The conventional view of vitamins reflects a diverse group of small molecules that facilitate critical aspects of metabolism and prevent potentially fatal deficiency syndromes. However, vitamins also contribute to the shaping and maintenance of the human phenome over lifecycle and evolutionary timescales, enabling a degree of phenotypic plasticity that operates to allow adaptive responses that are appropriate to key periods of sensitivity (i.e., epigenetic response during prenatal development within the lifecycle or as an evolved response to environmental challenge over (...) a great many lifecycles). Individually, vitamins are important, but their effect is often based on nutrient‐nutrient (vitamin‐vitamin), nutrient‐gene (vitamin‐gene), and gene‐gene interactions, and the environmental influence of shifting geophysical cycles, as well as evolving cultural practices. These ideas will be explored within what I refer to as the “adaptive vitome (vitomics)” paradigm. (shrink)

Introduction: Globally, vitamin D deficiency is one of the most common deficiencies, affecting nearly half the world's population. The objective of this survey was to assess and compare the knowledge about vitamin D and the perceived state of health in Emirati and international tourist female students in Dubai, UAE. Methods: This is a cross-sectional study that took place in universities in Dubai, UAE. This survey consisted of 17 multiple choice questions. The first part of the survey assessed (...) levels of supplementation, diet and UV exposure. Another section evaluated the participants’ self-assessed state of health regarding vitamin D testing, symptoms related to vitamin D deficiency and general welbeing. The collected data were statistically analyzed using SPSS statistics for windows version 26.0 (SPSS Inc., Chicago, IL). Statistical significance was set at P<0.05. Results: 105 respondents were Emiratis and 65 were international students. The average age was 21, with an average BMI 23.3. Almost one-third of each group reported using Vitamin D supplements once weekly. The majority of both groups reported rarely getting tanned. Almost all participants reported regular consumption of Vitamin-D rich foods. In both groups, more than half reported consuming milk and cheese regularly and up to one-third reported consuming fish in a regular manner. Although more than half of the students rated their health as good; more than two-thirds reported experiencing muscle pain; only half reported having their blood Vitamin D levels measured once; half reported experiencing problems with concentration and more than three-quarters reported experiencing bad mood in the past month. The prevalence of these symptoms was almost similar across different categories of vitamin D supplementation, tanning habits, dietary intake, or nationality. No statistically significant differences were noted between the 2 groups. Conclusion: more Emirati students were aware of the association between vitamin D and osteoporosis than International tourist students (40% vs. 21.9%, respectively; p<0.05). On the other hand, both groups had lower knowledge about the relationship between vitamin D deficiency and depression, Rheumatoid Arthritis and Hypertension, and the optimal vitamin D level; however, no statistically significant differences were noted regarding this knowledge of Emiratis and international students. (shrink)

This article asserts that traditionally dominant models of health promotion in the US are fairly characterized by methodological individualism. This schema produces a focus on the individual as the node of intervention. Such emphasis results in a number of scientific and ethical problems. I identify three principal ethical deficiencies: first, the health promotions used are generally ineffective, which violates canons of distributive justice because scarce health resources are expended on interventions that are unlikely to produce health benefits. Second, the health (...) promotions used tend to expand health inequalities between the affluent and the least well-off. Third, the health promotions used are likely to intensify stigma against the least well-off, a deficiency that itself may exacerbate the ‘densely-woven patterns of disadvantage’ that characterize life on the tail of the social gradient. Because Powers and Faden’s health sufficiency model of social justice argues that the amelioration of such clusters of disadvantage should be the primary ethical goal of public health policy, methodologically individualist models of health promotion are ethically deficient and should not stand as primary approaches for health promotion in a just social order. (shrink)

