Sanfte Chemie was a concept formulated in the 1980s in Germany by a group of environmentally conscious scholars. It emerged within a unique environment, marked by its radical critique of dominant forms of rationality, and against the rich background of German philosophical technocritical traditions. Its purpose was to profoundly reshape the practice of chemistry and the organization of the chemical industry along the lines of sustainability. In contrast to later concepts like green or sustainable chemistry, Sanfte Chemie went (...) beyond setting new research directions; it critically reevaluated the entire epistemological foundation upon which the science of chemistry was built. Under the auspices of the German Green Party, the concept flourished in the 1980s before falling out of grace in the following decade. While largely deemed overly radical in its time and then subsequently forgotten, Sanfte Chemie not only anticipated some of the most promising trends in sustainability science today but also offered unique insights that may shed new light on the challenges of the ongoing environmental crisis. (shrink)

Research in ecology and evolutionary biology (evo-eco) often tries to emulate the “hard” sciences such as physics and chemistry, but to many of its practitioners feels more like the “soft” sciences of psychology and sociology. I argue that this schizophrenic attitude is the result of lack of appreciation of the full consequences of the peculiarity of the evo-eco sciences as lying in between a-historical disciplines such as physics and completely historical ones as like paleontology. Furthermore, evo-eco researchers have (...) gotten stuck on mathematically appealing but philosophi- cally simplistic concepts such as null hypotheses and p-values defined according to the frequentist approach in statistics, with the consequence of having been unable to fully embrace the complexity and subtlety of the problems with which ecologists and evolutionary biologists deal with. I review and discuss some literature in ecology, philosophy of science and psychology to show that a more critical methodological attitude can be liberating for the evo-eco scientist and can lead to a more fecund and enjoyable practice of ecology and evolutionary biology. With this aim, I briefly cover concepts such as the method of multiple hypotheses, Bayesian analysis, and strong inference. (shrink)

Synthetic biology, materials chemistry and soft robotics are fast becoming leading disciplines within the field of practices which look to nature for inspiration and opportunities. In this article I discuss how these molecular-scale practices fit within the existing trends of bio-informed design defined at the macro level, that is, bionics, biomimetics and more specifically biomimicry. Based on the metaphysical views underlying bio-informed design practices, I argue that none of them currently fit the biomimicry model, as they are not (...) consistently concerned with environmental sustainability. While biomimetic chemistry loosely belongs to the field of biomimetics, and soft robotics to the field of bionics, both practices have a profound impact on their respective fields, as they question the places of nature and engineers. (shrink)

Much of the philosophical attention directed to Kant’s intervention into biology has been directed toward Kant’s idea of a transcendental limit upon what can be understood constitutively. Kant’s own wider philosophical practice, however, was principally oriented toward solving problems and the scientific benefits of his methodology of teleology have been largely underappreciated, at least in the English language literature. This paper suggests that all basic biology has had, and continues to have, a need for some form of heuristic “bracketing” and (...) that a renewal of some form of, albeit flexible, teleological methodological bracketing can better complement the productive assimilation into developmental biology of continuing advances in our understanding of the mesoscale physics and chemistry of soft, excitable condensed matter, than what has been the prevailing and de facto use of a form of bracketing shaped by the neoDarwinian Modern Synthesis. Further we offer a concept of biogeneric processes and a framework of physico-genetic “dynamical patterning modules”, that can begin to account for the appearance of new Kantian “stocks of Keime und Anlagen”, capable of potentiating some range of possible organismal forms, and provide grounds for moving up the teleological “goalposts”, i.e., expanding the range of what can be accounted for on a constitutive basis. (shrink)

