Providing a precise statement of their position has long been a central challenge facing the scientific realist. This paper draws some morals about how realism ought to be formulated from the renormalization group framework in high energy physics.

Discussing authorial power, landscape metaphor and the notions of community and sense of place, this explores the ways in which spatial and cultural analysis have found much common ground in making sense of ourselves and the landscape we inhabit.

This paper defends Flatland—the view that there exist neither determination nor dependence relations, and that everything is therefore fundamental—from the objection from explanatory inefficacy. According to that objection, Flatland is unattractive because it is unable to explain either the appearance as of there being determination relations, or the appearance as of there being dependence relations. We show how the Flatlander can meet the first challenge by offering four strategies—reducing, eliminating, untangling and omnizing—which, jointly, explain the appearance as of determination relations (...) where no such relations obtain. Since, plausibly, dependence relations just are asymmetric determination relations, we argue that once we come mistakenly to believe that there exist determination relations, the existence of other asymmetries (conceptual and temporal) explains why it appears that there are dependence relations. (shrink)

This paper defends Flatland—the view that there exist neither determination nor dependence relations, and that everything is therefore fundamental—from the objection from explanatory inefficacy. According to that objection, Flatland is unattractive because it is unable to explain either the appearance as of there being determination relations, or the appearance as of there being dependence relations. We show how the Flatlander can meet the first challenge by offering four strategies—reducing, eliminating, untangling and omnizing—which, jointly, explain the appearance as of there being (...) determination relations where no such relations obtain. Since, plausibly, dependence relations just are asymmetric determination relations, we argue that once we come mistakenly to believe that there exist determination relations, the existence of other asymmetries (conceptual and temporal) explains why it appears that there are dependence relations. (shrink)

DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for (...) the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

It is widely thought that grounding is a hyperintensional phenomenon. Unfortunately, the term ‘hyperintensionality’ has been doing double-duty, picking out two distinct phenomena. This paper clears up this conceptual confusion. We call the two resulting notions hyperintensionalityGRND and hyperintensionalityTRAD. While it is clear that grounding is hyperintensionalGRND, the interesting question is whether it is hyperintensionalTRAD. We argue that given well-accepted constraints on the logical form of grounding, to wit, that grounding is irreflexive and asymmetric, grounding is hyperintensionalTRAD only if one (...) endorses a sentential operator view of grounding. We argue that proponents of the sentential operator view will need to distinguish two importantly different kinds of hyperintensionalityTRAD—weak and strong—and we offer them a way to do so. (shrink)

It has recently become popular to suggest that questions of ontology ought be settled by determining, first, which fundamental things exist, and second, which derivative things depend on, or are grounded by, those fundamental things. This methodology typically leads to a hierarchical view of ontology according to which there are chains of entities, each dependent on the next, all the way down to a fundamental base. In this paper we defend an alternative ontological picture according to which there is no (...) ontological hierarchy. Such a picture appears counterintuitive (at least to many), in part because in the absence of a hierarchical structure to our world, there would be no structure apt to back metaphysical explanations. There are two reasons to suppose this is so. First, there would be no structure apt to back metaphysical explanations because there would be a fatal mismatch between the formal features of metaphysical explanation, on the one hand, and the structure of the world, on the other hand. Second, in the absence of an ontological hierarchy there would be no structure apt to back metaphysical explanations because the only connections that would obtain between relevant facts are mere correlational connections. But mere correlations are not the right kinds of relations to back metaphysical explanations: explanation requires something more. This paper aims to show that neither of these is a good reason to prefer a hierarchical view of ontology. (shrink)

Commentaries on the target article offer diverse perspectives on integrative experiment design. Our responses engage three themes: (1) Disputes of our characterization of the problem, (2) skepticism toward our proposed solution, and (3) endorsement of the solution, with accompanying discussions of its implementation in existing work and its potential for other domains. Collectively, the commentaries enhance our confidence in the promise and viability of integrative experiment design, while highlighting important considerations about how it is used.

