A partire dal riepilogo per fasi temporali distinte delle vicende dell’architettura italiana del Novecento si propone in queste note un’interpretazione del suo ultimo trentennio. Si tratta di un periodo particolarmente importante, situato tra la fine del “secolo breve” e l’inizio del nuovo, nel quale l’eredità moderna si confronta in Italia, come in altri paesi, con tematiche contemporanee. Tale eredità dà vita a una molteplicità talmente accentuata di orientamenti da risultare a volte difficilmente decifrabile nelle intenzioni che esprime e nei risultati (...) conseguiti. Qualche paragrafo del testo è stato dedicato a illustrare la singolarità teorica e operativa dell’architettura italiana, soprattutto per ciò che concerne il suo rapporto con la modernità. Un rapporto contrattato più volte, sulla base di alcune condizioni ritenute essenziali, che appare ancora oggi incompleto e controverso. Tornando al trentennio in esame lo si è diviso in tre stagioni, identificate sia da logiche interne all’architettura italiana sia da fenomeni e da avvenimenti esterni. Esso vede il dibattito disciplinare confrontarsi con alcune nuove situazioni che lo stanno modificando in profondità. La rivoluzione digitale, la globalizzazione, il primato della tecnica, la presenza degli specialismi, la pressione mediatica, la prevalenza del presente, la sostenibilità definiscono nel loro insieme un campo problematico quanto mai complesso e contradditorio. La cultura architettonica italiana reagisce a questa condizione dividendosi tra il rifletterla e il contrastarla. Nell’analisi di questo periodo si è cercato non tanto di esporre opinioni e giudizi su ciò che è stato sintetizzato, quanto di costruire un elenco di temi e di motivi il più possibile completo che mettesse il lettore in grado di formulare liberamente alcune possibili ipotesi interpretative riguardanti un arco temporale denso di elementi di notevole interesse storico e critico. (shrink)

Through extensive training, experts acquire specialized knowledge and abilities. In this paper, I argue that experts also acquire specialized visual experiences. Specifically, I articulate and defend the account that experts enjoy visual experiences that represent gestalt properties through perceptual learning. I survey an array of empirical studies on face perception and perceptual expertise that support this account. I also look at studies on perceptual adaptation that some might argue present a problem for my account. I show how the (...) data are subject to an interpretation that is friendly to it. Last, I address two theoretical objections to the claim that visual experiences represent gestalt properties. (shrink)

This paper explains conceptual modeling within the framework of Frame-Based Terminology (Faber, 2012; 2015; 2022), as applied to EcoLexicon (ecolexicon.ugr.es), a specialized knowledge base on the environment (León-Araúz, Reimerink &, Faber, 2019; Faber & León-Araúz, 2021). It describes how a frame-based terminological resource is currently being restructured and reengineered as an initial step towards its formalization and subsequent transformation into an ontology. It also explains how the information in EcoLexicon can be integrated in environmental ontologies such as ENVO (Buttigieg, (...) Morrison, Smith, Mungall & Lewis, 2013; Buttigieg, Pafilis, Lewis, Schildhauer, Walls & Mungall, 2016), particularly at the bottom tiers of the Ontology Learning Layer Cake (Cimiano, 2006; Cimiano, Maedche, Staab & Volker, 2009). The assumption is that frames, as a conceptual modeling tool, and information extracted from corpora can be used to represent the conceptual structure of a specialized domain. (shrink)

Specialized Justice addresses the question of the desirability of specialization in the administration of justice. Should there be more, rather than less, sub-division of the judiciary into specialized tribunals? What is most desirable in terms of efficiency, speed, true justice, and cost? The author attempts to answer these questions both by examining theoretical paradigms and also by describing the results of an empirical study which he has undertaken. He concludes by examining variables that apply in different jurisdictions and (...) which should, if accounted for properly, allow generalized lessons to be extracted from the individual studies. (shrink)

Three proteins used to initiate DNA replication and carry out site‐specific recombination in E. coli generate organized nucleoprotein structures at their target sites. The association of proteins bound at multiple sites on DNA presumably folds or winds the DNA to produce a specific three‐dimensional conformation. This specialized nucleoprotein structure may be a general mechanism for achieving very high fidelity in DNA transactions in which even a rare mistake must be avoided. The overall interaction is more complex than that of (...) prokaryotic transcription regulators studied so far, but might be characteristic of eukaryotic transcription regulators, for which the problem of site‐localization is more difficult. (shrink)

