Activity-dependent neuroprotective protein, discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder, including cognitive and motor deficits, the ADNP syndrome. One of the most important cellular processes associated with ADNP is the autophagy pathway, recently discovered by us as a key player in the pathophysiology of schizophrenia. In this regard, given the link between the microtubule and (...) autophagy systems, the ADNP microtubule end binding protein motif, namely, the neuroprotective NAP, was found to enhance autophagy while protecting microtubules and augmenting ADNP's association with both systems. Thus, linking autophagy and ADNP is proposed as a major target for intervention in brain diseases from autism to Alzheimer's disease and our findings introduce autophagy as a possible novel target for treating schizophrenia. Activity-dependent neuroprotective protein binds to microtubule-associated protein light chain 3, which forms the membrane of the autophagosome, a key organelle in the autophagy process and regulates beclin1 formation, an inducer of autophagy. Autophagy plays a major role in Alzheimer's disease and as recently discovered in schizophrenia and autism. (shrink)

Alan Turing’s 1950 imitation game has been widely understood as a means for testing if an entity is intelligent. Following a series of papers by Diane Proudfoot, I offer a socio-technological interpretation of Turing’s paper and present an alternative way of understanding both the imitation game and Turing’s concept of intelligence. Turing, I claim, saw intelligence as a social concept, meaning that possession of intelligence is a property determined by society’s attitude toward the entity. He realized that as long as (...) human society held a prejudiced attitude toward machinery—seeing machines a priori as mindless objects—machines could not be said to be intelligent, by definition. He also realized, though, that if humans’ a priori, chauvinistic attitude toward machinery changed, the existence of intelligent machines would become logically possible. Turing thought that such a change would eventually occur: He believed that when scientists overcome the technological challenge of constructing sophisticated machines that could imitate human verbal behavior—i.e., do well in the imitation game—humans’ prejudiced attitude toward machinery will have altered in such a way that machines could be said to be intelligent. The imitation game, for Turing, was not an intelligence test, but a technological aspiration whose realization would likely involve a change in society’s attitude toward machines. (shrink)

The late Shlomo Pines (1908-1990) was this century's outstanding historian of Islamic philosophy and science. This volume offers, for the first time in English. Pines' doctoral dissertation on Islamic atomism; the German version appeared in 1936. Pines presents the atomic theories of matter, time and space, as they are found in the literature of kalam, as well their exposition in the writings of Abŭ Bakr al - Râzî; and then investigates in detail possible sources in the Greek, Indian, and (...) other traditions. The present publication incorporates a few revisions which Pines himself had made in a draft translation. A number of the texts, which Pines consulted in the manuscript, have since been published, and some important studies on the kalam have appeared. Nonetheless, it can be stated in confidence that, sixty years after its first publication, Pines' monograph is till today the most significant work on the subject. (shrink)

ABSTRACTThis paper introduces the category of ‘non-deceptive manipulation that causes false beliefs’, analyzes how it narrows the traditional scope of ‘deception’, and draws moral implications.

Libertarian paternalism's notion of “nudging” refers to steering individual decision making so as to make choosers better off without breaching their free choice. If successful, this may offer an ideal synthesis between the duty to respect patient autonomy and that of beneficence, which at times favors paternalistic influence. A growing body of literature attempts to assess the merits of nudging in health care. However, this literature deals almost exclusively with health policy, while the question of the potential benefit of nudging (...) for the practice of informed consent has escaped systematic analysis. This article focuses on this question. While it concedes that nudging could amount to improper exploitation of cognitive weaknesses, it defends the practice of nudging in a wide range of other conditions. The conclusion is that, when ethically legitimate, nudging offers an important new paradigm for informed consent, with a special potential to overcome the classical dilemma between paternalistic beneficence and respect for autonomy. (shrink)

This paper presents a new approach to the demarcation of social emotions, based on their dependence on social appraisals that are designed to assess events bearing on social concerns. Previous theoretical attempts to characterize social emotions are compared, and their inconsistencies highlighted. Evidence for the present formulation is derived from theory and research into links between appraisals and emotions. Emotions identified as social using our criteria are also shown to bring more consistent consequences for social behavior than nonsocial emotions. We (...) conclude by considering ways of validating and refining our classification. (shrink)

