Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

The tourism economy has become a new driving force for economic growth, and film-induced tourism in particular has been widely proven to promote economic and cultural development. Few studies focus on analyzing the inherent characteristics of the economic and cultural effects of film-induced tourism, and the research on the dynamic mechanism of the sustainable development of film-induced tourism is relatively limited. Therefore, from the perspective of the integration of culture and industry, the research explores the dynamic mechanism of sustainable development (...) between film-induced culture and film-induced industry through a questionnaire survey of 1,054 tourism management personnel, combined with quantitative empirical methods. The conclusion shows that the degree of integration of culture and tourism is an important mediating role that affects the dynamic mechanism of sustainable development of film-induced tourism, and the development of film-induced tourism depends on the integration of culture and industry. Constructing a diversified industrial integration model according to local conditions and determining the development path of resource, technology, market, product integration, and administrative management can become the general trend of the future development of film-induced tourism. (shrink)

90 nian dai, Du Weiming xian sheng de geng duo jing li zai yu kai zhan "wen hua Zhongguo" de lun yu."Wen hua Zhongguo" zhuo mo zui duo de shi ru jia de ren wen jing shen, yi jiu zheng jiang ru jia ru shi de jia zhi qu xiang he fan su ren wen zhu yi hun wei yi tan de yin xiang, tu xian ru jia yi mai xiang cheng de pi pan jing shen.

Du Weiming xian sheng shi dang dai yan jiu he chuan bo ru jia wen hua de zhong yao si xiang jia. Ta 1940 nian chu sheng yu Kunming, xian hou qiu xue yu Taiwan dong hai da xue he Meiguo Hafo da xue, ren jiao yu Pulinsidun da xue, Bokeli Jiazhou da xue. Zi 1981 nian, Du Weiming xian sheng yi zhi zai Hafo da xue Dong Ya xi dan ren li shi ji zhe xue jiao shou,qi jian huo (...) xuan Meiguo ren wen she hui ke xue yuan yuan shi, hai ceng dan ren Hafo Yanjing xue she she zhang. Chang qi yi lai, Du Weiming xian sheng zhi li yu ru xue di 3 qi fa zhan, quan shi Zhongguo wen hua, fan si xian dai jing shen, chang dao wen ming dui hua, zai hai nei wai xiang you hen gao de xue shu sheng yu. Du xian sheng fei chang re xin Zhongguo you xiu chuan tong wen hua zai ben tu de chuan bo, duo ci hui guo can jia jiao yu he xue shu jiao liu huo dong. Ta yu Beijing da xue you zhe te shu de yuan fen,zao zai 1985 nian jiu lai Beijing da xue jiang shou ru jia zhe xue. Zui jin Du Weiming xian sheng yi zheng shi shou pin wei Beijing da xue gao deng ren wen yan jiu yuan yuan zhang. (shrink)

本书从历史、文化、科学、哲学角度,遵循老子“道法自然”去识道,观察天文,以明阴阳时变。.

Ben shu tong guo yin ru xi fang xian dai yu yan zhe xue, mei xue de fang fa yu Zhongguo chuan tong wen hua zhi si zhan dui hua yu jiao liu, shi jie, wen xue de ben zhi guan lian ru shou, jie shi chu xing cheng yan yu yi zhi jian mao dun yu zhang li de ben yuan: cun zai ben shen zi xing xian xian (cheng ming) bing zi xing yin ni (zhe bi) de te (...) xing, shi ta zai xian xiang shang yong yuan cheng xian chu you (zai chang) yu wu (bu zai chang) de dong tai yun dong, er zhe zhong yun dong ben shen qia qia you gou cheng le yan yu yi de yong heng dong neng he zhang li. (shrink)

Ben shu tong guo yin ru xi fang xian dai yu yan zhe xue, mei xue de fang fa yu Zhongguo chuan tong wen hua zhi si zhan dui hua yu jiao liu, shi jie, wen xue de ben zhi guan lian ru shou, jie shi chu xing cheng yan yu yi zhi jian mao dun yu zhang li de ben yuan: cun zai ben shen zi xing xian xian (cheng ming) bing zi xing yin ni (zhe bi) de te (...) xing, shi ta zai xian xiang shang yong yuan cheng xian chu you (zai chang) yu wu (bu zai chang) de dong tai yun dong, er zhe zhong yun dong ben shen qia qia you gou cheng le yan yu yi de yong heng dong neng he zhang li. (shrink)

本书共七章,内容包括:舜帝与中华道德统绪,舜帝葬所与舜帝陵庙,舜帝陵祭祀与舜德传承,舜帝与礼乐文明,舜文化的阐释与演进等.

