Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)

ABSTRACT During the first half of the nineteenth century, while Georges Cuvier ruled over natural history and the Muséum d’Histoire Naturelle (MHN) was at its institutional acme, a French banker and industrialist with a Swiss family background, Benjamin Delessert, was developing an important botanical museum in Paris. His private collection included both a rich botanical library and a massive herbarium: the close integration of these two dimensions, together with the magnanimity of Delessert’s patronage, contributed to making this private institution (...) a worthy rival to the powerful and state-funded MHN. Delessert’s museum had the favor of both professional and amateur naturalists. Knowledgeable and dedicated assistants (Antoine Guillemin and Antoine Lasègue) curated the collections. Moreover, Delessert was an intimate friend of the Genevan botanist Augustin-Pyramus de Candolle. Although Delessert’s herbarium followed the Linnaean order, the Delessert Botanical Museum (DBM) contributed to the development of Candolle’s natural system, especially through the publication of costly volumes of engravings, the Icones selectae plantarum rariorum. This essay draws together the main steps in the evolution of Delessert’s collections, stressing the interdependency between books and dried plants. It focuses on the DBM as a case of cooperation between institutional and amateur expertise, private and public collections, and field collectors and cabinet naturalists. (shrink)

This paper focuses on the geography of the botanical community in Paris, under the July Monarchy. At that time, the Muséum d’Histoire naturelle was at its institutional acme and, under the impulse of François Guizot, its budget was increasing dramatically. However, closer attention to manuscript sources reveals that the botanists of the time favoured other private institutions, located both on the Right and Left Banks of the Seine. The MHN was prestigious for its collections and professors but it was relatively (...) remote from the centre of Paris, and its plant samples were sometimes difficult to access. Several other first-class private herbaria granted liberal access to botanists: those of Jacques Gay, Phillip Barker Webb, and Benjamin Delessert. Thanks to their wealth, these plant amateurs had ownership of historical herbaria consisting of species types alongside rich botanical libraries. Botanists visiting Paris from foreign countries or other provinces of France also spent some time studying less general plant collections, like those of Count Jaubert, or specialized collections, like Montagne’s or Léveillé’s on cryptogams. Other botanists also enjoyed renown at the time, although they published little, if anything. Living in crammed apartments, literally in the middle of their plant samples, these botanists were key nodes in botanical networks, although they had no relation with the prestigious MHN. (shrink)

This chapter offers a proceduralist argument against capital punishment. More specifically, it contends that the possibility of irrevocable mistakes precludes the just administration of the death penalty. At stake is a principle of political morality: legal institutions must strive to remedy their mistakes and to compensate those who suffer from wrongful sanctions. The incompatibility of remedy and execution is the crux of the irrevocability argument: because the wrongly executed cannot enjoy the morally required compensation, execution is impermissible. Along with defending (...) his key premises, Yost explains the complicated role that sentencing uncertainty plays in the argument. He concludes by noting some of the flaws in substantive consequentialist and retributivist justifications of capital punishment. (shrink)

We perceive smells as perduring complex entities within a distal array that might be conceived of as smellscapes. However, the philosophical orthodoxy of Odor Theories has been to deny that smells are perceived as having a distal location. Recent challenges have been mounted to Odor Theories’ veracity in handling the timescale of olfactory perception, how it individuates odors as a distal entities, and their claim that olfactory perception is not spatial. The paper does not aim to dispute these criticisms. Rather, (...) what will be shown is that Molecular Structure Theory, a refinement of Odor Theory, can be further developed to handle these challenges. The theory is further refined by focusing on distal perception that requires considering the perceptual object as mereologically complex persisting odor against a background scene conceived of as a smellscape. What will be offered is an expansion of Molecular Structure Theory to account for distal smell perception within natural environments. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

Capital punishment—the legally authorized killing of a criminal offender by an agent of the state for the commission of a crime—stands in special need of moral justification. This is because execution is a particularly severe punishment. Execution is different in kind from monetary and custodial penalties in an obvious way: execution causes the death of an offender. While fines and incarceration set back some of one’s interests, death eliminates the possibility of setting and pursuing ends. While fines and incarceration narrow (...) one’s routes to happiness, death eliminates its possibility. Not surprisingly, there is much debate about the moral permissibility of capital punishment. This entry maps the terrain of this debate. The first section discusses justifications of the death penalty as they appear in major theories of punishment. The second section surveys moral objections to execution that apply to most justifications. The third addresses procedural criticisms, which do not target the morality of execution so much as the justice of its implementation. (shrink)

