Inventing Superstition weaves a powerfully coherent argument that will transform our understanding of religion in Greek and Roman culture and the wider ancient ...

Both fairness and efficiency are important considerations in market design and regulation, yet many regulators have neither defined nor measured these concepts. We develop an evidencebased policy framework in which these are both defined and measured using a series of empirical proxies. We then build a systems estimation model to examine the 2003–2011 explosive growth in algorithmic trading on the London Stock Exchange and NYSE Euronext Paris. Our results show that greater AT is associated with increased transactional efficiency and reduced (...) information leakage in top quintile stocks. For less liquid stocks, manipulation at the close declines. We also document the tradeoff between reduced spreads and increased manipulation or information leakage following the introduction of MiFID1. (shrink)

We develop a framework for assessing security market quality, relating five elements of market design to three metrics of market integrity and two metrics of market efficiency. We empirically implement this integrity–efficiency MQ framework by testing a hypothesis that trade-based ramping manipulation at the close raises execution costs on 24 security markets worldwide. Estimating a simultaneous equations model of ramping incidence, spreads, and the probability of deploying real-time surveillance, we show that quoted bid-ask spreads are positively related to the incidence (...) of MTC across seven liquidity deciles. The magnitude is economically significant; improving market integrity by cutting MTC in half reduces spreads 6–11 %. Allowing direct market access in conjunction with RTS, conducting auctions at the close, and developing regulations that require surveillance, all reduce MTC and thereby lower spreads, assuring better market integrity and enhancing market efficiency. Introducing circuit breakers or prohibiting shorts poses integrity–efficiency tradeoffs. (shrink)

Both fairness and efficiency are important considerations in market design and regulation, yet many regulators have neither defined nor measured these concepts. We develop an evidencebased policy framework in which these are both defined and measured using a series of empirical proxies. We then build a systems estimation model to examine the 2003–2011 explosive growth in algorithmic trading on the London Stock Exchange and NYSE Euronext Paris. Our results show that greater AT is associated with increased transactional efficiency and reduced (...) information leakage in top quintile stocks. For less liquid stocks, manipulation at the close declines. We also document the tradeoff between reduced spreads and increased manipulation or information leakage following the introduction of MiFID1. (shrink)

DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient inhibitors of this protein have been known for more than 20 years, none of them have enjoyed prolonged pharmaceutical success. It is only recently that the mechanisms of inhibition for some of these classes of drugs have been established unequivocally by X‐ray crystallography. It is hoped that this detailed structural information will assist the design of novel, effective inhibitors of DNA gyrase.

This paper explores the relationship of mourning and the gift in the work of Jacques Derrida. I argue that mourning is not a Derridean gift, but mourning does open us to the gift. Reading the works of Aristotle, Cicero, and Kierkegaard on friendship and love to the dead in the wake of Derrida’s Politics of Friendship makes this relation among mourning and the gift apparent for he presents mourning as the opening to a democracy to-come whose logic is the gift. (...) Through these accounts, I maintain that in preparing us for the gift, mourning the dead other can help us to relate better with the living other in ethical, political, and ontological terms. (shrink)

This paper introduces a new, expanded range of relevant cognitive psychological research on collaborative recall and social memory to the philosophical debate on extended and distributed cognition. We start by examining the case for extended cognition based on the complementarity of inner and outer resources, by which neural, bodily, social, and environmental resources with disparate but complementary properties are integrated into hybrid cognitive systems, transforming or augmenting the nature of remembering or decision-making. Adams and Aizawa, noting this distinctive complementarity argument, (...) say that they agree with it completely: but they describe it as “a non-revolutionary approach” which leaves “the cognitive psychology of memory as the study of processes that take place, essentially without exception, within nervous systems.” In response, we carve out, on distinct conceptual and empirical grounds, a rich middle ground between internalist forms of cognitivism and radical anti-cognitivism. Drawing both on extended cognition literature and on Sterelny’s account of the “scaffolded mind” (this issue), we develop a multidimensional framework for understanding varying relations between agents and external resources, both technological and social. On this basis we argue that, independent of any more “revolutionary” metaphysical claims about the partial constitution of cognitive processes by external resources, a thesis of scaffolded or distributed cognition can substantially influence or transform explanatory practice in cognitive science. Critics also cite various empirical results as evidence against the idea that remembering can extend beyond skull and skin. We respond with a more principled, representative survey of the scientific psychology of memory, focussing in particular on robust recent empirical traditions for the study of collaborative recall and transactive social memory. We describe our own empirical research on socially distributed remembering, aimed at identifying conditions for mnemonic emergence in collaborative groups. Philosophical debates about extended, embedded, and distributed cognition can thus make richer, mutually beneficial contact with independently motivated research programs in the cognitive psychology of memory. (shrink)