The nature of the Plague described by Thucydides in Book 2, chapter 49, has long been discussed both by medical and by classical scholars. Of numerous suggested identifications none has found general approval; and it is doubtful whether any opinion is more prevalent today than that the problem is insoluble. The classical scholar is handicapped by his ignorance of medical science; his medical colleague has often been led astray by translations deficient in exactitude if not disfigured by error. The difficulties (...) are great enough: but there is one indispensable preliminary task which can be undertaken with some prospect of success. If Thucydides' description is to be compared with modern records, it is necessary first to determine what the Greek words mean; and that can only be done by determining how far the Greek is expressed in the technical terms of contemporary medical science. It is obvious that Thucydides required a special vocabulary for this part of his work; and in fact over forty words in chapters 49 and 50 are unexampled elsewhere in his History, and a dozen more are used in meanings unexampled elsewhere. It is certain that a number of medical treatises were in circulation in Thucydides' lifetime, and that a more or less standard vocabulary had been or was being established. Now if it can be shown that the great majority of the terms employed by Thucydides in ch. 49 recur, apparently with the same meanings, as standard terms in the contemporary doctors, our second task—the comparison of Thucydides' description with modern records—will become a more rational undertaking than it was before, no longer the doubtful speculation which many of the modern doctors suppose it to be, thinking as they do that they have to deal with a layman's generalities expressed in literary language. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:109 HUME'S MISSING SHADE OF BLUE, INTERPRETED AS INVOLVING HABITUAL SPECTRA David Hume claimed that his hypothetical case of the unseen shade of blue posed no fundamental problem to his general empiricist principle. But I believe it well may show exactly what he denied it showed — viz., that his empiricism rests on a mistake. Hume says: Suppose... a person to have enjoyed his sight for thirty years, and (...) to have become perfectly well acquainted with colours of all kinds, excepting one particular shade of blue, for instance, which it never has been his fortune to meet with. Let all the different shades of that colour, except that single one, be plac'd before him, descending gradually from the deepest to the lightest; 'tis plain, that he will perceive a blank, where that shade is wanting, and will be sensible, that there is a greater distance in that place betwixt the contiguous colours, than in any other. Now I ask, whether 'tis possible for him, from his own imagination, to supply this deficiency, and raise up to himself the idea of that particular shade, tho' it had never been conveyed to him by his senses? I believe there are few but will be of opinion that he can.... Sometimes one is surprised by the colour which emerges when one mixes paints, powders or lights of different hues, in the sense that one is unable to imagine this resulting colour until one actually sees it. I often have analogous experiences when sightreading music on the trombone. If there is a large, unfamiliar interval between the note I am playing and the one to be played next, so I cannot 'hear' the next note inwardly, I bring the slide to the correct position, set my lips at approximately the right tension, and presto! the correct note appears, despite 110 my inability to predict what it was going to sound like. Only after I have heard it can I also 'hear' it, i.e, predict its occurrence in this melodic line. Cases like these are not puzzling philosophically, because in them, the note, colour, etc. arises primarily from the equipment used — e.g., paints, powders or lights, the trombone and tension of the lips, and so on — rather than from the mind of the person who uses these things. But in Hume's example, no extra-mental objects or events play a direct role in creating the imagined colour. In fact, this colour never appears at all outside the subject's mind, and he never sees it. Therefore here the imagined colour is produced entirely by the subject himself, without his having copied it from anything in the external world. Yet this contradicts the maxim Hume laid down at the beginning of the Treatise that all simple ideas arise from correspondingly simple (sense) impressions. Two points perhaps mitigate the seriousness of the problem set by the missing shade of blue. First, Hume saw clearly, as Locke did not, that "innate" does 2 not mean the same as "justified." He was not so much concerned with the question of where ideas come from, as with how these ideas can be shown to be legitimate. His answer to the latter question is that experience alone is competent to show this. Second, strictly speaking, no idea is itself a piece of knowledge, but only something with the help of which one constructs knowledge-claims; and it is necessary for a person to justify knowledge-claims which are composed of innate ideas, by checking them against experience, just as much as knowledge-claims composed of non-innate materials. For example, suppose I possess innately the idea (visual image) of blue and the idea (tactile image) of cool. To say that these ideas are innate means that they are merely triggered or activated in my Ill mind by experiences I happen to have, but are not created by these experiences, and are not necessarily copies of them. Nevertheless, in order for me to know something which involves these ideas, I first must put them together in a judgment, and then confirm that judgment by appeal to experience. For instance, I might use these ideas to make the judgment... (shrink)

Equity was first established as a terminus technicus by Aristotle, but the word was initially shaped by Plato in his Statesman. Aristotle considers equity as a necessary criterion of the interpretation of human action, i.e., the ultimate, the particular moral situation, given that law is general, and every moral agent makes different moral choices, since man exhibits a multiplicity of purposes as a being and every person acts on the basis of a variety of moral perspectives and values. Therefore, the (...) task of every judge is to trace the moral choice made by a moral agent, as well as to interpret the law and attribute justice, since, as it is attested, law may be deficient, whereas this does not necessarily apply to justice itself. (shrink)

