The functional approach to scientific progress has been mainly developed by Kuhn, Lakatos, Popper, Laudan, and more recently by Shan. The basic idea is that science progresses if key functions of science are fulfilled in a better way. This chapter defends the function approach. It begins with an overview of the two old versions of the functional approach by examining the work of Kuhn, Laudan, Popper, and Lakatos. It then argues for Shan’s new functional approach, in (...) which scientific progress is defined as an increase of usefulness of exemplary practices. (shrink)

This article develops and defends a new functional approach to scientific progress. I begin with a review of the problems of the traditional functional approach. Then I propose a new functional account of scientific progress, in which scientific progress is defined in terms of usefulness of problem defining and problem solving. I illustrate and defend my account by applying it to the history of genetics. Finally, I highlight the advantages of my new functional (...) approach over the epistemic and semantic approaches and dismiss some potential objections to my approach. (shrink)

The Cobb-Douglas regression, a statistical technique developed to estimate what economists called a 'production function', was introduced in the late 1920s. For several years, only economist Paul Douglas and a few collaborators used the technique, while vigorously defending it against numerous critics. By the 1950s, however, several economists beyond Douglas's circle were using the technique, and by the 1970s, Douglas's regression, and more sophisticated procedures inspired by it, had become standard parts of the empirical economist's toolkit. This volume is the (...) story of the Cobb-Douglas regression from its introduction to its acceptance as general-purpose research tool. The story intersects with the histories of several important empirical research programs in twentieth century economics, and vividly portrays the challenges of empirical economic research during that era. Fundamentally, this work represents a case study of how a controversial, innovative research tool comes to be widely accepted by a community of scholars. (shrink)

In all disciplines there is the question of how to promote progress and offset decline. But, what are progress and decline ? For this short article, the main discussion centers on biology. A solution called functional specialization begins to emerge as relevant to all of the sciences, technologies and arts. This introductory article ends with some heuristics on various follow-up issues.

The Cobb-Douglas regression, a statistical technique developed to estimate what economists called a 'production function', was introduced in the late 1920s. For several years, only economist Paul Douglas and a few collaborators used the technique, while vigorously defending it against numerous critics. By the 1950s, however, several economists beyond Douglas's circle were using the technique, and by the 1970s, Douglas's regression, and more sophisticated procedures inspired by it, had become standard parts of the empirical economist's toolkit. This volume is the (...) story of the Cobb-Douglas regression from its introduction to its acceptance as general-purpose research tool. The story intersects with the histories of several important empirical research programs in twentieth century economics, and vividly portrays the challenges of empirical economic research during that era. Fundamentally, this work represents a case study of how a controversial, innovative research tool comes to be widely accepted by a community of scholars. (shrink)

Ordinal functions may be iterated transfinitely in a natural way by taking pointwise limits at limit stages. However, this has disadvantages, especially when working in the class of normal functions, as pointwise limits do not preserve normality. To this end we present an alternative method to assign to each normal function f a family of normal functions Hyp[f]=〈fξ〉ξ∈OnHyp[f]=〈fξ〉ξ∈On, called its hyperation, in such a way that f0=idf0=id, f1=ff1=f and fα+β=fα∘fβfα+β=fα∘fβ for all α, β.Hyperations are a refinement of the Veblen hierarchy (...) of f. Moreover, if f is normal and has a well-behaved left-inverse g called a left adjoint, then g can be assigned a cohyperationcoH[g]=〈gξ〉ξ∈OncoH[g]=〈gξ〉ξ∈On, which is a family of initial functions such that gξgξ is a left adjoint to fξfξ for all ξ. (shrink)

‘Virtue signaling’ is the practice of using moral talk in order to enhance one’s moral reputation. Many find this kind of behavior irritating. However, some philosophers have gone further, arguing that virtue signaling actively undermines the proper functioning of public moral discourse and impedes moral progress. Against this view, I argue that widespread virtue signaling is not a social ill, and that it can actually serve as an invaluable instrument for moral change, especially in cases where moral argument alone (...) does not suffice. Specifically, virtue signaling can change the broader public’s social expectations, which can in turn motivate the adoption of new, positive social norms. I also argue that the reputation-seeking motives underlying virtue signaling impose important constraints on virtue signalers’ behavior, which serve to keep the worst excesses of virtue signaling in check. (shrink)

