Asymmetric cell division generates cell diversity and contributes to cellular aging and rejuvenation. Here, we review the molecular mechanisms enabling budding yeast to recognize spindle pole bodies (SPB, centrosome equivalent) based on their age, and guide their non‐random mitotic segregation: SPB inheritance requires the distinction of old from new SPBs and is regulated by the SPB‐inheritance network (SPIN) and the mitotic exit network (MEN). The SPIN marks the pre‐existing SPB as old and the MEN recognizes these marks translating them into (...) spindle orientation. We next revisit other molecules and structures that partition depending on their age rather than their abundance at mitosis as, for example, DNA, centrosomes, mitochondria, and histones in yeast and other systems. The recurrence of this differential behavior suggests a functional significance for numerous cell types, which we then discuss. We conclude that non‐random segregation may facilitate asymmetric cell fate determination and thereby indirectly aging and rejuvenation. (shrink)

Human beings are endowed by the Source of their existence on earth with those inalienable rights which all members of humanity ought to respect. Freedom, in all its basic forms, is the root of these rights, but sadly, it is not the patrimony of all the people of the world. Political, societal, even domestic situations often deprive persons of this personal endowment. Basically, a philosophy of life, construed on a set of false premises, rejects some persons and/or peoples as unworthy (...) of the freedom which is their right. (shrink)

En los últimos años la historiografía incrementó su interés por el análisis comparado entre estados y evoluciones político-sociales, una excelente perspectiva para el análisis de la historia contemporánea. Las diferentes manifestaciones de clientelismo político que se desarrollaron en la Europa mediterránea desde el último cuarto del siglo XIX, caso del caciquismo español, el opportunisme francés y el transformismo italiano, vienen a ser la plasmación del pragmatismo político independientemente de la condición ideológica, y además, sirvieron de puente entre el fin del (...) liberalismo y la instauración de las democracias. Pero estas relaciones de poder oficiosas también fueron el intento de las élites y notables por fortalecer su posición ante los nuevos movimientos e ideologías que eclosionan con la sociedad de masas. Con esta comunicación pretendemos reflejar cómo las políticas clientelares desarrolladas en la Europa mediterránea en la transición del siglo XIX al XX permitieron: a) la estabilidad necesaria para iniciar reformas en un ambiente sociopolítico todavía en formación; b) fueron sistemas donde se hicieron visibles las contradicciones entre el marco legal, fundamentado en los principios liberales, y la aplicación de los mismos por parte de unas élites que pretendían mantener un orden político y social que les era favorable. (shrink)

The purpose of the work is to compare aquinas and merleau-Ponty and see whether the thought of thomas is relevant today. It is, As presenting a different insight into being. They agree in their purposes, But seek reality differently. Thomas looks for ultimate cause, Eternal truths, And claims the soul of man is an independent, Spiritual entity; merleau-Ponty looks to phenomena to find essences, Sees truth as elusive, And claims the soul is developmental. Both affirm the unity of man, However.

Motor inhibitory control, the ability to suppress unwanted actions, has been previously shown to rely on domain-general IC processes that are involved in a wide range of IC tasks. Nevertheless, the existence of effector-specific regions and activation patterns that would differentiate manual vs. oculomotor response inhibition remains unknown. In this study, we investigated the brain dynamics supporting these two response effectors with the same IC task paradigm. We examined the behavioral performance and electrophysiological activity in a group of healthy young (...) people with a Go/NoGo task using the index finger for the manual modality and the eyes for the oculomotor modality. By computing topographic analysis of variance, we found significant differences between topographies of scalp recorded potentials of the two response effectors between 250 and 325 ms post-stimulus onset. The source estimations localized this effect within the left precuneus, a part of the superior parietal lobule, showing stronger activity in the oculomotor modality than in the manual modality. Behaviorally, we found a significant positive correlation in response time between the two modalities. Our collective results revealed that while domain-general IC processes would be engaged across different response effectors in the same IC task, effector-specific activation patterns exist. In this case, the stronger activation of the left precuneus likely accounts for the increased demand for visual attentional processes in the oculomotor Go/NoGo task. (shrink)

Estudio exploratorio-descriptivo realizado en posgrado de una universidad pública de México; objetivo: identificar obstáculos de comunicación, de índole socioafectivo y tecnológica, que durante pandemia cobraron relevancia en el proceso de investigación para tesis. Método: cuantitativo con uso de cuestionario y entrevista estructurada. Inferencias: los obstáculos de índole socio afectivo repercuten en el proceso de investigación, especialmente en tiempos de crisis; la relación con el asesor de tesis es factor fundamental para la continuidad y permanencia; las tecnologías facilitan la comunicación asesor-asesorado; (...) el proceso de investigación implicó modificaciones y replanteamientos de problemas de investigación en contextos virtuales. (shrink)

Life-Sharing for a Creative Tomorrow is a study of human beings as arising from Nature, yet transcending it; related to each other as members of the human race, yet free to choose personal ties with and commitment to others in interpersonal relations. The trials and risks of love, the specific characterization of being human within moral and aesthetic expressions are considered in the context of the communal social structures in the world. The truth and integrity of selfhood, vis-à-vis psychological influences (...) and outside pressures is presented as the necessary safeguard of one's identity, while sharing a creative life of beauty and wisdom, in solidarity with Others, for a truly human future. (shrink)