Assisted migration, an ecosystem engineering technology, is receiving increasing attention and significant support as a means to save biodiversity in a changing climate. Few substantive, or not obviously deficient, reasons have been offered for why pursuing this conservation goal via these means might be good. Some proponents of AM, including those who identify themselves as “pragmatists,” even suggest there is little need for such argument. We survey the principal reasons offered for AM, as well as reasons offered for not offering (...) reasons. As exemplified by the case for translocating whitebark pine, which may at first seem especially strong, we note the incongruence of framing the goal of AM in terms of “saving biodiversity,” neglect of some crucial moral questions, marginalization of normative and scientific context when AM is cast as the lesser of two evils in a “crisis,” doubtful validity and, in any case, marginal importance of arguments that AM projects ought to be undertaken, inconsistent use of scientific facts, and omission of science that counters sanguine assessments. All told—even in cases such as whitebark pine for which AM may seem most defensible—there is little reason to think that AM projects are good as means to “save biodiversity,” or good as means to other goals that have accreted into arguments for these projects. (shrink)

Some philosophers understand natural kinds to be the categories which are constraints on enquiry. In order to elaborate the metaphysics appropriate to such an account, I consider the complicated history of scurvy, citrus, and vitamin C. It may be tempting to understand these categories in a shallow way (as mere property clusters) or in a deep way (as fundamental properties). Neither approach is adequate, and the case instead calls for middle-range ontology: starting from categories which we identify in the (...) world and elaborating their structure, but not pretending to jump ahead to a complete story about fundamental being. (shrink)

This article deals with the complex relation between providence and descent in Neoplatonism, with particular reference to Proclus and especially his Commentary on the First Alcibiades. At least according to this work, descent is only a species of providence, because there can be providence without any descent. Whereas the gods provide for our cosmos without descending to it, a large group of souls provide for our cosmos by descending to it. The former kind of providence is better than the latter, (...) even if it is necessary that souls descend in order to give existence to the beautiful cosmos. The following study deals with providence as descent, looking at it from two angles. In the first section I show that Proclus designates this form of providence in two rather surprising ways. One term he uses for it, which will be well known to readers of Plotinus, is τόλµα —this despite the word’s negative connotations due to its Neopythagorean and Gnostic origin. A second name for descended providence is ἐπιστροφή. Again, this may be surprising, since we usually expect this term to express the ‘turning back’ of a lower effect to its cause. In Proclus, the word ἐπιστροφή too can have negative connotations, but he also uses it in a positive way when applying it to providence. In the second part of the paper, I explain how Socrates’ providence for Alcibiades can be undefiled, even if Socrates necessarily descends as he offers providential guidance. Proclus’ comparison of Socrates with Hercules, who went to the Underworld in order to save Theseus, serves as a positive illustration of Socrates’ divinelike providence, and marks the deficiency of Socrates compared to the transcendent and undefiled providence of Neoplatonic divinities. (shrink)

John Barrow is increasingly recognized as one of our most elegant and accomplished science writers, a brilliant commentator on cosmology, mathematics, and modern physics. Barrow now tackles the heady topic of impossibility, in perhaps his strongest book yet. Writing with grace and insight, Barrow argues convincingly that there are limits to human discovery, that there are things that are ultimately unknowable, undoable, or unreachable. He first examines the limits on scientific inquiry imposed by the deficiencies of the human mind: our (...) brain evolved to meet the demands of our immediate environment, Barrow notes, and much that lies outside this small circle may also lie outside our understanding. Barrow investigates practical impossibilities, such as those imposed by complexity, uncomputability, or the finiteness of time, space, and resources. Is the universe finite or infinite? Can information be transmitted faster than the speed of light? The book also examines the deeper theoretical restrictions on our ability to know, including Godel's theorem--which proved that there were things that could not be proved--and Arrow's Impossibility theorem about democratic voting systems. Finally, having explored the limits imposed on us from without, Barrow considers whether there are limits we should impose upon ourselves. For instance, if the secrets of the atom are to be found only by recreating extreme environments at great financial cost, just how much should we devote to that quest? Weaving together this intriguing tapestry, he illuminates some of the most profound questions of science, from the possibility of time travel to the very structure of the universe. (shrink)