The paper discusses the sense in which the changes undergone by normative economics in the twentieth century can be said to be progressive. A simple criterion is proposed to decide whether a sequence of normative theories is progressive. This criterion is put to use on the historical transition from the new welfare economics to social choice theory. The paper reconstructs this classic case, and eventually concludes that the latter theory was progressive compared with the former. It also briefly comments on (...) the recent developments in normative economics and their connection with the previous two stages. (Published Online April 18 2006) Footnotes1 This paper suspersedes an earlier one entitled “Is There Progress in Normative Economics?” (Mongin 2002). I thank the organizers of the Fourth ESHET Conference (Graz 2000) for the opportunity they gave me to lecture on this topic. Thanks are also due to J. Alexander, K. Arrow, A. Bird, R. Bradley, M. Dascal, W. Gaertner, N. Gravel, D. Hausman, B. Hill, C. Howson, N. McClennen, A. Trannoy, J. Weymark, J. Worrall, two annonymous referees of this journal, and especially the editor M. Fleurbaey, for helpful comments. The editor's suggestions contributed to determine the final orientation of the paper. The author is grateful to the LSE and the Lachmann Foundation for their support at the time when he was writing the initial version. (shrink)

This article explores the relationship between sexual science and evolutionary models of human development and progress. It examines the ways in which late 19th- and early 20th-century Western European sexual scientists constructed the sexual instinct as an evolutionary force that not only served a reproductive purpose, but was also pivotal to the social, moral, and cultural development of human societies. Sexual scientists challenged the idea that non-reproductive sexualities were necessarily perverse, pathological, or degenerative by linking sexual desire to the (...) evolution of sociality, often focusing on forms of relationality and care that exceeded biological kinship. As a result, non-reproductive sexual expressions, including homosexual and non-reproductive heterosexual behaviours, were interpreted as manifestations of a sexual instinct operating in the service of human development. These claims were reliant on cross-cultural and historical comparisons of sexual values, behaviours, and customs that rehearsed and reinforced imperial narratives of development premised on racialized, gendered, and classed hierarchies. Sexual scientists mapped diverse sexual behaviours in terms of their perceived evolutionary benefits, contributing to colonial narratives that distinguished between different cultures according to imagined trajectories of development. These contestations around the sexual instinct and its developmental functions played a vital role in allowing sexual science to authorize itself as a field of knowledge that promised to provide expertise required to manage sexual life and secure the global development of human civilization. (shrink)

Progress Unchained reinterprets the history of the idea of progress using parallels between evolutionary biology and changing views of human history. Early concepts of progress in both areas saw it as the ascent of a linear scale of development toward a final goal. The 'chain of being' defined a hierarchy of living things with humans at the head, while social thinkers interpreted history as a development toward a final paradise or utopia. Darwinism reconfigured biological progress as (...) a 'tree of life' with multiple lines of advance not necessarily leading to humans, each driven by the rare innovations that generate entirely new functions. Popular writers such as H. G. Wells used a similar model to depict human progress, with competing technological innovations producing ever-more rapid changes in society. Bowler shows that as the idea of progress has become open-ended and unpredictable, a variety of alternative futures have been imagined. (shrink)

In the course of developing an account of scientific progress, C. D. McCoy (2022) appeals centrally to understanding as well as to problem-solving. On the face of it, McCoy’s account could thus be described as a kind of hybrid of the understanding-based account that I favor (Dellsén 2016, 2021) and the functional (a.k.a. problem-solving) account developed most prominently by Laudan (1977; see also Kuhn 1970; Shan 2019). In this commentary, I offer two possible interpretations of McCoy’s account and (...) explain why I do not find it entirely compelling on either interpretation. (shrink)

In this chapter, we discuss a specific kind of progress that occurs in most branches of economics today: progress involving the repeated use of mathematical models. We adopt a functional account of progress to argue that progress in economics occurs through the use of what we call “common recipes” and model templates for defining and solving problems of relevance for economists. We support our argument by discussing the case of 20th century business cycle research. By (...) presenting this case study in detail, we show how model templates are not only reapplied to different phenomena. We also show how scientists first develop them and how, once they are considered less useful, they are replaced with new ones. Finally, our case also illustrates that it is not only the mathematical structure that is reused but that such reuse also requires a shared conceptual vision of the core properties of the phenomenon to be studied. If that vision is no longer shared among economists, a model template can become useless and has to be replaced, sometimes against resistance, with a different one. (shrink)