This article examines a scientific controversy that raged for twenty years in physical organic chemistry during the second half of the twentieth century. After explaining what was at stake in the non-classical ion debate, I attempt—by examining the methodological reflections of some of the participants—a partial explanation of what sustained this controversy, particularly during its early stages. Instead of suggesting a breakdown of scientific method or the unavoidable historical contingency of scientific development, the endurance of this controversy instead reveals (...) the heuristic and pragmatic character of many of the explanations and predictions generated by theoretical organic chemistry. The results in this case are used to suggest a new role for the study of scientific controversies in revealing the economics of scientific inquiry. 1 Introduction2 The Non-classical Ion Debate3 Models for the 2-Norbornyl System4 Soft Theories and Reasoning by Analogy5 Scientific Controversy and the Non-classical Ion Debate6 Conclusion. (shrink)

Emergence is often described as the idea that the whole is greater than the sum of the parts: interactions among the components of a system lead to distinctive novel properties. It has been invoked to describe the flocking of birds, the phases of matter and human consciousness, along with many other phenomena. Since the nineteenth century, the notion of emergence has been widely applied in philosophy, particularly in contemporary philosophy of mind, philosophy of science and metaphysics. It has more recently (...) become central to scientists' understanding of phenomena across physics, chemistry, complexity and systems theory, biology and the social sciences. The Routledge Handbook of Emergence is an outstanding reference source and exploration of the concept of emergence, and is the first collection of its kind. Thirty-two chapters by an international team of contributors are organised into four parts: Foundations of emergence Emergence and mind Emergence and physics Emergence and the special sciences Within these sections important topics and problems in emergence are explained, including the British Emergentists; weak vs. strong emergence; emergence and downward causation; dependence, complexity and mechanisms; mental causation, consciousness and dualism; quantum mechanics, soft matter and chemistry; and evolution, cognitive science and social sciences. Essential reading for students and researchers in philosophy of mind, philosophy of science and metaphysics, The Routledge Handbook of Emergence will also be of interest to those studying foundational issues in biology, chemistry, physics and psychology. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Asian Eels and Global Warming:A Posthumanist Perspective on Society and the EnvironmentAndrew Pickering (bio)My idea in this essay is to talk about how some recent developments in my field—science and technology studies—might pass over into environmental studies. In particular, I want to talk about a certain posthumanist perspective, as I call it, on the relation between people and things, because I think that it transfers nicely from thinking about (...) people and machines to thinking about people and the environment.1 I want to say in advance that while the word 'posthumanist' might sound a bit peculiar, the posthumanist perspective is straightforward enough. If scholars have taken a long time to arrive it, the difficulty lies, I believe, in a disciplinary division of labor rather than in any intrinsic incomprehensibility. And I can start with a few general remarks about that.The basic point to note is that the academic disciplines carve up the visible world in a systematic way. On the one hand, the natural sciences, engineering, and so on, like to talk about a world of things from which people are notably absent. This is clear in fields like physics and chemistry, but it is probably true enough in the environmental sciences, too. Human beings might disturb ecosystems, say, but the job of the ecologist [End Page 29] is to understand the systems themselves, not the disturbances. The social sciences and humanities, in contrast, like to talk about people but not about things. Durkheimian sociology is a great example. Durkheim insisted that the social was a separate reality, sui generis, and that the social therefore has its own pure dynamics, cut off from, say, the material world.We find, then, a beautiful disciplinary dualism: to the harder sciences goes the world of things; to the softer sciences goes the world of people. What about the interface of people and things, the zone of intersection? This is of no concern to the hard sciences: one can easily imagine the world of things going on without people. But what about the soft sciences? One can't really imagine a world of people without things. Here various maneuvers have traditionally served to maintain the humanist purity of disciplines like sociology; I will just mention one. We encounter the material world, it is said, not in its raw state (as studied by physicists or ecologists, say) but as drenched in meaning. The world means something, or many different things, to us. And the point to note is that 'meaning' functions here as a cut-off, a circuit-breaker. Meanings are in our heads and in society; they are not in the material world. So, sociologists can go ahead and study the meanings that people attach to machines or nature without encroaching on the territory of the hard sciences, and the disciplinary division of labor, enshrined in the universities since the 19th century, can live on. The social sciences are about the human meanings of, or attitudes towards, machines, the environment, or whatever; the hard sciences are about things in themselves. That is the basic split that I want to focus on in what follows—actually, to undo it. But I can quickly mention one further twist for the sake of clarity.The basic split between meanings and things-in-themselves is an index of a certain realism—a bow from the soft sciences to the harder sciences, an acknowledgment that the latter somehow gets things right and that what the soft sciences study is a soggy social residue. But some social scientists have refused to bend the knee. They argue that we are all humans, even hard scientists. Therefore we can never get beyond meanings. And therefore we should think of the material world as itself somehow constructed in social practice. The harder sciences find this view absurd, but it is manifest in a split in the social sciences between 'realists' [End Page 30] and 'constructivists'—a split which shows up in many places, including geography and environmental studies. The point I would stress, however, is that the social retains its purity, even in social constructivism—it is simply that there 'the social' expands without limit to encompass... (shrink)