This paper will proceed from the assumption of scholars like Anne Fernihough, Peter Fjagsund, Michael Black, and Michael Bell that there are sufficient connecting links between the literary oeuvre of D.H. Lawrence and the philosophizing of Martin Heidegger that they warrant consideration in each other's company. The paper will attempt to provide more evidence for what these scholars have been contending. It seeks to make the case that although D.H. Lawrence and Martin Heidegger start from very different beginning points, the (...) one literary, the other epistemological (so to speak), they arrive at surprisingly similar conclusions about the deficiencies in the specifically modern way of viewing human existence and the world. The paper isolates certain of Lawrence and Heidegger's key passages relevant to the themes of science, humanism, art and death and reveals them as looking at these fundamental issues from a remarkably similar standpoint. These two metaphysicians were groping for the right path forward from the intellectual and social crises of the twentieth century and the evidence suggests they saw it as lying in the same direction. (shrink)

The vegetation eaten by animals on large areas of several continents is deficient in phosphate and deleterious effects on physiology, particularly reproduction, ensue. Records on bone chewing behaviour by both pastoral andwild game animals extend over two centuries. In laboratory investigation of this apt behaviour it has been shown that the appetite for bones is innate and specific and cued predominantly by olfactory stimuli. It is suppressed by rapidly increasing the plasma phosphate concentration to normal but not influenced by increasing (...) the phosphate concentration in cerebrospinal fluid. The central organization of this genetically programmed behaviour appears to differ from systems subserving thirst and sodium appetite. (shrink)

In January 1990, the Parti Réformateur Libéral inaugurated a brand new management, called "bicephalism ": instead of the traditional presidentialsystem, one "ticket" with a president and a vice-president was commissioned to ensure the leadership of the party.The bicephalism was only the result of a tricky internal compromise, stemming from the discontent following the return of the party in the opposition and strengthened after the defeat at the European polls.The "two-headed" system wanted to restore the credibility and to reinforce the cohesion (...) of the PRL. In fact, this genuine political "curiosity" mainly revealed the structural and ideological deficiency which made its coming possible. lts ultimate defeat - at the 24 November1991 polls - caused itsfalling down.The bicephalism was bound to an identity problem of the french Belgian liberalism but also some features of the experience refer to a more general crisis of the values carried by the old traditional political movements. (shrink)

This paper addresses the silence about the Haitian revolution in the oeuvre of Karl Marx. He, who regarded revolutions as “locomotives of world history,” ignored the history of the revolution in Haiti and remained silent about its protagonists. In a brief approach to this paradox, I argue that the main reason for this blank space was Marx’s deficient analysis of contemporary racism. This is made clear in relation to 1) his acceptance of the biological meaning of race, 2) his involvement (...) in two main racisms of the time, antisemitism and colonial racism, and 3) his differentiation and gradation of historical subjects. The consequences were dramatic not because of Marx’s involvement in the racist zeitgeist but insofar as his learning process with regard to the relevance of anti-colonial movements and his awareness of negative societalization as well as its significance were not reflected in a theory of racism. This was to prove a debacle for subsequent attempts at a Marxist analysis of racism and has had effects that are still evident today. (shrink)

In this paper we argue that an operational organism concept can help to overcome the structural deficiency of mathematical models in biology. In our opinion, the structural deficiency of mathematical models lies mainly in our inability to identify functionally relevant biological characters in biological systems, and not so much in a lack of adequate mathematical representations of biological processes. We argue that the problem of character identification in biological systems is linked to the question of a properly formulated (...) organism concept. Lastly, we demonstrate how a decomposition of an organism into independent characters in the context of a specific biological process--such as adaptation by means of natural selection--depends on the dynamical properties and invariance conditions of the equations that describe this process. (shrink)

A number of cognitive and behavioral variables influence the performance in tasks of theory of mind (ToM). Since two of the most important variables, memory and explicit expression, are impaired in schizophrenic patients, the ToM appears inconsistent in these patients. An ideal instrument of ToM should therefore account for deficient memory and impaired ability of these patients to explicitly express intentions. If such an instrument is developed, it should provide information that can be used not only to understand the pathophysiology (...) but also to monitor patients. (shrink)

The protein tyrosine kinase activity of the v‐abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation. Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre‐B cell stage. Recent reports have characterized these cells expressing high v‐abl kinase activity as deficient in detectable NF‐kB DNA binding activity and low level RAG gene expression. These observations suggest that (...) v‐abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway. (shrink)

The key to wealth in health care is the physician, who certifies to third-party payers that health care items and services are necessary for patient care. To compete more effectively for this wealth, physician specialists are organizing their practices into for-profit corporations and employing other physicians. Focusing on neonatology, this article describes the prevailing business model of these for-profit medical groups as controlling employed physicians through restrictive employment contract provisions, e.g., non-compete and mandatory arbitration clauses. With this business model and (...) because of deficiencies in current law, for-profit medical groups eliminate competition from other physician specialists to the detriment of patients and consumers. (shrink)