In this chapter, we discuss a specific kind of progress in economics, namely, progress that is pushed by the repeated use of mathematical models in most sub-branches of economics today. We adopt a functional account of progress to argue that progress in economics occurs via the use of what we call ‘common recipes’ and the use of model templates to define and solve problems of relevance for economists. We support our argument by discussing the case (...) of twentieth-century business cycle research. By presenting this case study in detail, we show how model templates are not only re-applied to different phenomena. We also show how scientists come up with them in the first place and how – once they are considered less useful – they are replaced with new ones. Finally, our case also illustrates that it is not only the mathematical structure that is re-used but that such a re-use also requires a shared conceptual vision of core properties of the phenomenon. If that vision is not shared anymore among economists, a model template can become useless and has to be replaced – sometimes through overcoming resistance – with a different one. (shrink)

In a series of recent papers, I have made three arguments about how to define “disease” and evaluate and apply possible definitions. First, I have argued that definitions should not be seen as traditional conceptual analyses, but instead as proposals about how to define and use the term “disease” in the future. Second, I have pointed out and attempted to address a challenge for dysfunction-requiring accounts of disease that I call the “line-drawing” problem: distinguishing between low-normal functioning and dysfunctioning. Finally, (...) I have used a dysfunction-requiring approach to argue that some extremely prevalent conditions, such as high blood pressure, high cholesterol, and ductal carcinoma in situ, are not diseases, but instead are risk factors. Four of the papers in this issue directly engage my previous work. In this commentary, I applaud the advances these authors make, address points of disagreement, and make suggestions about where the discussion should go next. (shrink)

A moral right to health or health care is a special instance of a right to fair equality of opportunity. Nation-states generally have the capabilities to specify the entitlements of such a right and to raise the resources needed to satisfy those entitlements. Can these functions be replicated globally, as a global right to health or health care requires? The suggestion that “better global governance” is needed if such a global right is to be claimed requires that these two central (...) capabilities be present. It is unlikely that nation-states would concede these two functions to a form of global governance, for doing so would seriously compromise the authority that is generally included in sovereignty. This claim is a specification of what is often recognized as the “sovereignty problem.” The argument of this paper is not an “impossibility” claim, but a best guess about whether the necessary conditions for better global governance that supports a global right to health or health care can be achieved. (shrink)

The additional data, perspectives, questions, and criticisms contributed by the commentaries strengthen our view that local cortical processors coordinate their activity with the context in which it occurs using contextual fields and synchronized population codes. We therefore predict that whereas the specialization of function has been the keynote of this century the coordination of function will be the keynote of the next.

Neuroscientists have long sought to study the dynamic activity of the human brain—what's happening in the brain, that is, while people are thinking, feeling, and acting. Ideally, an inside look at brain function would simultaneously and continuously measure the biochemical state of every cell in the central nervous system. While such a miraculous method is science fiction, a century of progress in neuroimaging technologies has made such simultaneous and continuous measurement a plausible fiction. Despite this progress, practitioners of (...) modern neuroimaging struggle with two kinds of limitations: those that attend the particular neuroimaging methods we have today and those that would limit any method of imaging neural activity, no matter how powerful.In this essay, I consider the liabilities and potential of techniques that measure human brain activity. I am concerned here only with methods that measure relevant physiologic states of the central nervous system and relate those measures to particular mental states. I will consider in particular the preeminent method of functional neuroimaging: BOLD fMRI. While there are several practical limits on the biological information that current technologies can measure, these limits—as important as they are—are minor in comparison to the fundamental logical restraints on the conclusions that can be drawn from brain imaging studies. (shrink)

Three related intuitions are explicated in this paper. The first is the idea that there must be some kind of probabilistic version of the HD-method, a ‘Hypothetico-Probabilistic (HP-) method’, in terms of something like probabilistic consequences, instead of deductive consequences. According to the second intuition, the comparative application of this method should also be functional for some probabilistic kind of empirical progress, and according to the third intuition this should be functional for something like probabilistic truth approximation. (...) In all three cases, the guiding idea is to explicate these intuitions by explicating the crucial notions as appropriate ‘concretizations’ of their deductive analogs, being ‘idealizations’. It turns out that the comparative version of the proposed HP-method amounts to the likelihood comparison (LC-) method applied to the cumulated evidence. This method turns out to be not only functional for probabilistic empirical progress but also for probabilistic truth approximation. The latter is based on a probabilistic threshold theorem constituting for this reason the analog of the deductive success theorem. (shrink)