Linear chromosomes shorten in every round of replication. In Drosophila, telomere‐specialized long interspersed retrotransposable elements (LINEs) belonging to the jockey clade offset this shortening by forming head‐to‐tail arrays at Drosophila telomere ends. As such, these telomeric LINEs have been considered adaptive symbionts of the genome, protecting it from premature decay, particularly as Drosophila lacks a conventional telomerase holoenzyme. However, as reviewed here, recent work reveals a high degree of variation and turnover in the telomere‐specialized LINE lineages across Drosophila. (...) There appears to be no absolute requirement for LINE activity to maintain telomeres in flies, hence the suggestion that the telomere‐specialized LINEs may instead be neutral or in conflict with the host, rather than adaptive. (shrink)

In C. elegans and D. melanogaster, specialized sites have an important role in meiotic recombination. Recent evidence has shown that these sites in C. elegans have a role in synapsis. Here we compare the initiation of synapsis in organisms with specialized sites and those without. We propose that, early in prophase, synapsis requires an initiator to overcome inhibitory factors that function to prevent synaptonemal complex (SC) formation between nonhomologous sequences. These initiators of SC formation can be stimulated by (...) crossover sites, possibly other types of recombination sites and also specialized sites where recombination does not occur. BioEssays 29: 217–226, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

RESUMEN La discapacidad que afecta a la población infantil constituye un problema emergente; diagnosticarla y tratarla de manera integral es parte del trabajo diario del profesional de Enfermería en la atención primaria de salud. Durante el estudio se identificaron carencias en las habilidades profesionales de los licenciados en Enfermería respecto a este saber. Se aplicó un entrenamiento encaminado al desarrollo de habilidades profesionales especializadas para la atención integral a la discapacidad infantil en este personal. Por ello el objetivo del presente (...) trabajo está dirigido a exponer los resultados del entrenamiento. Los métodos y técnicas empleados incluyeron la observación científica, encuesta, entrevista, la técnica de grupo focal y el criterio de expertos. El entrenamiento se sometió al criterio de expertos. Se corroboró su impacto positivo como una vía importante para la preparación y desarrollo de habilidades profesionales en la muestra seleccionada. ABSTRACT The disability that affects the children population constitutes an emergent problem; to diagnose it and to treat it as an integral way is a part of the daily work of the professional of Infirmary in the primary health care. During the study, lacks in the professional skills of the Bachelors of Infirmary with regard to this know ledge were identified. There was applied a training directed to the development of specialized professional skills for the integral attention to the infant disability in this personnel. That is why the objective of the present work is directed to exhibit the results of the training. The methods and techniques used included the scientific observation, polls, interviews, the technique of focal group and the experts' criteria. The training was surrendered to the experts' criteria. It was corroborated its positive impact as an important route for the preparation and development of professional skills in the chosen sample. (shrink)

By the decree of the Presidium of the Higher Attestation Commission of Ukraine of 08.02.1996. Approved composition of the Specialized Academic Council D. 01.25.05 on specialty 05.00.11 - Religious studies. The Council was established at the Department of Religious Studies at the Institute of Philosophy of the National Academy of Sciences of Ukraine. Being the only one in Ukraine on its profile, it is the main link in the system of certification of scientific personnel of the highest qualification in (...) this specialty. (shrink)

The remodel the structure of chromatin (RSC) nucleosome remodeling complex is a conserved chromatin regulator with roles in chromatin organization, especially over nucleosome depleted regions therefore functioning in gene expression. Recent reports in Saccharomyces cerevisiae have identified specificities in RSC activity toward certain types of nucleosomes. RSC has now been shown to preferentially evict nucleosomes containing the histone variant H2A.Z in vitro. Furthermore, biochemical activities of distinct RSC complexes has been found to differ when their nucleosome substrate is partially unraveled. (...) Mammalian BAF complexes, the homologs of yeast RSC and SWI/SNF complexes, are also linked to nucleosomes with H2A.Z, but this relationship may be complex and extent of conservation remains to be determined. The interplay of remodelers with specific nucleosome substrates and regulation of remodeler outcomes by nucleosome composition are tantalizing questions given the wave of structural data emerging for RSC and other SWI/SNF family remodelers. (shrink)

