Synthetic biology, as a research field, brings together molecular life scientists, computational biologists, and social scientists to engineer biological systems toward societally desired goals. Given the field’s broad multidisciplinarity and relatively young age, innovative educational methods are required to provide students with the needed background knowledge to push the field forward in the future. The international Genetically Engineered Machine competition is such an example where education and high-level research merge, providing the synthetic biology field with trained students, new ideas, and (...) novel results. In the 2021 edition alone, 343 teams from across the world completed the competition to tackle societal problems with synthetic biology. As Wageningen University & Research celebrates 10 years of participation in iGEM, we share our thoughts and experiences on supervising iGEM teams, which is especially relevant to organizers of current and new teams, and also others interested in the iGEM competition. (shrink)

First Published in 2004. Routledge is an imprint of Taylor & Francis, an informa company.

Robert Batterman examines a form of scientific reasoning called asymptotic reasoning, arguing that it has important consequences for our understanding of the scientific process as a whole. He maintains that asymptotic reasoning is essential for explaining what physicists call universal behavior. With clarity and rigor, he simplifies complex questions about universal behavior, demonstrating a profound understanding of the underlying structures that ground them. This book introduces a valuable new method that is certain to fill explanatory gaps across disciplines.

But do animals know that other creatures have minds? And how would we know if they do? In "Mindreading Animals," Robert Lurz offers a fresh approach to the hotly debated question of mental-state attribution in nonhuman animals.

This article discusses minimal model explanations, which we argue are distinct from various causal, mechanical, difference-making, and so on, strategies prominent in the philosophical literature. We contend that what accounts for the explanatory power of these models is not that they have certain features in common with real systems. Rather, the models are explanatory because of a story about why a class of systems will all display the same large-scale behavior because the details that distinguish them are irrelevant. This story (...) explains patterns across extremely diverse systems and shows how minimal models can be used to understand real systems. (shrink)

This paper examines contemporary attempts to explicate the explanatory role of mathematics in the physical sciences. Most such approaches involve developing so-called mapping accounts of the relationships between the physical world and mathematical structures. The paper argues that the use of idealizations in physical theorizing poses serious difficulties for such mapping accounts. A new approach to the applicability of mathematics is proposed.

It is relatively easy to state that information retrieval is a scientific discipline but it is rather difficult to understand why it is science because what is science is still under debate in the philosophy of science. To be able to convince others that IR is science, our ability to explain why is crucial. To explain why IR is a scientific discipline, we use a theory and a model of scientific study, which were proposed recently. The explanation involves mapping the (...) knowledge structure of IR to that of well-known scientific disciplines like physics. In addition, the explanation involves identifying the common aim, principles and assumptions in IR and in well-known scientific disciplines like physics, so that they constrain the scientific investigation in IR in a similar way as in physics. Therefore, there are strong similarities in terms of the knowledge structure and the constraints of the scientific investigations between IR and scientific disciplines like physics. Based on such similarities, IR is considered a scientific discipline. (shrink)

This paper concerns what Jerry Fodor calls a 'metaphysical mystery': How can there by macroregularities that are realized by wildly heterogeneous lower level mechanisms? But the answer to this question is not as mysterious as many, including Jaegwon Kim, Ned Block, and Jerry Fodor might think. The multiple realizability of the properties of the special sciences such as psychology is best understood as a kind of universality, where 'universality' is used in the technical sense one finds in the physics literature. (...) It is argued that the same explanatory strategy used by physicists to provide understanding of universal behavior in physics can be used to explain how special science properties can be heterogeneously multiply realized. (shrink)

This paper examines the role of mathematical idealization in describing and explaining various features of the world. It examines two cases: first, briefly, the modeling of shock formation using the idealization of the continuum. Second, and in more detail, the breaking of droplets from the points of view of both analytic fluid mechanics and molecular dynamical simulations at the nano-level. It argues that the continuum idealizations are explanatorily ineliminable and that a full understanding of certain physical phenomena cannot be obtained (...) through completely detailed, non-idealized representations. (shrink)

