Psychosocial distress is highly prevalent in cancer patients, approaching rates around 40% across various cancer sites according to multicenter studies. As such, distress screening procedures have been developed and implemented to identify and respond to cancer patients' psychosocial distress and concerns. However, many cancer patients continue to report unmet psychosocial needs suggesting gaps in connecting patients with psychosocial services. Presently, there is a paucity of research examining sex-based disparities in referral rates to behavioral oncology services, particularly for adolescent and young (...) adult cancer patients. Informed by gender role conflict and empirical literature documenting disparities in cancer care and treatment based on a variety of sociocultural variables, this study aimed to examine the presence of sex disparities in referral rates to behavioral oncology services for AYA cancer patients. Data for this study consisted of 1,700 AYA cancer patients who completed a distress screening at a large cancer center of a teaching hospital in the Midwestern United. Results indicated that patient sex significantly predicted the odds of behavioral oncology referral. This finding indicates that female AYA cancer patients are 2.5 times more likely to be referred to behavioral oncology services compared to male AYA cancer patients after controlling for psychosocial distress and emotional, family, and practical problems. Additionally, we found that emotional problems significantly moderated the odds of referral for males and females, however the odds of referral for males who endorsed emotional problems were lower than males who did not endorse emotional problems. This contrasted with female AYA cancer patients where the endorsement of emotional problems increased the odds of referral to behavioral oncology services. Findings are discussed with particular focus on how to enhance equitable care and reduce sex and other sociocultural-based disparities in AYA psychosocial oncology. (shrink)

Disjointism is the view that co-located objects do not share any parts. A human-shaped statue is composed from a torso, head and limbs; the co-located lumpof clay is only composed from chunks of clay. This essay discusses the tenability of this relatively neglected view, focusing on two objections. The first objection is that disjointism implies co-located copies of microphysical particles. I argue that it doesn’t imply this and that there are more plausible disjointist views of tiny parts available. The second (...) objection is that disjointism is at a loss to explain how material objects can be co-located and why the weights of co-located objects don’t add up. The standard pluralist account appeals to the fact that co-located objects stand in mereological relations and this account is not available to the disjointist. I sketch an alternative account that appeals to a notion of ‘material identity’: the statue is taken to be the same matter as the lump of clay. The resort to a new theoretical primitive may seem to invite a quick rejection on grounds of unnecessary theoretical complexity but I argue that an abductive comparison with rival forms of pluralism shows that such a rejection is misguided. (shrink)

Although shared decision-making is a standard in medical care, unilateral decisions through process-based conflict resolution policies have been defended in certain cases. In patients who do not stand to receive proportional clinical benefits, the harms involved in interventions such as cardiopulmonary resuscitation seem to run contrary to the principle of non-maleficence, and provision of such interventions may cause clinicians significant moral distress. However, because the application of these policies involves taking choices out of the domain of shared decision-making, they face (...) important ethical and legal problems, including a recent challenge to their constitutionality. In light of these concerns, we suggest a re-conceptualization of informed non-dissent as an alternative approach in cases where the application of process-based policies is being considered. This clinician-directed communication model still preserves what is valuable in such policies and salvages professional integrity, while minimising ethical and legal challenges. (shrink)

This essay is dedicated to the memory of Katherine Hawley.1Bitcoin was invented to serve as a digital currency that demands no trust in financial institutions, such as commercial and central banks. This paper discusses metaphysical aspects of bitcoin, in particular the view that bitcoin is socially constructed, non-concrete, and genuinely exists. If bitcoin is socially constructed, then one may worry that this reintroduces trust in the communities responsible for the social construction. Although we may have to rely on certain communities, (...) I argue that social construction doesn’t imply a demand for trust because the relevant communities don’t take on any relevant commitments. Bitcoin is indeed trust-free. (shrink)

Evidence for the contribution of the neocortex to memory is overwhelming. However, the theory proposed by Ruchkin et al. does not only ignore subcortical contributions, but also introduces an unnecessary and empirically unsupported division between the posterior cortex, assumed to represent information, and the prefrontal cortex, assumed to control activation. We argue instead that the representational power of the neocortex is not restricted to its posterior part.

