses several recent models of how linguistic systems and the cognitive capacities involved in language learning may have co‐evolved. He illustrates how combined pressures on language learning and communication/use produce compositionally structured languages. Once in place, a (culturally transmitted) communication system creates new selection pressures on the capacity for acquiring these systems.

The ability to learn cause–effect relations from experience is critical for humans to behave adaptively — to choose causes that bring about desired effects. However, traditional experiments on experience-based learning involve events that are artificially compressed in time so that all learning occurs over the course of minutes. These paradigms therefore exclusively rely upon working memory. In contrast, in real-world situations we need to be able to learn cause–effect relations over days and weeks, which necessitates long-term memory. 413 participants completed (...) a smartphone study, which compared learning a cause–effect relation one trial per day for 24 days versus the traditional paradigm of 24 trials back- to- back. Surprisingly, we found few differences between the short versus long timeframes. Subjects were able to accurately detect generative and preventive causal relations, and they exhibited illusory correlations in both the short and long timeframe tasks. These results provide initial evidence that experience-based learning over long timeframes exhibits similar strengths and weaknesses as in short timeframes. However, learning over long timeframes may become more impaired with more complex tasks. (shrink)

Genomic and biobank research has undergone exponential growth in Africa. Traditionally this resulted in exploitative research practices in the form of so-called ‘parachute research’ with little or no consideration for capacity building. However there has been a recent growth of research and consortia where capacity building and equitable research have been a key objective of the research, and attention is now focused on the governance of this research. The importance of solidarity in genomic biobank research in high income countries is (...) well established and such an ethos reflects the communal based worldviews prevalent in many African communities. However, if the governance of the research is to foster equitable research practices, there must be some reciprocal benefit. This chapter will explore the impact that reciprocity will have on solidarity and how this may manifest in a governance framework in Africa. Particular focus will be given to capacity building and benefit sharing to enable the research to develop for the benefit of the local population, in a manner that promotes trust and fairness. This chapter will conclude with some recommendations on how to ensure reciprocity is enshrined in a governance framework for genomic biobank research in Africa. (shrink)

Many philosophers have argued that "degree of belief" or "credence" is a more fundamental state grounding belief. Many other philosophers have been skeptical about the notion of "degree of belief", and take belief to be the only meaningful notion in the vicinity. This paper shows that one can take belief to be fundamental, and ground a notion of "degree of belief" in the patterns of belief, assuming that an agent has a collection of beliefs that isn't dominated by some other (...) collection in terms of the overall balance of truth and falsity that it could contain. (shrink)

Many philosophers have become worried about the use of standard real numbers for the probability function that represents an agent's credences. They point out that real numbers can't capture the distinction between certain extremely unlikely events and genuinely impossible ones—they are both represented by credence 0, which violates a principle known as “regularity.” Following Skyrms 1980 and Lewis 1980, they recommend that we should instead use a much richer set of numbers, called the “hyperreals.” This essay argues that this popular (...) view is the result of two mistakes. The first mistake, which this essay calls the “numerical fallacy,” is to assume that a distinction that isn't represented by different numbers isn't represented at all in a mathematical representation. In this case, the essay claims that although the real numbers do not make all relevant distinctions, the full mathematical structure of a probability function does. The second mistake is that the hyperreals make too many distinctions. They have a much more complex structure than credences in ordinary propositions can have, so they make distinctions that don't exist among credences. While they might be useful for generating certain mathematical models, they will not appear in a faithful mathematical representation of credences of ordinary propositions. (shrink)