The dominant paradigm of experiments in the social and behavioral sciences views an experiment as a test of a theory, where the theory is assumed to generalize beyond the experiment's specific conditions. According to this view, which Alan Newell once characterized as “playing twenty questions with nature,” theory is advanced one experiment at a time, and the integration of disparate findings is assumed to happen via the scientific publishing process. In this article, we argue that the process of integration is (...) at best inefficient, and at worst it does not, in fact, occur. We further show that the challenge of integration cannot be adequately addressed by recently proposed reforms that focus on the reliability and replicability of individual findings, nor simply by conducting more or larger experiments. Rather, the problem arises from the imprecise nature of social and behavioral theories and, consequently, a lack of commensurability across experiments conducted under different conditions. Therefore, researchers must fundamentally rethink how they design experiments and how the experiments relate to theory. We specifically describe an alternative framework, integrative experiment design, which intrinsically promotes commensurability and continuous integration of knowledge. In this paradigm, researchers explicitly map the design space of possible experiments associated with a given research question, embracing many potentially relevant theories rather than focusing on just one. Researchers then iteratively generate theories and test them with experiments explicitly sampled from the design space, allowing results to be integrated across experiments. Given recent methodological and technological developments, we conclude that this approach is feasible and would generate more-reliable, more-cumulative empirical and theoretical knowledge than the current paradigm – and with far greater efficiency. (shrink)

Experiential evidence shows that pain is associated with common meanings. These include a meaning of threat or danger, which is experienced as immediately distressing or unpleasant; cognitive meanings, which are focused on the long-term consequences of having chronic pain; and existential meanings such as hopelessness, which are more about the person with chronic pain than the pain itself. This interdisciplinary book - the second in the three-volume Meanings of Pain series edited by Dr Simon van Rysewyk - aims to better (...) understand pain by describing experiences of pain and the meanings these experiences hold for the people living through them. The lived experiences of pain described here involve various types of chronic pain, including spinal pain, labour pain, rheumatic pain, diabetic peripheral neuropathic pain, fibromyalgia, complex regional pain syndrome, endometriosis-associated pain, and cancer-related pain. Two chapters provide narrative descriptions of pain, recounted and interpreted by people with pain. Language is important to understanding the meaning of pain since it is the primary tool human beings use to manipulate meaning. As discussed in the book, linguistic meaning may hold clues to understanding some pain-related experiences, including the stigmatisation of people with pain, the dynamics of patient-clinician communication, and other issues, such as relationships between pain, public policy and the law, and attempts to develop a taxonomy of pain that is meaningful for patients. Clinical implications are described in each chapter. This book is intended for people with pain, their family members or caregivers, clinicians, researchers, advocates, and policy makers. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Whereas a number of recent articles have focussed upon whether the thesis of content externalism is compatible with a certain sort of knowledge that is gained via first-person authority,1 far less attention has been given to the relationship that this thesis bears to the possession of knowledge in general and, in particular, its relation to internalist and externalist epistemologies. Nevertheless, although very few actual arguments have been presented to this end, there does seem to be a shared suspicion that content (...) externalism must be incompatible with epistemic internalism. In a recent and influential paper, however, James Chase has challenged this conventional wisdom by offering a subtle defence of the view that content externalism and epistemic internalism are, in fact, compatible after all.2 Our aim here is twofold. First, to show that Chase is only able to achieve this result because he focuses upon the internalist conception of justification, rather than knowledge. Second, to formulate one prima facie argument which shows that an internalist conception of knowledge is incompatible with an externalist conception of content, an argument which, moreover, is not touched by Chase. (shrink)

A recent book about Agricola's conquest of Scotland presents a Scottish historian's take on a subject that has been dominated by archaeologists: the whereabouts of Mons Graupius, the scene of Agricola's final battle. Unfortunately, in confidently locating it in Perthshire, author James Fraser builds his case on shaky foundations.

A puzzle about warranted belief, often attributed to Kripke, has recently come to prominence. This puzzle claims to show that it follows from the possession of a warrant for one's belief in an empirical proposition that one is entitled to dismiss all subsequent evidence against that proposition as misleading. The two main solutions that have been offered to this puzzle in the recent literature - by James Cargile and David Lewis - argue for a revisionist epistemology which, respectively, either (...) denies the so-called 'Closure' principle that warrants transmit across known entailments, or 'contextualizes' the epistemic operator in question. In contrast, it is argued here that such revisionism is unnecessary because the puzzle in fact depends upon an ambiguity in the notion of warrant. It is claimed that once this ambiguity is made explicit then the puzzle dissipates. (shrink)

The Ashgate Research Companion to Multiculturalism brings together a collection of new essays by leading and emerging scholars in the humanities and social sciences on some of the key issues facing multiculturalism today. It provides a comprehensive and cutting-edge treatment of this important and hotly contested field, offering scholars and students a clear account of the leading theories and critiques of multiculturalism that have developed over the past twenty-five years, as well as a sense of the challenges facing multiculturalism in (...) the future. Key leading scholars, including James Bohman, Barbara Arneil, Avigail Eisenberg, Ghassan Hage, and Paul Patton, discuss multiculturalism in different cultural and national contexts and across a range of disciplinary approaches. In addition to contributions, Duncan Ivison also provides a comprehensive Introduction which surveys the field and offers an extensive guide to further reading. (shrink)

