Efforts from diverse disciplines, including evolutionary studies and biomechanical experiments, have yielded new insights into the genetic, signaling, and mechanical control of tooth formation and functions. Evidence from fossils and non‐model organisms has revealed that a common set of genes underlie tooth‐forming potential of epithelia, and changes in signaling environments subsequently result in specialized dentitions, maintenance of dental stem cells, and other phenotypic adaptations. In addition to chemical signaling, tissue forces generated through epithelial contraction, differential growth, and skeletal constraints (...) act in parallel to shape the tooth throughout development. Here recent advances in understanding dental development from these studies are reviewed and important gaps that can be filled through continued application of evolutionary and biomechanical approaches are discussed. (shrink)

How does Newton approach the challenge of mechanizing gravity and, more broadly, natural philosophy? By adopting the simple machine tradition’s mathematical approach to a system’s co-varying parameters of change, he retains natural philosophy’s traditional goal while specifying it in a novel way as the search for impressed forces. He accordingly understands the physical world as a divinely created machine possessing intrinsically mathematical features, and mathematical methods as capable of identifying its real features. The gravitational force’s physical cause remains an (...) outstanding problem, however, as evidenced by Newton’s onetime reference to active principles as the “genuine principles of the mechanical philosophy”. (shrink)

The YAP/TAZ family of transcriptional co‐activators drives cell proliferation in epithelial tissues and cancers. Yet, how YAP and TAZ are physiologically regulated remains unclear. Here we review recent reports that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells differentiate an apical membrane domain, and being activated when cells contact the extracellular matrix via their basal membrane domain. Apical signalling occurs via the canonical Crumbs/CRB‐Hippo/MST‐Warts/LATS kinase cascade to phosphorylate and inhibit YAP/TAZ. Basal signalling occurs (...) via Integrins and Src family kinases to phosphorylate and activate YAP/TAZ. Thus, YAP/TAZ is localised to the nucleus in basal stem/progenitor cells and cytoplasm in differentiated squamous cells or columnar cells. In addition, other signals such as mechanical forces, tissue damage and possibly receptor tyrosine kinases (RTKs) can influence MST‐LATS or Src family kinase activity to modulate YAP/TAZ activity. (shrink)

The remodeling of biological membranes is crucial for a vast number of cellular activities and is an inherently multiscale process in both time and space. Seminal work has provided important insights into nanometer‐scale membrane deformations, and highlighted the remarkable variation and complexity in the underlying molecular machineries and mechanisms. However, how membranes are remodeled at the micron‐scale, particularly in vivo, remains poorly understood. Here, we discuss how using regulated exocytosis of large (1.5–2.0 μm) membrane‐bound secretory granules in the salivary gland (...) of live mice as a model system, has provided evidence for the importance of the actomyosin cytoskeleton in micron‐scale membrane remodeling in physiological conditions. We highlight some of these advances, and present mechanistic hypotheses for how the various biochemical and biophysical properties of distinct actomyosin networks may drive this process. (shrink)

Correlations of spins in a system of entangled particles are inconsistent with Kolmogorov’s probability theory (KPT), provided the system is assumed to be non-contextual. In the Alice–Bob EPR paradigm, non-contextuality means that the identity of Alice’s spin (i.e., the probability space on which it is defined as a random variable) is determined only by the axis $\alpha _{i}$ chosen by Alice, irrespective of Bob’s axis $\beta _{j}$ (and vice versa). Here, we study contextual KPT models, with two properties: (1) Alice’s (...) and Bob’s spins are identified as $A_{ij}$ and $B_{ij}$ , even though their distributions are determined by, respectively, $\alpha _{i}$ alone and $\beta _{j}$ alone, in accordance with the no-signaling requirement; and (2) the joint distributions of the spins $A_{ij},B_{ij}$ across all values of $\alpha _{i},\beta _{j}$ are constrained by fixing distributions of some subsets thereof. Of special interest among these subsets is the set of probabilistic connections, defined as the pairs $\left( A_{ij},A_{ij'}\right) $ and $\left( B_{ij},B_{i'j}\right) $ with $\alpha _{i}\not =\alpha _{i'}$ and $\beta _{j}\not =\beta _{j'}$ (the non-contextuality assumption is obtained as a special case of connections, with zero probabilities of $A_{ij}\not =A_{ij'}$ and $B_{ij}\not =B_{i'j}$ ). Thus, one can achieve a complete KPT characterization of the Bell-type inequalities, or Tsirelson’s inequalities, by specifying the distributions of probabilistic connections compatible with those and only those spin pairs $\left( A_{ij},B_{ij}\right) $ that are subject to these inequalities. We show, however, that quantum-mechanical (QM) constraints are special. No-forcing theorem says that if a set of probabilistic connections is not compatible with correlations violating QM, then it is compatible only with the classical–mechanical correlations. No-matching theorem says that there are no subsets of the spin variables $A_{ij},B_{ij}$ whose distributions can be fixed to be compatible with and only with QM-compliant correlations. (shrink)