Ben shu ba zhe xue shi yan jiu, bi jiao zhe xue yan jiu, wen hua wen ti yan jiu he wen xian shi liao yan jiu he wei yi ti, dui Wang Yangming zhe xue de nei rong jin xing le quan mian he shen ru de fen xi, bing dui qi zhe xue de nei rong jin xing le quan mian he shen ru de fen xi, bing dui qi zhe xue de bu tong fa zhan jie duan (...) jin xing le xi zhi de kao cha, li tu cheng xian chu Wang Yangming zhe xue de ji ben xing ge he zheng ti mian mao. (shrink)

The role of emotion in human action has long been neglected in the philosophy of action. Some prevalent misconceptions of the nature of emotion are responsible for this neglect: emotions are irrational; emotions are passive; and emotions have only an insignificant impact on actions. In this paper we argue that these assumptions about the nature of emotion are problematic and that the neglect of emotion's place in theories of action is untenable. More positively, we argue on the basis of recent (...) research in cognitive neuroscience that emotions may significantly affect action generation as well as action execution and control. Moreover, emotions also play a crucial role in people's explanation of action. We conclude that the concept of emotion deserves a more distinctive and central place in philosophical theories of action. (shrink)

Military metaphors are pervasive in biomedicine, including HIV research. Rooted in the mind set that regards pathogens as enemies to be defeated, terms such as “shock and kill” have become widely accepted idioms within HIV cure research. Such language and symbolism must be critically examined as they may be especially problematic when used to express scientific ideas within emerging health-related fields. In this article, philosophical analysis and an interdisciplinary literature review utilizing key texts from sociology, anthropology, history, and Chinese and (...) African studies were conducted to investigate the current proliferation of military metaphors. We found the use of these metaphors to be ironic, unfortunate, and unnecessary. To overcome military metaphors we propose to give them less aggressive meanings, and/or replace them with more peaceful metaphors. Building on previous authors' work, we argue for the increased use of “journey” metaphors as meaningful, cross-culturally app... (shrink)

: Since the late 1970s, American appraisals of Chinese medical ethics and Chinese responses to American bioethics range from frank criticism to warm appreciation, from refutation to acceptance. Yet in the United States as well as in China, American bioethics and Chinese medical ethics have been seen, respectively, as individualistic and communitarian. In this widely-accepted general comparison, the great variation in the two medical moralities, especially the diversity of Chinese experiences, has been unfortunately minimized, if not totally ignored. Neither American (...) bioethics nor Chinese medical ethics is a field with only one dominant way of thinking. Medical moralities in America and China--traditional and modern--have always been plural and diverse. For example, American and Chinese cultures and medical moralities both exhibit individualistic and communitarian traditions. For this reason, bioethics in general and cross-cultural bioethics in particular must be fundamentally interpretive. Interpretive cross-cultural bioethics appreciates the plurality of medical morality within any culture. It can serve as a vital means of social and cultural criticism through engaged interpretations. (shrink)

Shame is frequently viewed as a destructive emotion; but it can also be understood in terms of change and growth. This essay highlights the problematic values that cause pervasive and frequent shame and the importance of resisting and changing these values. Using Confucian insights, I situate shame in an interactive process between the individual's values and that of their society, thus, being vulnerable to shame represents both one's connection to a community and an openness to others’ negative feedback. This process (...) provides an important arena where personal values interact with communal ones. The Confucian tradition, I argue, affords individuals a degree of autonomy in internalization through urging them to cultivate and maintain a keen sense of shame. My discussion also offers resources for understanding the various aspects of this interactive process—how individuals with similar experiences of shame may, through channeling their experiences, influence social values and propel moral progress. (shrink)