Science and emotions are typically juxtaposed: science is considered rational and unattached to outcomes, whereas emotions are considered irrational and harmful to science. Ethnographic studies of the daily lives of scientists have problematized this opposition, focusing on the emotional experiences of scientists as they go about their work, but they reveal little about disciplinary differences. We build on these studies by analyzing Citation Classics: accounts about the making of influential science. We document how highly cited scientists retrospectively describe emotional aspects (...) of their research and assess variation in these narratives across six diverse disciplines: Chemistry; Clinical Medicine; Neurobiology; Physics; Plant and Animal Science; and Psychology and Psychiatry. Using correspondence analysis, we develop a multidimensional model to explain disciplinary variation in scientists’ accounts of emotions and link this variation to internal, external, and material aspects of the disciplines. We find differences in norms of appropriate emotional expression, or “feeling rules,” between the “hard” and “soft” sciences, the basic and applied sciences, and the sciences that study living organisms versus those that study organs, cells, or atoms. By comparing accounts across disciplines and elaborating the structuring principles underlying these patterns, we integrate knowledge from varied case studies into an integrative and multifaceted model. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Problem with BreathÉglantine Colon (bio)On day 1, when my comrades and I talked about it, we couldn't quite figure out how it happened. It just seemed as though we had suddenly been incited not to communicate or enact our love for each other. This time, no policy had been formulated, no law had been issued. It was harder than usual to locate where, to which parts of the (...) apparatus, we should direct our attention.On day 2, we were at a loss. We had gotten so good at reading the apparatus. We had developed wonderfully efficient techniques of resistance. Each and every one of us had become most brilliant at crafting discrete gestures of love. On day 3 onwards, we were misfiring on a regular basis, falling in and out of love with the same wrong comrades, over and over again, and always out of sync. The loving gestures we composed were barely legible and when we would intuitively find a genre in which to communicate our love, something would inevitably break down. Voices, generally. Sometimes the entire figurative system. Bodies, always. We would lose sleep and appetite over love and get useless for weeks.And then, the problem with love became a problem with breath. On day 6, the air got hot and busy with ashes and all sunsets turned red. At every breath, for all we knew, we could be inhaling particles of carbonized pine sap, debris of melted trailer parts, or burnt baby birds in bits. I quit smoking. I bought boxes of white masks at the construction store. The dominant smell during these days was a cagey mix of ghost paint, polymer fibers, and dry chemistry.On day 17, the air got cold and saturated with drops of viral poison. The city shut down. An incredibly sad number of lungs, too. The perspective to live in pods and die alone, disconnected from each other's breath, hyper-connected to life-support machines, plunged many of us, myself included, into brand new strands of historical despair. For those of us whose lungs had been weakened by bad inner-city fumes, evil chemicals, or entire centuries of racialized exposure to horrendous air quality, the problem with breath became plain lethal.Our neighborhoods were saturated with wildfire smoke and unnecessary death. Elsewhere, the streets were not empty. And when I say not empty, I mean they were just not. Or not yet. Usual metallic densities on the bridge. Geometrical glows of digital light in the underground. [End Page 237]Abnormally, no bodies of any ancestries were being captured, or hanged, or tortured, or kneeled upon. Nothing tangible, nothing blatantly repressive this time. No gas, no gag, no name, no whip, no rope. No strangulating remnant of sovereignty within no softness of biopower. A racist and classist brand of distributive pneumocracy is what it was, or at least this is how it initially appeared.On day 25, "Critical Pandemic Studies" became a thing, and "Pod Theory" a subgenre in post-social anthropology. Denounced as a "white fantasy of networked individualism," (in one of its purest forms) as "domestic fascism dressed as elective affinity," the pod appeared to us, from the get-go, as a thoroughly ratchet social formation. On day 29, the "podtag" emerged as a timely intervention in existing forms of street art. Equational in its form, efficient in its power of evocation, and satirical in its poetic economy, the podtag proliferated on the privatized walls of neighborhoods where the biggest challenges presented to breathing were unreasonably difficult Pilates classes on Zoom. Click for larger view View full resolutionOn day 35, the air got complex and full of knots, so striated that we could no longer count on our capacity to share the same air. A meal was being cooked, an instrument was being played, a child was given birth to, and suddenly the rhythm of all breaths would break. Sometimes a pair of lungs would refuse, stubbornly, to take in any oxygen until someone else's pair of lungs had released its own dose of carbon dioxide. At other times, the quantity of air available to each one of us would decrease with... (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense.] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics and there are many new abstractions from advances in mathematics. Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense.] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics and there are many new abstractions from advances in mathematics. Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

