Despite some clinical promise, using fetal transplants for degenerative and traumatic brain injury remains controversial and a number of issues need further attention. This response reexamines a number of questions. Issues addressed include: temporal factors relating to neural grafting, the role of behavioral experience in graft outcome, and the relationship of rebuilding of neural circuitry to functional recovery. Also discussed are organization and type of transplanted tissue, the of transplant viability, and whether transplants are really needed to obtain functional (...) recovery after brain damage. (shrink)

Grafts of embryonic neural tissue into the brains of adult patients are currently being used to treat Parkinson's disease and are under serious consideration as therapy for a variety of other degenerative and traumatic disorders. This target article evaluates the use of transplants to promote recovery from brain injury and highlights the kinds of questions and problems that must be addressed before this form of therapy is routinely applied. It has been argued that neural transplantation can promote functional recovery (...) through the replacement of damaged nerve cells, the reestablishment of specific nerve pathways lost as a result of injury, the release of specific neurotransmitters, or the production of factors that promote neuronal growth. The latter two mechanisms, which need not rely on anatomical connections to the host brain, are open to examination for nonsurgical, less intrusive therapeutic use. Certain subjective judgments used to select patients who will receive grafts and in assessment of the outcome of graft therapy make it difficult to evaluate the procedure. In addition, little long-term assessment of transplant efficacy and effect has been done in nonhuman primates. Carefully controlled human studies, with multiple testing paradigms, are also needed to establish the efficacy of transplant therapy. (shrink)

Anamniote animals, such as fish and amphibians, are able to regenerate damaged CNS nerves following injury, but regeneration in the mammalian CNS tracts, such as the optic nerve, does not occur. However, severed adult mammalian retinal axons can regenerate into peripheral nerve segments grafted into the brain and this finding has emphasized the importance of the environment in explaining regenerative failure in the adult mammalian CNS. Following lesions, regenerating axons encounter the glial cells, oligodendrocytes and astro‐cytes, and their (...) derivatives, respectively myelin and the astrocytic scar. Experiments to investigate the influence of these components on axon growth in culture have revealed cell‐surface and extracellular matrix molecules that inhibit axon extension and growth cone motility. Structural and functional characterization of these ligands and their receptors is underway, and may solve the interesting neurobiological conundrum posed by the failure of mammalian CNS regeneration. Simultaneously, this might allow new possibilities for treatment of the severe clinical disabilities resulting from injury to the brain and spinal cord. (shrink)

A major problem in developing an effective gene therapy for the nervous system lies in understanding the principles that maintain or turn off the expression of genes following their transfer into the CNS.

We investigate the semantics of the logical systems obtained by introducing the modalities and into the family of substructural implication logics (including relevant, linear and intuitionistic implication). Then, in the spirit of the LDS (Labelled Deductive Systems) methodology, we "import" this semantics into the classical proof system KE. This leads to the formulation of a uniform labelled refutation system for the new logics which is a natural extension of a system for substructural implication developed by the first two (...) authors in a previous paper. (shrink)

Grafting: do we ever do anything other than that? And are we ever free from vegetal influences when we engage in its operations? For the philosopher Michael Marder, our reflections on vegetal life have a fundamental importance in how we can reflect on our own conceptions of ethics, politics, and philosophy in general. Taking as his starting point the simple vegetal conception of grafting, Marder guides the reader through his concise and numerous reflections on what could be described (...) as a vegetal philosophy. Grafts are transplants either of a shoot inserted into the trunk of another tree or, surgically, of skin (among other living tissues). They are delicate operations intended to preserve, improve, and modify both the grafted materials and the body that receives them. To graft is to create unlikely encounters, hybrid mixes, and novel surfaces. Moving across disciplinary lines, Grafts combines the lessons of plant science with the history of philosophy, semiotics, literary compositions, and political theory. Co-authoring some of the texts with other philosophers, plant scientists and artists, Marder allows their insights to be grafted onto his own, and vice versa. Weighing in on contemporary debates such as the ethics of biotechnology, dietary practices or political organization, Marder inserts an unmistakable vegetal perspective into topics of discussion where it normally wouldnt be found. Transferring the living tissue of his own texts into another context, he helps them live better, more fully, than otherwise. (shrink)