This book is an excellent general introduction to existentialist thought. It organizes the subject-matter under traditional philosophic disciplines beginning with an account of the method and proceeding to ontology, epistemology, ethics, social and religious thought. The author concentrates on the writings of the leading figures in the movement--Kierkegaard, Heidegger, Marcel, Sartre, Jaspers--and delineates the areas of agreement and disagreement among them. The arrangement of materials around traditional problems facilitates the detection of changes in approach, emphasis, and formulation. The most important (...) aspect of the book lies in the attempt to view the movement as a part of the philosophical tradition, to explain the methods and doctrines against which the Existentialists react as well as their heroes in the tradition. The achievements of the movement are measured against its claims, and its major deficiencies are pointed out in the last chapter. Throughout the book the author manages to preserve a clarity and economy that are a welcome contrast to the style of existentialist writings.--T. D. Z. (shrink)

In this paper we describe the objectives of teaching medical ethics to undergraduates and the teaching methods used. We describe a workshop used in the University of Liverpool Department of Psychiatry, designed to enhance ethical sensitivity in psychiatry. The workshop reviews significant historical and current errors in the ethical practice of psychiatry and doctors' defence mechanisms against accepting responsibility for deficiencies in ethical practice. The workshop explores the student doctors' own group ethos in response to ethical dilemmas, and demonstrates how (...) the individual contributes to and is responsible for the group ethos through participation and also through nonparticipation. The student feedback about the workshop is reviewed. The Toronto Ethical Sensitivity Instrument was used to assess whether or not the workshop altered sensitivity. Compared to a control group the attenders' sensitivity was significantly increased (on Student's t-test p equals or is less than 0.002). (shrink)

Machiavelli's much advertised science of politics turns out, in the long run, to falter. Machiavelli's various stratagems for controlling political outcomes are workable a small percentage of the time at best. Unpredictability works continually against the theory of practical action. A large part of Machiavelli's adaptation to this deficiency is to turn at many crucial moments, to the unambiguous and startling clarity of murder as a political instrument. It is this central position of murder that helps to account for (...) worrying guiltiness that sticks to The Prince despite many years of efforts to soften the book's message. In the final analysis, one might even suggest that a kind of erotic fascination lurks within the book's texture of murder. (shrink)

I argue that Plantinga’s Proper Function and Evolutionary arguments fail against liberal naturalism defined in a broad sense as the view that „there aren’t any supernatural beings”. The former argument can be interpreted in at least three ways: deductively, inductively and theistically. None of these, however, is successful. The latter argument suffers from several deficiencies of which two major ones are: The unlikelihood of the reliability of our cognitive faculties, given naturalism and evolutionism, is not shown. Agnosticism with respect to (...) the likelihood of our cognitive reliability is insufficient to establish the self-defeating character of naturalistic evolutionism, unless it is also shown that the belief in this reliability lacks an independent warrant. The last condition has been neglected by Plantinga. (shrink)

In “Epistemic Modals,” Seth Yalcin argues that what explains the deficiency of sentences containing epistemic modals of the form ‘p and it might be that not-p’ is that sentences of this sort are strictly contradictory, and thus are not instances of a Moore-paradox as has been previous suggested. Benjamin Schnieder, however, argues in his Yalcin’s explanation of these sentences’ deficiency turns out to be insufficiently general, as it cannot account for less complex but still defective sentences, such as (...) ‘Suppose it might be raining.’ Consequently, Schnieder proposes his own, expressivist treatment of epistemic modals which he thinks can explain the deficiency of both the original sentence type as well as more complex cases of embedded sentences containing epistemic modals. In this study, I argue that although Schnieder is right to draw our attention to the explanatory failure of Yalcin’s account, we aren’t forced to adopt Schnieder’s expressivist account of epistemic modals. I defend instead a contextualist-friendly alternative which explains the deficiencies of all the relevant sentence types, while avoiding both the defects of Yalcin’s account and the intuitive costs of expressivism. (shrink)

Brandt's purpose is to clarify and help resolve the fundamental issues of moral philosophy by using "non-traditional types of evidence and non-traditional argument." Observing the deficiencies of common approaches to morality that build on alleged linguistic or moral "intuitions", he proposes instead to build on the findings of "contemporary psychology." Despite the promised novelty of Brandt's approach, however, his ultimate substantive findings differ relatively little from those of other contemporary Anglo-American writers on moral philosophy such as Rawls, and his method (...) of arguing for them suffers from some of the same defects that characterize more overtly intuitionistic approaches. (shrink)