This book examines the interface between mathematics and applied sciences. The editor examines the present and future needs for the interaction between various science and engineering areas. This edited book brings together the cutting-edge research on mathematics, combining various fields of science and engineering. The book begins with an introduction to computing and modeling. Next, computation and modeling trends are covered, along with chapters on structural static and vibration problems, heat conduction and diffusion problems, and fluid dynamics problems. Soft (...) computing and machine intelligence based modeling are also discussed, along with bio medical problems. The book concludes with a chapter on modeling in mining, electrical, electronics, and chemical problems. This book is a reference for students and researchers in various fields of engineering such as computer, mechanical, civil, aerospace, electrical, and chemical, as well as and other sciences such as applied mathematics, physics, chemistry, and life sciences. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense.] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics and there are many new abstractions from advances in mathematics. Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Asian Eels and Global Warming:A Posthumanist Perspective on Society and the EnvironmentAndrew Pickering (bio)My idea in this essay is to talk about how some recent developments in my field—science and technology studies—might pass over into environmental studies. In particular, I want to talk about a certain posthumanist perspective, as I call it, on the relation between people and things, because I think that it transfers nicely from thinking about (...) people and machines to thinking about people and the environment.1 I want to say in advance that while the word 'posthumanist' might sound a bit peculiar, the posthumanist perspective is straightforward enough. If scholars have taken a long time to arrive it, the difficulty lies, I believe, in a disciplinary division of labor rather than in any intrinsic incomprehensibility. And I can start with a few general remarks about that.The basic point to note is that the academic disciplines carve up the visible world in a systematic way. On the one hand, the natural sciences, engineering, and so on, like to talk about a world of things from which people are notably absent. This is clear in fields like physics and chemistry, but it is probably true enough in the environmental sciences, too. Human beings might disturb ecosystems, say, but the job of the ecologist [End Page 29] is to understand the systems themselves, not the disturbances. The social sciences and humanities, in contrast, like to talk about people but not about things. Durkheimian sociology is a great example. Durkheim insisted that the social was a separate reality, sui generis, and that the social therefore has its own pure dynamics, cut off from, say, the material world.We find, then, a beautiful disciplinary dualism: to the harder sciences goes the world of things; to the softer sciences goes the world of people. What about the interface of people and things, the zone of intersection? This is of no concern to the hard sciences: one can easily imagine the world of things going on without people. But what about the soft sciences? One can't really imagine a world of people without things. Here various maneuvers have traditionally served to maintain the humanist purity of disciplines like sociology; I will just mention one. We encounter the material world, it is said, not in its raw state (as studied by physicists or ecologists, say) but as drenched in meaning. The world means something, or many different things, to us. And the point to note is that 'meaning' functions here as a cut-off, a circuit-breaker. Meanings are in our heads and in society; they are not in the material world. So, sociologists can go ahead and study the meanings that people attach to machines or nature without encroaching on the territory of the hard sciences, and the disciplinary division of labor, enshrined in the universities since the 19th century, can live on. The social sciences are about the human meanings of, or attitudes towards, machines, the environment, or whatever; the hard sciences are about things in themselves. That is the basic split that I want to focus on in what follows—actually, to undo it. But I can quickly mention one further twist for the sake of clarity.The basic split between meanings and things-in-themselves is an index of a certain realism—a bow from the soft sciences to the harder sciences, an acknowledgment that the latter somehow gets things right and that what the soft sciences study is a soggy social residue. But some social scientists have refused to bend the knee. They argue that we are all humans, even hard scientists. Therefore we can never get beyond meanings. And therefore we should think of the material world as itself somehow constructed in social practice. The harder sciences find this view absurd, but it is manifest in a split in the social sciences between 'realists' [End Page 30] and 'constructivists'—a split which shows up in many places, including geography and environmental studies. The point I would stress, however, is that the social retains its purity, even in social constructivism—it is simply that there 'the social' expands without limit to encompass... (shrink)

