Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

1. Ronri to gengo -- 2-3. Imi to yōsō -- 4. Shinri to imi.

西田幾多郎(一八七〇‐一九四五)の人生。それは一人の人間の個別的な営みを超え、明治から昭和に至る奔流のただなかに姿を見せ始めた「日本」を集約し、体現するものだった。同時代の多彩な資料に基づく実証的手法 によって克明に描き出される哲学者の苦悩と格闘の人生に、近代日本の成立過程に現出した幾多の問題系を照射する斬新な評伝的批評。.

The paper attempts to construct a global model of a social contract using well-known metaphors of two great philosophers: Jean-Jacques Rousseau and John Locke. By modelling a global social contract, I mean the formulation of a social contract using two sets of data: one is global citizens' preferences about values and norms while the other is sovereign states' participation in multilateral treaties. Both Rousseau and Locke formulate their versions of social contract theories in the national context of eighteenth-century Europe. This (...) paper tries my hands on extending their theories to the global context. This paper attempts to link empirically the relationship between global citizens' preferences as gauged by the World Values Survey and sovereign states' participation in 120 multilateral treaties deposited to the United Nations. To see the link between citizens and treaties (quasi-legislative outcomes, sort of), dimensional similarities of the cosmos of citizens' preference and the cosmos of sovereign states' willingness to join multilateral treaties are examined. Once done, all the sovereign states are located in each of the two cosmoses, citizens and states, and the correlation coefficients between them are measured. Based on these empirical results, the nature of the global quasi-legislative process is clarified. Conclusions and implications are drawn. (shrink)

Molecular and biochemical analysis of the biogenesis of peroxisomes has made rapid progress in recent years. Research on the mechanism of targeting of peroxisomal proteins has revealed that many, but not all, peroxisomal proteins have a conserved tripeptide motif in their carboxy‐terminal portions which is required for entry into peroxisomes; the topogenic signal mechanism thus differs in these instances from those employed in mitochondria and endoplasmic reticulum. Other factors involved in peroxisome biogenesis are also coming to light.

闇斎門下の個性豊かな諸家の事跡を通して、垂加神道の史的展開を検討すると共に、『日本書紀』神代巻の解釈に見える思想の根幹を明らかにする。.

ABSTRACTAnother individual’s gaze automatically shifts an observer’s attention to a location. This reflexive response occurs even when the gaze is presented subliminally over a short period. Another’s gaze also increases the preference level for items in the gaze direction; however, it was previously unclear if this effect occurs when the gaze is presented subliminally. This study showed that the preference levels for nonsense figures looked at by a subliminal gaze were significantly greater than those for items that were subliminally looked (...) away from. Targets that were looked at by a subliminal gaze were detected faster ; however, the participants were unable to detect the gaze direction. These results indicate that another individual’s gaze automatically increases the preference levels for items in the gaze direction without conscious awareness. (shrink)

Modal realism -- Time, space, world -- Existence -- Actuality -- Modal realism and modal tense -- Transworld individuals and their identity -- Existensionalism -- Impossibility -- Proposition and relief -- Fictional worlds -- Epistemology.

This book constitutes the thoroughly refereed joint post-proceedings of three international workshops organized by the Japanese Society for Artificial Intelligence, held in Tokyo, Japan in June 2006 during the 20th Annual Conference JSAI 2006. The volume starts with eight award winning papers of the JSAI 2006 main conference that are presented along with the 21 revised full workshop papers, carefully reviewed and selected for inclusion in the volume.

The paper explores the logical strength of Isbell's zig‐zag theorem using the framework of reverse mathematics. Working in, we show that is equivalent to Isbell's zig‐zag theorem for countable monoids: If B is a monoid extension of A, then is dominated by A if and only if b has a zig‐zag over A. Our proof of Isbell's zig‐zag theorem avoids use of strong comprehension axioms common in traditional proofs. We also analyze the strength of theorems concerning binary relations.