At least some of your beliefs are commitments. When you believe that P as a commitment, your stance on P is such that you believe it on the basis of your considered judgement. Sometimes, you also believe that you believe P. Such self‐beliefs can also be commissive in a sense, as when they are reflective endorsements of your lower‐order commissive beliefs. In this paper I argue that one's commissive self‐beliefs ontologically constitute one's lower‐order commissive beliefs because one's commissive self‐beliefs instantiate (...) the same inferential dispositions that are constitutive of one's lower‐order commissive beliefs. Constitutive relations between commissive self‐beliefs and first‐order commissive beliefs are maximally epistemically secure because they do not result from any epistemic procedure by which one must try (and possibly fail) to detect one's first‐order commissive beliefs. This maximal epistemic security suffices to warrant one's commissive self‐beliefs, such that one possesses commissive self‐knowledge of an especially privileged sort. (shrink)

Kant famously insists that free will is a condition of morality. The difficulty of providing a demonstration of freedom has left him vulnerable to devastating criticism: critics charge that Kant's post-Groundwork justification of morality amounts to a dogmatic assertion of morality's authority. My paper rebuts this objection, showing that Kant offers a cogent demonstration of freedom. My central claim is that the demonstration must be understood in practical rather than theoretical terms. A practical demonstration of x works by bringing x (...) into existence, and what the demonstration of freedom brings into existence is a moral will, a will regulated by the moral law and capable of acting in accordance with it. Since to act morally is to act freely, bringing a moral will into existence actualizes our capacity for freedom and demonstrates that we possess it. To confirm the viability of such a demonstration, Kant must establish that agents can regulate their wills by practical principles, and that practical judgments are efficacious of themselves (i.e., that non-Humean motivational internalism is true). Kant, I argue, is successful on both counts. (shrink)

Nietzsche distinguished between two forces in art: Apollonian, which represents order and reason, and Dionysian, which represents chaos and energy. Economists, Ward argues, have operated for too long under the assumption that their work reflects the scientific, Apollonian principals that inform physics when they simply do not apply to economics: 'constants' in economics stand in for variables, and the core scientific principles of prediction and replication are all but ignored by economists. Ward encourages economists to reintegrate the standard rigor of (...) the scientific method into their work while embracing the fact of the shape-shifting changeability of human beings. Economists can still aspire to scientific standards, as is demonstrated by the success of biology, in which there is considerable Dionysian variability. Economists must avoid the temptation to wish away dynamic complexity and diversity and must recognize, among other things, that the desire to take risks is fundamentally human. The second half of the book takes some first steps toward creating this new Dionysian Economics. (shrink)

Valorising the biocultural heritage of common goods could enable peasant farmers to achieve socially and economically inclusive sustainability. Increasingly appreciated by consumers, peasant heritage products offer small farmers promising opportunities for economic, social and territorial development. Identifying the obstacles and levers of this complex, multi-scale and multi-stakeholder objective requires an integrative framework. We applied the panarchy conceptual framework to two cases of participatory research with small quinoa producers: a local fair in Chile and quinoa export production in Bolivia. In both (...) cases, the “commoning” process was crucial both to bring stakeholders together inside their communities and to gain outside recognition for their production and thus achieve social and economic inclusion. Despite the differences in scale, the local fair and the export market shared a similar marketing strategy based on short value chains promoting quality products with high identity value. In these dynamics of biocultural heritage valorisation, the panarchical approach revealed the central place as well as the vulnerability of the community territory. As a place of both anchoring and opening, the community territory is the privileged space where autonomous and consensual control over the governance of common biocultural resources can be exercised. (shrink)

Journal Name: Semiotica Issue: Ahead of print.

The romance customarily termed “classical” occupies a special place within Cambodian literature as a whole. The term betrays a certain Eurocentrism and is justified only because the written language of this type of text is neither the old Khmer of epigraphic inscriptions, nor modern Khmer, but the form of the language known as “middle Khmer,” which in theory designates the period from the fourteenth century through the end of the nineteenth century, and of which we have written records from the (...) eighteenth and nineteenth centuries, in the romances as we know them. While these romances share one significant feature with Khmer literature as a whole, they are distinguished by other characteristics that are peculiar to them. (shrink)

The present paper examines how discursive representations and emotive constructions underpin an argumentative dynamic that emerges from apparently non-argumentative statements, like those found in newspaper headlines. Our data comes from Greek broadsheet newspapers in the polarized context of the Greek crisis. First, we outline an analytic synergy that scrutinizes representational meaning and the semiotization of emotions in headlines. We then move towards the reconstruction of the inferential passage, contained in the headlines, that unites the implicit standpoint with its supporting argument.