BackgroundMany procedures currently require the use of bone grafts to replace or recover bone volume that has been resorbed. However, the patient’s opinion and preferences must be taken into account before implementing any treatment. Researchers have focused primarily on assessing the effectiveness of bone grafts rather than on patients' perceptions. Thus, the aim of this study was to explore patients' opinions regarding the different types of bone grafts used in dental treatments.MethodsOne hundred patients were randomly chosen participated in the (...) study. A standardized survey of 10 questions was used to investigate their opinions regarding the different types of bone grafts used in dental treatments. Descriptive statistics were calculated for the different variables, and absolute frequencies and percentages were used as summary measures. A value of p <0.05 was selected as the threshold for statistical significance.ResultsThe highest rate of refusal was observed for allografts and xenografts. The grafts with the lowest rates of refusal were autologous grafts and alloplastics. No significant differences were found between the various types of bone grafts in the sociodemographic variables or the refusal/acceptance variable. Similarly, no significant relations were observed between a specific religious affiliation and the acceptance/refusal rates of the various types of graft.ConclusionsAllografts and xenografts elicited the highest refusal rates among the surveyed patients, and autologous bone and alloplastics were the most accepted bone grafts. Moreover, no differences were found in the sociodemographic variables or religious affiliations in terms of the acceptance/refusal rates of the different bone grafts. (shrink)

Over the past two decades, research on neural transplantation in animal models of neurodegeneration has provided provocative in sights into the therapeutic use of grafted tissue for various neurological diseases. Although great strides have been made and functional benefits gained in these animal models, much information is still needed with regard to transplantation in human patients. Several factors are unique to human disease, for example, age of the recipient, duration of disease, and drug interaction with grafted cells; these need (...) to be explored before grafting can be considered a safe and effective therapeutic tool. (shrink)

The transplantation of cholinergic neurons into the hippocampal formation has been well characterized. We describe our studies on the effects of cholinergic transplants in the retrosplenial cortex. These transplants were capable of ameliorating spatial navigation deficits in rats with septohippocampal lesions. In addition, we provide evidence for the modulation of transplanted neurons by the host brain.

Grafting embryonic brain tissue into the brain of patients with visual field loss due to cerebral lesions may become a method to restore visual function. This method is not without risk, however, and will only be considered in cases of complete blindness after bilateral occipital lesions, when other, risk-free neuropsychological methods fail.

The discovery of neurogenesis and neural stem cells (NSC) in the adult CNS has overturned a long‐standing and deep‐routed “dogma” in neuroscience, established at the beginning of the 20th century. This dogma lasted for almost 90 years and died hard when NSC were finally isolated from the adult mouse brain. The scepticism in accepting adult neurogenesis has now turned into a rush to find applications to alleviate or cure the devastating diseases that affect the CNS. Here we highlight a (...) number of methodological, technical and conceptual drawbacks responsible for the historical denial of adult neurogenesis. Furthermore, we discuss old and new issues that need to be faced before NSC or endogenous neurogenesis can safely enter into the doctor's bag for therapies. BioEssays 30:135–145, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In spite of Stein and Glasier's justifiable conclusion that initial optimism concerning the immediate clinical applicability of neural transplantation was premature, there exists much experimental evidence to support the potential for incorporating this procedure into a therapeutic arsenal in the future. To realize this potential will require continued evolution of our knowledge at multiple levels of the clinical and basic neurosciences.