Pastor and author Martin Thielen has compiled a list of ten things people need to believe, and ten things they don't, in order to be a Christian. This lively and engaging book will be a help to seekers as well as a comfort to believers who may find themselves questioning some of the assumptions they grew up with. With an accessible, storytelling style that's grounded in solid biblical scholarship, Thielen shows how Christians don't need to believe that sinners will (...) be "left behind" to burn in hell or that it's heresy to believe in evolution. And while we must always take the Bible seriously, we don't always have to take it literally. At the same time, Christians do need to believe in Jesus--his life, his teachings, his death and resurrection, and his vision for the world. A great benefit of those beliefs is that they provide promising answers to life's most profound questions, including: Where is God? What matters most? What brings fulfillment? What about suffering? Is there hope? Thielen articulates centrist, mainline Christianity in a way that's fresh and easy to understand, and offers authentic Christian insights that speak to our deepest needs. This new edition includes a leader's guide, previously only available online, and a new introduction from the author that reflects on the book's reception. The leader's guide features unique and easily implemented aids for carrying out a seven-week, congregation-wide initiative that will help local churches reach out to their communities. More information is available at thielen.wjkbooks.com. (shrink)

I am trying...to go back through all those places where I was exiled-enclosed so he could constitute his there. To read his text to try to take back from it what he took from me irrecoverably...I am trying to re-discover the possibility of a relation to air. Don’t I need one, well before starting to speak?

Taking precautions to prevent harm. Whether principe de précaution, Vorsorgeprinzip, føre-var prinsippet, or försiktighetsprincip, etc., the precautionary principle embodies the idea that public and private interests should act to prevent harm. Furthermore, the precautionary principle suggests that action should be taken to limit, regulate, or prevent potentially dangerous undertakings even in the absence of absolute scientific proof. Such measures also naturally entail taking economic costs into account. With the environmental disasters of the 1980s, the precautionary principle established itself as an (...) operational concept. On the eve of the 1997 Climate Summit in Kyoto, precaution, as the precautionary principle is often referred to, has now become a key legal principle in environmental law, in general, and in current international climate negotiations, in particular, attempts to understand why. It examines in turn the natural affinity between the precautionary principle and climate change, reviews a series of issues which the principle raises, and discusses avenues which it opens paper, climate change fulfills the theoretical requirements set for the application of the precautionary principle. It comes as no surprise that the actual application of the precautionary principle in the context of climate change raises high political stakes. As a result, climate change science, in particular, and science, in general, is under the fire of politically-motivated scientific skeptics. Thus, by way of the counter-measures which must be put into effect, the precautionary principle calls for a greater sense of responsibility on the part of scientists and the public at large. Specifically, from scientists, it demands perseverance in rigor, excellence in communication, and committment to education. However, even if special efforts are made to implement the precautionary principle in the context of climate change, the success of climate change mitigation will constitute no test of the validity, the usefulness, or the efficiency of the precautionary principle. Indeed, the degree to which climate change mitigation succeeds only provides a measure of our kind's ability to manage responsibly the global commons which we inherited from our ancestors and which our generation enjoys, the global commons which we will pass on to today's children and to generations to come. (shrink)

The concept of individualism has gone through a fundamental change, according to distinguished political theorist Nadia Urbinati. In the nineteenth century, individualism was a philosophical and ethical perspective that permitted each person to respect and cooperate with others as equals in rights and dignity for the betterment of the community as a whole. Today, the individualist is a more self-interested entity whose maxim might best be expressed as “I don’t give a damn.” This contemporary form of individualism is possessive and (...) conformist, litigious and docile, all too prone to manipulate norms and to submit to the tyrannical sway of private interests. As such, Urbinati believes, it represents the most radical risk that modern democracy currently faces. This well-reasoned and thought-provoking polemic is an attempt to detect the “tyranny of the moderns,” with the ultimate aim of recovering the role of the individual citizen as a free and equal agent of democratic society. It explores the concept of communitarianism as a form of individualism applied to the group itself, and advances the idea that the rescue of true individualism from the current ideology is a basic condition for the defense of democratic citizenship. (shrink)

Pragmatic arguments seek to demonstrate that you can be placed in a situation in which you will face a sure and foreseeable loss if you do not behave in accordance with some principle P. In this article I show that for every P entailed by the principle of maximizing expected utility you will not be better off from a pragmatic point of view if you accept P than if you don’t, because even if you obey the axioms of expected utility (...) theory it is possible to place you in a situation in which you will face a certain and foreseeable loss. This shows that for a large class of Ps, there is no pragmatic difference between people who accept P and those who don’t. (shrink)

One reason why humans don't behave according to standard game theoretical rationality is because it's not realistic to assume that everyone else is behaving rationally. An individual is expected to have psychological mechanisms that function to maximize his/her long-term payoffs in a world of potentially “irrational” individuals. Psychological decision theory has to be individualistic because individuals make decisions, not groups.