Building on more than two decades offeminist analysis of the family, this article takes a neoinstitutionalist approach to examine some of the ways that sex, gender, and sexual orientation intersect in lesbianheaded two-parent families, affecting how they construct their roles as mothers. Institutionalist theory tends to de-emphasize how actors deliberately construct social arrangements such as parenting roles within the family. The authors' analysis of interviews from 14 lesbian mothers remedies this deficiency by focusing both on how they draw upon (...) and transform institutionalized scripts, practices, and understandings of family roles and relations. Their findings reveal how these mothers reinscribed gendered understandings while simultaneously challenging heteronormative ones in their efforts to construct and maintain socially viable two-parent families. (shrink)

In this paper we argue that an operational organism concept can help to overcome the structural deficiency of mathematical models in biology. In our opinion, the structural deficiency of mathematical models lies mainly in our inability to identify functionally relevant biological characters in biological systems, and not so much in a lack of adequate mathematical representations of biological processes. We argue that the problem of character identification in biological systems is linked to the question of a properly formulated (...) organism concept. Lastly, we demonstrate how a decomposition of an organism into independent characters in the context of a specific biological process—such as adaptation by means of natural selection—depends on the dynamical properties and invariance conditions of the equations that describe this process. (shrink)

This dissertation responds to a long-standing debate among scholars regarding the nature of Platonic Eros and its relation to lack. The more prominent account of Platonic Eros presents the lack of Eros as a deficiency or need experienced by the lover with respect to the object needed, lacked, or desired, so that the nature of Eros is construed as self-interested or acquisitive, subsisting only so long as the lover lacks the beloved object. This dissertation argues that such an interpretation (...) neglects the different senses of lack present in the Symposium and presents an alternative interpretation of Eros based on the Symposium's presentation of Eros as the child of Poverty and Resource. Chapter one examines the origin and development of the position that Platonic Eros is acquisitive or egocentric and the influence this has had on subsequent interpretations of Plato's thought. Chapter two argues that Diotima's theogony of Eros that presents him as a child of Poverty and Resource is central to understanding the account of Eros propounded in her discourse. Chapter three examines the development and refinement of the concepts of lack and poverty that are offered alongside those of Eros throughout Socrates' account of Eros in the Symposium. Chapters four and five discuss the relationship of these concepts of lack to the depiction of Eros as an intermediary and the ethical consequences of this relationship. Chapter six shows how the disposition of poverty serves as the source of the erotic ascent toward the vision of the beautiful itself. Chapter seven, drawing upon the analysis of previous chapters, argues that the reexamination of the role of poverty in the Symposium reveals that the account of Eros offered there describes a katharsis of the affective element in human beings, parallel to the katharsis of the rational element described in Plato's Phaedo. This katharsis involves the embrace of poverty as a way of living, loving, and knowing. Thus, the poverty of Eros does not indicate a lack that is egocentric or acquisitive, but describes a kind of asceticism or spiritual discipline that is requisite for the philosophical and moral life. (shrink)

This paper compares clinical intuition and phenomenological intuition. I begin with a brief analysis of Husserl’s conception of intuition. Second, I review the attitude toward clinical intuition by physicians and philosophers. Third, I discuss the Aristotelian conception of intellectual intuition or nous and its relation to phronesis. Phronesis provides a philosophical ground for clinical intuition by linking medicine as both a techné and praxis. Considering medicine as a techné, Pellegrino and Thomasma exclude clinical intuitions from their philosophy of medicine. However, (...) in modeling clinical reasoning on phronesis, they link Aristotelian nous with clinical reasoning. While supporting the application of phronesis to clinical reasoning, I consider Pellegrino and Thomasma’s model deficient for eliminating intuition as an inalienable element of clinical reasoning. Rather, clinical intuitions are necessary in linking medicine as both art and practice. This becomes more obvious through the phenomenological analysis of clinical intuitions. Clinical reasoning and phenomenological intuitions are similar in joining the perceptual and intellectual aspects of human judgment. Furthermore, clinical intuitions can be extended to become phenomenological intuitions through phenomenological reflection. Clinical intuitions may be examined phenomenologically for their originary foundations. In this way, medicine acts as a phenomenological clue. Phenomenology provides a method to restore the Hippocratic synthesis of empirical observation and wholism associated with clinical intuitions. (shrink)