Weiner’s attribution theory of motivation and emotion assumes emotions are determined by beliefs about causality. Individuals share a naïve understanding of this linkage between causal attribution and emotions and use it in order to draw inferences from and influence others’ emotions. Evidence for such uses is provided and recent research and theory that goes beyond the attribution–emotion linkage is discussed. Specifically, recent research considers the naïve use of a larger set of emotions and appraisals and their connections, and the role (...) of context in this process. However, still missing is a fuller understanding when this naïve knowledge is employed and how and when it is based on an explicit understanding of the emotion–appraisal linkage rather than more automatic processes. (shrink)

The nocebo effect, the mirror-phenomenon to the placebo effect, is when the expectation of a negative outcome precipitates the corresponding symptom or leads to its exacerbation. One of the basic ethical duties in health care is to obtain informed consent from patients before treatment; however, the disclosure of information regarding potential complications or side effects that this involves may precipitate a nocebo effect. While dilemmas between the principles of respect for patient autonomy and of nonmaleficence are recognized in medical ethics, (...) there has not yet been an ethical discussion focused on the potential dilemma raised by the nocebo effect of informed consent. This dilemma is especially pernicious, since it involves a direct causality of harm by the caregiver that is unparalleled by other potential harmful effects of information disclosure. This paper articulates the dilemma of the NEIC and offers a seminal ethical analysis. (shrink)

Beneficence and respect for autonomy are two of the most fundamental moral duties in general and in bioethics in particular. Beyond the usual questions of how to resolve conflicts between these duties in particular cases, there are more general questions about the possible forms of the interactions between them. Only recognition of the full spectrum of possible interactions will ensure optimal moral deliberation when duties potentially conflict. This paper has two simultaneous objectives. The first is to suggest a typological scheme (...) of all possible modes of interaction; these will be classified under the “discrete,” “semi-discrete,” and “non-discrete” categories, according to whether the meaning and/or forms of expression of each duty are treated as independent from or rather as constrained by the other. The second objective is to show that all logical possibilities of interaction indeed have real expressions in medical ethics, to provide clear illustrations of each, and in particular to stress those that have usually escaped recognition. (shrink)

The nonidentity problem is a deep puzzle challenging the moral intuition that what is bad must be bad for someone. The first part of the paper constructs a new theory of harming, whereas the second part builds on the conclusions of the first to offer a new solution to the NIP. The first part discusses the neglected question of when a burden inflicted in the context of overall benefitting can be discretized as a separate entity—only when it can, is it (...) possible to identify the burden as harm, and only then is it possible to harm in bringing into overall good existence. The second part explains how, in those cases where creating is indeed harming, we can use the logic of concept expansion to construct a concept of wronging that applies to creation cases. (shrink)

Anyone who is not a deontological absolutist regarding truthfulness will readily agree with Christopher Meyers’s thesis that there are cases in which...

“de-extinction” refers to the process of resurrecting extinct species by genetic methods. This science-fiction-sounding idea is in fact already in early processes of scientific implementation. Although this recent “revival of the dead” raises deep ethical questions, the ethics of de-extinction has barely received philosophical treatment. Rather than seeking a verdict for or against de-extinction, this paper attempts an overview and some novel analyses of the main ethical considerations. Five dimensions of the ethics of de-extinction are explored: (a) the possible contribution (...) of de-extinction to promoting ecological values, (b) the deontological argument that we owe de-extinction to species we rendered extinct, (c) the question of “playing God” through de-extinction, (d) the utilitarian perspective, and (e) the role of aesthetic considerations in the ethics of de-extinction. A general feature arising from the paper’s discussion is that, due to de-extinction’s special character, it repeatedly tests the limits of our ethical notions. (shrink)

A central debate in the ethics of deception concerns the moral comparison among the three media through which deception is executed: lying, falsely implicating, or nonlinguistic deception. The two prominent views are that lying is morally worse or that the choice of medium is morally insignificant. This article refutes both and argues for a new position. The article first presents a theory on the moral significance of the medium of deception as such: it argues that the medium of communication affects (...) the reliability of beliefs formed through it, which amounts to gradations in the warrant of truth of different media. Breach of lower warrant of truth is a lesser breach of trust; it therefore deserves lighter condemnation. Consequently, the article shows that, morally speaking, lying is either worse than or equal to falsely implicating and that there is no a priori gradation between nonlinguistic deception and the two linguistic media. (shrink)