Kurt Gödel is almost as famous—one might say “notorious”—for his extreme platonist views as he is famous for his mathematical theorems. Moreover his platonism is not a myth; it is well-documented in his writings. Here are two platonist declarations about set theory, the first from his paper about Bertrand Russell and the second from the revised version of his paper on the Continuum Hypotheses.Classes and concepts may, however, also be conceived as real objects, namely classes as “pluralities of things” or (...) as structures consisting of a plurality of things and concepts as the properties and relations of things existing independently of our definitions and constructions.It seems to me that the assumption of such objects is quite as legitimate as the assumption of physical bodies and there is quite as much reason to believe in their existence.But, despite their remoteness from sense experience, we do have something like a perception also of the objects of set theory, as is seen from the fact that the axioms force themselves upon us as being true. I don't see any reason why we should have less confidence in this kind of perception, i.e., in mathematical intuition, than in sense perception.The first statement is a platonist declaration of a fairly standard sort concerning set theory. What is unusual in it is the inclusion of concepts among the objects of mathematics. This I will explain below. The second statement expresses what looks like a rather wild thesis. (shrink)

An accessible, higher-level introduction to a key selection of continental European thinkers from Spinoza to Zizek. Covering 'classical' exponents of the tradition such as Hegel and Marx, 'moderns' like Gramsci and Habermas and 'postmoderns' like Lacan and Deleuze, the volume introduces the main ideas of each thinker and reflects on their enduring theoretical relevance. The impressive breadth and contemporary angle make this a unique, up-to-date collection that will be invaluable to students and teaching staff alike.

In this collection of essays -- a follow up to My Way and Our Stories -- John Martin Fischer defends the contention that moral responsibility is associated with "deep control." Fischer defines deep control as the middle ground between two untenable extreme positions: "superficial control" and "total control."Our freedom consists of the power to add to the given past, holding fixed the laws of nature, and therefore, Fischer contends, we must be able to interpret our actions as extensions of (...) a line that represents the actual past. In "connecting the dots," we engage in a distinctive sort of self-expression. In the first group of essays in this volume, Fischer argues that we do not need genuine access to alterative possibilities in order to be morally responsible. Thus, the line need not branch off at crucial points. In the remaining essays in the collection he demonstrates that deep control is the freedom condition on moral responsibility. In so arguing, Fischer contends that total control is too much to ask--it is a form of "metaphysical megalomania." So we do not need to "trace back" all the way to the beginning of the line in seeking the relevant kind of freedom or control. Additionally, he contends that various kinds of "superficial control"--such as versions of "conditional freedom" and "judgment-sensitivity" are too shallow; they don't trace back far enough along the line. In short, Fischer argues that, in seeking the freedom that grounds moral responsibility, we need to carve out a middle ground between superficiality and excessive penetration. Deep Control is the "middle way."Fischer presents a new argument that deep control is compatible not just with causal determinism, but also causal indeterminism. He thus tackles the luck problem and shows that the solution to this problem is parallel in important ways to the considerations in favor of the compatibility of causal determinism and moral responsibility. (shrink)

What if a tree told a joke in the woods and there was no one there to hear it? Occasionally I watch The Ellen DeGeneres Show. I have appreciated Ellen as a comedian since she first came on the public scene, and one part of her talk show that I enjoy is the dancing in the opening segment, where Ellen dances to music played by a DJ, and she goes up into the audience and the overwhelmingly female audience dances with (...) her. I like to dance and I enjoy watching other people dance, but the Ellen dance segment also holds a special fascination for me, as there is a style of dancing I have observed over the last twenty-five years or so, a style that might as well be called “lesbian,” and which, if you don’t .. (shrink)