This paper aims to draw attention to an explanatory problem posed by the existence of multiply realized or universal behavior exhibited by certain physical systems. The problem is to explain how it is possible that systems radically distinct at lower-scales can nevertheless exhibit identical or nearly identical behavior at upper-scales. Theoretically this is reflected by the fact that continuum theories such as fluid mechanics are spectacularly successful at predicting, describing, and explaining fluid behaviors despite the fact that they do not (...) recognize the discrete nature of fluids. A standard attempt to reduce one theory to another, is shown to fail to answer the appropriate question about autonomy. (shrink)

Big Data’s calculative ontology relies on and reproduces a form of hyperindividualism in which the ontological unit of analysis is the discrete data point, the meaning and identity of which inheres in itself, preceding, separate, and independent from its context or relation to any other data point. The practice of Big Data governed by an ontology of hyperindividualism is also constitutive of that ontology, naturalizing and diffusing it through practices of governance and, from there, throughout myriad dimensions of everyday life. (...) In this paper, I explicate Big Data’s ontology of hyperindividualism by contrasting it to a coconstitutive ontology that prioritizes relationality, context, and interdependence. I then situate the ontology of hyperindividualism in its genealogical context, drawing from Patrick Joyce’s history of liberalism and John Dewey’s pragmatist account of individualism, liberalism, and social action. True to its genealogical provenance, Big Data’s ontological politics of hyperindividualism reduces governance to the management of atomistic behavior, undermines the contribution of urban complexity as a resource for governance, erodes the potential for urban democracy, and eviscerates the possibility of collective resistance. (shrink)

The 3Rs, or the replacement, reduction, and refinement of animal research, are widely accepted as the best approach to maximizing high-quality science while ensuring the highest standard of ethical consideration is applied in regulating the use of animals in scientific procedures. This contrasts with the muted scientific interest in the 3Rs when they were first proposed in The Principles of Humane Experimental Technique. Indeed, the relative success of the 3Rs has done little to encourage engagement with their original text, which (...) remains little read and out of print. By adopting a historical perspective, this article argues that one explanation for this disjunction may be found in another, more celebrated, event of 1959: C. P. Snow’s Rede lecture on The Two Cultures. The moral outlook of The Principles of Humane Experimental Technique derived from an earlier ethos wherein humanistic and scientific values occupied a shared culture. While the synthetic style of The Principles has hindered its readership, this article concludes that there is value to recovering the notion that the humanities and social sciences can contribute to the improvement of animal research. (shrink)

A traditional view of mathematical modeling holds, roughly, that the more details of the phenomenon being modeled that are represented in the model, the better the model is. This paper argues that often times this ‘details is better’ approach is misguided. One ought, in certain circumstances, to search for an exactly solvable minimal model—one which is, essentially, a caricature of the physics of the phenomenon in question.

At the time of his death in the autumn of 2017, Robert W. Jenson was arguably America's foremost theologian. Over the course of a career spanning more than five decades, much of Jenson's thought was dedicated to the theological description of how Scripture should be read-what has come to be called theological interpretation. In this rapidly expanding field of scholarship, Jenson has had an inordinate impact. Despite its importance, study of Jenson's theology of scriptural interpretation has lagged, due in (...) large part to the longevity of his career and volume of his output. In this book, all of Jenson's writings on Scripture and its interpretation have been collected for the first time. Here readers will be able to see the evolution of Jenson's thought on this topic, as well as the scope and intensity of his late-period engagement with it. Where other twentieth-century thinkers rely on non-theological, secular methods of scriptural investigation, Jenson is willing to let go of "respectability" for the sake of a truly Christian theological interpretation. The result is a genuinely free, intellectually invigorating exercise in reading and theory from one of the greatest theologians in the last century. (shrink)

Autonomy -- Hydrodynamics -- Brownian motion -- From Brownian motion to bending beams -- An engineering approach -- The right variables and natural kinds.