The aim of this paper is to show how the incorporation of metaphoric and poetic ways of thinking into the evaluation of a leadership development programme both captured the imagination of the employees and benefited the core business of a manufacturing production plant. Qualitative data evaluating the effectiveness of a substantial leadership programme were presented back to all members of a manufacturing plant (executive and non-executive) in the form of composite narratives over an eighteen-month period. Recommendations were derived from (...) the text of the narrative and were progressively implemented. Such was the positive response to the written narratives that senior management asked the researchers to present the narratives in the form of a ‘live’ performance. Evaluation through qualitative methodology lends itself to an imaginative interpretation and presentation. Although qualitative and quantitative data tend to be regarded as complementary in applied research, it was management’s decision to employ only a qualitative process in this instance. The decision was fortuitous, given that the leadership development programme was initially judged to be a failure, as it triggered a subsequent imaginative engagement that turned a failure into a success. Indo-Pacific Journal of Phenomenology , Volume 7, Edition 1 May 2007. (shrink)

The spinal cord provides an alternative model for nerve tissue grafting experiments. Anatomo-functional correlations are easier to make here than in any other region of the CNS because of a direct implication of spinal cord neurons in sensorimotor activities. Lesions can be easily performed to isolate spinal cord neurons from descending inputs. The anatomy of descending monoaminergic systems is well defined and these systems offer a favourable paradigm for lesion-graft experiments.

The origins and nature of the judicial role of the senate in cases which under the republic were the business of the permanent quaestiones have been the subject of long debate, and a satisfactory explanation has yet to be found for the change that had undoubtedly taken place by the reign of Tiberius. The discovery and publication of the senatorial decree which concluded the investigation into the charge brought in A.D. 20 against Cn. Piso following the murder of Germanicus,2 (...) in addition to the wealth of new material it provides for the political history of the period and the understanding of the methods of the historian Tacitus, allows an insight into the relation of the senate to the quaestio maiestatis which may prove useful in unravelling some of the puzzles which have troubled scholars hitherto. (shrink)

The origins and nature of the judicial role of the senate in cases which under the republic were the business of the permanent quaestiones have been the subject of long debate, and a satisfactory explanation has yet to be found for the change that had undoubtedly taken place by the reign of Tiberius. The discovery and publication of the senatorial decree which concluded the investigation into the charge brought in A.D. 20 against Cn. Piso following the murder of Germanicus,2 (...) in addition to the wealth of new material it provides for the political history of the period and the understanding of the methods of the historian Tacitus, allows an insight into the relation of the senate to the quaestio maiestatis which may prove useful in unravelling some of the puzzles which have troubled scholars hitherto. (shrink)

The scientific, ethical, and policy issues raised by research involving the engraftment of human neural stem cells into the brains of nonhuman primates are explored by an interdisciplinary working group in this Policy Forum. The authors consider the possibility that this research might alter the cognitive capacities of recipient great apes and monkeys, with potential significance for their moral status.

Achieving regeneration of the central nervous system (CNS) is a major challenge for regenerative medicine. The inability of mammals to regrow a severed CNS contrasts with the amazing regenerative powers of their deuterostome kin, the echinoderms. Rapid CNS regeneration from a specialized autotomy plane in echinoderms presents a highly tractable and suitable non‐model system for regenerative biology and evolution. Starfish arm autotomy triggers mass cell migration and local proliferation, facilitating rapid CNS regeneration. Many regeneration events in nature are preceded by (...) autotomy and there are striking parallels between autotomy and regeneration in starfish and lizards. Comparison of these systems holds promise to provide insight into regeneration deficiency in higher vertebrates and to uncover evolutionarily conserved deuterostome‐chordate regenerative processes. This will help identify mechanisms that may be present but inactive in higher vertebrates to address the problem of their poor regenerative capacities and the challenge to achieve CNS repair and regrowth. (shrink)

We concur that basic research on the use of CNS grafts is needed. Two important model systems for functional studies of grafts are ignored by Stein & Glasier. In the first, reproductive function is restored in hypogonadal mice by transplantation of GnRH-synthesizing neurons. In the second, circadian rhythmicity is restored by transplantation of the suprachiasmatic nucleus.