The process of condensation of an amorphous solid into a rigid matrix can often trap molecules in reversible binding sites. Exchange of the same molecular species with such sites is known to be sensitive to small chemical differences and to distinguish between enantiomers. In addition to their usefulness in chromatographic processes, such materials can separate, by solid phase extraction, specific compounds from complex mixtures. Furthermore, the trapped molecules can have their reactions guided and catalytically changed. The combination of this spontaneously (...) formed system of templates and catalytic sites may support a type of replication cycle, and suggests some pathways from simple chemistry toward the complexities of biology. © 2005 Wiley Periodicals, Inc. Complexity 11: 30–35, 2005 -/- . (shrink)

We review the early works which were precursors of the Conceptual Density Functional Theory. Starting from Thomas–Fermi approximation and from the exact formulation of Density Functional Theory by Hohenberg and Kohn’s theorem, we will introduce electronegativity and the theory of hard and soft acids and bases. We will also present a general introduction to the Fukui functions, and their relation with nucleophilicity and electrophilicity, with an emphasis towards the importance of these concepts for chemical reactivity.

Organic chemistry provides fertile ground for scholars interested in understanding the role of non-linguistic representations in scientific thinking. In this discipline, it is not plausible to regard diagrams as simply heuristic aids for expressing or applying what is essentially a linguistic theory. Instead, it is more plausible to think of linguistic representation as supplementing theories whose principal expression is diagrammatic. Among the many sorts of diagrams employed by organic chemists, structural formulas are the most important. In this paper, by (...) examining two central episodes in the development of structural formulas—Kekulé’s proposal of a structure for benzene and Ingold’s explanation of dipole moments in terms of ‘mesomerism’—I investigate how the norms for the production and interpretation of structural formulas evolve in response to experimental results and theoretical developments. I conclude that one principal way in which structural formulas embody the theory of organic chemistry is through these evolving norms. (shrink)

