In clinical trials, it is common practice to follow up significant interactions between the factors under investigation with subgroup analyses. Such analyses pose at least two analytical and interpretational challenges. The first challenge is that performing multiple subgroup analyses increases the likelihood of obtaining spuriously significant results. This has been acknowledged and relevant guidance exists in the medical literature. The second challenge is that the effects that are obtained at the level of subgroup are composite. This has yet to be (...) fully acknowledged and discussed in the context of medical research. This paper aims to fill this lacuna. Using a simple additive model, we use recent findings from the CHARISMA trial on the efficacy of clopidogrel in addition to aspirin in the treatment of patients at risk for atherothrombotic events to demonstrate quantitatively the composition of effects at the level of subgroups. In the simplest case of a design involving an interaction (two crossed factors, with two levels each, i.e. a 2 x 2 design), effects at the level of subgroup consist of influences that stem (i) from the incidence of the measured outcome in the study population as a whole; (ii) from the factor of interest (e.g. treatment vs. placebo); (iii) from the second factor (e.g. patient group membership); (iv) from the interaction between the two factors; and (v) from random error in the measured outcome. The value of the approach illustrated here is that it is generalizable to any research design irrespective of its complexity and that it prompts clinicians to consider the multiple causality underlying medical research findings. (shrink)

Despite the growing profile of ‘implementation science’, its status as a field of study remains ambiguous. Implementation science originates in the evidence-based movement and attempts to broaden the scope of evidence-based medicine to improve ‘clinical effectiveness’ and close the ‘implementation gap’. To achieve this agenda, implementation science draws on methodologies from the social sciences to emphasise coherence between qualitative and quantitative approaches. In so doing, we ask if this is at the expense of ignoring the dominating tendencies of the evidence-based (...) movement and consider if some of the methodologies being drawn on should be considered irreconcilable with evidence-based methodologies. (shrink)

Trait emotional intelligence concerns people’s perceptions of their emotional functioning. Two studies investigated this construct in surgeons and comparison occupations. We hypothesized that trait EI profiles would differ both within surgical specialties as well as between them and other professions. Study 1 compared the trait EI profiles of four different surgical specialties. There were no significant differences amongst these specialties or between consultant surgeons and trainees in these specialties. Accordingly, the surgical data were combined into a single target sample that (...) was compared against samples of engineers, executives and senior managers, lawyers, junior military managers, nurses, and salespeople. Surgeons scored significantly higher on global trait EI than junior military managers, but lower than executives and senior managers, salespeople, and nurses. There were no significant differences vis-à-vis engineers or lawyers. A MANOVA confirmed a similar pattern of differences in the four trait EI factors. Global trait EI scores correlated strongly with single-question measures of job satisfaction and job performance in the surgical sample. These findings suggest that interventions to optimize the trait EI profiles of surgeons can be helpful in relation to job satisfaction, job performance, and overall psychological wellbeing. (shrink)

_Anthropic Bias_ explores how to reason when you suspect that your evidence is biased by "observation selection effects"--that is, evidence that has been filtered by the precondition that there be some suitably positioned observer to "have" the evidence. This conundrum--sometimes alluded to as "the anthropic principle," "self-locating belief," or "indexical information"--turns out to be a surprisingly perplexing and intellectually stimulating challenge, one abounding with important implications for many areas in science and philosophy. There are the philosophical thought experiments and paradoxes: (...) the Doomsday Argument; Sleeping Beauty; the Presumptuous Philosopher; Adam & Eve; the Absent-Minded Driver; the Shooting Room. And there are the applications in contemporary science: cosmology ; evolutionary theory ; the problem of time's arrow ; quantum physics ; game-theory problems with imperfect recall ; even traffic analysis. _Anthropic Bias_ argues that the same principles are at work across all these domains. And it offers a synthesis: a mathematically explicit theory of observation selection effects that attempts to meet scientific needs while steering clear of philosophical paradox. (shrink)

This book explores both the embodied nature of social life and the social nature of human bodily life. It provides an accessible review of the contemporary social science debates on the body, and develops a coherent new perspective. Nick Crossley critically reviews the literature on mind and body, and also on the body and society. He draws on theoretical insights from the work of Gilbert Ryle, Maurice Merleau-Ponty, George Herbert Mead and Pierre Bourdieu, and shows how the work of (...) these writers overlaps in interesting and important ways which, when combined, provide the basis for a persuasive and robust account of human embodiment. The Social Body provides a timely review of the theoretical approaches to the sociology of the body. It offers new insights, and a coherent new perspective on the body. It will be valuable reading for students and academics in sociology, philosophy, anthropology, psychology, and cultural studies. (shrink)