Heinrich Hertz dedicated the last four years of his life to a systematic reformulation of mechanics. One of the main issues that troubled Hertz in the customary formulation of mechanics was a "logical obscurity" in the notion of force. However, it is unclear what this logical obscurity was, hence it is unclear how Hertz took himself to have avoided it. -/- In this paper, I argue that a subtle ambiguity in Newton's original laws of motion lay at the basis (...) of Hertz's concerns; an ambiguity which led to the development of two slightly different notions of force. I then show how Hertz avoided this ambiguity by deriving a unitary notion of force, thus dispelling the obscurity that lurked in the customary representation of mechanics. (shrink)

How motor proteins induce mechanical movement at the molecular level has been a focus of biophysicists for a long time. While the whole picture is yet to be completely revealed, recent developments in looking at nanometer‐scale movement with millisecond‐time resolution driven by single motors have revealed important new details about the moving step size and amount of force generated per molecule.

The paper deals with the role of the concept of force in different classical mechanical and field theories, pointing out the existence in all cases of a Lorentz-type expression for force. In the case of the classical theory of the gravitational field we obtain the same Lorentz-type expression.

Newtonian forces are pushes and pulls, possessing magnitude and direction, that are exerted (in the first instance) by objects, and which cause (in particular) motions. I defend Newtonian forces against the four best reasons for denying or doubting their existence. A running theme in my defense of forces will be the suggestion that Newtonian Mechanics is a special science, and as such has certain prima facie ontological rights and privileges, that may be maintained against various challenges.

“Pick a card, any card. This has to be a completely free choice.” the magician tells you. But is it really? Although we like to think that we are using our free will to make our decisions, research in psychology has shown that many of our behaviours are automatic and unconsciously influenced by external stimuli (Ariely, 2008; Bargh & Chartrand, 1999; Newell & Shanks, 2014; Nisbett & Wilson, 1977), and that we are often oblivious to the cognitive mechanisms that underpin (...) our decision (Wegner, 2002, 2003). Magicians have exploited this illusory sense of agency for a long time, and have developed a wide range of techniques to influence and control spectators’ choices of such things as card, word, or number (Annemann, 1933; Banachek, 2002a; Jones, 1994; Turner, 2015). These techniques are instances of what is called forcing. -/- Many forces are extremely effective, illustrating various weaknesses in our sense of control over decisions and their outcomes. Researchers have started to investigate them in various ways (Kuhn, Pailh s, & Lan, 2020; Olson, Amlani, Raz, & Rensink, 2015; Pailhes & Kuhn, 2020b, 2020c; Shalom et al., 2013) and are beginning to obtain valuable insights into decision-making processes as well as a better understanding of the cognitive mechanisms that lead people to experience an illusory sense of free will and of agency. -/- Although magicians have acquired large amounts of knowledge in covertly controlling people’s choices, much of this knowledge is only discussed in the context of individual magic tricks, or in books that are not readily accessible to non-magicans. As we and others have argued elsewhere (Ekroll, Sayim, & Wagemans, 2017; Kuhn, 2019; Kuhn, Amlani, & Rensink, 2008; Kuhn, Caffaratti, Teszka, & Rensink, 2014; Macknik et al., 2008; Olson et al., 2015; Olson, Landry, Appourchaux, & Raz, 2016; Shalom et al., 2013; Thomas, Didierjean, Maquestiaux, & Gygax, 2015), a particularly effective way of making this knowledge more available is via the creation of taxonomies centered around psychological mechanisms (Rensink & Kuhn, 2015). For example, the psychologically based taxonomy of misdirection (Kuhn et al., 2014) helps draw links between misdirection and formal theories of perception and cognition. -/- Our aim here is to apply a similar process to the knowledge magicians have about forcing. The present paper develops a psychologically based taxonomy of forcing techniques with two goals in mind. Firstly, it should help uncover the various psychological mechanisms that underlie forcing techniques. Secondly, it should facilitate knowledge transfer between magicians and psychologists. Among other things, this knowledge will allow researchers to gain new insights into the mechanisms underlying decision-making, and the feeling of free will and of agency over choice. We start by defining the magician’s force and then look at some of the past classifications of forcing. (shrink)

