The metabolic requirements of differentiated neurons are significantly different from that of neuronal precursor and neural stem cells. While a re‐programming of metabolism is tightly coupled to the neuronal differentiation process, whether shifts in mitochondrial mass, glycolysis, and oxidative phosphorylation are required (or merely consequential) in differentiation is not yet certain. In addition to providing more energy, enhanced metabolism facilitates differentiation by supporting increased neurotransmitter signaling and underpinning epigenetic regulation of gene expression. Both epidemiological and animal studies demonstrate that micronutrients (...) (MNs) significantly influence many aspects of neonatal brain development, particularly neural migration and survival, neurite outgrowth, and process maturation. Here we review recent insights into the importance of metabolic reprogramming in neuronal differentiation, before considering evidence that micronutrient signaling may be key to regulating these processes. (shrink)

Theory-ladenness is the view that observation cannot function in an unbiased way in the testing of theories because observational judgments are affected by the theoretical beliefs of the observer. Its more radical cousin, incommensurability, argues that because there is no theory-neutral language, paradigms, or worldviews, cannot be compared because in different paradigms the meaning of observational terms is different, even when the word used is the same. There are both philosophical and practical components to these problems. I argue, using a (...) procedurally-defined, theory-neutral experiment that paradigms are indeed commensurable. The practical problems of theory ladenness include experimental design, failure to interpret observations correctly, possible experimenter bias, and difficulties in data acquisition. I suggest that there are methods to deal with these problems, although sometimes they cannot be dealt with completely. I believe that the philosophical problems of theory-ladenness have been solved, although the practical problems remain. (shrink)

Calibration, the use of a surrogate signal to standardize an instrument, is an important strategy for the establishment of the validity of an experimental result. In this paper, I present several examples, typical of physics experiments, that illustrate the adequacy of the surrogate. In addition, I discuss several episodes in which the question of calibration is both difficult to answer and of paramount importance. These episodes include early attempts to detect gravity waves, the question of the existence of a 17–keV (...) neutrino, and the question of the existence of a Fifth Force in gravity. I argue that in these more complex cases, the adequacy of calibration, in an extended sense, was both considered and established. (shrink)

ABSTRACT As doctoral students from New Zealand and Australia, advised by supervision teams with a diversity of critical realist experience from limited to none, we came independently to the 2018 Critical Realism conference – primed to seek increased understanding, confidence, motivation, and reassurance. We certainly found these things from the pre-conference, presentations, and individuals within the critical realist community. We also found each other, and a virtual writing group was born. This article is a description of what we did, why, (...) and the outcomes we experienced over the final two years completing our theses. It identifies the structures, contexts, motivations, and mechanisms from which our emotional, critical realist and writing-related outcomes emerged. We outline the roles of serendipitous timing, culture, different disciplinary approaches, administrative structures, and types of interactions on the social learning we developed. We anchor our discussion in recent theoretical literature about the role of writing groups in doctoral education. (shrink)

In this article I suggest a tripartite classification of scientific activity; discovery, pursuit, and justification. I believe that such a classification can give us a more adequate description of scientific practice, help illuminate the various roles that evidence plays in science, and may also help to partially resolve differences between “constructivist” and “epistemologist” views of science. I argue that although factors suggested by the constructivists such as career goals, professional interests, utility for future practice, and agreement with existing commitments do (...) enter into pursuit, it is experimental evidence that is decisive in justification. I illustrate this with two case studies from the history of contemporary science, experiments on atomic parity violation and their relation to the Weinberg-Salam unified theory of electroweak interactions and the fifth force in gravity. I also answer some of the criticisms offered of my earlier account of the episode of atomic parity violation. (shrink)

Theurgy, the religious magic practised by the later Neoplatonists, has been commonly regarded as the point at which Neoplatonism degenerates into magic, superstition and irrationalism.1 A superficial glance at the ancient lives of the Neoplatonists, and in particular at Eunapius’ Lives of the Sophists, reveals a group of people interested in animating statues, favoured with visions of gods and demons, and skilled in rain-making. But when we look more closely at the works of the Neoplatonists themselves, rather than the stories (...) biographers tell about them, we find a considerable diversity of attitudes towards theurgy and a number of attempts to fit theurgy into their philosophical system. (shrink)

To explain the meaning of the Prometheus the late Dr. Walter Headlam quoted the famous lines from theAgamemnon:‘ Sing praise; ’Tis he hath guided, say, Man's feet in Wisdom's way, Stablishing fast for learning's rule That Suffering be her school….’ ‘This,’ he said, ‘is the school in which Prometheus himself is being gradually taught the wise humility; at present he is still in the rebellious stage. And it is with this idea that Io is introduced into the Prometheus Bound; she, (...) too, is an example of the seeming cruelty of Zeus; but it is a blessing in disguise, for she is to be the mother of the blessed Epaphus, and it is a son of Zeus by Alcmena, a descendant of her own, that is to set Prometheus free.’. (shrink)