"Ethical thought has no chance of being everything it seems." Bernard Williams offered this cryptic remark in Ethics and the Limits of Philosophy, and in this chapter I argue that understanding it is the key to understanding Williams' skepticism about moral theory and about systematization in ethics. The difficulty for moral philosophy, Williams believed, is that ethics looks one way to embodied, active agents, but looks entirely different when considered from the standpoint of theory. This, in turn, means that following (...) a moral theory is a sure route to practical alienation. I argue that once we see it for what it is, we can see that Williams own skepticism undermines his later attempts to vindicate Truthfulness. Moreover, given the pervasiveness of reflective practical alienation in ordinary life, it leaves us with a difficult question: what would a non-alienated ethical existence even look like for us? (shrink)

We begin by showing that every theory of the value of uncertain prospects must have one of three unpalatable properties. _Reckless_ theories recommend giving up a sure thing, no matter how good, for an arbitrarily tiny chance of enormous gain; _timid_ theories permit passing up an arbitrarily large potential gain to prevent a tiny increase in risk; _non-transitive_ theories deny the principle that, if A is better than B and B is better than C, then A must be better than (...) C. Having set up this trilemma, we study its horns. Non-transitivity has been much discussed; we focus on drawing out the costs and benefits of recklessness and timidity when it comes to axiology, decision theory, and normative uncertainty. (shrink)

Why does time pass and space does not? Are there just three dimensions? What is a quantum particle? Nick Huggett shows that philosophy -- armed with a power to analyze fundamental concepts and their relationship to the human experience -- has much to say about these profound questions about the universe. In Everywhere and Everywhen, Huggett charts a journey that peers into some of the oldest questions about the world, through some of the newest, such as: What shape is (...) space? Does it have an edge? What is the difference between past and future? What is time in relativity? Is time travel possible? Are there other universes? Huggett shows that answers to these profound questions are not just reserved for physics, and that philosophy can not only address but help advance our view of our deepest questions about the universe, space, and time, and their implications for humanity. His lively, accessible introduction to these topics is suitable for a general reader with no previous exposure to these profound and exciting questions. (shrink)

What is the purpose of art? What drives us to make it? Why do we value it? Nick Zangwill argues that the function of art is to have certain aesthetic properties in virtue of its non-aesthetic properties, and this function arises because of the artist's insight into the nature of these dependence relations and her intention to bring them about.

A dizzying trip through the mind(s) of the provocative and influential thinker Nick Land. During the 1990s British philosopher Nick Land's unique work, variously described as “rabid nihilism,” “mad black deleuzianism,” and “cybergothic,” developed perhaps the only rigorous and culturally-engaged escape route out of the malaise of “continental philosophy” —a route that was implacably blocked by the academy. However, Land's work has continued to exert an influence, both through the British “speculative realist” philosophers who studied with him, and (...) through the many cultural producers—writers, artists, musicians, filmmakers—who have been invigorated by his uncompromising and abrasive philosophical vision. Beginning with Land's early radical rereadings of Heidegger, Nietzsche, Kant and Bataille, the volume collects together the papers, talks and articles of the mid-90s—long the subject of rumour and vague legend (including some work which has never previously appeared in print)—in which Land developed his futuristic theory-fiction of cybercapitalism gone amok; and ends with his enigmatic later writings in which Ballardian fictions, poetics, cryptography, anthropology, grammatology and the occult are smeared into unrecognisable hybrids. Fanged Noumena gives a dizzying perspective on the entire trajectory of this provocative and influential thinker's work, and has introduced his unique voice to a new generation of readers. (shrink)

Self–other discrimination was investigated with point-light displays in which actions were presented with or without additional auditory information. Participants first executed different actions in time with music. In two subsequent experiments, they watched point-light displays of their own or another participant’s recorded actions, and were asked to identify the agent . Manipulations were applied to the visual information and to the auditory information . Results indicate that self-recognition was better than chance in all conditions and was highest when observing relatively (...) unconstrained patterns of movement. Auditory information did not increase accuracy even with the most ambiguous visual displays, suggesting that judgments of agent identity depend much more on motor cues than on auditory or audiovisual information. (shrink)

To what extent should we use technological advances to try to make better human beings? Leading philosophers debate the possibility of enhancing human cognition, mood, personality, and physical performance, and controlling aging. Would this take us beyond the bounds of human nature? These are questions that need to be answered now.