An extensive, and controversial, literature concluding that prolactin (PRL), growth hormone (GH), insulin-like growth factor-I (IGF-I), and thyroid hormones are critical immunoregulatory factors has accumulated. However, recent studies of mice deficient in the production of these hormones or expression of their receptors indicate that there are only a few instances in which these hormones are required for lymphocyte development or antigen responsiveness. Instead, a case is made that their primary role is to counteract the effects of negative immunoregulatory factors, such (...) as glucocorticoids, which are produced when the organism is subjected to major stressors. The immunoprotective actions of PRL, GH, IGF-I, and/or thyroid hormones in these instances may ensure immune system homeostasis and reduce the susceptibility to stress-induced disease. These immuno-enhancing effects could be exploited clinically in instances where the immune system is depressed due to illness or various treatment regimens. BioEssays 23:288–294, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Mitochondrial DNA (mtDNA) mutations escalate with increasing age in higher organisms. However, it has so far been difficult to experimentally determine whether mtDNA mutation merely correlates with age or directly limits lifespan. A recent study shows that budding yeast can also lose functional mtDNA late in life. Interestingly, independent studies of replicative lifespan (RLS) and of mtDNA‐deficient cells show that the same mutations can increase both RLS and the division rate of yeast lacking the mitochondrial genome. These exciting, parallel findings (...) imply a potential causal relationship between mtDNA mutation and replicative senescence. Furthermore, these results suggest more efficient methods for discovering genes that determine lifespan. (shrink)

Methylmalonyl CoA mutase deficiency (methylmalonic acidemia) has been a paradigm for biochemical and somatic cell genetic approaches to human disease. Recently, genes encoding this enzyme have been cloned from several species. These studies have provided information about the primary structure and evolution of this enzyme, the mutations which underlie its deficiency state, and the structure‐function determinants which are required for its activity. Gene transfer studies now permit restitution of this enzyme to genetically deficient cells and may enable somatic (...) gene therapy to be undertaken. Molecular genetic studies not only provide more detailed information about this enzyme, but introduce new perspectives on the molecular mechanisms and dynamics of its function and raise new questions about the dyshomeostatic consequences of its deficiency. (shrink)

Examining health policy and its recent reform misadventures in the United States from a moral viewpoint is painful. That the nation devotes 14% of its Gross Domestic Product to health servicesand yet lets more than 40 million citizens go without health coverage strikes critics, both foreign and domestic, as a disgrace explicable only by ethical deficiencies distinctive to the American value system. There is certainly merit in this critique, which understandably incites fire and brimstone about the urgent moral imperative of (...) getting the nation on the path of righteousness at last. (shrink)

We perceive color everywhere and on everything that we encounter in daily life. Color science has progressed to the point where a great deal is known about the mechanics, evolution, and development of color vision, but less is known about the relation between color vision and psychology. However, color psychology is now a burgeoning, exciting area and this Handbook provides comprehensive coverage of emerging theory and research. Top scholars in the field provide rigorous overviews of work on color categorization, color (...) symbolism and association, color preference, reciprocal relations between color perception and psychological functioning, and variations and deficiencies in color perception. The Handbook of Color Psychology seeks to facilitate cross-fertilization among researchers, both within and across disciplines and areas of research, and is an essential resource for anyone interested in color psychology in both theoretical and applied areas of study. (shrink)

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Anna Chavlovski,1 Greg A Knoll,1–3 Timothy Ramsay,4 Swapnil Hiremath,1–3 Deborah L Zimmerman1–31University of Ottawa, 2Ottawa Hospital, 3Kidney Research Centre, Ottawa Hospital Research Institute, 4Ottawa Methods Centre, Ottawa, ON, CanadaBackground: In patients with end-stage renal disease, use of vitamin D and calcium-based phosphate binders have been associated with progression of vascular calcification that might have an impact on renal transplant candidacy. Our objective was to examine management of mineral metabolism in patients wait-listed for renal transplant and to determine the impact (...) on cardiac perfusion imaging.Methods: Data was collected retrospectively on patients wait-listed for a renal transplant, being either active and on hold. Demographic data, medications, serum concentrations of calcium, phosphate, parathyroid hormone, and cardiac perfusion imaging studies were collected from the electronic health record. Chi-square and Student’s t-tests were used to compare active and on-hold patients as appropriate. Logistic regression was used to examine variables associated with worsening cardiac imaging studies.Results: The wait-listed patients were of mean age 56 ± 14 years and had been on dialysis for 1329 ± 867 days. On-hold patients had received a significantly greater total dose of calcium and were more likely to have developed worsening cardiovascular imaging studies. Total doses of calcium and calcitriol were associated with worsening cardiovascular imaging studies.Conclusion: Patients on hold on the renal transplant waiting list received higher total doses of calcium. A higher total dose of calcium and calcitriol was also associated with worsening cardiovascular imaging. Time on dialysis before transplant has been associated with worse post-transplant outcomes, and it is possible that the total calcium and calcitriol dose received contributed to these inferior outcomes.Keywords: dialysis, calcium, cardiac, transplantation. (shrink)