In his recent works on daily face-to-face encounters, Zahavi claims that the phenomenon of sharing involves reciprocity. Following Zahavi’s line of thought, we wonder what exactly reciprocity amounts to and how the shared experience emerges from the dynamic process of interaction. By turning to the highly specialized field of elite sports dance, we aim at exploring the way in which reciprocity unfolds in intensive deliberate practices of movement. In our analysis, we specifically argue that the ongoing dynamics of two separate (...) flows of movement constitute a shared experience of dancing together. In this sense, moving together, in sports dance, is a practical way of understanding each other. In agreement with Zahavi, our analysis emphasizes the bi-directed nature of sharing. However, at the same time, we contribute to Zahavi’s ongoing endeavour as the special case of sports dance reveals how reciprocity can be deliberately shaped through the mutual coordination and affective bound dynamics of movement. Our article thus both pursues the methodological point that qualitative research of expert competences can constructively enrich phenomenological analysis and indicates how movement can be fundamental to the reciprocity of shared experience. (shrink)

ABSTRACTIn Western and non‐Western societies, it is a widely held belief that the concept of human rights is, by and large, a Western cultural norm, often at odds with non‐Western cultures and, therefore, not applicable in non‐Western societies. The Universal Draft Declaration on Bioethics and Human Rights reflects this deep‐rooted and popular assumption. By using Chinese culture as an illustration, this article points out the problems of this widespread misconception and stereotypical view of cultures and human rights. It highlights the (...) often ignored positive elements in Chinese cultures that promote and embody universal human values such as human dignity and human rights. It concludes, accordingly, with concrete suggestions on how to modify the Declaration. (shrink)

Emoji appear to be an important cue to judge whether a statement is sarcastic in computer-mediated communication. In this study, we investigated whether the smiling emoji, an indicator of sarcastic intention in the Chinese culture, exerts an influence on sarcasm interpretation across the lifespan. Statements accompanied with or without a smiling emoji were compared in unambiguous (Experiment 1) and ambiguous (Experiment 2) contexts. The results of Experiment 1 illustrated that for teenagers and the 20-year-olds the smiling emoji enhanced the perceived (...) sarcasm of sarcastic statements significantly. However, there was no difference in interpreting sarcastic statements with or without a smiling emoji in other age groups. Experiment 2 replicated the results of Experiment 1. We found both teenagers and the 20-year-olds were more likely to arrive at a sarcastic interpretation of the ambiguous statement followed by a smiling emoji, which were less frequent in participants aged in their 30s, 40s, 50s and individuals over 60 years old. This might be because people of varying ages differ in decoding the emotions of the emoji. Age-related differences in the use of sarcasm and participants’ experiences with using emoji might be possible factors that were closely related to the interpretation of emoji-based sarcasm. (shrink)

This book presents a variety of discussions from different countries about regulations and applications of ethics in business practice. It demonstrates how Ethics, both in the world of business and in academic life, is consistently a central and unavoidable issue that institutions must devise new regulations on a regular basis to address. Given that applying such regulations becomes complicated in a global business landscape and that International companies have lost large amounts of revenues due to fraudulent activities, the book provides (...) insights for professionals in business world to teach, learn, apply, measure and report on companies' daily business. Business and Professional Ethics: Theories, Standards, and Analysis is essential reading for researchers and students in business schools around the world. (shrink)

One stable marker of face perception appears to be left-side bias, the tendency to rely more on information conveyed by the left side of the face than the right. Previous studies have shown that left-side bias is influenced by familiarity and prior experience with face stimuli. Since other-race facial recognition is characterized by reduced familiarity, in contrast to own-race facial recognition, the phenomenon of left-side bias is expected to be weaker for other-race faces. Among Chinese participants, face inversion has been (...) found to eliminate the left-side bias associated with own-race faces. Therefore, it is of interest to know whether face inversion influences left-side bias for non-Chinese research participants and can be generalized across own- and other-race faces. This study assessed 65 Caucasian participants using upright and inverted chimeric Caucasian and Asian faces in an identity similarity-judgment task. Although a significant left-side bias was observed for upright own-race faces, this bias was eliminated by facial inversion, indicating that such a bias depends on the applicability of configural processing strategies. For other-race faces, there was no left-side bias in the upright condition. Interestingly, the inverted presentation yielded a right-side bias. These results show that while left-side bias is affected by familiarity differences between own- and other-race faces, it is a universal phenomenon for upright faces. Inverted presentation strongly reduces left-side bias and may even cause it to revert to right-side bias, suggesting that left-side bias depends on configural face processing. (shrink)

