Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

Previous research has successfully used feature integration theory to operationalise the predictions of Perceptual Load Theory, while simultaneously testing the predictions of both models. Building on this work, we test the extent to which these models hold up in a 3D world. In two experiments, participants responded to a target stimulus within an array of shapes whose apparent depth was manipulated using a combination of monoscopic and stereoscopic cues. The search task was designed to test the predictions of feature integration (...) theory, as the target was identified by a single feature or a conjunction of features and embedded in search arrays of varying size, and perceptual load theory, as the task included congruent and incongruent distractors presented alongside search tasks imposing high or low perceptual load. Findings from both experiments upheld the predictions of feature integration theory, regardless of 2D/3D condition. Longer search times in conditions with a combination of monoscopic and stereoscopic depth cues suggests that binding features into three-dimensional objects requires greater attentional effort. This additional effort should have implications for perceptual load theory, yet our findings did not uphold its predictions; the effect of incongruent distractors did not differ between conjunction search trials and feature search trials. Individual differences in susceptibility to the effects of perceptual load were evident and likely explain the absence of load effects. Overall, our findings suggest that feature integration theory may be useful for predicting attentional performance in a 3D world. (shrink)

The Politics of Method in the Human Sciences provides a remarkable comparative assessment of the variations of positivism and alternative epistemologies in the contemporary human sciences. Often declared obsolete, positivism is alive and well in a number of the fields; in others, its influence is significantly diminished. The essays in this collection investigate its mutations in form and degree across the social science disciplines. Looking at methodological assumptions field by field, individual essays address anthropology, area studies, economics, history, the philosophy (...) of science, political science and political theory, and sociology. Essayists trace disciplinary developments through the long twentieth century, focusing on the decades since World War II. Contributors explore and contrast some of the major alternatives to positivist epistemologies, including Marxism, psychoanalysis, poststructuralism, narrative theory, and actor-network theory. Almost all the essays are written by well-known practitioners of the fields discussed. Some essayists approach positivism and anti-positivism via close readings of texts influential in their respective disciplines. Some engage in ethnographies of the present-day human sciences; others are more historical in method. All of them critique contemporary social scientific practice. Together, they trace a trajectory of thought and method running from the past through the present and pointing toward possible futures. Contributors. Andrew Abbott, Daniel Breslau, Michael Burawoy, Andrew Collier , Michael Dutton, Geoff Eley, Anthony Elliott, Stephen Engelmann, Sandra Harding, Emily Hauptmann, Webb Keane, Tony Lawson, Sophia Mihic, Philip Mirowski, Timothy Mitchell, William H. Sewell Jr., Margaret R. Somers, George Steinmetz, Elizabeth Wingrove. (shrink)

Aboutness has been studied from any number of angles. Brentano made it the defining feature of the mental. Phenomenologists try to pin down the aboutness-features of particular mental states. Materialists sometimes claim to have grounded aboutness in natural regularities. Attempts have even been made, in library science and information theory, to operationalize the notion. But it has played no real role in philosophical semantics. This is surprising; sentences have aboutness-properties if anything does. Aboutness is the first book to examine through (...) a philosophical lens the role of subject matter in meaning. A long-standing tradition sees meaning as truth-conditions, to be specified by listing the scenarios in which a sentence is true. Nothing is said about the principle of selection--about what in a scenario gets it onto the list. Subject matter is the missing link here. A sentence is true because of how matters stand where its subject matter is concerned. Stephen Yablo maintains that this is not just a feature of subject matter, but its essence. One indicates what a sentence is about by mapping out logical space according to its changing ways of being true or false. The notion of content that results--directed content--is brought to bear on a range of philosophical topics, including ontology, verisimilitude, knowledge, loose talk, assertive content, and philosophical methodology. Written by one of today's leading philosophers, Aboutness represents a major advance in semantics and the philosophy of language. (shrink)