James Sterba describes the egoist as thinking only egoist reasons decide the rationality of choices of action, the altruist, only altruistic reasons, that each in effect begs the question of what reasons there are against the other, and that the only non-question-begging and therefore rationally defensible position in this controversy is the middle-ground position that high-ranking egoistic reasons should trump low ranking-altruistic considerations and vice versa, this position being co-extensive with morality. Therefore it is rationally obligatory choose morally. I (...) object that the mere fact that a position is intermediate between two extremes does not mean it isn’t question-begging; that Sterba’s style of argument could be used to prove anything and therefore proves nothing; that it can be used to prove obvious falsehoods and therefore doesn’t necessarily track the truth; that it can be used to prove the truth of contingent, empirically obvious falsehoods when, since it is necessary a prior that one ought to be moral, something can be a good argument for the rationality of morality only if the argument’s style would entail only truths necessary a priori; that Sterba’s argument cannot inherit plausibility from what Sterba describes as the decision theoretic idea that when choosing among options where we have no evidence that one is more appropriate than the other, we must treat them as equally choice-worthy, since there is no such idea in decision theory, and shouldn’t be (for when, for example, there is no evidence that x exists and no evidence that x does not exist, one should believe that x does not exist; one should not chose as if x’s existence and non-existence were equally likely); that Sterba’s argument style is not analogous to the compromise strategies recommended in bargaining theory, nor in negotiating situations (although it would profit Sterba to consider David Gauthier’s approach in seeking to demonstrate that morality is both a middle ground between egoism and altruism, and is rationally obligatory); that it is problematic to see egoistic and altruistic reasons as commensurable and therefore admitting of a middle ground, especially a unique middle ground; that in any case, egoistic and altruistic reasons are not exhaustive of the reasons there could be; that the only sense in which moving to middle ground results in the parties not begging the question against each other is that it means they would be agreeing with each other and therefore not holding positions against each other, whether question-beggingly or otherwise, a fact which offers neither any rationally compelling reason to move her position closer to that of the other (for how can the mere fact that if we agreed we wouldn’t be begging the question against each other be a reason to agree?); and that even if morality is both rationally obligatory and a middle ground between egoism and altruism, it won’t be in any interesting sense true that this holds because the alternative would be question-begging, which means that analyzing the basis of the rationality of morality as being found in this principle of argumentation theory misconceives the nature of morality. (shrink)

There have been two distinctive aspects to James Tully’s approach to the study of imperialism over the years, and both are put to work in these remarkable volumes. The first is his belief in two seemingly contradictory claims: (i) that imperialism is much more pervasive than usually thought (conceptually, historically and practically); and yet (ii) that there are many more forms of resistance to it than usually appreciated. (Part of a symposium in Political Theory on James Tully's 'Public (...) Philosophy in a New Key'). (shrink)

A review essay on Russell Hardin’s *One For All* and James Tully’s *Strange Multiplicity*.

In the past 250 years, David Hume probably had a greater impact on the field of philosophy of religion than any other single philosopher. He relentlessly attacked the standard proofs for God's existence, traditional notions of God's nature and divine governance, the connection between morality and religion, and the rationality of belief in miracles. He also advanced radical theories of the origin of religious ideas, grounding such notions in human psychology rather than in divine reality. In the last decade of (...) his life Hume wrote 'I cou'd cover the Floor of a large Room with Books and Pamphlets wrote against me'. Indeed, most of these targeted his writings on religion. This, the third part of the Early Responses to Hume series, and perhaps the most eagerly awaited, collects responses to Hume's writings on religion published during his life, namely, 'Of Miracles', 'Of a Particular Providence and a Future State', The Natural History of Religion , and the posthumously published works Dialogues Concerning Natural Religion , 'Of Suicide' and 'Of the Immortality of the Soul'. The set covers a wide range of the replies Hume's writings provoked, including contributions by Philip Skelton, William Adams, Thomas Rutherforth, William Warburton, Anthony Ellys, John Douglas, John Leland, Thomas Stona, Voltaire, George Campbell, Herman Andrew Pistorius, Duncan Shaw, William Samuel Powell, Thomas Hayter, Joseph Milner, William Paley, Charles Moore, Richard Joseph Sulivan, John Hey, Samuel Vince, Lord Brougham and Thomas De Quincey. (shrink)

Philosophical Investigations, EarlyView.