Information on the factors influencing parents’ decision-making process following a lethal, life-limiting or severely debilitating prenatal diagnosis remains deficient. A comprehensive systematic review and meta-synthesis was conducted to explore the influencing factors for parents considering termination or continuation of pregnancy following identification of lethal, life-limiting or severely debilitating fetal abnormalities. Electronic searches of 13 databases were conducted. These searches were supplemented by hand-searching Google Scholar and bibliographies and citation tracing. Thomas and Harden’s thematic synthesis method was used to synthesise data (...) from identified studies. Twenty-four papers were identified and reviewed, but two papers were removed following quality assessment. Three main themes were identified through systematic synthesis. Theme 1, entitled ‘all life is precious’, described parents’ perception of the importance of the fetus’ life, a fatalistic view of their situation alongside moral implications as well as the implications decisions would have on their own life, in consideration of previous life experiences. Theme 2 contained two sub-themes which considered the parent’s own imagined future and the influence of other people’s experiences. Finally, Theme 3 presented three sub-themes which may influence their parental decision-making: These described parental consideration of the quality of life for their unborn child, the possibility of waiting to try for another pregnancy, and their own responsibilities and commitments. The first review to fully explore parental decision-making process following lethal, life-limiting, or severely debilitating prenatal diagnosis provided novel findings and insight into which factors influenced parents’ decision-making process. This comprehensive and systematic review provides greater understanding of the factors influential on decision-making, such as hope, morality and potential implications on their own and other’s quality of life, will enable professionals to facilitate supported decision-making, including greater knowledge of the variables likely to influence parental choices. (shrink)

The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoimmune disease, and infection. It does this by controlling the activation of the vitamin D receptor (VDR), a type 1 nuclear receptor and DNA transcription factor. Molecular biology is rapidly coming to (...) an understanding of the multiplicity of roles played by the VDR, but clinical medicine is having difficulty keeping up with the pace of change. For example, the FDA recently proposed a rule change that will encourage high levels of vitamin D to be added to even more foods, so that the manufacturers can claim those foods “reduce the risk of osteoporosis”. The FDA docket does not review one single paper detailing the transcriptional activity of vitamin D, even though, on average, one new paper a day is being published on that topic. Nor do they review whether widespread supplementation with vitamin D, an immunomodulatory secosteroid, might predispose the population to immune dysfunction. This BioEssay explores how lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease. BioEssays 30:173–182, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Over the past two decades, the understanding of the roles of vitamin D has expanded to include many nonskeletal effects such as reduced risk of acute respiratory tract infections, autoimmune diseases, cancer, cardiovascular disease, diabetes mellitus, neurological diseases, and adverse pregnancy and birth outcomes. The role of vitamin D for optimal health is well known in Western developed countries but less so in Central Asian countries. This narrative review compares the status of vitamin D between Central Asian (...) countries and Northern European countries. The analysis also summarizes the evidence for the beneficial effects of vitamin D and recommendations for Central Asian countries. (shrink)

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

General knowledge of the role of vitamin D3 in human physiology has been shaped by its discovery as a preventive agent of nutritional rickets, a defect in bone development due to inadequate uptake of dietary calcium. Studies on the function of the hormonal form of vitamin D3, 1α,25‐dihydroxyvitamin D3, have been greatly accelerated by the molecular cloning and structural analysis of the vitamin D3 receptor, which is a ligand‐activated regulator of gene transcription. Molecular genetic techniques including genomics (...) have helped reveal that 1α,25‐dihydroxyvitamin D3 can control more than calcium homeostasis. It has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Moreover, accumulating epidemiological and molecular evidence suggests that 1α,25‐dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon. Here, we survey the most‐recent findings and discuss their implications for the potential therapeutic uses of vitamin D analogues. BioEssays 26:21–28, 2004. © 2003 Wiley Periodicals, Inc. (shrink)