We review the various factors that limit adaptation by natural selection. Recent discussion of constraints on selection and, conversely, of the factors that enhance “evolvability”, have concentrated on the kinds of variation that can be produced. Here, we emphasise that adaptation depends on how the various evolutionary processes shape variation in populations. We survey the limits that population genetics places on adaptive evolution, and discuss the relationship between disparate literatures. BioEssays 22:1075–1084, 2000. © 2000 John Wiley & Sons, Inc.

The human brain has some capabilities that the brains of other animals lack. It is to these distinctive capabilities that our species owes its dominant position. Other animals have stronger muscles or sharper claws, but we have cleverer brains. If machine brains one day come to surpass human brains in general intelligence, then this new superintelligence could become very powerful. As the fate of the gorillas now depends more on us humans than on the gorillas themselves, so the fate of (...) our species then would come to depend on the actions of the machine superintelligence. But we have one advantage: we get to make the first move. Will it be possible to construct a seed AI or otherwise to engineer initial conditions so as to make an intelligence explosion survivable? How could one achieve a controlled detonation? To get closer to an answer to this question, we must make our way through a fascinating landscape of topics and considerations. Read the book and learn about oracles, genies, singletons; about boxing methods, tripwires, and mind crime; about humanity's cosmic endowment and differential technological development; indirect normativity, instrumental convergence, whole brain emulation and technology couplings; Malthusian economics and dystopian evolution; artificial intelligence, and biological cognitive enhancement, and collective intelligence. (shrink)

Articulate and perceptive, Intersubjectivity is a text that explains the notions of intersubjectivity as a central concern of philosophy, sociology, psychology, and politics. Going beyond this broad-ranging introduction and explication, author Nick Crossley provides a critical discussion of intersubjectivity as an interdisciplinary concept to shed light on our understanding of selfhood, communication, citizenship, power, and community. The volume traces the contributions of key thinkers engaged within the intersubjectivist tradition, including Husserl, Buber, Kojeve, Merlau-Ponty, Mead, Wittgenstein, Schutz, and Habermas. A (...) clear, concise introduction to a range of difficult concepts and thinkers, Intersubjectivity demystifies this very interdisciplinary subject for advanced and graduate-level students of philosophy, sociology, social psychology, and social and political theory. (shrink)

'The Probabilistic Mind' is a follow-up to the influential and highly cited 'Rational Models of Cognition'. It brings together developments in understanding how, and how far, high-level cognitive processes can be understood in rational terms, and particularly using probabilistic Bayesian methods.

This article responds to recent debates in critical algorithm studies about the significance of the term “algorithm.” Where some have suggested that critical scholars should align their use of the term with its common definition in professional computer science, I argue that we should instead approach algorithms as “multiples”—unstable objects that are enacted through the varied practices that people use to engage with them, including the practices of “outsider” researchers. This approach builds on the work of Laura Devendorf, Elizabeth Goodman, (...) and Annemarie Mol. Different ways of enacting algorithms foreground certain issues while occluding others: computer scientists enact algorithms as conceptual objects indifferent to implementation details, while calls for accountability enact algorithms as closed boxes to be opened. I propose that critical researchers might seek to enact algorithms ethnographically, seeing them as heterogeneous and diffuse sociotechnical systems, rather than rigidly constrained and procedural formulas. To do so, I suggest thinking of algorithms not “in” culture, as the event occasioning this essay was titled, but “as” culture: part of broad patterns of meaning and practice that can be engaged with empirically. I offer a set of practical tactics for the ethnographic enactment of algorithmic systems, which do not depend on pinning down a singular “algorithm” or achieving “access,” but which rather work from the partial and mobile position of an outsider. (shrink)

Previously proposed strategies for tackling hermeneutical injustices take for granted the interests people have in certain things about them being intelligible to them and/or to others, and seek to enable them to satisfy these interests. Strategies of this sort I call interests-as-given strategies. I propose that some hermeneutical injustices can instead be tackled by doing away with certain of these interests, and so with the possibility of their unfair non-satisfaction. Strategies of this sort I call interests-in-question strategies. As a case (...) study in when such an interests-in-question strategy ought to be pursued, I look at how to tackle hermeneutical injustices arising in the context of gender-affirming healthcare as provided to adults by the National Health Service in the UK. I argue that considerations of trust, privacy, and respect all support pursuing such a strategy. One way to do so, I suggest, would be by replacing the existing gatekeeping model with an informed consent model for the provision of gender-affirming healthcare. Considerations of hermeneutical justice can hence be added to the already-impressive case for undertaking this shift. (shrink)

Our paradigms of aesthetic value condition the philosophical questions we pose and hope to answer about it. Theories of aesthetic value are typically individualistic, in the sense that the paradigms they are designed to capture, and the questions to which they are offered as answers, center the individual’s engagement with aesthetic value. Here I offer some considerations that suggest that such individualism is a mistake and sketch a communitarian way of posing and answering questions about the nature of aesthetic value.