Explanations in genetics have intriguing aspects to both biologists and philosophers, and there is no account that satisfactorily elucidates such explanations. The aim of this article is to analyze the kind of explanations usually given in Classical (Transmission) Genetics (CG) and to present in detail the application of an account of explanation as ampliative, specialized nomological embedding to elucidate the such explanations. First, we present explanations in CG in the classical format of inferences with the explanans as the premises (...) and the explanandum as the conclusion and compare them with explanations in other paradigmatic explanatory fields such as Classical Mechanics. Second, we summarize the main aspects discussed in the literature with regard the peculiarities of genetic explanations. Third, we introduce the account of scientific explanation as ampliative, specialized nomological embedding making use of Sneedian structuralism, in particular the notions of theory-net, fundamental law or guiding principle, specialization, and special laws. Finally, we apply this account to the case of CG and show that this analysis sheds light to the intriguing aspects of genetic explanations and remove most of their alleged oddities. (shrink)

At present, specialized knowledge of human beings, society, and culture can be subdivided into the three principal conventional modalities: the philosophical, the humanistic, and the social-scientific. Each of those modalities is identifiable by its specific foundations, which are determined by the orientation, object, methods, and results of knowledge.

This study analyzes the interests of Spanish audiences in travel magazines within the current context of press consumption. The objectives are to identify the readers' reading frequency and reasons for reading, what contents interest them, and what aspects of the photographs attract them. The methodology involves a structured questionnaire completed by a representative sample of the Spanish population (n=1000). The main results reveal a low reading frequency, great interest in practical information, preference for landscape photography (over the age of 54) (...) and nightlife photography (young people), and indifference regarding the journalistic source of the images. These data provide relevant information on which to adapt travel magazines' content strategy. (shrink)

Face recognition is a computationally challenging classification task. Deep convolutional neural networks (DCNNs) are brain‐inspired algorithms that have recently reached human‐level performance in face and object recognition. However, it is not clear to what extent DCNNs generate a human‐like representation of face identity. We have recently revealed a subset of facial features that are used by humans for face recognition. This enables us now to ask whether DCNNs rely on the same facial information and whether this human‐like representation depends on (...) a system that is optimized for face identification. In the current study, we examined the representation of DCNNs of faces that differ in features that are critical or non‐critical for human face recognition. Our findings show that DCNNs optimized for face identification are tuned to the same facial features used by humans for face recognition. Sensitivity to these features was highly correlated with performance of the DCNN on a benchmark face recognition task. Moreover, sensitivity to these features and a view‐invariant face representation emerged at higher layers of a DCNN optimized for face recognition but not for object recognition. This finding parallels the division to a face and an object system in high‐level visual cortex. Taken together, these findings validate human perceptual models of face recognition, enable us to use DCNNs to test predictions about human face and object recognition as well as contribute to the interpretability of DCNNs. (shrink)

Is it possible to use the courts - or rights instruments - to advance fair access to health care? This article examines this question within the context of the Norwegian public health care system - one special example of the Scandinavian welfare system. In particular, it asks four basic questions: What are the normative justifications for rights to health care? What were the political processes and concerns leading up to the current Patients Rights Act in Norway? What kind of legal (...) status do these rights have? How can rights to access be implemented?Patient rights do not only concern the right to access to health care; they also include the right to information, the right to participate in decision-making, and informed consent. This article examines only the former aspect, the use of the legal system to secure access to prioritized specialized health care services. (shrink)

Is it possible to use the courts - or rights instruments - to advance fair access to health care? This article examines this question within the context of the Norwegian public health care system - one special example of the Scandinavian welfare system. In particular, it asks four basic questions: What are the normative justifications for rights to health care? What were the political processes and concerns leading up to the current Patients Rights Act in Norway? What kind of legal (...) status do these rights have? How can rights to access be implemented?Patient rights do not only concern the right to access to health care; they also include the right to information, the right to participate in decision-making, and informed consent. This article examines only the former aspect, the use of the legal system to secure access to prioritized specialized health care services. (shrink)