In this third paper in a series of four, we explore some ways of doing education differently. An education that moves beyond the persistent failures and irredeemable injustices of modern mass schooling episteme. The episteme for education we adumbrate – an episteme of life continuance – begins with a recognition of interdependency and the value of diversity, diverse knowledges and relations of tolerance. We propose an escape from the extinction ethics which modern schools perpetuate and a new grammar of living (...) in which education and politics are processes of re-learning, co-learning, decision taking, limit testing, and conflict resolution in relation to an uncertain future. To achieve this, we outline a set of open and ‘unplanned’ commoning activities that would take place within local social infrastructures focused on re-politising learning itself and practicing the care of oneself, others, community and the environment. The proposal for a different education as common(ing) activities undertaken within social infrastructures, is about reimagining political and environmental relations, and co-creating a sense of collective ownership of and responsibility for the environment. A form of community that it is practical, rather than utopian, and that would be both the means and ends for such an education. (shrink)

This chapter examines the concepts of revelation and faith, as well as their relation to one another. The idea of revelation common to Judaism, Christianity, and Islam can be divided in different ways: general revelation and specific revelation, propositional revelation and non-propositional revelation. I argue that an account of specific revelation is most rich when both propositional and non-propositional kinds of revelation are admitted. I also explore why the more recent non-propositional conceptions became relevant due to the controversies concerning the (...) inspiration, inerrancy, and infallibility of scripture. The concept of faith stands parallel to that of revelation, as it too embodies both a sense of belief in a set of propositions as well as a trusting relationship with God inexpressible, in part, by propositions. I then examine the role of reason in religious faith and particularly the many ways the two might relate between the poles of religious rationalism and fideism. (shrink)

In light of many recent critiques of Western modernity and its conceptual foundations, the problem of adequately justifying our most basic moral and political values looms large. Without recourse to traditional ontological or metaphysical foundations, how can one affirm — or sustain — a commitment to fundamentals? The answer, according to Stephen White, lies in a turn to “weak” ontology, an approach that allows for ultimate commitments but at the same time acknowledges their historical, contestable character. This turn, White (...) suggests, is already underway. His book traces its emergence in a variety of quarters in political thought today and offers a clear and compelling account of what this might mean for our late modern self-understanding. (shrink)

In this book, Stephen Read sets out to rescue logic from its undeserved reputation as an inflexible, dogmatic discipline by demonstrating that its technicalities and processes are founded on assumptions which are themselves amenable to philosophical investigation. He examines the fundamental principles of consequence, logical truth and correct inference within the context of logic, and shows that the principles by which we delineate consequences are themselves not guaranteed free from error. Central to the notion of truth is the beguiling (...) issue of paradox. Its philosophical value, Read shows, lies in exposing the invalid assumption on which the paradox is built. Thinking About Logic also discusses logical puzzles which introduce questions relating to language, the world, and their relationship. (shrink)

To what extent should parents be allowed to use reproductive technologies to determine the characteristics of their future children? Is there something morally wrong with choosing what their sex will be, or with trying to 'screen out' as much disease and disability as possible before birth? Stephen Wilkinson offers answers to such questions.

Mark Colyvan (2010) raises two problems for ‘easy road’ nominalism about mathematical objects. The first is that a theory’s mathematical commitments may run too deep to permit the extraction of nominalistic content. Taking the math out is, or could be, like taking the hobbits out of Lord of the Rings. I agree with the ‘could be’, but not (or not yet) the ‘is’. A notion of logical subtraction is developed that supports the possibility, questioned by Colyvan, of bracketing a theory’s (...) mathematical aspects to obtain, as remainder, what it says ‘mathematics aside’. The other problem concerns explanation. Several grades of mathematical involvement in physical explanation are distinguished, by analogy with Quine’s three grades of modal involvement. The first two grades plausibly obtain, but they do not require mathematical objects. The third grade is likelier to require mathematical objects. But it is not clear from Colyvan’s example that the third grade really obtains. (shrink)

Kripke, argued like this: it seems possible that E; the appearance can't be explained away as really pertaining to a "presentation" of E; so, pending a different explanation, it is possible that E. Textbook Kripkeans see in the contrast between E and its presentation intimations of a quite general distinction between two sorts of meaning. E's secondary or a posteriori meaning is the set of all worlds w which E, as employed here, truly describes. Its primary or a priori meaning (...) is the set of all w such that if w is actual, then E is true. "Conceivability error" occurs when a primary possibility is mistaken for a secondary one. Textbook Kripkeanism is rejected on the grounds that it makes meaning too modal and modality too much a matter of meaning. (shrink)