Biological forms are very complex, and mechanisms of pattern formation are not well understood. Although developmental biology deals with the mechanistic explanation of patterns, currently we do not know how to understand the mechanisms of pattern formation from huge amounts of molecular information. In this article, I present one useful tool, mathematical modeling, to obtain a mechanistic understanding of biological pattern formation, and show an actual example in lung branching morphogenesis. In this example, mathematical modeling plays an indispensable role in (...) understanding the biological phenomena. The model successfully reproduces the basic features of morphogenesis in vitro, but mechanism in vivo still remains to be elucidated. (shrink)

「意識のクオリア」も五感も、すべては錯覚だった。「心は脳が作り上げた幻想である」ことを述べた著者が、自己意識や五感が錯覚であることに的を絞って説明。.

There are many gene families that are specific to multicellular animals. These have either diverged from ancestral genes that are shared with fungi and/or plants or evolved from an ancestral gene unique to animals. The evolution of gene families involved in cell–cell communication and developmental control has been studied to establish whether the number of member genes increased dramatically immediately prior to or in concert with the Cambrian explosion. A molecular phylogeny‐based analysis of several animal‐specific gene families has revealed that (...) gene diversification by duplication occurred during two active periods interrupted by a long intervening quiescent period. Intriguingly, the Cambrian explosion is situated in the silent period, indicating that there is no direct link between the first burst of gene diversification and the Cambrian explosion itself. The importance of gene recruitment as a possible molecular mechanism for morphological diversity, and its possible role for the Cambrian explosion, are discussed. BioEssays 23:1018–1027, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

This article contributes to the critical engagement with luck egalitarianism by advancing two arguments. Firstly, it questions the cogency of the dichotomies – e.g., luck/choice, person/circumstance, agency/structure – and the accompanying moral ideal of pure voluntarism. This makes it difficult for luck egalitarianism to dissect appropriately the inequalities embedded in social relations, such as social networks and involuntary associations, in which voluntariness and contingency as well as agency and structure are intertwined. Secondly, it suggests that the relational approach, which has (...) been developed, inter alia, in the empirical study of inequality, provides a morally and practically adequate perspective on egalitarian justice. The relational approach achieves this by converging upon those in‐between social relations that are irreducible to the macro‐level structure and to micro‐level agency. Moreover, a relationally sensitive perspective on inequality can adeptly respond to the difficulties that luck‐egalitarian theories encounter. (shrink)

Graphical AbstractYeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.

Samuel Huntington's influential clash of civilizations hypothesis (Huntington, 1993; Huntington, 1996) has been widely debated, but empirical tests of his ideas about core states remain limited at the micro-level. In this paper, we bring new evidence to bear, focusing on the : Greater Asia and the Pacific. Using the AsiaBarometer, we examine the extent to which publics in the region identify with the core states of the supposedly most contentious civilizations in the region and the factors that influence those perceptions. (...) We give attention to the role of globalization and nationalism and whether both may be subsumed by religiosity as Huntington suggests. Our descriptive evidence affirms some of the tensions between the US, China, and Islamic-predominant Asia identified by Huntington as areas of potential conflict. At the same time, we find no evidence to suggest that attitudes toward core states are zero-sum; Asian publics often see rival powers as mutually good influences. Using multivariate analysis, we find that religiosity, as the clash paradigm surmises, boosts Iranian influence and undermines American influence in several predominantly Islamic states. We also find, contrary to Huntington, that overall exposure to foreign cultures leads to a more positive assessment of American influence among Chinese and Pakistanis, as well as American perceptions of China. When foreign exposure influences perceptions of Iran, the effect is modestly, but consistently, negative. Taken together, the findings raise questions about two key assumptions of the Huntington framework and suggest that alternative approaches in recent civilizations literature show greater empirical promise. (shrink)

本研究は、史料的裏付けにもとづく、東アジア三地域における気の思想・文化の歴史や内容、特徴を明らかにし、東アジアにおける気の総合的・体系的研究の基礎を構築している。.