Since the late 1970s, American appraisals of Chinese medical ethics and Chinese responses to American bioethics range from frank criticism to warm appreciation, from refutation to acceptance. Yet in the United States as well as in China, American bioethics and Chinese medical ethics have been seen, respectively, as individualistic and communitarian. In this widely-accepted general comparison, the great variation in the two medical moralities, especially the diversity of Chinese experiences, has been unfortunately minimized, if not totally ignored. Neither American bioethics (...) nor Chinese medical ethics is a field with only one dominant way of thinking. Medical moralities in America and China--traditional and modern--have always been plural and diverse. For example, American and Chinese cultures and medical moralities both exhibit individualistic and communitarian traditions. For this reason, bioethics in general and cross-cultural bioethics in particular must be fundamentally interpretive. Interpretive cross-cultural bioethics appreciates the plurality of medical morality within any culture. It can serve as a vital means of social and cultural criticism through engaged interpretations. (shrink)

Previous studies have explored children’s intergroup resource allocation in the context of preexisting intergroup resource inequality. However, resource inequality between social groups often originates from different factors. This study explored the role of the origins of resource inequality on children’s intergroup resource allocations. In experiment 1, when there was no explicit origin of the intergroup inequality, children of different ages mainly allocated resources in an equal way and 5- to 6-year-olds showed ingroup bias. In experiment 2, we examined the influence (...) of different origins of intergroup inequality and found that 5- to 6-year-olds perpetuated intergroup inequality when resource inequality was based on either a structural or an internal factor. However, 10- to 11-year-olds rectified inequality or allocated equally when intergroup inequality was based on regional disparity and perpetuated resource inequality when intergroup inequality was based on performance difference. The origins of inequality appear to play an important role in children’s intergroup resource allocations, and older children can distinguish different origins of intergroup inequality in resource allocation. (shrink)

In Western and non-Western societies, it is a widely held belief that the concept of human rights is, by and large, a Western cultural norm, often at odds with non-Western cultures and, therefore, not applicable in non-Western societies. The Universal Draft Declaration on Bioethics and Human Rights reflects this deep-rooted and popular assumption. By using Chinese culture(s) as an illustration, this article points out the problems of this widespread misconception and stereotypical view of cultures and human rights. It highlights the (...) often ignored positive elements in Chinese cultures that promote and embody universal human values such as human dignity and human rights. It concludes, accordingly, with concrete suggestions on how to modify the Declaration. (shrink)

In this essay I critically examine Daniel Wegner’s account of conscious will as an illusion developed in his book The Illusion of Conscious Will. I show that there are unwarranted leaps in his argument, which considerably decrease the empirical plausibility and theoretical adequacy of his account. Moreover, some features essential to our experience of willing, which are related to our general understanding of free will, moral responsibility and human agency, are largely left out in Wegner’s account of conscious will. This (...) substantially diminishes its implications and significance for some profound philosophical issues. (shrink)

Drawing from a wide range of primary historical and sociological sources, this book presents medical ethics in China from a Chinese-Western comparative perspective, and in doing so it provides a fascinating exploration of cultural differences and commonalities exhibited by China and the West in medicine and medical ethics. The book focuses on a number of key issues in medical ethics including: attitudes towards foetuses; disclosure of information by medical professionals; informed consent; professional medical ethics; and human rights. This careful examination (...) not only provides insights into Chinese viewpoints, but also sheds light on the appropriate methods for comparative culture and ethical research. Through its analysis, Jing-Bao Nie seeks to put forward a theory of "transcultural bioethics", an ethical paradigm which upholds the primacy of morality whilst resisting cultural stereotypes, and appreciating the internal plurality, richness, dynamism and openness of medical ethics in any culture. Medical Ethics in China will be of particular interest to students and academics in the fields of Medical Law, Bioethics and Medical Ethics as well as Chinese/Asian Studies and Comparative (Chinese-Western) Cultural Studies. (shrink)

Scholars have made great efforts to investigate the antecedents of knowledge sharing. In the current study, we applied the proactive motivation model (Parker, Bindl, and Strauss, 2010) to propose a theoretical model to advance this research line and examined the relationship between coaching and knowledge sharing. A total of 197 supervisor–subordinate dyads from a logistics company completed the survey questionnaire. Our results show that leaders’ coaching behavior positively relates to employees’ knowledge sharing behavior via psychological availability. Furthermore, our results show (...) that team psychological safety climate moderates the relationship between psychological availability and employees’ knowledge sharing behavior, as well as the indirect effect between leaders’ coaching behavior and employees’ knowledge sharing. (shrink)