The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

On the basis of an analysis of a single paper on plate tectonics, a paper whose actual content is nowhere in evidence, Frederick Suppe concludes that no standard model of confirmation—hypothetico-deductive, Bayesian-inductive, or inference to the best explanation—can account for the structure of a scientific paper that reports an experimental result. He further argues on the basis of a survey of scientific papers, a survey whose data and results are also absent, that papers which have a rather stringent length limit, (...) such as the one on plate tectonics, are typical of science. Thus, he concludes that no standard confirmation scheme is capable of dealing with scientific practice. Suppe also requires that an adequate model of philosophical testing should be able to account for everything in such scientific papers, in which space is at a premium. (shrink)

Many critics have condemned, some have defended, Euripides for composing a play ‘altogether wanting in the satisfaction which nothing but a unity of ideas could produce.’ It helps us little to marvel, with Paley, at the ‘obtuseness of critics who forsooth prefer “unity of ideas” to profoundly moving incidents, etc.,’ though it may be admitted that Paley has detected part of the truth when he calls attention to the importance of the fact that Athens is, throughout the play, the only (...) possible asylum for the hero. Verrall's analysis has the merit that it attempts to account for the play as a whole, but it is hard to believe that the Athenian audience was composed of subtle critics, endowed with Verrall's ingenuity and acumen. Still, though it is easy to disagree with Verrall, it is less easy to give the reasons for one's disagreement. In detail one can say: ‘The straightforward and obvious sense of the words is adequate; the subtle suggestion is not likely to have occurred to an audience which had never heard of Schlegel or of Swinburne.’ That leaves us with the fact that the impression made on most of us by the whole work is not one of formal perfection. To most readers there seem to be three episodes, each excellent, but not intimately connected with the other two: in the first we are concerned for the fate of the tyrant Lycus, and rejoice at his just destruction; in the second we are moved by the sudden reversal in the fortunes of the beneficent Heracles; and in the third we are impressed by the magnanimity, and, perhaps, delighted with the Athenian connections, of the excellent Theseus. There is a good deal of talk which we ascribe to the tendency of Euripides to make his characters the mouthpieces for current debate. There are choral odes which we think charming, but, on the whole and as a rule, slightly irrelevant to the main ‘incidents.’ My purpose in this paper is to suggest, first, that the audience was occupied with certain quite familiar ideas upon which Euripides has built his play, and was, therefore, not at leisure to catch at subtleties of detail, suggestions, ambiguities, ironies, points of logic and of lack of logic, such as Verrall emphasizes; and, secondly, that if we also remember these ideas, we shall find both unity in the construction and relevance in the choral odes. (shrink)

To explain the meaning of the Prometheus the late Dr. Walter Headlam quoted the famous lines from theAgamemnon:‘ Sing praise; ’Tis he hath guided, say, Man's feet in Wisdom's way, Stablishing fast for learning's rule That Suffering be her school….’ ‘This,’ he said, ‘is the school in which Prometheus himself is being gradually taught the wise humility; at present he is still in the rebellious stage. And it is with this idea that Io is introduced into the Prometheus Bound; she, (...) too, is an example of the seeming cruelty of Zeus; but it is a blessing in disguise, for she is to be the mother of the blessed Epaphus, and it is a son of Zeus by Alcmena, a descendant of her own, that is to set Prometheus free.’. (shrink)

This article examines how business students route themselves through the process of cognitive moral development (CMD) to arrive at a more autonomous level of CMD when there is an impetus to do so. In this study, two groups were given Rest’s Defining Issues Test; half the test 1 week and half three weeks later. In between, one group viewed a film of Milgram’s obedience study as a stimulus towards a more autonomous level of CMD. The results of the analysis indicate (...) that viewing the Milgram study produced a positive response regarding subjects’ level of autonomous CMD. However, the response was not uniform across the subject pool. Females showed a greater consistent significant positive response to viewing Milgram while male subjects varied their response contingent upon their functional area of study. While subjects’ functional area of study alone made little difference in the results, when taken in conjunction with gender, significant differences were found between groups. Thus, researchers should take care when investigating differences between subjects’ area of study since gender differences may be present even within an apparently homogenous population-like business students. (shrink)

Theurgy, the religious magic practised by the later Neoplatonists, has been commonly regarded as the point at which Neoplatonism degenerates into magic, superstition and irrationalism.1 A superficial glance at the ancient lives of the Neoplatonists, and in particular at Eunapius’ Lives of the Sophists, reveals a group of people interested in animating statues, favoured with visions of gods and demons, and skilled in rain-making. But when we look more closely at the works of the Neoplatonists themselves, rather than the stories (...) biographers tell about them, we find a considerable diversity of attitudes towards theurgy and a number of attempts to fit theurgy into their philosophical system. (shrink)