Non-representational approaches to cognition have struggled to provide accounts of long-term planning that forgo the use of representations. An explanation comes easier for cognitivist accounts, which hold that we concoct and use contentful mental representations as guides to coordinate a series of actions towards an end state. One non-representational approach, ecological-enactivism, has recently seen several proposals that account for “high-level” or “representation-hungry” capacities, including long-term planning and action coordination. In this paper, we demonstrate the explanatory gap in these accounts that (...) stems from avoiding the incorporation of long-term intentions, as they play an important role both in action coordination and perception on the ecological account. Using recent enactive accounts of language, we argue for a non-representational conception of intentions, their formation, and their role in coordinating pre-reflective action. We provide an account for the coordination of our present actions towards a distant goal, a skill we call distal engagement. Rather than positing intentions as an actual cognitive entity in need of explanation, we argue that we take them up in this way as a practice due to linguistically scaffolded attitudes towards language use. (shrink)

Prior research found correlations between reflection test performance and philosophical tendencies among laypeople. In two large studies (total N = 1299)—one pre-registered—many of these correlations were replicated in a sample that included both laypeople and philosophers. For example, reflection test performance predicted preferring atheism over theism and instrumental harm over harm avoidance on the trolley problem. However, most reflection-philosophy correlations were undetected when controlling for other factors such as numeracy, preferences for open-minded thinking, personality, philosophical training, age, and gender. Nonetheless, (...) some correlations between reflection and philosophical views survived this multivariate analysis and were only partially confounded with either education or self-reported reasoning preferences. Unreflective thinking still predicted believing in God whereas reflective thinking still predicted believing that (a) proper names like ‘Santa’ do not necessarily refer to entities that actually exist and (b) science does reveal the fundamental nature of the world. So some robust relationships between reflection and philosophical tendencies were detected even among philosophers, and yet there was clearly more to the link between reflection and philosophy. To this end, demographic and metaphilosophical hypotheses are considered. (shrink)

With very advanced technology, a very large population of people living happy lives could be sustained in the accessible region of the universe. For every year that development of such technologies and colonization of the universe is delayed, there is therefore a corresponding opportunity cost: a potential good, lives worth living, is not being realized. Given some plausible assumptions, this cost is extremely large. However, the lesson for standard utilitarians is not that we ought to maximize the pace of technological (...) development, but rather that we ought to maximize its safety, i.e. the probability that colonization will eventually occur. This goal has such high utility that standard utilitarians ought to focus all their efforts on it. Utilitarians of a ‘person-affecting’ stripe should accept a modified version of this conclusion. Some mixed ethical views, which combine utilitarian considerations with other criteria, will also be committed to a similar bottom line. (shrink)

How sexuality should be regulated in a liberal political community is an important, controversial theoretical and empirical question—as shown by the recent criminalization of possession of some adult pornography in the United Kingdom. Supporters of criminalization argue that Mill, often considered a staunch opponent of censorship, would support prohibition due to his feminist commitments. I argue that this account underestimates the strengths of the Millian account of private conduct and free expression, and the consistency of Millian anticensorship with feminist values. (...) A Millian contextual defense of liberty, however, suggests several other policy approaches to addressing the harms of pornography. (shrink)