The physical origin of inertial forces is shown to be a consequence of the local interaction of Dirac's real covariant ether model(1) with accelerated microobjects, considered as real extended particlelike solitons, piloted by surrounding subluminal real wave fields packets.(2) Their explicit form results from the application of local inertial Lorentz transformations to the particles submitted to noninertial velocitydependent accelerations, i.e., constitute a natural extension of Lorentz's interpretation of restricted relativity.(3) Indeed Dirac's real physical covariant ether model implies inertial forces if (...) one considers the real accelerated noninertial motions of general relativity, defined within the absolute local inertial frames associated with the observed local isotropy of the 2.7° K background microwave radiation.(4) Inertia thus appears as a necessary consequence of the real particle motions described by the E.d.B.B. formalism of quantum mechanics. (shrink)

This article discusses the quest for the mechanical advantage of the wedge in the eighteenth century. As a case study, the wedge enlightens our understanding of eighteenth-century mechanics in general and the controversy over “force” or vis viva in particular. In this article, I show that the two different approaches to mechanics, the one that favoured force in terms of velocities and the one that primarily used displacements—known as the ‘Newtonian’ and ‘Leibnizian’ methods, respectively—were not at all (...) on par in their ability to solve the problem of the wedge. In general, only those who used the Leibnizian concept of force or some related notion were able to get to the conventional results. This article thus rebuts the received view that the vis viva controversy was merely a semantic one. Instead, it shows that different understandings of “force” led to real and pragmatic differences in eighteenth-century mechanics. (shrink)

This article discusses the quest for the mechanical advantage of the wedge in the eighteenth century. As a case study, the wedge enlightens our understanding of eighteenth-century mechanics in general and the controversy over “force” or vis viva in particular. In this article, I show that the two different approaches to mechanics, the one that favoured force in terms of velocities and the one that primarily used displacements—known as the ‘Newtonian’ and ‘Leibnizian’ methods, respectively—were not at all (...) on par in their ability to solve the problem of the wedge. In general, only those who used the Leibnizian concept of force or some related notion were able to get to the conventional results. This article thus rebuts the received view that the vis viva controversy was merely a semantic one. Instead, it shows that different understandings of “force” led to real and pragmatic differences in eighteenth-century mechanics. (shrink)