Carnage in the classroom, misogynists in high office, sociopaths in uniform, masculinity is a killer. From styles of dress to the stunted capacity for expressing a diversity of emotions, becoming a man involves killing off and repudiating anything that in our society is held as feminine. When a person is unable to show compassion and tenderness, or when exposed for their frailties, feels angry and humiliated, they have problems. Problems that none of us are immune to. Masculinity, Cremin provocatively declares, (...) is a generic disorder of a sick society that afflicts even the best of us. Neither a condition of being human nor even of male, it is a disorder, as she illustrates, of a capitalist society that depends and even thrives upon its very symptoms. From the perspective of a trans woman raised to be a man, the book maps the disorder and speculates on the possible means to overcome it. Instead of signifying weakness, catastrophes can be prevented when the qualities men often fear and women often feel subordinated to are prioritised, affirmed and nourished. Drawing, amongst others, on Marx and Freud, Cremin eloquently demonstrates why there can be no future other than one in which we are all reconciled as a society with the feminine. In such a future, the terms 'masculine' and 'feminine' will neither define us nor determine our relationship to one another. (shrink)

According to proper functionalist theories of warrant, a belief is warranted only if it is formed by cognitive faculties that are properly functioning according to a good, truth-aimed design plan, one that is often thought to be specified either by intentional design or by natural selection. A formidable challenge to proper functionalist theories is the Swampman objection, according to which there are scenarios involving creatures who have warranted beliefs but whose cognitive faculties are not properly functioning, or are poorly designed, (...) or are not aimed at truth. In this paper, we draw lessons from cognitive science in order to develop a novel argument for the conclusion that the Swampman objection fails against proper functionalist theories of warrant. Our argument not only shows that the underlying, central intuition motivating Swampman-like scenarios is false but also motivates proper function as a necessary condition for warrant, thereby lending support to the claim that any theory of knowledge that lacks a proper function requirement is false. (shrink)

Cross-situational learning is a mechanism for learning the meaning of words across multiple exposures, despite exposure-by-exposure uncertainty as to the word's true meaning. We present experimental evidence showing that humans learn words effectively using cross-situational learning, even at high levels of referential uncertainty. Both overall success rates and the time taken to learn words are affected by the degree of referential uncertainty, with greater referential uncertainty leading to less reliable, slower learning. Words are also learned less successfully and more slowly (...) if they are presented interleaved with occurrences of other words, although this effect is relatively weak. We present additional analyses of participants’ trial-by-trial behavior showing that participants make use of various cross-situational learning strategies, depending on the difficulty of the word-learning task. When referential uncertainty is low, participants generally apply a rigorous eliminative approach to cross-situational learning. When referential uncertainty is high, or exposures to different words are interleaved, participants apply a frequentist approximation to this eliminative approach. We further suggest that these two ways of exploiting cross-situational information reside on a continuum of learning strategies, underpinned by a single simple associative learning mechanism. (shrink)

Expected accuracy arguments have been used by several authors (Leitgeb and Pettigrew, and Greaves and Wallace) to support the diachronic principle of conditionalization, in updates where there are only finitely many possible propositions to learn. I show that these arguments can be extended to infinite cases, giving an argument not just for conditionalization but also for principles known as ‘conglomerability’ and ‘reflection’. This shows that the expected accuracy approach is stronger than has been realized. I also argue that we should (...) be careful to distinguish diachronic update principles from related synchronic principles for conditional probability. (shrink)

Si le développement du web a rendu accessibles des masses de données numériques, facilitant la collecte de textes et le développement de corpus, il a également donné naissance à de nouveaux genres qui défient les représentations, les méthodes et les grilles d’analyses développées jusqu’à présent. Ainsi a-t-on vu apparaître des corpus assez éloignés des premiers corpus écrits traditionnels, regroupés sous la bannière de la CMR (Communication Médiée par les Réseaux / Computer-Mediated Communica...

Bayesianism is a collection of positions in several related fields, centered on the interpretation of probability as something like degree of belief, as contrasted with relative frequency, or objective chance. However, Bayesianism is far from a unified movement. Bayesians are divided about the nature of the probability functions they discuss; about the normative force of this probability function for ordinary and scientific reasoning and decision making; and about what relation (if any) holds between Bayesian and non-Bayesian concepts.