Numerous ethical issues are raised in cancer treatment and research. Informed consent is challenging due to complex treatment modalities and prognostic uncertainty. Busy oncology clinics limit the ability of oncologists to spend time reinforcing patient understanding and facilitating end-of-life planning. Despite these issues and the ethics consultations they generate, clinical ethicists receive little if any focused education about cancer and its treatment. As the field of clinical ethics develops standards for training, we argue that a basic knowledge of cancer should (...) be included and offer an example of what cancer ethics training components might look like. We further suggest some specific steps to increase collaboration between clinical ethicists and oncology providers in the outpatient setting to facilitate informed consent and proactively identify ethical issues. (shrink)

Not many studies have focused on the analysis of the rhetorical organization of a genre and the respective frequency of occurrence of moves and steps as they occur in a corpus across disciplines – particularly, with a complementary qualitative-quantitative approach. This article aims to become a step in helping to fill this gap in research on Spanish. In this way, the textbook genre, the occurrence of its rhetorical macro-moves, moves and steps and disciplinarity are the central focus of this study. (...) More specifically, in this article we seek to determine and to compare the frequency of occurrence of macro-moves, moves and steps in a corpus of 126 university textbooks across the academic discourse of four disciplines. We distinguish the major areas of knowledge as well as the specific disciplines. The main findings show there are differences between the occurrence of some discourse moves and steps across the texts of disciplines under study, which reveals a distinctive feature in the didactic component of textbooks. So we can infer that knowledge construction process through this genre is not carried out in the same way and that disciplinarity plays an important role in the diversifying organizational discourse patterns detected. (shrink)

The goal of this paper is to present and defend an empiricist, neo-Hempelian account of scientific explanation as ampliative, specialized embedding. The proposal aims to preserve what I take to be the core of Hempel’s empiricist account, by weakening it in some respects and strengthening it in others, introducing two new conditions that solve most of Hempel’s problems without abandoning his empiricist strictures. According to this proposal, to explain a phenomenon is to make it expectable by introducing new conceptual/ontological (...) machinery and using special, and non-ad hoc, non-accidental regularities. The new conditions are elaborated making essential use of two central structuralist ideas, namely T-theoreticity and specialization. I first introduce and qualify the project, then present the new account in detail and assess it vis-à-vis its rivals, and finally discuss some possible objections, concluding that the account fares better than its monistic rivals and well enough to qualify as a promising neo-Hempelian account. Even for those unpersuaded by its monistic goals, it has the merit of calling attention to two new necessary conditions not explicitly emphasized thus far and showing how they serve to answer many of the criticisms addressed against Hempel’s account. (shrink)

Specificities associated with chromosomal linearity are not restricted to telomeres. Here, recent results obtained on fission and budding yeast are summarized and an attempt is made to define subtelomeres using chromatin features extending beyond the heterochromatin emanating from telomeres. Subtelomeres, the chromosome domains adjacent to telomeres, differ from the rest of the genome by their gene content, rapid evolution, and chromatin features that together contribute to organism adaptation. However, current definitions of subtelomeres are generally based on synteny and are largely (...) gene‐centered. Taking into consideration both the peculiar gene content and dynamics as well as the chromatin properties of those domains, it is discussed how chromatin features can contribute to subtelomeric properties and functions, and play a pivotal role in the emergence of subtelomeres. (shrink)

Plant cell culture systems have become an attractive and sustainable approach to produce high‐value and commercially significant metabolites under controlled conditions. Strategies involving elicitor supplementation into plant cell culture media are employed to mimic natural conditions for increasing the metabolite yield. Studies on nanoparticles (NPs) that have investigated elicitation of specialized metabolism have shown the potential of NPs to be a substitute for biotic elicitors such as phytohormones and microbial extracts. Customizable physicochemical characteristics allow the design of monodispersed‐, stimulus‐responsive‐, (...) and hormone‐carrying‐NPs of precise geometries to enhance their elicitation capabilities based on target metabolite/plant cell culture type. We contextualize advances in NP‐mediated elicitation, especially stimulation of specialized metabolic pathways, the underlying mechanisms, impacts on gene regulation, and NP‐associated cytotoxicity. The novelty of the concept lies in unleashing the potential of designer NPs to enhance yield, harness metabolites, and transform nanoelicitation from exploratory investigations to a commercially viable strategy. (shrink)