It is difficult to evaluate the role of activity - of force or of that which has causal efficacy - in Descartes’ natural philosophy. On the one hand, Descartes claims to include in his natural philosophy only that which can be described geometrically, which amounts to matter (extended substance) in motion (where this motion is described kinematically).’ Yet on the other hand, rigorous adherence to a purely geometrical description of matter in motion would make it difficult to account for (...) the interactions among the particles that constitute Descartes’ universe, since the notions of extension and kinematical motion do not in themselves imply any causal agency. There is, after all, no reason to expect that a particle whose single essence is extension, even if we suppose it to be moving, should impart motion to another particle, while conversely, there is no reason to expect a resting particle to hinder the motion of an impinging one. Descartes' hankering for an austere ontology of matter in motion is in danger of excluding causal agency (force, conceived dynmically) from matter. To the modern reader it may seem obvious that Descartes did not get himself into such a fix, since matter in motion so readily reminds us of kinetic energy or of some more primitive notion of force. Yet by no means is it obvious that Descartes attributed causal efficacy to matter in motion per se. Serious scholars have held opposite positions on this issue. Westfall, Gabbey, and others’ have argued that although on the metaphysical plane Descartes attempted to eliminate force from his mechanical universe, nonetheless ‘force is a real feature’ of his mechanical world. The thrust of this view is that Descartes conceived of force as ‘the capacity of a body in motion to act’, by means of impact, upon other bodies. An opposing interpretation, defended here, is that Descartes did in fact deny causal agency to moving matter per se, restricting agency to immaterial substances such as the human mind, angels, and God. The intention of this interpretation is not to de-emphasize the role of matter in motion in Descartes’ explanation of nature, but rather to stress the fact that Descartes did not conceive of this moving matter dynamically. -/- Reprinted in Descartes, ed. by J. Cottingham, Oxford Readings in Philosophy (Oxford: Oxford University Press, 1998), 281–310. (shrink)

Analysis of grip force signals tailored to hand and finger movement evolution and changes in grip force control during task execution provide unprecedented functional insight into somatosensory cognition. Somatosensory cognition is a basis of our ability to manipulate, move, and transform objects of the physical world around us, to recognize them on the basis of touch alone, and to grasp them with the right amount of force for lifting and manipulating them. Recent technology has permitted the wireless (...) monitoring of grip force signals recorded from biosensors in the palm of the human hand to track and trace human grip forces deployed in cognitive tasks executed under conditions of variable sensory (visual, auditory) input. Non-invasive multi-finger grip force sensor technology can be exploited to explore functional interactions between somatosensory brain mechanisms and motor control, in particular during learning a cognitive task where the planning and strategic execution of hand movements is essential. Sensorial and cognitive processes underlying manual skills and/or hand-specific (dominant versus non-dominant hand) behaviors can be studied in a variety of contexts by probing selected measurement loci in the fingers and palm of the human hand. Thousands of sensor data recorded from multiple spatial locations can be approached statistically to breathe functional sense into the forces measured under specific task constraints. Grip force patterns in individual performance profiling may reveal the evolution of grip force control as a direct result of cognitive changes during task learning. Grip forces can be functionally mapped to from-global-to-local coding principles in brain networks governing somatosensory processes for motor control in cognitive tasks leading to a specific task expertise or skill. Under the light of a comprehensive overview of recent discoveries into the functional significance of human grip force variations, perspectives for future studies in cognition, in particular the cognitive control of strategic and task relevant hand movements in complex real-world precision task, are pointed out. (shrink)

Why does one theory "succeed" while another, possibly clearer interpretation, fails? By exploring two observationally equivalent yet conceptually incompatible views of quantum mechanics, James T. Cushing shows how historical contingency can be crucial to determining a theory's construction and its position among competing views. Since the late 1920s, the theory formulated by Niels Bohr and his colleagues at Copenhagen has been the dominant interpretation of quantum mechanics. Yet an alternative interpretation, rooted in the work of Louis de Broglie in the (...) early 1920s and reformulated and extended by David Bohm in the 1950s, equally well explains the observational data. Through a detailed historical and sociological study of the physicists who developed different theories of quantum mechanics, the debates within and between opposing camps, and the receptions given to each theory, Cushing shows that despite the preeminence of the Copenhagen view, the Bohm interpretation cannot be ignored. Cushing contends that the Copenhagen interpretation became widely accepted not because it is a better explanation of subatomic phenomena than is Bohm's, but because it happened to appear first. Focusing on the philosophical, social, and cultural forces that shaped one of the most important developments in modern physics, this provocative book examines the role that timing can play in the establishment of theory and explanation. (shrink)