Moral reflection and deliberation on both deception and manipulation is hindered by lack of agreement on the precise meanings of these concepts. Specifically, there is disagreement on how to understand their relation vis-à-vis each other. Curiously, according to one prominent view, all deceptions are instances of manipulations, while according to another, all manipulations are instances of deceptions. This paper makes that implicit disagreement explicit, and argues that both views are untenable. It concludes that deception and manipulation partially overlap, and takes (...) further steps in delineating the border between these concepts. The paper ends with the conclusion that moral judgments regarding either manipulation or deception cannot be transferred wholesale from the one concept to the other just by virtue of the relations between the concepts. (shrink)

A longstanding debate exists in both academic literature and popular culture about whether non-informative marketing tactics are manipulative. However, given that we tend to believe that some marketing tactics are manipulative and some are not, the question that marketers, their critics, and consumers need to ask themselves is that of how to actually determine whether any particular marketing tactic is manipulative and whether a given manipulative tactic is, in fact, immoral. This article proposes to operationalize criteria that can be used (...) by marketers for making such determinations and attempts to provide some clarification toward our under- standing of the concept of manipulation and the conditions for the moral acceptability of manipulative marketing practices. It argues that a marketing tactic is manipulative if it is intended to motivate by undermining what the marketer believes is his/her audience’s normal decision-making process either by deception or by playing on a vulnerability that the marketer believes exists in his/her audience’s normal decision-making process. Such a tactic is morally objectionable on several grounds, which make it morally impermissible unless outweighed by sufficient “redemptive” moral considerations. (shrink)

Shlomo Pines The Philosophical Purport of Maimonides' Halachic Works and the Purport of The Guide of the Perplexed Maimonides' principal halachic works, ...

We reviewed 272 phase I oncology trial consent forms and then created an improved informed consent template in both English and Spanish by redesigning and rewording the consent form to be specific to phase I trials, to avoid repetition, and to use simplified language, identifiable sections framed by first-person questions, and tables to present information. The resulting consent form template is shorter than average and considerably easier to read . The template also meets the recommended eighth-grade maximum reading level for (...) consent forms. Use of this template should help improve the informed consent process. (shrink)

Like many other foreign students, Chinese students studying at American universities face special challenges in value-centered humanities courses as cultural outsiders. Moral and political philosophy can be particularly difficult, since these subjects focus on delicate issues of great personal significance, yet rely on cultural norms, discourse contexts, and basic assumptions that Chinese students may not share, understand, or feel comfortable discussing. Programs that invite American professors to teach summer classes to such students in China for American university credit allow for (...) interesting new opportunities to circumvent some of the learning obstacles these students face in the United States. This essay reflects upon general teaching strategies that take advantage of these opportunities, and presents promising approaches to three sensitive topics in this teaching context: cultural relativism as a normative moral theory, diversity, and human rights. Many of the approaches and examples discussed may also be applicable to teaching Chinese students in the U.S. or discussing key issues with them in office hours. (shrink)

There is a disturbing kind of situation that presents agents with only two possibilities of moral action—one especially praiseworthy, the other condemnable. I describe such scenarios and argue that moral action in them exhibits a unique set of parameters: performing the commendable action is especially praiseworthy; not performing is not blameworthy; not performing is wrong. This set of parameters is distinct from those which characterize either moral obligation or supererogation. It is accordingly claimed that it defines a distinct, yet unrecognized, (...) deontic category, to which the name ‘Forced Supererogation’ is appropriate. The moral parameters of Forced Supererogation and the relations between them are discussed, especially the divergence of wrongness and blame. I argue that this new category allows a more accurate classification of moral actions than that imposed by the strained dichotomy of obligation versus supererogation. (shrink)

Recent research, especially with functional brain imaging, demonstrated cases where the administration of a placebo produces objective effects in tissues that are indistinguishable from those of the real therapeutic agents. This phenomenon has been shown in treatments of pain, depression, Parkinsonism, and more. The main ethical complaint against placebo treatment is that it is a kind of deception, where supposedly we substitute what works just psychologically for a real drug that actually works on the tissue level. We claim that the (...) scientific findings bring to a new level the seeming deconstruction of the distinction between “placebo” and “real” drugs, and that instances of placebo treatment which fulfill this criterion should be recognized as a unique category—we call it “comparable placebo treatment” (CPT). The paper uses an analysis of the notion of deception to argue that CPT does not amount to deception; that it can preserve patient autonomy; and that it is therefore morally legitimate. (shrink)