NIK1 is a receptor‐like kinase involved in plant antiviral immunity. Although NIK1 is structurally similar to the plant immune factor BAK1, which is a key regulator in plant immunity to bacterial pathogens, the NIK1‐mediated defenses do not resemble BAK1 signaling cascades. The underlying mechanism for NIK1 antiviral immunity has recently been uncovered. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down‐regulate translational machinery genes, resulting in translation inhibition of host and viral (...) mRNAs and enhanced tolerance to begomovirus. Therefore, the NIK1 antiviral immunity response culminates in global translation suppression, which represents a new paradigm for plant antiviral defenses. Interestingly, transcriptomic analyses in nik1 mutant suggest that NIK1 may suppress antibacterial immune responses, indicating a possible opposite effect of NIK1 in bacterial and viral infections. (shrink)

Specificities of enzymes involved in plant specialized metabolism, including flavonoid biosynthesis, are generally promiscuous. This enzyme promiscuity has served as an evolutionary basis for new enzyme functions and metabolic pathways in land plants adapting to environmental challenges. This phenomenon may lead, however, to inefficiency in specialized metabolism and adversely affect metabolite‐mediated plant survival. How plants manage enzyme promiscuity for efficient specialized metabolism is, thus, an open question. Recent studies of flavonoid biosynthesis addressing this issue have revealed a (...) conserved strategy, namely, a homolog of chalcone isomerase with no catalytic activity binds to chalcone synthase, a key flavonoid pathway enzyme, to narrow (or rectify) the enzyme's highly promiscuous product specificity. Reducing promiscuity via specific protein–protein interactions among metabolic enzymes and proteins may be a solution adopted by land plants to achieve efficient operation of specialized metabolism, while the intrinsic promiscuity of enzymes has likely been retained incidentally. (shrink)

Probing semantic relations Exploration and identification in specialized texts Alain Auger and Caroline Barrière In recent years, several scientific ...

The reception of the translations of Aristotelian and pseudo-Aristotelian works at the University of Paris in the thirteenth century promoted a new understanding of the sciences as specialized fields of knowledge. The huge amount of translations required a new organization of knowledge, which included novel subjects and categories. Among these there is a very special case, namely the pseudo-Aristotelian De plantis, translated from Arabic into Latin and then back into Greek to be re-translated into Latin again. De plantis was (...) included in the new curriculum in Ripoll 109, and constituted the main source for botanical studies until the sixteenth century. Throughout this paper we will explore the reception and impact of De plantis in both the Arabic and the Latin traditions. We aim to show its foundational role in the development of botany as a theoretical discipline within the natural sciences. (shrink)

Secondo un recente bilancio della filosofia del Novecento di Rossi e Viano, nel nostro secolo «il successo maggiore è toccato alle dottrine filosofiche che si sono proposte di offrire alternative alla conoscenza tecnico-scientifica e che sostengono la possibilità di alleggerire i vincoli che il sapere positivo porrebbe al modo di pensare e ai progetti di azione»2. Tali dottrine prospettano un ritorno all’antica metafisica, a cui «si ricorre non come a una forma di sapere sistematico, bensì come alla testimonianza di una (...) possibilità di pensare qualcosa che vada al di là del sapere positivo»3. Perciò il Novecento si è concluso con la vittoria, se non del «duro conservatorismo di Heidegger», almeno di «un più blando tradizionalismo, che si limita a sostenere il primato della cultura umanistica tradizionale rispetto alla cultura tecnico-scientifica»4. Per Rossi e Viano la filosofia del Novecento ha avuto questo esito poiché è risultata insostenibile la convinzione, diffusa nella filosofia analitica all’inizio degli anni Trenta, «che la filosofia avesse imboccato la strada giusta per inserirsi nel mondo del sapere scientifico specializzato»5. Dopo «che si era affermata la specializzazione del sapere, la filosofia aveva cercato di stabilire una posizione di dominio legandosi a quelle che erano sembrate le discipline titolari di un qualche primato: ora a quelle matematiche, ora a quelle naturalistiche, ora a quelle storiche»6. Essa, inoltre, aveva cercato di accreditare l’idea che l’analisi logica delle teorie scientifiche fosse comunque lo strumento più attendibile per fare filosofia. Questo tentativo della filosofia analitica, però, è fallito, e così nella cultura contemporanea è diventato chiaro che non «ci sono legami particolarmente stretti tra la filosofia e qualche scienza particolare»7. Insieme all’idea che esistesse un legame privilegiato tra la filosofia e qualche scienza particolare, «la cultura filosofica del Novecento respingeva anche l’idea che l’analisi logica delle teorie scientifiche fosse comunque lo strumento più attendibile per fare filosofia»8.. (shrink)