The aim of this paper is to explain and defend a type of argument common in the doing/allowing literature called a “contrast argument.” I am concerned with defending a particular type of contrast argument that is intended to demonstrate the moral irrelevance of the doing/allowing distinction. This type of argument, referred to in this paper as an “irrelevance argument,” is exemplified by an argument offered by James Rachels (1975) that employs the Smith and Jones bathtub cases. My main contention (...) in this paper is that none of the objections to the use of irrelevance arguments are successful, and that they still pose a genuine challenge to defenders of the moral relevance of the doing/allowing distinction. (shrink)

"Hume's History of Great Britain, published in the middle of the eighteenth century, remained the standard work for well over a century. It is a masterpeice, even if its author is now better known for A treatise on human nature. Grounded on an almost sociological view of the 'progress of society', Hume's is perhaps the most European of all the classic narrative histories of Britain. Moreover it embraces far more than the merely political, and it was Adam Smith who pointed (...) out that Hume was the first historian to deduce political effects from commercial and industrial causes. The volume, covering the years 1603-49, was the first to be written and was published as a self-contained entity. Hume's own view was that it was 'by far the best', because the subject admitted of 'greater nicety of reasoning and more acute distinctions'"--Page 4 of cover. (shrink)

This paper examines the philosophy of Jean-Francois Lyotard in relation to the analytic philosophy of deep disagreement. It argues not just that his work has relevance for this debate, but that it offers a challenge to the ‘epistemic paradigm’ present in its academic literature, represented by the two most prominent sets of theories within it – the ‘fundamental epistemic principle’ and ‘hinge epistemology’ views, arguably most strongly represented by Michael Lynch and Duncan Pritchard, respectively. Focussing on Lyotard’s text ‘The (...) Differend’, I show how its conceptual framework and philosophy of language locates the cause of deep disagreement not in the epistemic realm, but in things which do not fully submit to epistemic evaluation: the radically incomplete and open nature of language, and our increasingly politically pluralistic world full of incommensurable differences that do not always admit of rational resolution. Lyotard’s work calls for us to conceptualize deep disagreements as problems of politics, not epistemology, and to find new ways of dealing with disagreements that do not force a solution on them (which often comes at the cost of one party being wronged, or worse) and to create new ways of speaking so that our collective conceptual resources can be increased to better deal with specific cases of dispute. Lyotard’s relevance for the philosophy of deep disagreement is also further discussed with references to Miranda Fricker’s work on ‘epistemic injustice’, which Lyotard, in a different vocabulary, is also concerned with and analyses in ‘The Differend’. (shrink)

This article explores “pragmatic arguments” for theistic belief – that is, arguments for believing in God that appeal, not to evidence in favor of God’s existence, but rather to alleged practical benefits that come from belief in God. Central to this exploration is a consideration of Jeff Jordan’s recent defense of “the Jamesian wager,” which portrays itself as building on the case for belief presented in William James’s essay “The Will to Believe.” According to Jordan, religious belief creates significant (...) gains in this‐worldly happiness , and provided the individual does not have decisive evidence against God’s existence, these gains give the individual sufficient reason to strive to believe in God. In its exploration of this argument, the article presents an overview of recent social scientific work on the this‐worldly effects of religious belief. It canvases several challenges to pragmatic arguments, namely, a challenge according to which happiness rooted in false belief is worth less than that rooted in truth, a perfectionistic challenge alleging that one should strive for personal excellence rather than happiness, and a challenge alleging that any happiness gains of religious belief are outweighed by the potential harms brought about by religious belief. (shrink)

In the fall of 1998 Trent Lott used his power as Senate Majority Leader to prevent the confirmation of James C. Hormel, an openly gay San Francisco philanthropist who was then President Clinton’s nominee for Ambassador to Luxembourg.[2] Mr. Lott made it clear that his opposition to Hormel was based on his opposition to homosexuality in general. Asked by a television interviewer during the controversy whether homosexuality is a sin, Mr. Lott answered "Yes, it is"; he went on to (...) compare gay people to alcoholics, sex addicts, and kleptomaniacs.[3] Shortly thereafter, Dick Armey, the House Majority Leader, seconded Lott’s view, adding that “[t]he Bible is very clear on this…Both myself and Senator Lott believe very strongly in the Bible.”. (shrink)

This chapter both explains the origins of emotivism in C. K. Ogden and I. A. Richards, R. B. Braithwaite, Austin Duncan-Jones, A. J. Ayer and Charles Stevenson (along with the endorsement by Frank P. Ramsey, and the summary of C. D. Broad), and looks at MacIntyre's criticisms of emotivism as the inevitable result of Moore's attack on naturalistic ethics and his ushering in the fact/value, which was a historical product of the Enlightenment.