Three related intuitions are explicated in this paper. The first is the idea that there must be some kind of probabilistic version of the HD-method, a 'Hypothetico-Probabilistic method', in terms of something like probabilistic consequences, instead of deductive consequences. According to the second intuition, the comparative application of this method should also be functional for some probabilistic kind of empirical progress, and according to the third intuition this should be functional for something like probabilistic truth approximation. In (...) all three cases, the guiding idea is to explicate these intuitions by explicating the crucial notions as appropriate 'concretizations' of their deductive analogs, being 'idealizations'. It turns out that the comparative version of the proposed HP-method amounts to the likelihood comparison method applied to the cumulated evidence. This method turns out to be not only functional for probabilistic empirical progress but also for probabilistic truth approximation. The latter is based on a probabilistic threshold theorem constituting for this reason the analog of the deductive success theorem. (shrink)

Flight delay is one of the most challenging threats to operation of air transportation network system. Complex network was introduced into research studies on flight delays due to its low complexity, high flexibility in model building, and accurate explanation about real world. We surveyed recent progress about flight delay which makes extensive use of complex network theory in this paper. We scanned analyses on static network and temporal evolution, together with identification about topologically important nodes/edges. And, we made a (...) clarification about relations among robustness, vulnerability, and resilience in air transportation networks. Then, we investigated studies on causal relations, propagation modellings, and best spreaders identifications in flight delay. Ultimately, future improvements are summarized in fourfold. Under Complex Network, flight operation relevant subsystems or sublayers are discarded by the majority of available network models. Hierarchical modelling approaches may be able to improve this and provide more capable network models for flight delay. Traffic information is the key to narrow the gap between topology and functionality in current situations. Flight schedule and flight plan could be employed to detect flight delay causalities and model flight delay propagations more accurately. Real flight data may be utilized to validate and revise the detection and prediction models. It is of great importance to explore how to predict flight delay propagations and identify best spreaders at a low cost of calculation complexity. This may be achieved by analyzing flight delay in frequency domain instead of time domain. Summation of most critical nodes/edges may not be the most crucial group to network resilience or flight delay propagations. Effective algorithm for most influential sequence is to be developed. (shrink)

The American administrative state is a feature of the new liberalism that is largely irreconcilable with the old, founding-era liberalism. At its core, the administrative state, with its delegation of legislative power to the bureaucracy, combination of functions within bureaucratic agencies, and weakening of presidential control over administration undercuts the separation-of-powers principle that is the base of the founders' Constitution. The animating idea behind the features of the administrative state is the separation of politics and administration, which was championed by (...) James Landis, the New-Deal architect of the administrative state for President Franklin Roosevelt. The idea of separating politics and administration, and the faith such a separation requires in the objectivity of administrators, did not originate with Landis or the New Deal but, instead, with the Progressives who had come a generation earlier. Both Woodrow Wilson and Frank Goodnow were pioneers in advocating the separation of politics and administration, and made it the centerpiece of their broad arguments for constitutional reform. (shrink)

Price discrimination is widely considered unethical/unfair by consumers, as has been borne out by decades of psychological research and mainstream press reporting. However, little academic work has been done to investigate the ethics of price discrimination. The work that has been done to date concludes that while price discrimination is not unethical, despite widespread lay perceptions, it is at best morally neutral. We argue price discrimination ismoreethical than unitary pricing, when done ‘progressively,’ meaning firms charge customers as a function of (...) their willingness-to-pay. We introduce this specific kind of price discrimination as ‘Progressive Pricing’ and demonstrate it ethically outperforms a ‘Unitary Pricing’ scheme (where everyone pays the same price, regardless of their willingness-to-pay), at least within a broadly consequentialist framework. We do this by comparing a Unitary Pricing scheme to a Progressive one, analyzing them through the lenses of four different consequentialist ‘Social Welfare Functions’ (Utilitarian, Egalitarian, Prioritarian, and Leximin), which are used by welfare economists and philosophers to rank the distributions of different social outcomes, concluding that Progressive Pricing is preferred regardless of which Social Welfare Function(s) one finds most plausible. (shrink)