We present a toy theory that is based on a simple principle: the number of questions about the physical state of a system that are answered must always be equal to the number that are unanswered in a state of maximal knowledge. Many quantum phenomena are found to have analogues within this toy theory. These include the noncommutativity of measurements, interference, the multiplicity of convex decompositions of a mixed state, the impossibility of discriminating nonorthogonal states, the impossibility of a universal (...) state inverter, the distinction between bipartite and tripartite entanglement, the monogamy of pure entanglement, no cloning, no broadcasting, remote steering, teleportation, entanglement swapping, dense coding, mutually unbiased bases, and many others. The diversity and quality of these analogies is taken as evidence for the view that quantum states are states of incomplete knowledge rather than states of reality. A consideration of the phenomena that the toy theory fails to reproduce, notably, violations of Bell inequalities and the existence of a Kochen-Specker theorem, provides clues for how to proceed with this research program. (shrink)

The principles of the 3Rs—replacement, refinement, and reduction—strongly shape discussion of methods for performing more humane animal research and the regulation of this contested area of technoscience. This special issue looks back to the origins of the 3Rs principles through five papers that explore how it is enacted and challenged in practice and that develop critical considerations about its future. Three themes connect the papers in this special issue. These are the multiplicity of roles enacted by those who use and (...) care for animals in research, the distribution of “feelings that matter” across species and spaces of laboratory animal practice, and the growing importance of “cultures of care” in animal research. (shrink)

If we are flexible, hybrid and unfinished creatures that tend to incorporate or at least employ technological artefacts in our cognitive lives, then the sort of technological regime we live under should shape the kinds of minds we possess and the sorts of beings we are. E-Memory consists in digital systems and services we use to record, store and access digital memory traces to augment, re-use or replace organismic systems of memory. I consider the various advantages of extended and embedded (...) approaches to cognition in making sense of E-Memory and some of the problems that debate can engender. I also explore how the different approaches imply different answers to questions such as: does our use of internet technology imply the diminishment of ourselves and our cognitive abilities? Whether or not our technologies can become actual parts of our minds, they may still influence our cognitive profile. I suggest E-Memory systems have four factors: totality, practical cognitive incorporability, autonomy and entanglement which conjointly have a novel incorporation profile and hence afford some novel cognitive possibilities. I find that thanks to the properties of totality and incorporability we can expect an increasing reliance on E-Memory. Yet the potentially highly entangled and autonomous nature of these technologie pose questions about whether they should really be counted as proper parts of our minds. (shrink)

This volume is a collection of fourteen essays by leading philosophers on issues concerning the nature, existence, and our knowledge of animal minds. The nature of animal minds has been a topic of interest to philosophers since the origins of philosophy, and recent years have seen significant philosophical engagement with the subject. However, there is no volume that represents the current state of play in this important and growing field. The purpose of this volume is to highlight the state of (...) the debate. The issues which are covered include whether and to what degree animals think in a language or in iconic structures, possess concepts, are conscious, self-aware, metacognize, attribute states of mind to others, and have emotions, as well as issues pertaining to our knowledge of and the scientific standards for attributing mental states to animals. (shrink)

In its broadest sense, "universality" is a technical term for something quite ordinary. It refers to the existence of patterns of behavior by physical systems that recur and repeat despite the fact that in some sense the situations in which these patterns recur and repeat are different. Rainbows, for example, always exhibit the same pattern of spacings and intensities of their bows despite the fact that the rain showers are different on each occasion. They are different because the shapes of (...) the drops, and their sizes can vary quite widely due to differences in temperature, wind direction, etc. There are different questions one might ask about such patterns. For instance, one might ask why the particular rainbow... (shrink)

While 4E cognitive science is fundamentally committed to recognising the importance of the environment in making sense of cognition, its interest in the role of artefacts seems to be one of its least developed dimensions. Yet the role of artefacts in human cognition and agency is central to the sorts of beings we are. Internet technology is influencing and being incorporated into a wide variety of our cognitive processes. Yet the dominant way of viewing these changes sees technology as an (...) outside force “impacting” on our minds. Within this context, Material Engagement Theory seems well poised to help make sense of our cognitive involvement with the Internet as MET is precisely concerned with grasping the role of material culture in human cognition. This paper explores some of the resources MET provides to think through the effects the internet is having on human agency. This paper uses MET as a starting point for examining the way Internet technology can be involved with human agency, both to the provide a much needed and more adequate theorization of these phenomena, but also to illustrate ways in which the consideration of artefacts can be given a more central and adequate place within the 4E cognitive sciences. (shrink)

This paper looks at emergence in physical theories and argues that an appropriate way to understand socalled “emergent protectorates” is via the explanatory apparatus of the renormalization group. It is argued that mathematical singularities play a crucial role in our understanding of at least some well-defined emergent features of the world.