In this paper, I critically assess different interpretations of Bohmian mechanics that are not committed to an ontology based on the wave function being an actual physical object that inhabits configuration space. More specifically, my aim is to explore the connection between the denial of configuration space realism and another interpretive debate that is specific to Bohmian mechanics: the quantum potential versus guidance approaches. Whereas defenders of the quantum potential approach to the theory claim that Bohmian mechanics is better formulated (...) as quasi-Newtonian, via the postulation of forces proportional to acceleration; advocates of the guidance approach defend the notion that the theory is essentially first-order and incorporates some concepts akin to those of Aristotelian physics. Here I analyze whether the desideratum of an interpretation of Bohmian mechanics that is both explanatorily adequate and not committed to configuration space realism favors one of these two approaches to the theory over the other. Contrary to some recent claims in the literature, I argue that the quasi-Newtonian approach based on the idea of a quantum potential does not come out the winner. (shrink)

In Descartes’s reformulation of natural philosophy, two aspects of what came to be known as the mechanical philosophy were intimately joined: mechanism as an ontology of nature, according to which all natural things had only ‘mechanical’ properties; and mechanism as a method of explanation. One could, and many philosophers did, adopt mechanism as a method of explanation without adopting a mechanistic ontology. I examine two successors of Descartes who did just that, and one who did not. Giovanni Alfonso (...) Borelli in his De motu animalium and Charles Perrault in his Mécanique de animaux propose and argue for a variety of mechanical accounts of the operations of animals, in particular of their muscles. They reject, however, the Cartesian reduction of animal souls to mechanical forces; the principle of animal motion for them remains a non-mechanical soul. Pierre Sylvain Régis in his Cours entier de philosophie follows Descartes in taking the ‘physical cause’ of motion in animals to be the fermentation of blood in the heart, and thus denies animal souls any role in his physiology. That he can do so while taking over, sometimes word for word, Perrault’s accounts of animal motion shows that mechanistic explanation and mechanistic ontology could easily part company. (shrink)

In this paper I discuss two questions. What does Kant understand by mechanical explanation in the Critique of judgment? And why does he think that mechanical explanation is the only type of the explanation of nature available to us? According to the interpretation proposed, mechanical explanations in the Critique of judgment refer to a particular species of empirical causal laws. Mechanical laws aim to explain nature by reference to the causal interaction between the forces of the (...) parts of matter and the way in which they form into complex material wholes. Just like any other empirical causal law, however, mechanical laws can never be known with full certainty. The conception according to which we can explain all of nature by means of mechanical laws, it turns out, is based on what Kant calls ‘regulative’ or ‘reflective’ considerations about nature. Nothing in Kant’s Critique of judgment suggests that these considerations can ever be justified by reference to how the natural world really is. I suggest that what, upon first consideration, appears to be a thoroughly mechanistic conception of nature in Kant is much more limited than one might have expected. (shrink)

During morphogenesis, tissues undergo extensive remodeling to get their final shape. Such precise sculpting requires the application of forces generated within cells by the cytoskeleton and transmission of these forces through adhesion molecules within and between neighboring cells. Within individual cells, microtubules together with actomyosin filaments and intermediate filaments form the composite cytoskeleton that controls cell mechanics during tissue rearrangements. While studies have established the importance of actin‐based mechanical forces that are coupled via intercellular junctions, relatively little is known (...) about the contribution of other cytoskeletal components such as microtubules to cell mechanics during morphogenesis. In this review the focus is on recent findings, highlighting the direct mechanical role of microtubules beyond its well‐established role in trafficking and signaling during tissue formation. (shrink)

This history of physics focuses on the question, "How do bodies act on one another across space?" The variety of answers illustrates the function of fundamental analogies or models in physics as well as the role of so-called unobservable entities. Forces and Fields presents an in-depth look at the science of ancient Greece, and it examines the influence of antique philosophy on seventeenth-century thought. Additional topics embrace many elements of modern physics--the empirical basis of quantum mechanics, wave-particle duality and the (...) uncertainty principle, and the action-at-a-distance theory of Wheeler and Feynman. 1961 ed. (shrink)