Volume 16 of Progress in Self Psychology, _How Responsive Should We Be_, illuminates the continuing tension between Kohut's emphasis on the patient's subjective experience and the post-Kohutian intersubjectivists' concern with the therapist's own subjectivity by focusing on issues of therapeutic posture and degree of therapist activity. Teicholz provides an integrative context for examining this tension by discussing affect as the common denominator underlying the analyst's empathy, subjectivity, and authenticity. Responses to the tension encompass the stance of intersubjective contextualism, advocacy (...) of "active responsiveness," and emphasis on the thorough-going bidirectionality of the analytic endeavor. Balancing these perspectives are a reprise on Kohut's concept of prolonged empathic immersion and a recasting of the issue of closeness and distance in the analytic relationship in terms of analysis of "the tie to the negative selfobject." Additional clinical contributions examine severe bulimia and suicidal rage as attempts at self-state regulation and address the self-reparative functions that inhere in the act of dreaming. Like previous volumes in the series, volume 16 demonstrates the applicability of self psychology to nonanalytic treatment modalities and clinical populations. Here, self psychology is brought to bear on psychotherapy with placed children, on work with adults with nonverbal learning disabilities, and on brief therapy. Rector's examination of twinship and religious experience, Hagman's elucidation of the creative process, and Siegel and Topel's experiment with supervision via the internet exemplify the ever-expanding explanatory range of self-psychological insights. (shrink)

My title is intended to echo Hans Reichenbach's The Rise of Scientific Philosophy (1951), and the phrase "scientific epistemology" is intended in two Reichenbachian senses. One involves the epistemology of science; the other involves epistemology undertaken with a scientific orientation. Talk of "progress and procedures" is intended in a similar dual sense. I start by looking back over the last century, at how a family of problems was tackled by scientifically oriented philosophers. These are problems with the nature of (...) evidence and testing – with how, given our limited access to the world and the ambitious reach of our theories, we can have good reason to believe one such theory over another. These discussions were informed especially by skeptical treatments of the problem in Hume. We see in this period a number of different theoretical strands. These are characterized by different raw materials, and by different organizing or paradigm cases – different bets regarding the parts of scientific practice that should function as exemplars. (shrink)

One of the key interpretative problems generated by the development of quantum theory was the conceptual consistency underlying scientific change, a problem not adequately treated by any of the leading theories of scientific development. In different but related ways Quine, Sellars, and Davidson have treated the problem of conceptual consistency by showing how one can begin with ordinary language and proceed to specialized extensions. Their techniques have not been applied to modern physics. However, one basis for applying them arises from (...) the deep similarities between some of the work of these analysts and the Copenhagen interpretation rightly interpreted. To make this more concrete three concepts whose meanings have changed as a result of scientific progress are considered: 'atom', 'state of a system', and 'particle'. Each functions in a different way and requires a different type of analysis. (shrink)

In his fortieth anniversary commemoration of the Cooper Union Museum for the Arts and Decoration in 1937, John Dewey wrote confidently about the development of museums as educational institutions. As Dewey argued, “[o]ne of the most striking features of recent American culture has been the rapid growth of museums in all lines, artistic, commercial and industrial; of natural history, anthropology and antiquities.” Dewey explained that it “has become generally recognized” that museums “occupy as necessary a place in popular education as (...) do public libraries,” arguing that “[v]ision of [museums’] educational function has kept pace with their material expansion.” In general, Dewey contended, a “museum that is directed... (shrink)

We are living in a world which is severely crisis-ridden and faces some major challenges. The fact that we are currently facing a genuine global pandemic brings about even more uncertainty. The social and political institutions, which emerged and consolidated during the 20th century, and which created stability, have become fragile. The young generation born in the 1990s and onwards have experienced 9/11 and the ‘war against terrorism’, the financial crisis of 2008, changes to climate, environmental degradation, and most recently (...) the COVID-19 pandemic. The generation born between 1960 and 1990 have had the same experiences along with severe economic crises in the 1970s and 1980s and the Cold War. Some of these challenges are in different ways intertwined with capitalism and its crises, while others are linked to the rapid development of new technologies, in particular innovations within communication and information technologies. This introduction lists the most important grand challenges facing the world as they have emerged more recently. The five articles following this introduction address some of these challenges, with particular attention to the problems of capitalism and democracy and the relation between these two areas. Most authors agree that climate change and the destruction of the environment are the biggest and most pertinent problems to address, but it is their stance that we can only meet these challenges if democracy is functioning well. (shrink)