A Zen Maoist koan: Bill is developing a crazy synthesis that brings together Buddhism, Maoism, and French Marxism, especially Badiou. Running through all three are themes concerning emptiness, letting go, and contingency. On the other hand, when Bill's mind runs toward just making up stuff that seems funny to him, it is hard for him to stop. This “essay” is a meeting point between these two activities, and at some point in the underdetermined, contingent future there will have to be (...) expansion upon these themes and “examples” – “Joke Ideas,” as Bill calls them – and some serious analysis of what we have learned in this experiment. Best read with John Cage playing in the background – and we don’t mean 4′33″. That would be silly. (shrink)

My aim in what follows is to contribute to recent discussions concerning the place of phenomenology within the tradition of transcendental philosophy. Very broadly, the issue here is whether phenomenology aspires to provide transcendental results, and if so, whether it can hope meet those aspirations. This is a large and many-faceted question; my aim here is to explore one rather narrow slice of it. I shall for the most part confine my attention to the version of the phenomenological enterprise found (...) in Division I of Being and Time. And I shall concern myself not with the full range of questions raised by the idea of a transcendental inquiry but rather myopically with a set of questions concerning the distinctive logical modality of purported transcendental results. This modality can be identified in various ways, but we can see it at work in the oft-repeated thought that transcendental philosophy aims to identify the conditions on the possibility of certain facts or features of our experience. If A is a condition on the possibility of B, then it would seem that A must obtain, given the actuality of B. We might accordingly frame the issue as a question about the modality of necessity in the context of Heideggerian phenomenology. Even so narrowed, the issues here are still pretty large and thorny. I don’t pretend here to be able to resolve them; my hope is that I can at least sharpen the questions and perhaps thereby render them more tractable. In pursuing these issues I shall pay particular attention to a recent illuminating analysis proposed and elaborated by Taylor Carman. (shrink)

We argue that explanationist views in epistemology continue to face persistent challenges to both their necessity and their sufficiency. This is so despite arguments offered by Kevin McCain in a paper recently published in this journal which attempt to show otherwise. We highlight ways in which McCain’s attempted solutions to problems we had previously raised go awry, while also presenting a novel challenge for all contemporary explanationist views.

In 2014 the Essex Autonomy Project undertook a six month project, funded by the AHRC, to provide technical advice to the UK Ministry of Justice on the question of whether the Mental Capacity Act is compliant with the United Nations Convention on the Rights of Persons with Disabilities. Over the course of the project, the EAP research team organised a series of public policy roundtables, hosted by the Ministry of Justice, and which brought together leading experts to discuss and debate (...) the issues. A one-day public conference was held at the Institute for Government in July. In September 2014, the EAP research team submitted its findings to the Ministry of Justice. (shrink)

ISBN-13: 978-0-8229-4317-4 (cloth : alk. paper) ISBN-10: 0-8229-4317-4 (cloth : alk. paper) 1. Science — Philosophy. 2. Science — Social aspects. 3. Values. 4. Science and civilization. I. Carrier, Martin. II. Howard, Don, professor. III. Kourany ...

Planctomycetes, Verrucomicrobia and Chlamydia are prokaryotic phyla, sometimes grouped together as the PVC superphylum of eubacteria. Some PVC species possess interesting attributes, in particular, internal membranes that superficially resemble eukaryotic endomembranes. Some biologists now claim that PVC bacteria are nucleus‐bearing prokaryotes and are considered evolutionary intermediates in the transition from prokaryote to eukaryote. PVC prokaryotes do not possess a nucleus and are not intermediates in the prokaryote‐to‐eukaryote transition. Here we summarise the evidence that shows why all of the PVC traits (...) that are currently cited as evidence for aspiring eukaryoticity are either analogous (the result of convergent evolution), not homologous, to eukaryotic traits; or else they are the result of horizontal gene transfers. (shrink)

This paper continues a recent exchange in this journal concerning explanationist accounts of epistemic justification. In the first paper in this exchange, Byerly argues that explanationist views judge that certain beliefs about the future are unjustified when in fact they are justified. In the second paper, McCain defends a version of explanationism which he argues escapes Byerly’s criticism. Here we contribute to this exchange in two ways. In the first section, we argue that McCain’s defense of explanationism against Byerly’s objection (...) is unsuccessful. Then, in the second section, we develop an independent objection to explanationism from a different direction. If our arguments in each section are sound, then not only do explanationist accounts of epistemic justification judge beliefs that are justified to be unjustified, but they judge beliefs that are unjustified to be justified. Explanationism faces problems on both sides. (shrink)

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)