Newtonian mechanics is more than just an empirically successful theory of matter in motion: it is an account of what knowledge of the physical world should look like. But what is this account? What is distinctive about it? To answer these questions, I begin by introducing the laws of motion, the relations among them, and the spatio-temporal framework that is implicit in them. Then I turn to the question of their methodological character. This has been the locus of philosophical discussion (...) from Newton’s time to the present, and I survey the views of some of the major contributors. I show that while Newtonian mechanics motivates a number of philosophical ideas about force, mass, motion, and causality – and through this, ideas about space and time – the laws are themselves the outcome of a philosophical or critical conceptual analysis. (shrink)

Reprint of: Gary Hatfield, Force (God) in Descartes' physics, Studies in History and Philosophy of Science Part A 10 (2):113-140 (1979) -/- Abstract. It is difficult to evaluate the role of activity - of force or of that which has causal efficacy - in Descartes’ natural philosophy. On the one hand, Descartes claims to include in his natural philosophy only that which can be described geometrically, which amounts to matter (extended substance) in motion (where this motion is described (...) kinematically).’ Yet on the other hand, rigorous adherence to a purely geometrical description of matter in motion would make it difficult to account for the interactions among the particles that constitute Descartes’ universe, since the notions of extension and kinematical motion do not in themselves imply any causal agency. There is, after all, no reason to expect that a particle whose single essence is extension, even if we suppose it to be moving, should impart motion to another particle, while conversely, there is no reason to expect a resting particle to hinder the motion of an impinging one. Descartes' hankering for an austere ontology of matter in motion is in danger of excluding causal agency (force, conceived dynmically) from matter. To the modern reader it may seem obvious that Descartes did not get himself into such a fix, since matter in motion so readily reminds us of kinetic energy or of some more primitive notion of force. Yet by no means is it obvious that Descartes attributed causal efficacy to matter in motion per se. Serious scholars have held opposite positions on this issue. Westfall, Gabbey, and others’ have argued that although on the metaphysical plane Descartes attempted to eliminate force from his mechanical universe, nonetheless ‘force is a real feature’ of his mechanical world. The thrust of this view is that Descartes conceived of force as ‘the capacity of a body in motion to act’, by means of impact, upon other bodies. An opposing interpretation, defended here, is that Descartes did in fact deny causal agency to moving matter per se, restricting agency to immaterial substances such as the human mind, angels, and God. The intention of this interpretation is not to de-emphasize the role of matter in motion in Descartes’ explanation of nature, but rather to stress the fact that Descartes did not conceive of this moving matter dynamically. (shrink)

Newton’s First Law of Motion is typically understood to govern only the motion of force-free bodies. This paper argues on textual and conceptual grounds that it is in fact a stronger, more general principle. The First Law limits the extent to which any body can change its state of motion –– even if that body is subject to impressed forces. The misunderstanding can be traced back to an error in the first English translation of Newton’s Principia, which was published (...) a few years after Newton’s death. (shrink)

We develop and defend the thesis that the Hilbert space formalism of quantum mechanics is a new theory of probability. The theory, like its classical counterpart, consists of an algebra of events, and the probability measures defined on it. The construction proceeds in the following steps: (a) Axioms for the algebra of events are introduced following Birkhoff and von Neumann. All axioms, except the one that expresses the uncertainty principle, are shared with the classical event space. The only models for (...) the set of axioms are lattices of subspaces of inner product spaces over a field K. (b) Another axiom due to Soler forces K to be the field of real, or complex numbers, or the quaternions. We suggest a probabilistic reading of Soler's axiom. (c) Gleason's theorem fully characterizes the probability measures on the algebra of events, so that Born's rule is derived. (d) Gleason's theorem is equivalent to the existence of a certain finite set of rays, with a particular orthogonality graph (Wondergraph). Consequently, all aspects of quantum probability can be derived from rational probability assignments to finite "quantum gambles". (e) All experimental aspects of entanglement- the violation of Bell's inequality in particular- are explained as natural outcomes of the probabilistic structure. (f) We hypothesize that even in the absence of decoherence macroscopic entanglement can very rarely be observed, and provide a precise conjecture to that effect .We also discuss the relation of the present approach to quantum logic, realism and truth, and the measurement problem. (shrink)