Musks, the foundation of many perfumes, as well as other ingredients of perfumes, were critical objects of study for establishing theoretical concepts about large ring chemical compounds and polymerization in the 1920s and 1930s. Because fragrance chemistry has been underdeveloped in the historiography, doubtless partly because it has become associated with the feminine, this has been ignored in the historiography. This essay highlights the strategic importance of perfume research, looking in particular at the work of Leopold Ružičkač, 1939 Nobel (...) laureate in chemistry who had close ties to the fragrance industry, and Wallace Carothers at DuPont, whose well-known work on polymerization was intimately concerned with large ring compounds, including musk, and which indeed led to DuPont producing a synthetic musk in the 1930s. (shrink)

Chemistry deals with substances and their transformations. School chemistry provides a picture of this in terms of small balls called atoms and ball-and-stick structures called molecules which, despite its crudity, has been taken to justifiably reflect a reductionist conception of macroscopic concepts like the chemical substances and chemical reactions. But with the recent interest in chemistry within the philosophy of science, an extensive and determined criticism has developed of the idea that the macroscopic world has been, or (...) is likely to be, reduced to microscopic theory. From this perspective, it is of interest to see macroscopic ontology treated autonomously. I try to take a first few steps towards spelling this out. It involves recognising entities falling into two broad categories: continuants-things which can have different properties at different times — and processes — things whose temporal parts may have different features, but which themselves stand in contrast to continuants in this respect. The character of each and their interrelations depends on their mereological structure of parts, the exploration of which is one of the prime purposes of the paper. (shrink)

When, how, and by whom scientific knowledge is recognized with highest honors is illustrated by this avowedly atypical episode involving the Nobel Prize awarded to Walther Nernst for 1920. Mine is not a postmortem “wie es eigentlich gewesen” evaluation of the cognitive legitimation of his 1905 third law of thermodynamics, of whether the debates surrounding his work were justified, or whether the prize was merited. Rather, it is an admittedly close reading of many new and some old sources, an intrusive (...) scrutiny of human imperfection and an excursion into the cultural symbolism of the Nobel Prize, the twentieth century’s emblematic arbiter in matters scientific. (shrink)

The emergence of conferences in the late nineteenth century significantly changed the ways in which the international scientific community functioned and experienced itself. In the early modern Republic of Letters, savants mainly related through print and correspondence, and apart from at local and later national levels, scholars rarely met. International conferences, by contrast, brought scientists together regularly, in the flesh and in great numbers. Their previously imagined community now became tangible. This paper examines how conferencing reshaped the collective of international (...) scientists by zooming in on the massive meetings of the International Congress of Applied Chemistry, 1893–1914. Drawing on Emile Durkheim's studies of religious gatherings it analyses the ritualization of routine conference practices, such as plenary ceremonies, toasts, ladies’ programmes and committee meetings. It looks at how roles were distributed as participants performed as hosts and guests, and in masculine and feminine and national and international identities. Importantly, it shows both how the sacralization of chemistry as a higher aim served to instil senses of dedication in order to organize labour and mitigate conflict, and how the self-perception of the international chemical community was based on contemporary understandings of parliament, democracy and representation. (shrink)

In previous works (Floridi 2018) I introduced the distinction between hard ethics (which may broadly be described as what is morally right and wrong independently of whether something is legal or illegal), and soft or post-compliance ethics (which focuses on what ought to be done over and above existing legislation). This paper analyses the applicability of soft ethics to the General Data Protection Regulation and advances the theory that soft ethics has a dual advantage—as both an opportunity (...) strategy and a risk management solution. (shrink)

While temporal considerations are of prime importance for chemical reactions, as well as for molecular stability, most chemical concepts are not explicitly formulated on a diachronic basis. It will be argued here that a formulation explicitly incorporating temporal and epistemological considerations enables us to treat chemical reactions and chemical substances on ontologically equivalent terms, instead of assigning a more fundamental status to the latter. After all, in collision theory, a chemical substance is just a collision complex that takes too long. (...) How long qualifies as “too long”, and “too long” in relation to what, are crucial questions that distinguish chemical substances from chemical reactions, and reversible reactions from irreversible ones, thereby introducing anthropocentric considerations into these distinctions. Too long for a lab chemist is very different from too long for an astrochemist studying chemical reactions between chemical substances in inter-stellar space on cosmological timescales. Examining several physical and chemical properties on the basis of which chemical substances are distinguished from one another, the role of temporal and anthropocentric considerations in defining molecular properties is emphasized. I conclude with some observations on the much-debated reduction of chemistry to other disciplines, arguing that such reduction depends on our aesthetic choices as to what kinds of observations demand explanation, and what kinds of explanation are acceptable. (shrink)