This is a phenomenological description of what is happening when we experience the death of another that interprets surviving or living on after such death by employing the term event. This term of art from phenomenology and hermeneutics is used to describe a disruptive and transformative experience of singularity. I maintain that the death of the other is an experience of an event because such death is unpredictable or without a horizon of expectation, excessive or without any principle of sufficient (...) reason, and transformative or a death of the world itself. (shrink)

Since Heidegger, at least, the theme of the event has become a focal point of current debate in continental philosophy. While scholars recognize the important contributions that Jacques Derrida has made to this debate, the significance of his considerations of the death of the other for his conception of the event has not yet been fully appreciated. This essay focuses on Derrida’s efforts to develop the notion of the event in reference to the death of the other through his engagement (...) with Paul Celan in “Rams—Between Two Infinities, The Poem.” I argue that Derrida’s approach results in a three-fold contribution to the debate about the character of the event. Derrida turns to one of Celan’s poems in an effort to find the kind of speech that attests to the event in its singularity, and in this turn, he develops not only the structure of the event’s appearance in the death of the world when the other dies but also the ethical impetus that accompanies this event of the death of the other, namely a call for workless mourning. Through Derrida’s contribution, we learn that the concern for the event not only includes novel approaches to ontology but also attempts to weave together ontological, ethical, as well as existential concerns. (shrink)

Due to constraints on institutional capacity and financial resources, the road to universal health coverage (UHC) involves difficult policy choices. To assist with these choices, scholars and policy makers have done extensive work on criteria to assess the substantive fairness of health financing policies: their impact on the distribution of rights, duties, benefits and burdens on the path towards UHC. However, less attention has been paid to the procedural fairness of health financing decisions. The Accountability for Reasonableness Framework (A4R), which (...) is widely applied to assess procedural fairness, has primarily been used in priority-setting for purchasing decisions, with revenue mobilization and pooling receiving limited attention. Furthermore, the sufficiency of the A4R framework’s four criteria (publicity, relevance, revisions and appeals, and enforcement) has been questioned. Moreover, research in political theory and public administration (including deliberative democracy), public finance, environmental management, psychology, and health financing has examined the key features of procedural fairness, but these insights have not been synthesized into a comprehensive set of criteria for fair decision-making processes in health financing. A systematic study of how these criteria have been applied in decision-making situations related to health financing and in other areas is also lacking. This paper addresses these gaps through a scoping review. It argues that the literature across many disciplines can be synthesized into 10 core criteria with common philosophical foundations. These go beyond A4R and encompass equality, impartiality, consistency over time, reason-giving, transparency, accuracy of information, participation, inclusiveness, revisability and enforcement. These criteria can be used to evaluate and guide decision-making processes for financing UHC across different country income levels and health financing arrangements. The review also presents examples of how these criteria have been applied to decisions in health financing and other sectors. (shrink)

Søren Kierkegaard used his literary, philosophical, and theological voice to reintroduce Christianity to Christendom. In this effort, he repeatedly uses the Apostle Paul's first letter to the church in Corinth. Though some have noted the importance of 1 Corinthians for Kierkegaard, they have not explained this importance nor this letter's role in Kierkegaard's corpus. This essay seeks to fill this gap in Kierkegaard scholarship by explaining the role this letter plays in Kierkegaard's Climacean authorship. Paul's battle with the Corinthian view (...) of wisdom and Kierkegaard's battle with Hegelian philosophy, which seeks to go beyond faith through speculative thinking, share similarities that engender both their works. In their battles with their respective foes, both develop a Christocentric epistemology that displaces the import of human understanding and cognitive content with the person Jesus who inverts their opponents' epistemic values by salvifically redefining wisdom and knowledge. This epistemology of a different kind is an offense, foolishness, and absurd to their opponents because it cannot be intellectually grasped by human understanding, but rather in and through the passion of faith, which places the individual in relation with Jesus. For both authors, this relation is the essential point for the Christian life. (shrink)