Subjects of ectogenesis—human beings that are developing in artificial wombs (AWs)—share the same moral status as newborns. To demonstrate this, I defend two claims. First, subjects of partial ectogenesis—those that develop in utero for a time before being transferred to AWs—are newborns (in the full sense of the word). Second, subjects of complete ectogenesis—those who develop in AWs entirely—share the same moral status as newborns. To defend the first claim, I rely on Elizabeth Chloe Romanis’s distinctions between fetuses, newborns and (...) subjects of ectogenesis. For Romanis, the subject of partial ectogenesis ‘is neither a fetus nor a baby’ but is, instead, a ‘new product of human reproduction’. In this essay, I begin by, expanding upon Romanis’s argument that subjects of partial ectogenesis are not fetuses while arguing that those subjects are newborns. Next, I show that the distinction that Romanis draws between subjects of partial ectogenesis and newborns needs to be revised. The former is a kind of the latter. This leads us to an argument that shows why different moral statuses cannot be justifiably assigned to subjects of partial ectogenesis and subjects of complete ectogenesis, respectively. As subjects of partial ectogenesis share the same moral status as newborns, it follows that subjects of complete ectogenesis share the same moral status as newborns as well. I conclude by considering implications that this essay may have for the research and development of AW technology and conceptual links between a subject’s moral status and birth. (shrink)

It is common to allocate scarce health care resources by maximizing QALYs per dollar. This approach has been attacked by disability-rights advocates, policy-makers, and ethicists on the grounds that it unjustly discriminates against the disabled. The main complaint is that the QALY-maximizing approach implies a seemingly unsatisfactory conclusion: other things being equal, we should direct life-saving treatment to the healthy rather than the disabled. This argument pays insufficient attention to the downsides of the potential alternatives. We show that this sort (...) of discrimination is one of four unpalatable consequences that any approach to priority setting in health care must face. We argue that, given the alternatives, it is far from clear that we should revise the QALY-maximizing approach in response to this objection. (shrink)

In the wake of the spectacular success of Miranda Fricker's Epistemic Injustice, philosophers have paid a great deal of attention to testimonial injustice. Testimonial injustice occurs when recipients of testimony discount it in virtue of its source: usually, their social identity. The remedy for epistemic injustice is almost always listening better and giving greater weight to the testimony we hear, on most philosophers' implicit or explicit view. But Fricker identifies another kind of epistemic injustice: hermeneutical injustice. This kind of injustice (...) occurs when someone can't articulate their own experience or understand their situation for lack of the hermeneutical tools. There is a possible tension between these kinds of injustice, we suggest: sincere testimony may be misleading (may fail to identify significant harms the testfier is subject, or may fail to register its magnitude, or to categorize it as the kind of harm it is) in virtue of a lack of hermeneutical resources. This tension raises the possibility that there are situations in which experts - those who possess hermeneutical tools - may be able to correct the testimony of those who experience harms in virtue of their identity. In this paper, we identify possible cases in which epistemic injustice might be reduced through such correction: in which an increase in testimonial injustice might serve to decrease it in the longer run, for example. We also suggest how the obvious dangers of a too great readiness to see testimony as in need of expert correction might be mitigated, and how the expert might suggest corrections without ceasing to listen. (shrink)

Remarkable progress in the mathematics and computer science of probability has led to a revolution in the scope of probabilistic models. In particular, ‘sophisticated’ probabilistic methods apply to structured relational systems such as graphs and grammars, of immediate relevance to the cognitive sciences. This Special Issue outlines progress in this rapidly developing field, which provides a potentially unifying perspective across a wide range of domains and levels of explanation. Here, we introduce the historical and conceptual foundations of the approach, explore (...) how the approach relates to studies of explicit probabilistic reasoning, and give a brief overview of the field as it stands today. (shrink)

I argue that at least one of the following propositions is true: the human species is very likely to become extinct before reaching a ’posthuman’ stage; any posthuman civilization is extremely unlikely to run a significant number of simulations of its evolutionary history ; we are almost certainly living in a computer simulation. It follows that the belief that there is a significant chance that we shall one day become posthumans who run ancestor-simulations is false, unless we are currently living (...) in a simulation. I discuss some consequences of this result. (shrink)

Views on addiction are often polarised - either addiction is a matter of choice, or addicts simply can't help themselves. But perhaps addiction falls between the two? This book contains views from philosophy, neuroscience, psychiatry, psychology, and the law exploring this middle ground between free choice and no choice.

We present a theory of decision by sampling (DbS) in which, in contrast with traditional models, there are no underlying psychoeconomic scales. Instead, we assume that an attribute’s subjective value is constructed from a series of binary, ordinal comparisons to a sample of attribute values drawn from memory and is its rank within the sample. We assume that the sample reflects both the immediate distribution of attribute values from the current decision’s context and also the background, real-world distribution of attribute (...) values. DbS accounts for concave utility functions; losses looming larger than gains; hyperbolic temporal discounting; and the overestimation of small probabilities and the underestimation of large probabilities. Ó 2005 Elsevier Inc. All rights reserved. (shrink)