To the extent that we have reasons to avoid these “bad B -properties”, these arguments provide reasons not to have an incoherent credence function b — and perhaps even reasons to have a coherent one. But, note that these two traditional arguments for probabilism involve what might be called “pragmatic” reasons (not) to be (in)coherent. In the case of the Dutch Book argument, the “bad” property is pragmatically bad (to the extent that one values money). But, it is not clear (...) whether the DBA pinpoints any epistemic defect of incoherent agents. The same can be said for Representation Theorem arguments, since they involve the structure of an agent’s preferences. (shrink)

Naive versions of decision theory take probabilities and utilities as primitive and use expected value to give norms on rational decision. However, standard decision theory takes rational preference as primitive and uses it to construct probability and utility. This paper shows how to justify a version of the naive theory, by taking dominance as the most basic normatively required preference relation, and then extending it by various conditions under which agents should be indifferent between acts. The resulting theory can make (...) all the decisions of classical expected utility theory, plus more in cases where expected utilities are infinite or undefined. Although the theory requires similarly strong assumptions to classical expected utility theory, versions of the theory can be developed with slightly weaker assumptions, without having to prove a new representation theorem for the weaker theory. This alternate foundation is particularly useful if probability is prior to preference, as suggested by the recent program to base probabilism on accuracy and alethic considerations rather than pragmatic ones. (shrink)

Frankfurt gave an account of “bullshit” as a statement made without regard to truth or falsity. Austin argued that a large amount of language consists of speech acts aimed at goals other than truth or falsity. We don't want our account of bullshit to include all performatives. I develop a modification of Frankfurt's account that makes interesting and useful categorizations of various speech acts as bullshit or not and show that this account generalizes to many other kinds of act as (...) well. I show that this illuminates some of Graeber's classification of “bullshit jobs,” though it doesn't fully agree with it. (shrink)

ACTION, EMOTION AND WILL "This a clear and persuasive book which contains as many sharp points as a thorn bush and an array of arguments that as neat and ...

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.4 (2003) 379-383 [Access article in PDF] Husserl at the Limits of Phenomenology: Including Texts by Edmund Husserl. Maurice Merleau-Ponty. Ed. Leonard Lawlor with Bettina Bergo. Trans. Leonard Lawlor. Evanston, IL: Northwestern University Press, 2002. Pp. 192. $19.95 pbk. The most striking characteristic of this volume is the manner that it presents layers of interpretation to the reader, particularly in that the writing is not intended (...) as a postmodern fête, and has limited value as a hermeneutic enterprise. Ultimately the book's true contribution is the seventy-nine pages devoted to the translation and printing of lecture notes used by [End Page 379] Merleau-Ponty in a class he gave at College de France, shortly before his death. However, the explanation of why this is so will have to be withheld until the end of this review.The course that Merleau-Ponty gave was organized around three essays published by Edmund Husserl. These essays are included in the volume reviewed here and must be briefly dealt with, as they are the core of whatever thinking occurs within and around this book. Interesting essays all, they deal with three longstanding issues of philosophical debate. The first essay challenges the classical notion of a transcendent ideal. Husserl attempts to show, through an examination of geometry, that an ideal is first called into existence when it is called into the realm of human experience, and he does this without ever resorting to the quality of detached being that Plato attributes to ideals. Then, in his second essay, Husserl attempts to defeat modernist cosmology, arguing, against Galileo, that the earth is a fixed point in the universe. Finally, his third essay hearkens back to Heraclitus and Parmenides, examining how human experience is able to extract a sense of atemporal quiddity in a world that is constantly falling into a past. A reader might be baffled that an intellectual could make such claims, but they are made from within the framework of phenomenology, and, within this paradigm as Husserl explains it, the claims he makes do not seem ridiculous at all. "The Origins of Geometry," "The Originary Ark, The Earth, Does Not Move," and "The World of the Living Present,"— these are the three essays that Merleau-Ponty forms his lecture course around. At sixty pages within this volume, they constitute one third of the text itself. For intellectual worth, I would say that these essays are the finest contribution in the text, but that claim is discounted because much of the essay material was already available in English translation. Nevertheless, it only makes sense to have it included in this volume in order to conveniently work back and forth between Merleau-Ponty's notes and Husserl's actual essays.However, that brings us to a significant problem within the text itself. If readers are like me, they will realize that it is often difficult to draw conclusions from the notes of others. Like secretarial shorthand, notes rely on a reader's ability to read both what has been written and what has been withheld in an expressive passage. There is no code that will allow us to recover what Merleau-Ponty recovered as he looked down on his podium at these notes and then raised his head to speak to his class. All that we have are the fragments, and they do not make a coherent argument, lacking both the clarity and the painstaking thoroughness that we find in books [End Page 380] such as The Phenomenology of Perception and The Visible and the Invisible. Certainly one cannot fault Merleau-Ponty for this—he did not write these notes for us, but for himself. His course might have been magnificent, even transcendent, but we will not know that from these fragments.I suppose it could be argued that the ambiguity inherent in such fragments liberates the text and opens it for some sort of radical hermeneutic exegesis; however, I sigh at the very thought of such an argument. Unless we intend to transform... (shrink)