The book starts with the assumption that vagueness is a fundamental property of this world. From a philosophical account of vagueness via the presentation of alternative mathematics of vagueness, the subsequent chapters explore how vagueness manifests itself in the various exact sciences: physics, chemistry, biology, medicine, computer science, and engineering.

The concepts of molecular structure and molecular shape are ubiquitous in the chemical literature, where they are often taken as synonyms, with unavoidable drawbacks in chemistry teaching. A third concept, molecular topology, is less frequent but it is a reference term in molecular research domains such as Quantitative Structure–Activity Relationships. The present paper proposes an epistemological analysis of these three notions, aimed at clarifying the nature of their relationship, as well as the contiguities and differences between them. At first, (...) we discuss the various acceptations of the terms molecular structure and molecular shape. Then, we examine some crucial milestones in the history of these concepts and we analyse the relationship between structure, shape and topology from an epistemological viewpoint. We point out the distinguishing features of each concept and we show that their semantic openness, that may be fruitful in a specialized context, turns into a source of incoherence and inaccuracy in the teaching context, fostered by the misleading use of these terms made by textbooks. Eventually, we propose a criterion fit to discriminate between the conceptual domains of molecular shape, molecular structure and molecular topology. (shrink)

The work performed by the clinical chemist may deeply affect the decisions of the doctor and the well-being of the patient. Yet in contrast to the doctor and to the nurse the clinical chemist usually has no personal relationship with the patient. Being encumbered by much technology and anonymity is itself a reason for scrutinising his involvement in issues of health care ethics. This is an attempt at clarifying some major aspects: the relationship of his professional ethics to medical ethics (...) as a whole, his ethical obligations to the patient and to society, and other aspects. (shrink)

Dr. K. Wray (2022) questioned my suggestion that T. W. Richards should be included as one of the scientists who contributed to the discovery of isotopes. This article provides additional support for inclusion of Richards as a contributor to the discovery.

For the last twenty years Luis Prieto, in his published work in French, has reiterated that the systematic study of the codes (other than natural languages) which were invented by men for communication purposes is in and of itself an undertaking essential for an understanding of both the laws of communication in general and of the mechanisms of these systems of communication—the totality of which would make up the (Saussurian) semiology of communication (Prieto 1966, 1968, 1975). Among these systems the (...) symbols of chemistry—referred to as such for a long time— and their combinatory rules constitute a very ancient code or series of codes (Crosland, 1962). Up to now this code has not been subjected to a genuine semiological study, except for the essay by Dagognet (1969, see Mounin 1970) which is more literary or poetical and metaphysical than scientific. (shrink)