Formal topology aims at developing general topology in intuitionistic and predicative mathematics. Many classical results of general topology have been already brought into the realm of constructive mathematics by using formal topology and also new light on basic topological notions was gained with this approach which allows distinction which are not expressible in classical topology. Here we give a systematic exposition of one of the main tools in formal topology: inductive generation. In fact, many formal topologies can be presented in (...) a predicative way by an inductive generation and thus their properties can be proved inductively. We show however that some natural complete Heyting algebra cannot be inductively defined. (shrink)

Presenting a series of historical portraits of Bantu, Thierry Secretan recounts his investigation into the compounds that housed the black labor of the gold mines of the Rand, around Johannesburg. The use of a « pass » to control the black miners prefigured the apartheid system. From 1904 to 1939,Alfred Martin Duggan-Cronin, an Irish guard at one of the compounds, began to photograph the different kind of people doing the hard labor in the mines. The results were some 7200 exposures (...) and working prints, on 13 /18 cm negatives. Hundreds of enlargements were exhibited from 1925 onward in a gallery in his own home in Kimberley. These photographs were rediscovered in 1998 by Thierry Secretan, who is still attempting to save them front slow destruction: they constitute an extraordinary catalogue of the Bantu cultures. (shrink)

"Based on the reading of the only twelfth-century manuscript of the Enigma extant, Charleville MS. 114, and an examination of the fifteenth-century manuscript Uppsala C. 79." Revision of the editor's thesis, Catholic University of America, 1971, presented under title: The enigma fidei of William of Saint Thierry, a translation and commentary. Bibliography: p. 119-120.

L’actualité bibliographique sur l’érotisme de l’homme romain ancien se répartit en trois grandes zones de recherche. La tradition académique d’abord, souvent embarrassée par des faits de civilisation difficilement explicables en termes contemporains. L’anthropologie culturelle de l’Antiquité ensuite, qui tente de replacer les comportements masculins dans les sphères culturelles du monde romain polythéiste. Les études gaies et lesbiennes enfin, qui annexent la sexualité masculine à Rome dans une très longue histoire de l’homosexualité occidentale.

Le but de cet article est de jeter un regard sur plusieurs aspects du roman La Panne de Friedrich Dürrenmatt. L’histoire est simple. À la suite d’une panne de voiture, un certain Traps est hébergé chez quatre amis. Invité à participer à un jeu, un procès où il aura le rôle de l’accusé, il accepte. Il est convaincu de meurtre, accepte sa culpabilité et se suicide. Après un bref condensé de l’histoire, l’article traite des thèmes suivants : le caractère de (...) Traps et sa transformation au cours du jeu ; le rôle ambigu des quatre amis ; le genre tragi-comique grec de l’œuvre ; les aspects comiques ; les aspects tragiques : l’atmosphère d’anxiété et de mort ; les symétries et inversions ; l’art littéraire. En épilogue, une lecture diamétralement opposée à l’interprétation traditionnelle de l’œuvre est discutée. (shrink)

In recent years, neurophysiological evidence has accumulated in favor of a common coding between perception and execution of action. We review findings from recent neuroimaging experiments in the action domain with three complementary perspectives: perception of action, covert action triggered by perception, and reproduction of perceived action (imitation). All studies point to the parietal cortex as a key region for body movement representation, both observed and performed.

Plusieurs de ceux qui présentent des problèmes de santé mentale se retrouvent dans le système judiciaire. Leur profil clinique se caractérise par une problématique complexe où se juxtaposent divers troubles ou déficits. Il n’est pas toujours facile de dépister ces personnes et d’intervenir auprès d’elles dans le cadre du processus judiciaire et pénal, qui n’est pas conçu pour répondre à leurs besoins cliniques. De son côté, le réseau de la santé et des services sociaux semble lui aussi peu adapté pour (...) intervenir auprès de cette clientèle marginale, souvent réfractaire à l’aide et parfois intimidante. Ces deux réseaux fonctionnent en parallèle, très peu familiers l’un de l’autre. Ils ont tendance à se renvoyer cette clientèle problématique. L’État doit s’assurer de soutenir et de coordonner des services qui peuvent rejoindre et aider ces personnes. (shrink)

The critique of the dogmatism of a-priorism from the Popperians suffered from the fact that Popper, too, was moving towards a certain dogmatic derivation. According to the a-priorists, in wanting to protect himself from any would-be-critics who would argue against the dogmatism of his approach, Popper left his philosophical foundation free to the critics. In fighting against German essentialism, he found himself in a position that necessitated the abandonment of either his presupposed anti-essentialism, or his critique of the positivists. Popper's (...) success stems less from his ability to rally the anti-historicist positivists towards the search for scientific foundations, than the fact that he was one of the greatest, if not the greatest, theoreticians of the scientific method, and critic of ideological simplicity. (shrink)