BackgroundHealth behavior change is among the top recommendations for improving health of patients with lifestyle-related chronic diseases. An array of behavior change techniques have been developed to support behavior change initiation and maintenance. These BCTs often show limited success when they are not informed by theory, leading to a mismatch between the intention of the BCT and patients’ needs or expectations. Previous studies have identified a number of resources which patients may require to initiate and maintain health behavior change. Indeed, (...) not yet well established is how BCTs address these resources, i.e., the functional mechanisms of BCTs.PurposeProvide a theoretical framework of the functional mechanisms of BCTs for developing and implementing successful interventions for health behavior change.MethodsConceptual review, including literature analysis and synthesis as well as conceptualization of a new model based on the synthesis.ResultsThrough the integration of dual-process models as well as reward and motivation proceeding, i.e., affective, emotional, or intuitive neurobiological cues, into the rational framework of rather linear cognitive or task-related decision progress, we categorize previously identified resources into three distinct sets: external, internal reflective, and internal affective resources. Based on this triad, we classify BCTs according to their functional mechanisms into facilitating, boosting, and nudging. Consequently, we present a simplified Behavior Change Resource Model that is centered on patients’ resources.ConclusionThe model can be applied to develop health behavior change interventions, which promote engagement and empowerment. Future studies should aim at testing the applicability and practicality of the BCRM. (shrink)

Functional analysis is the major theoretical perspective of contemporary sociology. Although many fruitful studies of social structure have resulted from the application of this perspective, it has been notably sterile in coping with questions of social change. Two major shortcomings of the functionalist view of change are here examined. The first type of shortcoming might be called 'evolutionary hangovers'. Under this heading we may include 'functional ahistoricism' and a 'commitment to progress'. The second major shortcoming refers to (...) weaknesses of functional theory per se — namely, a confusion of causal analysis with functional analysis, a lack of a theory of deviance, and an over-emphasis on stable equilibrium models. (shrink)

Social capital is frequently offered up as a variable to explain such educational outcomes as academic attainment, drop-out rates and cognitive development. Yet, despite its popularity amongst social scientists, social capital theory remains the object of some scepticism, particularly in respect of its explanatory ambitions. I provide an account of some explanatory options available to social capital theorists, focussing on the functions ascribed to social capital and on how these are used as explanatory variables in educational theory. Two of the (...) most influential writers in this field are Coleman and Bourdieu. I explore their commonalities and differences, both in respect of their writing and in respect of some of the many theorists they have influenced. I argue that social capital theorists have made substantial progress in responding to sceptically minded critics, but that significant questions remain, especially about the success of the more ambitious explanatory variants as these apply to educational outcomes—functional explanation in particular. Functional explanation, and its association with Bourdieu, is discussed in ‘Bourdieu and functional explanation’; thereafter I discuss the more modest ambition of identifying the functions associated with social capital. In ‘Coleman, intergenerational closure and educational outcomes’ I show how Coleman provides resources for revealing how social structure features in social explanation in an educational context, and in ‘Inequality, class and ethnicity’ I suggest that some of the questions raised in his account are most satisfactorily responded to by educational theorists who adopt Bourdieu’s emphasis on social class and inequality. (shrink)

Type 2 diabetes mellitus is related to a variety of cognitive impairments that may even progress to dementia. Studies have found the angular gyrus is a cross-modal integration hub that is involved in a variety of cognitive processes. However, few studies have focused on the patterns of resting-state functional connections of the AG in patients with T2DM. This study explored the functional connection between the AG and the whole brain and the relationship between the FC and clinical/cognitive (...) variables in patients with T2DM. 44 patients with T2DM and 43 sex-, age-, and education-matched healthy controls underwent resting-state fMRI and received neuropsychological assessments. Compared with the control group, the T2DM group showed abnormal rsFCs between the AG and multiple brain regions. The FC between the left AG and the left medial temporal lobe in the T2DM group was positively correlated with scores on the Montreal Cognitive Assessment, after a Bonferroni correction. Collectively, patients with T2DM have abnormal FCs between the AG and extensive brain regions that may be related to various cognitive processes. (shrink)

The empirical study of belief is emerging at a rapid clip, uniting work from all corners of cognitive science. Reliance on belief in understanding and predicting behavior is widespread. Examples can be found, inter alia, in the placebo, attribution theory, theory of mind, and comparative psychological literatures. Research on belief also provides evidence for robust generalizations, including about how we fix, store, and change our beliefs. Evidence supports the existence of a Spinozan system of belief fixation: one that is automatic (...) and independent of belief rejection. Independent research supports the existence of a system of fragmented belief storage: one that relies on large numbers of causally isolated, context-sensitive stores of belief in memory. Finally, empirical and observational data support at least two systems of belief change. One system adheres, mostly, to epistemological norms of updating; the other, the psychological immune system, functions to guard our most centrally held beliefs from potential inconsistency with newly formed beliefs. Refining our under- standing of these systems can shed light on pressing real-world issues, such as how fake news, propaganda, and brainwashing exploit our psychology of belief, and how best to construct our modern informational world. (shrink)