This popular selection of Wittgenstein’s key writings has now been updated to include new material relevant to recent debates about the philosopher. Follows the evolution of Wittgenstein’s philosophical thought from the Tractatus Logico-Philosophicus through to the Philosophical Investigations. Excerpts are arranged by topic and introduce readers to all the central concerns of Wittgenstein’s philosophy. Now includes a new chapter on ‘Sense, Nonsense and Philosophy’ incorporating material relevant to recent debates about Wittgenstein.

In the first paper, I discussed the basic claims of Bayesianism (that degrees of belief are important, that they obey the axioms of probability theory, and that they are rationally updated by either standard or Jeffrey conditionalization) and the arguments that are often used to support them. In this paper, I will discuss some applications these ideas have had in confirmation theory, epistemol- ogy, and statistics, and criticisms of these applications.

Elevations in brain stimulation reward (BSR) thresholds have been observed in rats undergoing nicotine withdrawal and have been proposed as a sensitive measure of the negative affective state associated with nicotine withdrawal. mGluR are presynaptic autoreceptors that decrease glutamate release when stimulated. The aim of this study was to examine the role of glutamate neurotransmission in nicotine dependence. The mGluR agonist LY314582 (2.5–7.5 mg/kg) precipitated nicotine withdrawal as measured by elevations in BSR thresholds in nicotine-treated rats but not in controls. (...) It was hypothesized that LY314582 precipitated nicotine withdrawal by decreasing glutamatergic tone at postsynaptic glutamate receptors. Therefore, the effects of MPEP (0.5–2 mg/kg), an mGluR antagonist, and MK-801 (0.01–1 mg/kg), an NMDA receptor antagonist, were examined. MPEP elevated BSR thresholds by an equal magnitude in control and nicotine-treated rats. At low doses, MK-801 (0.01–0.2 mg/kg) lowered BSR thresholds to a similar extent in control and nicotine-treated rats. At higher doses, MK-801 (0.25–1 mg/kg) disrupted performance in nicotine-treated and control rats. These data indicate that mGluR and NMDA receptors regulate BSR in opposite directions in non-dependent animals, and chronic nicotine treatment does not alter these effects. Most importantly, the data demonstrate that the mGluR is involved in nicotine dependence, but mGluR and NMDA receptors do not mediate mGluR actions in nicotine dependence. (shrink)

In a series of papers, Don Fallis points out that although mathematicians are generally unwilling to accept merely probabilistic proofs, they do accept proofs that are incomplete, long and complicated, or partly carried out by computers. He argues that there are no epistemic grounds on which probabilistic proofs can be rejected while these other proofs are accepted. I defend the practice by presenting a property I call ‘transferability’, which probabilistic proofs lack and acceptable proofs have. I also consider what this (...) says about the similarities between mathematics and, on the one hand natural sciences, and on the other hand philosophy. (shrink)