Speciesism, difference of treatment based on an appeal to species membership, is often likened to racism and sexism, and condemned on those grounds. Some philosophers, however, reject this argument by analogy and instead forward an argument for speciesism based on a postulated right of species to compete for survival. This paper attacks this strong form of speciesism by showing that the underlying concept of ‘species’ is incoherent in the context of morality, and that strong speciesism has unacceptable corollaries.

Speciesism, difference of treatment based on an appeal to species membership, is often likened to racism and sexism, and condemned on those grounds. Some philosophers, however, reject this argument by analogy and instead forward an argument for speciesism based on a postulated right of species to compete for survival. This paper attacks this strong form of speciesism by showing that the underlying concept of ‘species’ is incoherent in the context of morality, and that strong speciesism has unacceptable corollaries.

Higher education has been changing radically in recent years, with increasing numbers of students, and complaints about declining standards. This volume brings together leading intellectuals from the US and UK to examine the issues involved.

This study analyzes the ideals of responsibility and accountability, asking such questions as when it is legitimate to blame top officials of an organization for mistakes made by personnel below them in the bureaucratic hierarchy; when things go wrong in a large and complex organization like the Canadian Forces, who is responsible and accountable; and whether a plea of ignorance is a good excuse. The study also analyzes the doctrine of ministerial responsibility in both the British and Canadian parliamentary traditions, (...) asking whether it is realistic to expect that a government minister should be held responsible for everything that goes wrong in his/her department. Finally, traditional military values are examined, considering the kinds of attitudes and values expected from Canada's armed forces and the differences between the military and civilian sectors. (shrink)

Criminal offenders may be offered to participate in voluntary rehabilitation programs aiming at correcting undesirable behaviour, as a condition of early release. Behavioural treatment may include direct intervention into the central nervous system (CNS). This article discusses under which circumstances voluntary rehabilitation by CNS intervention is justified. It is argued that although the context of voluntary rehabilitation is a coercive circumstance, consent may still be effective, in the sense that it can meet formal criteria for informed consent. Further, for (...) a consent to be normatively valid (“take the wronging out of the act”) under a coercive circumstance, the subject to be treated must (1) have the sovereign authority to consent, and (2) the offer-giver must be in the right normative position to make the offer. While I argue that subjects do have the sovereign authority to consent to treatment, I also argue that inappropriate offers yield invalid consents. Considerations on inappropriate offers should therefore inform which kinds of CNS intervention-based rehabilitation schemes the state may propose as part of the criminal justice system. Yet as I conclude in this paper, while there are some intrinsic constraints on voluntary rehabilitation programs, the main constraints on voluntary rehabilitation are likely to be contingent overriders. However, CNS intervention is not ruled out as such in the context of voluntary rehabilitation. (shrink)

Expert knowledge about society and human nature is essential to governing human conduct. It figures in the formulation of the liberal and neoliberal rationalities of government that Foucault analyzed in his later work. It also figures in particular assemblages in which a governmental rationality is brought to bear on the definition of problems and the formulation of solutions. This article explores the use of expert knowledge in governmental assemblages directed towards optimizing relations between people and land in the global south. (...) Since colonial times liberal versions of these assemblages have highlighted cultural difference, and attempted to fix particular populations into non-market niches. Elements from liberal assemblages have been grafted into neoliberal ones, producing the curious figure of homo economicus minus the market, the collectivized and arborealized subject of contemporary conservation initiatives. (shrink)