The idea that we have special access to our own mental states has a distinguished philosophical history. Philosophers as different as Descartes and Locke agreed that we know our own minds in a way that is quite different from the way in which we know other minds. In the latter half of the twentieth century, however, this idea carne under serious attack, first from philosophy (Sellars 1956) and more recently from developmental psychology. The attack from developmental psychology arises from the (...) growing body of work on “mindreading,” the process of attributing mental states to people (and other organisms). During the last fifteen years, the processes underlying rnindreading have been a major focus of attention in cognitive and developmental psychology. Most of this work has been concerned with the processes underlying the attribution of mental states toother people.However, a number of psychologists and philosophers have also proposed accounts of the mechanisms underlying the attribution of mental states tooneself.This process ofreading one's own mindorbecoming self-awarewill be our primary concern in this paper. (shrink)

This book develops an alternative approach to sentence- and word-meaning, which I dub the speech-act theoretic approach, or STA. Instead of employing the syntactic and semantic forms of modern logic–principally, quantification theory–to construct semantic theories, STA employs speech-act structures. The structures it employs are those postulated by a novel theory of speech-acts. STA develops a compositional semantics in which surface grammar is integrated with semantic interpretation in a way not allowed by standard quantification-based theories. It provides a pragmatic theory of (...) truth, a treatment of logically complex discourse as expressive cognitive states, and a background metaphysics in which the world is a totality of logically simple states of affairs. The book also puts forward an account of how intentional states provide the simple, representational foundation for a superstructure of speech-act structures–a system of thoughts–that far outruns the expressive power of the intentional foundation. In short, it provides an account of cognitive foundations of a language and a naturalistic reduction of semantics through an expressive theory of semantic norms. (shrink)

Essence and causation are fundamental in metaphysics, but little is said about their relations. Some essential properties are of course causal, as it is essential to footprints to have been caused by feet. But I am interested less in causation's role in essence than the reverse: the bearing a thing's essence has on its causal powers. That essencemight make a causal contribution is hinted already by the counterfactual element in causation; and the hint is confirmed by the explanation essence offers (...) of something otherwise mysterious, namely, how events exactly alike in every ordinary respect, like the bolt'ssuddenly snapping and its snapping per se, manage to disagree in what they cause. Some prior difference must exist between these events to make their causal powers unlike. Paradoxically, though, it can only be in point of a property, suddenness, which both events possess in common. Only by postulating a difference in themanner — essential or accidental — of the property's possession is the paradox resolved. Next we need an account of causation in which essence plays an explicit determinative role. That account, based on the idea that causes should becommensurate with their effects, is thatx causesy only if nothing essentially poorer would have done, and nothing essentially richer was needed. (shrink)

Let us call dispositional monism the view that all natural properties have their identities fixed purely by their dispositional features, that is, by the patterns of stimulus and response in which they participate. DM implies that natural properties are pure powers: things whose natures are fully identified by their roles in determining the potentialities of events to cause or be caused. As pure powers, properties are meant to lack quiddities in Black's sense. A property possesses a quiddity just in case (...) its identity is fixed by something independent of the causal–nomological roles it may enter into. Paradigmatically, a categorical property is thought of as a property whose identity is fixed by a quiddity .The key question about the viability of DM as a theory of properties is how properties can be pure powers devoid of any quiddity. Bird provides an answer. According to Bird , ‘all there is to a property is a matter of second-order relations to other properties’. The second-order relation is just the relation that a disposition, its stimulus condition, and a manifestation condition bear to each other. Call this relation SR. SR is not causation or physical necessitation. The latter relations are first-order relations between concrete events. SR is a second-order relation. Its possession by properties explains why events featuring those properties can enter into certain first-order relations of causation or necessitation.Bird's thought then is this: the sense in which properties have their identities fixed purely by their causal–nomological roles is that they are relationally constituted, where the relation doing the constituting is SR. 1 This thesis of relational constitution does not imply that natural properties are themselves relations. Nothing prevents the identity …. (shrink)

I. The Conscious Mind is a hugely likable book. Perceptive, candid, and instructive page by page, the work as a whole sets out a large and uplifting vision with cheeringly un-Dover-Beach-ish implications for “our place in the universe.” A book that you can’t helping wanting to believe as much as you can’t help wanting to believe this one doesn’t come along every day. It is with real regret that I proceed to the story of why belief would not come.