This article argues that the religious epistemology of the rabbinic tradition, which preserves and respects multiple perspectives in intellectual debate, is best understood in comparison to the definitions of truth proposed by philosophical pragmatists, in particular William James and W. V. Quine, and in contrast to those of philosophical liberals, in particular J. S. Mill. Both the rabbis and the pragmatists emphasize the harmony that innovation must maintain with extant webs of meaning. Conceptions of objectivity and subjectivity in Jewish medieval (...) rationalism and in early modern mysticism are considered and compared with those of latter-day European and American epistemology. This article makes a case for a fundamentally pluralistic conception of truth and argues that it is exemplified in the social interaction of the talmudic sages. (shrink)

Ever since the discovery of Marx's Early Writings, most of the literature concerned with Marx's intellectual development has centred around the so-called gap between the 'young' Marx, who was considered to be a humanist thinker, and the 'older' Marx, who was held to be a determinist with little concern for anything outside his narrow theory of historical materialism. Dr Avineri claims that such a gap between the 'young' and 'older' Marx did not exist. He supports his claim by a detailed (...) study of the whole corpus of Marx's writing on social and political thought. (shrink)

This study in English of Hegel's political philosophy presents an overall view of the development of Hegel's political thinking. The author has drawn on Hegel's philosophical works, his political tracts and his personal correspondence. Professor Avineri shows that although Hegel is primarily thought of as a philosopher of the state, he was much concerned with social problems and his concept of the state must be understood in this context.

This monument of rabbinical exegesis written at the end of the twelfth century has exerted an immense and continuing influence upon Jewish thought. Its aim is to liberate people from the tormenting perplexities arising from their understanding of the Bible according only to its literal meaning. This edition contains extensive introductions by Shlomo Pines and Leo Strauss, a leading authority on Maimonides.

A new exploration of Karl Marx's life through his intellectual contributions to modern thought Karl Marx —philosopher, historian, sociologist, economist, current affairs journalist, and editor—was one of the most influential and revolutionary thinkers of modern history, but he is rarely thought of as a Jewish thinker, and his Jewish background is either overlooked or misrepresented. Here, distinguished scholar Shlomo Avineri argues that Marx’s Jewish origins did leave a significant impression on his work. Marx was born in Trier, then part (...) of Prussia, and his family had enjoyed equal rights and emancipation under earlier French control of the area. But then its annexation to Prussia deprived the Jewish population of its equal rights. These developments led to the reluctant conversion of Marx’s father, and similar tribulations radicalized many young intellectuals of that time who came from a Jewish background. Avineri puts Marx’s Jewish background in its proper and balanced perspective, and traces Marx’s intellectual development in light of the historical, intellectual, and political contexts in which he lived. (shrink)

_Interpretation in Religion_ is the work of a group of contemporary American, European, and Israeli scholars and philosophers, who analyze the crucial course of interpretation in religion — religion in general, and, in particular, Hinduism, ancient Egyptian religion, Judaism, christianity, and Islam.

This conversation took place in December 2002 but was published much later. It focuses on ethics.

Abraham ibn Ezra's scientific corpus represented an exceptional case: instead of the common Latin model embodied by the scholar coming from the Christian North to the Iberian Peninsula to initiate a translation enterprise, we have in Ibn Ezra the contrary case of an intellectual imbued with the Arabic culture, who abandons al-Andalus, roams around the Christian countries and delivers in his wandering through Italy, France and England, the scientific and cultural cargo that he amassed during his youth in al-Andalus. The (...) main purpose of this article is to provide a picture of Ibn Ezra's scientific corpus as comprehensive and detailed as possible given the present state of research. The paper will fall into two main parts: Ibn Ezra's scientific work will be broken up into three main genres: Mathematics, Astronomy, Scientific Instruments and Tools; The astrological encyclopaedia; Translations from Arabic into Hebrew. In the second part, Ibn Ezra's scientific corpus will be reassembled as a whole in order to provide a global characterization, trying to point out its general organization and shape, and to indicate its main aims and special traits revealing Ibn Ezra personal contribution. (shrink)