The presence of dual and ambivalent characters (good/ bad) has always constituted the aesthetic and educational content in children’s fairy tales. Since the Nineteenth century, fairy tales and children’s books have had as an essential reference increasingly complex images and illustrations with vivid colors. This, together with the narration, has allowed the flourishing of a genre of fairy tale noir, whose explicitly pedagogical content is grafted into the plots not always “to happy ending” of fairy tales. The book by (...) Heinrich Hoffmann, _Struwwelpeter_, and that by Ernst Theodor Hoffmann, _Der Sandmann_, which are at the heart of this essay, constituted a first, important example of this new kind of narrative. They have revealed, from a pedagogical-psychoanalytic perspective, the value of what Freud in a 1919 paper, _Das Unheimliche_, analyzed as a necessary manifestation of presence/absence (conscious and unconscious) in the phases of human growth. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Seven Poems NICOLAS CALAS (Translated by Avi Sharon) hellenizing surrealism: a greek door to europe Nicolas calas (Kalamares) may be considered merely a minor Greek poet, but he had a major global persona and influence. In the middle of the last century he played a catalyzing role in the international avant garde: He was a Zelig-like polemicist in three languages (Greek, French, and English) and across three cultural (...) capitals (Athens, Paris, and New York). But he always fought on a singular front: surrealism. Born in Lausanne in 1907, he grew up in Athens and by the later 1920s began to stand out in literary circles (he was over 6' 4") for his modernist if not revolutionary views. Starting from an interest in Freud and Marx, the subconscious and the revolutionary, Calas soon arrived at their natural synthesis—surrealism. Around the time when a distinctly Greek form of surrealist poetry emerged, with the 1935 publication of “Blast Furnace” by Andreas Embiricos, Calas was on his way to becoming its unofficial spokesman. He moved to the epicenter of the movement in Paris and with the 1938 publication of Foyers d’Incendie became the “most lucid and audacious” of founder André Breton’s acolytes, both prophet and demagogue of the group. Carried along in the current of European artists and thinkers leaving Europe for New York, he would continue the fight on the western wing of the faction (literally, coming to blows at a cocktail party with Clement Greenberg, representing the opposing Abstract Expressionist side). In 1942 he published another clarion pamphlet, Confound the Wise, giving the movement voice in English and befriending its most visible local supporters and practitioners, from Peggy Guggenheim to Marcel Duchamp. arion 27.1 spring/summer 2019 The Wyndham Lewis of the operation, Calas was a cross-border catalyst, evangelizing the role of surrealism as a liberating and generative force in modern literature and art. For him and other writers and poets, the weapon that would most effectively derange the reader’s habitual conformism into revelatory and revolutionary perception was the surrealist image, poetry’s lingua franca. For Greek practitioners it was completely natural for that magical representation to arise out of their god-infested, sun-filled landscape. Here they had a force that was both blinding and enlightening, penetrating and transformative, local and universal. For Calas, the primary echo or reflection of that essential image was the island of Santorini, referenced in several of the translations here (and reminiscent of his fellow national Nikos Gatsos’s use of the island of Amorgos in a similar context). It stood as the very symbol of fiery transformation, an image monstrous enough to shock the reader into a super-rational embrace of its own form of logic. This Hellenization of surrealism, like the Hellenization of modernism itself, was to become an important, transformative power in its own right. For many, the origin (and likewise, for many, the enclosing border ) of surrealism was France. “But it is French. It is their invention,” was how William Carlos Williams saw it, to his chagrin. Williams was convinced that the objective concentration on the image itself (“no ideas but in things”) could offer a salutary corrective to American poetry of his time. “It is the surrealists who have invented the living defense of literature,” he wrote in a 1929 essay. But for a poet so at one with the American Grain to be reconciled with surrealism’s ‘Francite’ he needed some way to cross the divide. His admiration for Calas’s work in clarifying and promoting the group’s ideas enabled the Greek poet to serve as a mediator, to allow the creative transference of its rebellious wisdom into Williams’s poetry. To borrow the title of one of his early American essays, Calas provided Williams a “Greek door to Europe.” In translating four of Calas’s French poems into English, published in 1941 with a frontispiece by the surrealist painter and magician Kurt Seligman, Williams leveraged Calas as the vehicle through which the “enabling foreignness” of surrealism could be grafted into the grain of his American modernist work, just as he set out on his magnum opus, Paterson. In a similar way... (shrink)