Background: The rapid pace of progress in medical research, the consequent need for the timely transfer of new knowledge into practice, and the increasing need for ethics support, is making the work of Ethics Committees (ECs) ever more complex and demanding. As a response, ECs in many countries exhibit large variation in number, mandate, organization and member competences. This cross-sectional study aims to give an overview of the different types of activities of Italian ECs and favour discussion at a (...) European level.Methods: A questionnaire was emailed to all Italian Ethics Committees contained in the national Registry of the Ministry of Health, enquiring whether the EC was conducting, or planning to conduct, 4 specific activities. A telephone interview was conducted to determine reasons for failure to respond.Results: Response rate was 53% (101 respondents out of 191). 20% of ECs restrict their responsibilities to research protocol review, 25% also offer ethical consultation to institutions, support on individual health care decisions and promotes educational initiatives, while the remaining 50% conduct a few of the examined activities to varying degrees. Large variation was observed across different types of hosting institutions and geographical locations.Conclusions: A common European model should be developed, defining EC functions, member selection modalities, necessary member competences, decision-making criteria and measures for work verification. In the absence of sound empirical evidence, it would be interesting to study the effectiveness and efficiency of the different existing models. (shrink)

In “Belief in the Face of Controversy,” Hilary Kornblith argues for a radical form of epistemic modesty: given that there has been no demonstrable cumulativeprogress in the history of philosophy – as there has been in formal logic, math, and science – Kornblith concludes that philosophers do not have the epistemic credibility to be trusted as authorities on the questions they attempt to answer. After reconstructing Kornblith's position, I will suggest that it requires us to adopt a different conception of (...) philosophy's epistemic value. First, I will argue that ‘progress’ has a different meaning in logic, science and philosophy, and that to judge one of these disciplines by the standards appropriate to one of the others obscures the unique epistemic functions of all. Second, I will argue that philosophy is epistemically unique in that it is a non-relativistic but historically determined excavation of foundations. Finally, drawing on Frank Herbert's Dune, I will suggest that Kornblith leaves us with a choice between two epistemic ideals: the hyper-logical ‘Mentat,’ or the historically informed ‘pre-born.’. (shrink)

Along with technological progress, vocational education and training (VET) is consistently changing. Workforce disruption has serious consequences for workers and international economies, often requiring adults to transition into different occupations or to upskill to maintain employment. We review recent literature covering VET trends, theoretical considerations for the 21st century, and present an approach to workforce training to help workers not only learn necessary skills but also become adaptable to constant change. We suggest a functional contextualist approach to mastery (...) learning achieves this aim. Specifically, we offer suggestions for pedagogy that not only develop skills but also encourage higher order thinking. Within a novice to expert continuum, we suggest deliberate practice, mental simulation, and reflective meaning making as methods to achieve efficiency and transfer—learning outcomes relevant to a changing workforce. This approach recognizes that learning is context bound and should promote broader human capabilities that support both employability and the continuing development of life literacies. (shrink)

Mehr et al.'s hypothesis that the origins of music lie in credible signaling emerges here as a strong contender to explain early adaptive functions of music. Its integration with evolutionary biology and its specificity mark important contributions. However, much of the paper is dedicated to the exclusion of popular alternative hypotheses, which we argue is unjustified and premature.

My topic is Kant’s theory of historical progress. My approach is primarily textual and contextual. I analyse in some detail Kant’s three most important essays on the topic: ‘Idea for a Universal History’, the third part of ‘Theory and Practice’ and the second part of The Conflict of the Faculties. I devote particular attention to the Kant-Herder debate about progress, but also discuss Rousseau, Mendelssohn, Hegel and others. In presenting, on Kant’s behalf, a strong case for his theory (...) of progress, I address the main objections which have been put to it. These are: (i) historical teleology is incoherent (history can’t have a goal because there is no intentional actor functioning at the historical level); (ii) historical teleology undermines morality (if things are getting better anyway, why do I have to try to make them better?); (iii) progress involves ‘chronological unfairness’ (if things are getting better, doesn’t this mean that earlier generations get a raw deal?); (iv) progress consigns the species to ‘spurious infinity’ (isn’t endless improvement endlessly unsatisfactory?); (v) progress amounts to pernicious homogenization (doesn’t the elimination of traditional practices and values impoverish our world?); (vi) the idea of progress is just ‘secularized’ religion (and should be rejected accordingly). In relation to (vi), I consider the Löwith-Blumenberg debate, and draw some general conclusions about the issue of ‘secularization’. In relating these to Kant, I argue for the following position: (a) his theory of progress is more than merely secularized religion; (b) to the extent that it can be described in terms of the secularization thesis, this reflects his ‘critical’ endeavour to rationalize Christianity; (c) in any case, the idea of progress by no means exhausts the rational potential of religion, and so should not be seen as intended to replace the latter. (shrink)