Our knowledge of the world comes from various sources. But it is sometimes said that testimony, unlike other sources, transmits knowledge from one person to another. In this book, Stephen Wright investigates what the transmission of knowledge involves and the role that it should play in our theorising about testimony as a source of knowledge. He argues that the transmission of knowledge should be understood in terms of the more fundamental concept of the transmission of epistemic grounds, and that (...) the claim that testimony transmits knowledge is not only defensible in its own right, but indispensable to an adequate theory of testimony. This makes testimony unlike other epistemic sources. (shrink)

Some skeptical theists use Wykstra’s CORNEA constraint to undercut Rowe-style inductive arguments from evil. Many critics of skeptical theism accept CORNEA, but argue that Rowe-style arguments meet its constraint. But Justin McBrayer argues that CORNEA is itself mistaken. It is, he claims, akin to “sensitivity” or “truth-tracking” constraints like those of Robert Nozick; but counterexamples show that inductive evidence is often insensitive. We here defend CORNEA against McBrayer’s chief counterexample. We first clarify CORNEA, distinguishing it from a deeper underlying principle (...) that we dub “CORE.” We then give both principles a probabilistic construal, and show how, on this construal, the counterexample fails. (shrink)

The real distinction between mind and body -- Is conceivability a guide to possibility? -- Textbook kripkeanism and the open texture of concepts -- Coulda, woulda, shoulda -- No fool's cold : notes on illusions of possibility -- Beyond rigidification : the importance of being really actual -- How in the world? -- Mental causation -- Singling out properties -- Wide causation -- Causal relevance : mental, moral, and epistemic.

Descartes's "conceivability argument" for substance-dualism is defended against Arnauld's criticism that, for all he knows, Descartes can conceive himself without a body only because he underestimates his true essence; one could suggest with equal plausibility that it is only for ignorance of his essential hairiness that Descartes can conceive himself as bald. Conceivability intuitions are defeasible but special reasons are required; a model for such defeat is offered, and various potential defeaters of Descartes's intuition are considered and rejected. At best (...) though Descartes shows the separability of mind from body, not (as he claims) their actual separateness. (shrink)

Are all instances of the T-schema assertable? I argue that they are not. The reason is the presence of conventional implicature in a language. Conventional implicature is meant to be a component of the rule-based content that a sentence can have, but it makes no contribution to the sentence's truth-conditions. One might think that a conventional implicature is like a force operator. But it is not, since it can enter into the scope of logical operators. It follows that the semantic (...) content of a sentence is not given simply by its truth-conditional content. So not all instances of the T-schema are assertable in the relevant sense. Consequently, there is a strong case to be made against truth-conditional semantics of the disquotational variety and deflationism about truth. (shrink)

….it [is] wholly irrational to regard as doubtful matters that are perceived clearly and distinctly by the understanding in its purity, on account of mere prejudices of the senses and hypotheses in which there is an element of the unknown.Descartes, Geometrical Exposition of the MeditationsSubstance dualism, once a main preoccupation of Western metaphysics, has fallen strangely out of view; today’s mental/physical dualisms are dualisms of fact, property, or event. So if someone claims to find a difference between minds and bodies (...) per se, it is not initially clear what he is maintaining. Maybe this is because one no longer recognizes ‘minds’ as entities in their own right, or ‘substances.’ However, selves - the things we refer to by use of ‘I’ - are surely substances, and it does little violence to the intention behind mind/body dualism to interpret it as a dualism of bodies and selves. If the substance dualist’s meaning remains obscure, that is because it can mean several different things to say that selves are not bodies. (shrink)