Experiments often disagree. How then can scientific knowledge be based on experimental evidence? In this paper I will examine four episodes from the history of recent physics: the suggestion of a Fifth Force, a modification of Newton’s law of gravitation; early attempts to detect gravitational radiation ; the claim that a 17-keV neutrino exists; and experiments on atomic-parity violation and on the scattering of polarized electrons and their relation to the Weinberg-Salam unified theory of electroweak interactions. In each of these (...) episodes discordant results were reported, and a consensus was later reached that one result—or set of results—was incorrect. I will examine the process of reaching that consensus. I will show that the decision was reached by reasoned discussion based on epistemological and methodological criteria. It then follows that we may use experimental evidence as the basis of scientific knowledge. (shrink)

Taking Parenting Public makes a compelling case that parenting has become dangerously undervalued in America today. It calls for a new investment—both personal and public—into the work of raising children and argues that we are all "stockholders" in the next generation. With a foreword by Sylvia Ann Hewlett and Cornel West, Taking Parenting Public crosses boundaries to bring together thinkers from diverse fields spanning the political spectrum. It features contributions from distinguished experts in economics, political science, public policy, child development, (...) public health, history, and the media. While recent books have focused on working mothers or absent fathers, Taking Parenting Public is the first volume to take a comprehensive look at the common struggles of parents. These essays go beyond the usual chest-beating about busy parents torn between work and family demands to suggest bold solutions. Instead of the typical call for "parent replacement"—more child care, more after school programs and more mentors—the contributors offer fresh strategies for "parent replenishment," ways to put mothers and fathers back into the lives of their children not only as economic providers, but also as emotional and moral providers. (shrink)

This paper presents the early findings of research into the experiences of pain for those who live with chronic pain and engage in BDSM (bondage and discipline, domination and submission, sadism and masochism), explored using a critical crip approach rooted in crip theory and feminist disability studies. The research took the form of a series of interviews with eight disabled people living with chronic pain who experience pain in their BDSM practices, developing a narrative of experiences. The majority of those (...) living with chronic pain, or who have diagnoses of chronic illnesses causing chronic pain, are women. Chronic pain is frequently assumed to be similar to acute pain; however, thinking through pain in terms of normativity and able-bodymindedness reveals the ableist structures that underpin normative attitudes towards pain and those who are in pain. Pain is understood as dehumanising—and thus the person living with chronic pain is understood as not human, abnormal, and disabled. The disabled body, the body in pain, is a horrifying object of abjection, and the non-disabled observer assumes that to be in pain is to suffer; therefore, living with chronic pain is understood as an ontological impossibility and must be stopped. BDSM is a series of practices forming a space in which the people living with chronic pain in this study are able to engage with their somatic experience in ways that do not expect normalcy, while being disabled and living with chronic pain gives them space to explore non-normative sexual practices. (shrink)

Ecclesiazusae, the first surviving work of Aristophanes from the fourth centuryb.c.e., has often been dismissed as an example of Aristophanes’ declining powers and categorized as being less directly rooted in politics than its fifth-century predecessors owing to the after-effects of Athens’ defeat in the Peloponnesian War. Arguing against this perception, which was largely based on the absence of ad hominem attacks characterizing Aristophanes’ earlier works, this paper explores howEcclesiazusaeengages with contemporary post-war Athenian politics in a manner which, while different to (...) his earlier comedies, remained closely rooted in the political and cultural concerns of the 390s. By examining the figure of Praxagora, I will first consider recent suggestions thatEcclesiazusaehints at the possibility of an anti-democratic coup. I will then examine how contemporary discussions of constitutional and legal reforms (including the invocation of ‘founding fathers’ such as Solon and Lycurgus) are incorporated into both Praxagora's language and the scenes featuring the Selfish Man and Hags that follow the establishment of Praxagora's regime. Examining these final scenes, I conclude thatEcclesiasuzaedoes not suggest that the idea of democratic equality itself is fundamentally flawed, but instead argues that Athens needs a suitable leader, well suited to the rough and tumble of assembly rhetoric, in order to successfully function. In the world ofEcclesiazusae,the men of Athens have failed too often to inspire any hope, putting their own interest above the state, and the new leader must be someone different. Thus Aristophanes sets up Praxagora as a female Solon to remake the state and lead the democracy. The second half of the play demonstrates this need for a strong leader, as problems arise both from the quarter of critical bystanders (the Selfish Man and Epigenes, the Young Man in the ‘hag scene’) and from over-zealous enforcers (the Old Women). (shrink)

ArgumentThis article explores the history of mummy unwrappings in the West, culminating in Margaret Murray's public unrolling of two mummies in Manchester in 1908. Mummy unwrappings as a practice have shifted often between public spectacles which displayed and objectified exotic artifacts, and scientific investigations which sought to reveal medical and historical information about ancient life. Although others have looked at Murray's work in the context of the history of mummy studies, I argue that her work should be viewed culturally as (...) poised between spectacle and science, drawing morbid public interest while also producing ground-breaking scientific work that continues to this day. Murray's main goal was to excite the interest of the public while at the same time educating them in the true history of ancient Egypt, while ascertaining new scientific information and contributing to the scholarly interpretations of ancient Egypt. (shrink)