Here I explore a novel no-collapse interpretation of quantum mechanics that combines aspects of two familiar and well-developed alternatives, Bohmian mechanics and the many-worlds interpretation. Despite reproducing the empirical predictions of quantum mechanics, the theory looks surprisingly classical. All there is at the fundamental level are particles interacting via Newtonian forces. There is no wave function. However, there are many worlds.

An in-depth look at the science of ancient Greece, this volume examines the influence of antique philosophy on 17th-century thought. Additional topics embrace many elements of modern physics: the empirical basis of quantum mechanics, wave-particle duality and the uncertainty principle, and the action-at-a-distance theory of Wheeler and Feynman. 1961 edition.

The Conventionality of Simultaneity espoused by Reichenbach, Grunbaum, Edwards, and Winnie is herein extended to mechanics and electrodynamics. The extension is seen to be a special case of a generally covariant formulation of physics, and therefore consistent with Special Relativity as the geometry of flat space-time. Many of the quantities of classical physics, such as mass, charge density, and force, are found to be synchronization dependent in this formulation and, therefore, in Reichenbach's terminology, "metrogenic." The relationship of these quantities (...) to 4-vectors and their physical significance is discussed. (shrink)

Cognitive neuroscientists have anticipated the union of neural and behavioral science with ethics (Gazzaniga 2005). The identification of an ethical rule—the dictum that we should treat others in the manner in which we would like to be treated—apparently widespread among human societies suggests a dependence on fundamental human brain mechanisms. Now, studies of neural and molecular mechanisms that underlie the feeling of fear suggest how this form of ethical behavior is produced. Counterintuitively, a new theory presented here states that it (...) is actually a loss of social information that leads to sharing others' fears with our own, thus allowing us to treat others as we would like to be treated. Adding to that hypothetical mechanism is the well-studied predilection toward affiliative behaviors. Thus, even as Chomsky hypothesizes that humans are predisposed to utter grammatical sentences, we propose that humans are 'wired for reciprocity'. However, these two neural forces supporting ethical behavior do not explain individual or collective violence. At any given moment, the ability to produce behavior that obeys this ethical rule is proposed to depend on a balance between mechanisms for prosocial and antisocial behaviors. That balance results not only from genetic influences on temperament but also from environmental effects particularly during critical neonatal and pubertal periods. (shrink)

This is an encyclopedia entry on the notion of force as entering into physical science.

The explanatory value of niche construction can be strengthened by firm footing in semiotic theory. Anthropologists have a unique perspective on the integration of such diverse approaches to human action and evolutionary processes. Here, we seek to open a dialogue between anthropology and biosemiotics. The overarching aim of this paper is to demonstrate that niche construction, including the underlying mechanism of reciprocal causation, is a semiotic process relating to biological development as well as cognitive development and cultural change. In making (...) this argument we emphasize the semiotic mechanisms underlying the niche concept. We argue that the “niche” in ecology and evolutionary biology can be consistent with the Umwelt of Jakob von Uexkull. Following John Deely we therefore suggest that investigations into the organism—environment interface constituting niche construction should emphasize the semiotic basis of experience. Peircean signs are pervasive and allow for flexible interpretations of phenomena in relation to the perceptual and cognitive capacities of the behaving organism, which is particularly pertinent for understanding the relation of proximate/ultimate selective forces as co-productive. Additionally, theoretical work by Kinji Imanishi on the evolution of daily life and Gregory Bateson’s relational view of evolution both support the linkage between proximate and ultimate evolutionary processes of causation necessitated by the niche construction perspective. We will then apply this theoretical framework to two specific examples: 1) hominin evolution, including uniquely human cultural behaviors with niche constructive implications; and 2) the multispecies and anthropocentric niche of human-dog coevolution from which complex cognitive capacities and semiotic relationships emerged. The intended outcome of this paper is the establishment of concrete semiotic mechanisms and theory underlying niche constructive behavior which can then be applied to a broad spectrum of organisms to contextualize the reciprocal relation between proximate and ultimate drivers of behavior. (shrink)