This paper reports on an analysis of the work of Leni Riefenstahl, and German expressionism, through the use of trans-disciplinary semantic associative search in specialized databased dictionaries1. Within this database space (Kitagawa and Kiyokim 1993), the quantitative data of objects as representation can be visualized by number. While the method of image analysis is qualitative, it is based on a quantitative analysis of visual representation. Through this analysis, Riefenstahl's film Olympia Fest der Vlker is compared with the Nazi ideology (...) of the body image. The film is often categorized as romantic; however, this paper proposes a new interpretation based on theories of Jonathan Crary, and Martin Jay, which are combined using the mechanism of connotation in searching database systems. We proposs that, in the context of Visual Culture Studies, the use of digital technologies may provide new possibilities for research in the humanities. (shrink)

The aim of this study was to explore patients’ experiences of using the Integrated Palliative care Outcome Scale (IPOS) during specialized palliative home care. The study adopted a qualitative approach with an interpretive descriptive design. Interviews were performed with 10 patients, of whom a majority were diagnosed with incurable cancer. Our findings suggest that the use of IPOS as a basis for conversation promotes safe care by making the patients feel confident that the care provided was adapted to them (...) which gives them a sense of safety. IPOS facilitated discussions between patients and nurses about care needs. The patients believed that using IPOS enabled reflection on their well‐being and life situation. In conclusion, the study finds that using IPOS is beneficial and provide ways to enable person‐centered care and with advantage could be used in specialized palliative home care. The results may help overcome barriers and facilitate the use of patient‐reported outcome measures (PROMs). To enable the use of PROMs such as IPOS in palliative home care, nurses need education and opportunities to develop routines that enable patients’ voice to be heard and thereby compose a basis for care. (shrink)

Eight focus groups were conducted in four public hospitals in Madrid to explore healthcare professionals’ perceptions of advance directives in order to improve the understanding of their lack of success among physicians and patients. A purposive sample of sixty healthcare professionals discussed ADs and reasons for their infrequent use. Three main themes were identified: perceptions about their meaning, appraisals of their use in clinical practice, and decision-making about them. Healthcare professionals perceived a lack of clarity about their definition and implementation. (...) There is insufficient awareness of their efficacy in improving the quality of clinical relationships and decision-making, and they are often perceived only as a bureaucratic procedure. Advance directives are not integrated in the clinical practice of Madrid’s healthcare specialist services because their application is exceedingly complex, because of insufficient education about them, and because of lack of procedural clarity. Consequently, healthcare professionals are not aware of how ADs could improve clinical decision-making, of when and for whom their use is appropriate, and of who has responsibility for providing ADs-related information to patients. These circumstances contribute to patients’ lack of interest in completing these documents and to physicians’ sceptical views about their usefulness. (shrink)

The present article is based on a interview with a Japanese experienced caregiver who specializes in patients with amyotrophic lateral sclerosis, which generally leads to the locked-in syndrome. Professional caregivers for ALS patients with ventilator experience two particular temporalities in their practice. First, they must monitor the patient continuously during a seven-hour stay. Because a single problem in the ventilator can have fatal consequences, the care of an ALS patient with a ventilator requires long periods of sustained concentration. Second, trying (...) to understand the signs of a patient with a ventilator sometimes requires three hours to go through ten alphabets. In addition to the huge effort that such communication requires, caregivers must complete the meaning of the signs with their imagination: the ten alphabets are not sufficient to understand what the patient really wants to say. This imaginative capacity, however, is based on a long relationship, which started when the patient was still able to speak and move. That is why, as this article will show, even when a patient has entered total LIS, the caregiver can continue to realize his or her wishes. (shrink)