ABSTRACTThis article meditates on the Christian command to love the neighbor as yourself by focusing on how both Jacques Derrida and Søren Kierkegaard have read this command. I argue that Derrida, failing in his faithfulness to Kierkegaard, makes a mistake when he includes this command in the Greek model of the politics of friendship in his Politics of Friendship. Such a mistake is illumined by Kierkegaard’s understanding of the neighbor in this command from Works of Love because this understanding helps (...) to develop Derrida’s vision of a democracy and politics that resists the hegemony of the masculine and remains open to the event of a non-hierarchical relation to the other. (shrink)

Everyday Humanism seeks to move the discussion of humanism's positive contributions to life away from the macro-level to focus on the everyday, or micro-dimensions of our individual and collective existence. How might humanist principles impact parenting? How might these principles inform our take on aging, on health, on friendship? These are just a few of the issues around everyday life that needed interpretation from a humanist perspective. Through attention to key issues, the volume seeks to promote the value of humanism (...) at the level of the ordinary, typical occurrences and conditions of our existence. (shrink)

Persuasion is communication that has the potential to change the recipient’s behavior. War can be very persuasive. However, fighting is not persuasive unless it carries a persuasive message—one that changes the enemy’s behavior. Thus, the battle to persuade the enemy can be more important than the battle to destroy the enemy. Superior force of arms can lose to superior persuasion.

This World Bank Report offers a new conception of fair decision processes in health financing. It argues that such procedural fairness can contribute to fairer outcomes, strengthen the legitimacy of decision processes, build trust in authorities, and promote the sustainability of reforms on the path to health coverage for all.

The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...) of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

To what extent do the mother's and father's jobs and occupational sex-typing influence the status and sex-typing of their children's occupation at first entry into the labour market? Referring to a database containing 5027 respondents of two merged Dutch surveys held between 1992 and 1995, this study finds that the effect of the mother's occupational status on her daughter's is significant, but smaller than either the effect of father's status on his son's or his daughter's status. The mother's occupational sex-typing (...) is related to her daughter's occupational sex-typing. The more female sex-typed the daughter's occupation, the lower her occupational status. In the same way, the father's occupational sex-typing is related to his son's occupational sex-typing. While the extension of the classical status attainment models by the mother's occupation and occupational sex-typing leads to interesting and new coefficients, the authors conclude that the more elementary classical model is not invalidated by these new perspectives. (shrink)

Le présent essai se propose d'appréhender la doctrine cartésienne selon laquelle ce qui existe ne saurait subsister sans que Dieu le soutienne dans l'être par une activité créatrice continuée. Comment Dieu soutient-il l'existence et pourquoi lui est-il nécessaire de le faire ? L'auteur analyse l'apparente contradiction, qui fait problème, entre la doctrine de la création continuée et l'affirmation par Descartes que le mouvement se poursuit à moins que n'intervienne quelque force extérieure. Il examine ensuite, pour la récuser, la thèse (défendue (...) par Gilson et par Gueroult) selon laquelle la doctrine de la création continuée impliquerait la discontinuité du temps. This essay seeks to understand Descartes's doctrine that what exists cannot continue to exist unless God sustains it by continuous creative activity. How does God sustain existence and why is it necessary for Him to do this ? The essay explores a puzzling apparent contrast between the doctrine of continuous creation and Descartes's claim that motion continues unless an external force interferes. Further, it considers and rejects the thesis (maintained by Gilson and Gueroult) that the doctrine of continuous creation entails that time is discontinuous. (shrink)

Le présent essai se propose d'appréhender la doctrine cartésienne selon laquelle ce qui existe ne saurait subsister sans que Dieu le soutienne dans l'être par une activité créatrice continuée. Comment Dieu soutient-il l'existence et pourquoi lui est-il nécessaire de le faire ? L'auteur analyse l'apparente contradiction, qui fait problème, entre la doctrine de la création continuée et l'affirmation par Descartes que le mouvement se poursuit à moins que n'intervienne quelque force extérieure. Il examine ensuite, pour la récuser, la thèse selon (...) laquelle la doctrine de la création continuée impliquerait la discontinuité du temps. This essay seeks to understand Descartes's doctrine that what exists cannot continue to exist unless God sustains it by continuous creative activity. How does God sustain existence and why is it necessary for Him to do this ? The essay explores a puzzling apparent contrast between the doctrine of continuous creation and Descartes's claim that motion continues unless an external force interferes. Further, it considers and rejects the thesis that the doctrine of continuous creation entails that time is discontinuous. (shrink)