이 글은 두가지 새로운 전제에 입각해 있다. 첫째, 중국 70년의 사회주의 역사는 이제 사회주의 신념보다는 국가경영의 차원에서 다루어져야 한다. 둘째, G2로서 중국은 신중화제국의 재구성이라는 목표를 두고 있는 만큼 변화된 위상에 맞는 질문을 해야 한다. ‘약한 타자’가 아닌 ‘강한 타자’로서 G2 중국에 어울리는 새로운 질문이 필요하다. 기존의 이데올로기 장막을 걷어내고 체제의 정치적 구조와 새롭게 부활한 21세기의 지정학을 주목해야 중국의 본 모습을 드러낼 수 있다.BR이 글은 ‘중국 지식’을 구성하는 두 가지 뼈대인 중화제국체제(조공체제)와 1949년 이후의 사회주의에 대한 보다 본질적 검토가 불가피한 상황에 이르렀다는 (...) 판단 아래 쓰여졌다. 이 검토를 위해 이 글은 ‘메타서사’라는 개념을 제시한다. 그 이유는 이 개념이 중국인의 심리를 지속적으로 지배해왔고 앞으로도 계속해서 지배할 것이라 보기 때문이다. 첫째, 서구제국주의로부터 받은 치욕을 되갚아주기 위해 중국이 150년 동안 힘써온 ‘부강’의 ‘가치’ 추구는 정당하다는 인식이다. 둘째, 중국의 봉건과 서구의 자본주의에 대한 동시극복을 위해 선택한 사회주의 신념이 인민공화국 건립 이후에도 관철되고 있었다는 인식이다. 셋째, ‘평화로운 조공체제’라는 ‘편견’과 이에 근거한 중화제국 체제의 21세기적 재구성은 정당하다는 인식이다. 넷째, 서구 근대의 식민주의가 문명화 담론과 인권을 가지고 비서구사회에 개입해왔다고 보고 이의 대안으로 중국을 내세우는 것은 정당하다는 인식이다. 이 ‘메타서사’를 현재까지 지속하게 해주는 사상적, 심리적 기제는 중화내셔널리즘이다.BR21세기 시진핑 정부의 목표는 다민족 신중화제국의 영광을 조공체제보다 확장적으로 재현하는 것이다. 이를 위해서는 ‘메타서사’의 실현이 전제조건이다. 그러나 역설적이게도 중국은 ‘메타서사’에 집착할수록 세계를 설득할만한 소프트파워를 생산할 가능성에서 멀어진다. 신중화제국체제의 재현과 소프트파워의 생산은 반대의 방향을 취하고 있기 때문이다. 아무리 경제가 성장한다 해도 문화의 최종심급인 정치민주가 요원하다면 비판과 창의는 보장받을 수 없다. 따라서 ‘메타서사’를 근원적 차원에서 성찰하지 않는 한 중국 21세기의 소프트파워의 생산 가능성은 높지 않다. ‘21세기 중국 소프트파워의 딜레마’는 바로 여기에 있다. 이 글은 위와 같은 문제 의식 아래 ‘메타서사’ 추구의 과정 자체가 성찰을 동반한 것이어야 한다고 주장한다. 이를 위해 이 글은 첫째, 20세기 초기 마이너리티 지식인의 사상의 소환을 제안한다. 둘째, G2와 리더국가로서 중국의 밖과 소통하기 위해서는 다양한 차원의 공공재를 제공하고 중국의 위상에 어울리는 책임과 역할을 적극적으로 고민해야 할 것을 제안한다. 그랬을 때만이 장기적으로 소프트파워의 생산이 가능하고 그들이 주장하는 소위 ‘아름다운 사회주의 현대화 강국’의 실현도 가능해질 것이다. (shrink)

In this paper, I compare how it is that inconsistencies are handled in mathematics to how they are handled in chemistry. In mathematics, they are very precisely formulated and identified, unlike in chemistry. So the chemists can learn from the precision and the very well-worked out strategies developed by logicians and deployed by mathematicians to cope with inconsistency. Some lessons can also be learned by the mathematicians from the chemists. Mathematicians tend to be intolerant towards inconsistencies. There are (...) some philosophers of chemistry who attribute to chemists, collectively, a more tolerant attitude towards inconsistency, and so, mathematicians can learn from the chemists’ attitude to inform their choice of strategies. (shrink)

In the paper it is demonstrated that Bell’s theorem is an unprovable theorem. The unprovable characteristic has, on the chemical side, repercussions for e.g. spin chemistry and the related magneto-reception studies. We claim that the unprovability of this basic mathematics cannot be ignored by the physics and chemical research community. The demonstrated mathematical multivaluedness could be an overlooked aspect of nature.