French modern philosophy to ethics as a core issue. Under the framework of the phenomenology, Levinas and Ricoeur to rethink the subject of freedom and responsibility. This paper briefly introduces the basic concepts of these two philosophers. Levinas greater emphasis on the unlimited personal ethical responsibility to others, and Ricoeur more emphasis on virtue, treat it as a starting point for ethical life. Although difficult to reconcile the different ethical positions, but they are very necessary to provide the resources to (...) think about modern ethical dilemma faced by life and its possible future. French contemporary philosophy considers moral philosophy as a central issue. Following the methods of phenomenology, Emmanuel Lévinas and Paul Ricoeur have reconsidered the freedom of the subject and his moral responsibility. This article presents briefly the fundamental conceptions of those two philosophers. While Levinas has stressed the unlimited responsibility of oneself toward other, Ricoeur has emphasized that virtue should be the starting point of moral life. Despite those differences and the difficulty to harmonize those two positions, they still provide necessary resources to think over the traps of modern moral life and the possibility to overcome them. (shrink)

In order to implement cost-benefit analysis of protective actions to reduce radiological exposures, one needs to attribute a monetary value to the avoided exposure. Recently, the International Commission on Radiological Protection has stressed the need to take into consideration not only the collective exposure to ionising radiation but also its dispersion in the population. In this paper, by using some well known and some recent results in the economics of uncertainty, we discuss how to integrate these recommendations in the valuation (...) of the benefit of protection. (shrink)

Devenir borgne! Difficile de ne pas vivre ce handicap comme un drame. Sans la vision binoculaire et stéréoscopique, le réel semble n'avoir plus d'épaisseur. L'auteur rapporte ce qu'il a éprouvé au cours de sa prise en charge ophtalmologique et interroge en même temps les peintres malvoyants et les philosophes : qu'est-ce que voir? Le handicap visuel permettrait-il de dépasser l'ordinaire de la vision? Pour répondre à ces questions, Monet, Degas, Victor Brauner sont interpellés dans leurs oeuvres ou encore Bruegel et (...) Rembrandt, en même temps que sont convoqués Platon, Descartes, Alain, Merleau-Ponty ou encore James Joyce et William Blake, sans oublier les Évangiles. Les bien-voyants ne se rendent pas compte qu'ils sont condamnés à vivre la tyrannie du réel. Et si les yeux empêchaient de voir en vrai? Le genre humain n'a peut-être pas vocation à voir mais à entrevoir. Dans ces conditions, ne devrait-on pas considérer la malvoyance comme un atout? Ne serait-il pas temps de voir autrement qu'avec les yeux? Peut-être, alors, sentira-t-on la présence de l'Être émerger de la pénombre"--Page 4 of cover. (shrink)

This paper revisits Fleeming Jenkin’s anonymous review of Charles Darwin’s _Origin of Species_, published in the _North British Review_ in June 1867. This review is usually revered for its impact on Darwin’s theory of descent with modification. Its classical interpretation states that Jenkin, a Professor of Engineering at the University of Edinburgh, made a compelling case against natural selection based on the fact of “blending inheritance” and the “swamping” of advantageous variations. Those themes, however, are strikingly absent from Jenkin’s text. (...) They were later read into Jenkin’s text by scholars trying to explain how Darwinian selection was reconciled with Mendelian genes and the birth of the Modern Synthesis. While many scholars have tried to measure Jenkin’s effect on Darwin, the value of the 1867 review remains unclear. This paper re-examines its content and concludes that Jenkin’s “able review” was in fact written by an engineer whose competencies in biology were very low. Focusing on the figure of the shipwrecked white sailor isolated on an island inhabited by Black people, this paper also underlines the racial assumptions behind Jenkin’s review. “Blending inheritance” is thus a theme linked to theoretical reworkings on the question of race and skin colors, taking its root in Galton’s typology of heredity. Darwin was probably mostly unimpressed by Jenkin’s review. The problems raised by the review were not so much “blending inheritance” and “swamping” but a conundrum of problems related to the effects of intercrossing on variation and reversion. (shrink)

En Occident, à partir de 1520, l’Ecclesia una se fragmente en confessions chrétiennes rivales. Cette réalité religieuse nouvelle ne peut être pensée sans mots; mais les néologismes lexicaux nécessaires sont lents à s’imposer. La situation paroxystique de ceux qui changent effectivement d’Église dans les années 1520-1650 est pourtant favorable à de telles créations. Elle permet de trouver les mots pour dire, et donc pour admettre, l’existence de l’Autre Église.