In this paper, I develop a serious new dilemma involving necessary truths for safety-based theories of knowledge, a dilemma that I argue safety theorists cannot resolve or avoid by relativizing safety to either the subject’s basis or method of belief formation in close worlds or to a set of related or sufficiently similar propositions. I develop this dilemma primarily in conversation with Duncan Pritchard’s well-known, oft-modeled safety-based theories of knowledge. I show that Pritchard’s well-regarded anti-luck virtue theory of knowledge (...) and his recently proposed (allegedly superior) anti-risk virtue theory of knowledge clearly succumb to the dilemma, and so they are inadequate as they stand. If Pritchard’s safety-based theories of knowledge are shown to be inadequate by the dilemma that is developed in this paper, then a number of other safety-based theories of knowledge (e.g., Beddor and Pavese’s, Luper’s, Dutant’s, early Pritchard’s, and others) look to be in jeopardy in this connection as well. (shrink)

The book called 'The Consolation of Philosophy' was throughout the Middle Ages, and down to the beginnings of the modern epoch in the sixteenth century, the scholar's familiar companion. Few books have exercised a wider influence in their time. It has been translated into every European tongue, and into English nearly a dozen times, from King Alfred's paraphrase to the translations of Lord Preston, Causton, Ridpath, and Duncan, in the eighteenth century.

This paper surveys attempts in the recent literature to offer a modal condition on knowledge as a way of resolving the problem of scepticism. In particular, safety-based and sensitivity-based theories of knowledge are considered in detail, along with the anti-sceptical prospects of an explicitly anti-luck epistemology.

This paper explores the prospects for safety-based theories of knowledge in the light of some recent objections.

Much of the recent debate regarding scepticism has focussed on a certain template sceptical argument and a rather restricted set of proposals concerning how one might deal with that argument. Throughout this debate the ‘Moorean’ response to scepticism is often cited as a paradigm example of how one should not respond to the sceptical argument, so conceived. As I argue in this paper, however, there are ways of resurrecting the Moorean response to the sceptic. In particular, I consider the prospects (...) for three such proposals in this regard: a classical epistemic internalist neo-Mooreanism, a classical epistemic externalist neo-Mooreanism, and a non-classical McDowellian epistemic internalist neo-Mooreanism, and maintain that the last two of these proposals (both of which make appeal to a disjunctivist account of perception, broadly conceived) merit further exploration. Indeed, I claim that a suitably qualified version of neo-Mooreanism would actually sit quite well with the general philosophical motivations behind other key anti-sceptical views and I argue that given this fact neo-Mooreanism is actually at a dialectical advantage relative to other views when it comes to dealing with the sceptical problem as it is typically conceived. (shrink)

The status of boundaries and borders, questions of global poverty and inequality, criteria for the legitimate uses of force, the value of international law, human rights, nationality, sovereignty, migration, territory, and citizenship: debates over these critical issues are central to contemporary understandings of world politics. Bringing together an interdisciplinary range of contributors, including historians, political theorists, lawyers, and international relations scholars, this is the first volume of its kind to explore the racial and imperial dimensions of normative debates over global (...) justice. (shrink)

How (Not) to Be Secular is what Jamie Smith calls "your hitchhiker's guide to the present" -- it is both a reading guide to Charles Taylor's monumental work A Secular Age and philosophical guidance on how we might learn to live in our times. Taylor's landmark book A Secular Age (2007) provides a monumental, incisive analysis of what it means to live in the post-Christian present -- a pluralist world of competing beliefs and growing unbelief. Jamie Smith's book is a (...) compact field guide to Taylor's insightful study of the secular, making that very significant but daunting work accessible to a wide array of readers. Even more, though, Smith's How (Not) to Be Secular is a practical philosophical guidebook, a kind of how-to manual on how to live in our secular age. It ultimately offers us an adventure in self-understanding and maps out a way to get our bearings in today's secular culture, no matter who "we" are -- whether believers or skeptics, devout or doubting, self-assured or puzzled and confused. This is a book for any thinking person to chew on. (shrink)