A new variational method, the principle of least radix economy, is formulated. The mathematical and physical relevance of the radix economy, also called digit capacity, is established, showing how physical laws can be derived from this concept in a unified way. The principle reinterprets and generalizes the principle of least action yielding two classes of physical solutions: least action paths and quantum wavefunctions. A new physical foundation of the Hilbert space of quantum mechanics is then accomplished and it is used (...) to derive the Schrödinger and Dirac equations and the breaking of the commutativity of spacetime geometry. The formulation provides an explanation of how determinism and random statistical behavior coexist in spacetime and a framework is developed that allows dynamical processes to be formulated in terms of chains of digits. These methods lead to a new foundation for Lorentz transformations and special relativity. The Parker-Rhodes combinatorial hierarchy is encompassed within our approach and this leads to an estimate of the interaction strength of the electromagnetic and gravitational forces that agrees with the experimental values to an error of less than one thousandth. Finally, it is shown how the principle of least-radix economy naturally gives rise to Boltzmann’s principle of classical statistical thermodynamics. A new expression for a general nonequilibrium entropy is proposed satisfying the Second Law of Thermodynamics. (shrink)

The sense of touch informs us of the physical properties of our surroundings and is a critical aspect of communication. Before touches are perceived, mechanical signals are transmitted quickly and reliably from the skin's surface to mechano‐electrical transduction channels embedded within specialized sensory neurons. We are just beginning to understand how soft tissues participate in force transmission and how they are deformed. Here, we review empirical and theoretical studies of single molecules and molecular ensembles thought to be involved (...) in mechanotransmission and apply the concepts emerging from this work to the sense of touch. We focus on the nematode Caenorhabditis elegans as a well‐studied model for touch sensation in which mechanics can be studied on the molecular, cellular, and systems level. Finally, we conclude that force transmission is an emergent property of macromolecular cellular structures that mutually stabilize one another. (shrink)

This paper defends the view that Newtonian forces are real, symmetrical and non-causal relations. First, I argue that Newtonian forces are real; second, that they are relations; third, that they are symmetrical relations; fourth, that they are not species of causation. The overall picture is anti-Humean to the extent that it defends the existence of forces as external relations irreducible to spatio-temporal ones, but is still compatible with Humean approaches to causation (and others) since it denies that forces are a (...) species of causation. (shrink)

The magnet served three interests of Restoration mechanical philosophers: it provided a model of cosmic forces, it suggested a solution to the problem of longitude determination, and evidence of its corpuscular mechanism would silence critics. An implicit condition of William Gilbert's ‘magnetic philosophy’ was the existence of a unique, immaterial magnetic virtue. Restoration mechanical philosophers, while claiming descent from their compatriot, worked successfully to disprove this, following an experimental regime of Henry Power. Magnetic philosophy lost its coherence and (...) became subsumed in the study of effluvia. This contradiction of a distinct, yet mechanical magnetic philosophy came to a head in 1684 in an argument between Robert Hooke and Martin Lister. An effluvial explanation of magnetism introduced great complexity to the North-seeking behaviour of compass needles, and undermined the already troubled longitude programme. Thus magnetic philosophy no longer furthered the interests which had maintained it, and it was abandoned. (shrink)

Apart from statics, about which I shall say nothing, there were three chief centres of interest in mechanics in the 1660's: the motions of pendulums; the laws of motion; the free fall of heavy bodies and the motion of projectiles.In the first the influence of Huygens was dominant; I have placed it so because it was of very lively contemporary concern. The second area of interest descended partly from Galileo and partly from Descartes; the third from Galileo alone. Perhaps one (...) should consider adding a fourth area, the investigation of central forces, but this in fact did not attract much attention as yet. (shrink)