Among discrete emotions, basic emotions are the most elemental; most distinct; most continuous across species, time, and place; and most intimately related to survival-critical functions. For an emotion to be afforded basic emotion status it must meet criteria of: (a) distinctness (primarily in behavioral and physiological characteristics), (b) hard-wiredness (circuitry built into the nervous system), and (c) functionality (provides a generalized solution to a particular survival-relevant challenge or opportunity). A set of six emotions that most clearly meet these criteria (enjoyment, (...) anger, disgust, fear, surprise, sadness) and three additional emotions (relief/contentment, interest, love) for which the evidence is not yet quite as strong is described. Empirical approaches that are most and least useful for establishing basic-emotion status are discussed. Basic emotions are thought to have a central organizing mechanism and to have the capacity to influence behavior, thoughts, and other fundamental processes. (shrink)

Canid and human barks and growls were examined in videotapes of 24 humans (Homo sapiens) and 24 dogs (Canis familiaris) playing with familiar and unfamiliar cross-species play partners. Barks and growls were exhibited by 9 humans and 9 dogs. Dogs barked and (less often) growled most frequently when being frustrated by humans and/or engaged in competitive games, and less often when being chased or inviting chase, and being instigated or captured. Dogs never growled when playing with an unfamiliar human, and (...) humans did so rarely when playing with an unfamiliar dog. Humans growled and (less often) barked most frequently when chasing and capturing the dog, less often when engaging in competitive games, being frustrated by the dog, and/or instigating the dog, and rarely when showing or throwing an object. Dog barks were most often requests for the human to make an object available to the dog. Dog growls were often pretend threats when competing for an object or being frustrated by the human’s actions. Human barks and growls were typically pretend threats, and were sometimes used to emphasize simultaneous behaviors. Human barks and growls allow humans to connect with their canid partner. (shrink)

St. Thomas Aquinas envisaged theology to be a kind of scientia which was considered as a kind of first cause science. However, science of that time is different from “modern” science. Recently, a theory of scientific study is developed, which outlines science by a theory and some models similar to knowledge in physics. According to this theory, sciences organize their knowledge consisting of theories, models and experiments interacting with physical situations. Perhaps, it is possible to organize knowledge of Christian theology (...) in a similar way as science (from the perspective of Christian belief). Doing this requires extensive and deep knowledge of both science and Christian theology. This paper only attempts to sketch such a theology, which is coined scientia theology to distinguish it from the existing scientific theology of McGrath. Our theology consists of a theory that is outlined here, several historical event models as well as various experiments that provide us with observations supporting the related models and principles. The theory of our theology interacts with the models which may retrodict or are supported by observations from the experiments that interact with the physical situations. (shrink)

Recently, information retrieval is shown to be a science by mapping information retrieval scientific study to scientific study abstracted from physics. The exercise was rather tedious and lengthy. Instead of dealing with the nitty gritty, this paper looks at the insights into how computer science can be made into a science by using that methodology. That is by mapping computer science scientific study to the scientific study abstracted from physics. To show the mapping between computer science and physics, we need (...) to define what is engineering science which computer science belongs to. Some principles and assumptions of engineering science theory are presented. To show computer science is a science, we presented two approaches. Approach 1 considers computer science as simulation of human behaviour similar to the goal of artificial intelligence. Approach 2 is closely related to the actual activities in computer science, and this approach considers computer science based on the theory of computation. Finally, we answer some of the common outstanding issues about computer science to convince our reader that computer science is a science. (shrink)