RNA modifications have recently emerged as an important regulatory layer of gene expression. The most prevalent and reversible modification on messenger RNA (mRNA), N6‐methyladenosine, regulates most steps of RNA metabolism and its dysregulation has been associated with numerous diseases. Other modifications such as 5‐methylcytosine and N1‐methyladenosine have also been detected on mRNA but their abundance is lower and still debated. Adenosine to inosine RNA editing is widespread on coding and non‐coding RNA and can alter mRNA decoding as well as protect (...) against autoimmune diseases. 2′‐O‐methylation of the ribose and pseudouridine are widespread on ribosomal and transfer RNA and contribute to proper RNA folding and stability. While the understanding of the individual role of RNA modifications has now reached an unprecedented stage, still little is known about their interplay in the control of gene expression. In this review we discuss the examples where such interplay has been observed and speculate that with the progress of mapping technologies more of those will rapidly accumulate. (shrink)

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)

Discrimination in the postmodern society can have many different causes and can affect people of different racial, ethnic, national or social backgrounds, such as communities of Asian or African descent, Roma people, indigenous peoples, Aboriginal people and people of different castes. Discrimination can also refer to people of different cultural, linguistic or religious backgrounds, people with disabilities or the elderly. Moreover, people can be discriminated because of their sexual orientation or preferences. Gender-based discrimination is also common, despite progress in (...) many countries. Women are also particularly prone to violent and abusive practices, and therefore often suffer from a double discrimination, both because of their race or origin and because of their gender, which is why feminist literature in recent years points to new acts or forms of discrimination against women. A major problem in the postmodern world is the discrimination that many people are subjected to, especially women and children, because they live in extreme poverty. These circumstances may force them to migrate and further contribute to a conceptual or social contamination, that may aggravate discriminatory tendencies in the societies where they migrate. The article aims to theoretically analyse the degree of functionality that the principle of non-discrimination based on gender, race, religion and sexual orientation has in the contemporary, postmodern, individualistic society. (shrink)

Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Alzheimer’s Disease is characterized by a constellation of limitations derived from progressive cognitive impairment, which is usually viewed as a global uniform phenomenon. In this paper it is argued that looking independently at the loss and recovery of pragmatic function related to illocutionary and perlocutionary abilities can be a productive way of understanding the progressive deterioration of communicative (...) capacities by patients or their improvement under targeted treatment. (shrink)

We examine the use of the notion of natural selection in the philosophical debate on functions in biology. This debate has been largely shaped by the way in which different accounts assess various selective pressures in justifying claims about biological functions. Cummins (Functions: new essays in the philosophy of psychology and biology. Oxford University Press, Oxford, pp 157–172, 2002), one of the main proponents of the causal role account of biological functions, argues that a correctly understood neo-Darwinian notion of natural (...) selection has nothing to do with functional talk in biology. In this paper, we counter Cummins’ account by showing that progress in the molecular approaches to evolutionary biology—specifically scientific data available in neo-functionalization research—offers valuable support to the etiological selectionist approach to functions in biological and biologically-related sciences. Finally, we use the presented data to build our own account of biological functions, which tries to avoid the wrong turns taken by both major strands in the biological function debate, namely causal role and etiological accounts. According to our account, the function of a certain gene or a protein in the biological system that contains it is a particular causal activity, or a group of causal activities whose manifestation is in a specific way determined by corresponding mechanisms of genetic expression. Also, we argue that in many important cases this particular expression of genetic activity was positively selected at a certain point in evolutionary history. Since we take selection as an important but not the only factor that grounds biological functions, we are committed to a weak etiological account. (shrink)

Adherens (AJ) and tight junctions (TJ) maintain cell‐cell adhesions and cellular polarity in normal tissues. Afadin, a multi‐domain scaffold protein, is commonly found in both adherens and tight junctions, where it plays both structural and signal‐modulating roles. Afadin is a complex modulator of cellular processes implicated in cancer progression, including signal transduction, migration, invasion, and apoptosis. In keeping with the complexities associated with the roles of adherens and tight junctions in cancer, afadin exhibits both tumor suppressive and pro‐metastatic functions. In (...) this review, we will explore the dichotomous roles that afadin plays during cancer progression. (shrink)