Cognitive deficits were produced in rats by different methods of damaging the brain: chronic ingestion of alcohol, causing widespread damage to diffuse cholinergic and aminergic projection systems; lesions (by local injection of the excitotoxins, ibotenate, quisqualate, and AMPA) of the nuclei of origin of the forebrain cholinergic projection system (FCPS), which innervates the neocortex and hippocampal formation; transient cerebral ischaemia, producing focal damage especially in the CA1 pyramidal cells of the dorsal hippocampus; and lesions (by local injection of the neurotoxin, (...) colchicine) of the granule cells of the dentate gyrus. Following chronic alcohol or lesions of the FCPS, transplants of cholinergically rich fetal brain tissue into the terminal areas (neocortex and/or hippocampus) restored performance almost to control levels, with a time course consistent with growth of the transplants and integration with host tissue; transplants of cholinergically poor fetal tissue (hippocampus) were without effect, as were transplants of cholinergically rich tissue into the region containing the nuclei of origin of the FCPS. Grafts of primary cells enriched in glia and cultured neuroblastoma cells into the terminal areas of the FCPS were equally effective, suggesting that there are multiple mechanisms by which neural transplants can restore cognitive function following diffuse cholinergic damage. In contrast, after ischaemia- or neurotoxin-induced damage to CA1 or dentate granule cells respectively, cholinergically rich fetal transplants into the damaged hippocampal formation were ineffective in restoring performance. After ischaemic damage, however, performance was restored by suspension grafts of CA1 cells but not by transplants containing CA3 pyramidal cells or granule cells; and after colchicine damage it was restored by solid grafts containing granule but not CA1 pyramidal cells. Furthermore, electrophysiological evidence has demonstrated functional, graft type-specific host-graft functional neuronal connectivity. Thus, restoration of cognitive function by neural transplants is possible after damage to either diffuse (cholinergic) or point-to-point (intrahippocampal) forebrain systems, but the transplant must be appropriate to the damage to be repaired. Because the different types of brain damage studied provide analogues of human alcoholic dementia, Alzheimer's disease, and heart attack, these results are encouraging with regard to the eventual application of neural transplant surgery to the treatment of cognitive deficits in humans. (shrink)

New possibilities to modify function and direct repair in the central nervous system (CNS) have been established by the merger of gene transfer technology with neural transplantation. Rapid advances in viral‐mediated DNA‐delivery procedures permit the study of novel gene expression in neurons and glial cells. Foreign genes, transferred by a virus vector, can be used to generate new cell lines, identify transplanted cells, and express growth factors or enzymes for neurotransmitter synthesis. In addition to CNS cell types, non‐neural cells are (...) also being studied with transgene technology in the nervous system. Functional effects have been obtained with grafts of genetically modified cells in animal models of several nervous system disorders, and the recent results set the stage for potential application of these techniques to human CNS gene therapy. (shrink)

The institutionalization of ethics is an important task for today's organizations if they are to effectively counteract the increasingly frequent occurrences of blatantly unethical and often illegal behavior within large and often highly respected organizations. This article discusses the importance of institutionalizing organizational ethics and emphasizes the importance of several variables (psychological contract, organizational commitment, and an ethically-oriented culture) to the institutionalization of ethics within any organization.... institutionalizing ethics may sound ponderous, but its meaning is straightforward. It means getting ethics (...) formally and explicitly into daily business life. It means getting ethics into company policy formation at the board and top management levels and through a formal code, getting ethics into all daily decision making and work practices down the line, at all levels of employment. It means grafting a new branch on the corporate decision tree — a branch that reads right/wrong (Purcell and Weber, 1979, p. 6). (shrink)