The members of the Six gene family were identified as homologues of Drosophila sine oculis which is essential for compound-eye formation. The Six proteins are characterized by the Six domain and the Six-type homeodomain, both of which are essential for specific DNA binding and for cooperative interactions with Eya proteins. Mammals possess six Six genes which can be subdivided into three subclasses, and mutations of Six genes have been identified in human genetic disorders. Characterization of Six genes from various animal (...) phyla revealed the antiquity of this gene family and roles of its members in several different developmental contexts. Some members retain conserved roles as components of the Pax-Six-Eya-Dach regulatory network, which may have been established in the common ancestor of all bilaterians as a toolbox controlling cell proliferation and cell movement during embryogenesis. Gene duplications and cis-regulatory changes may have provided a basis for diverse functions of Six genes in different animal lineages. (shrink)

We can easily discriminate self-produced from externally generated sensory signals. Recent studies suggest that the prediction of the sensory consequences of one’s own actions made by forward model can be used to attenuate the sensory effects of self-produced movements, thereby enabling a differentiation of the self-produced sensation from the externally generated one. The present study showed that attenuation of sensation occurred both when participants themselves performed a goal-directed action and when they observed experimenter performing the same action, although they clearly (...) reported that the tones were produced by other during action observation and by themselves during their own action. These results suggest that sensory prediction of action modulates ongoing auditory processing irrespective of who produces the sounds and that the explicit judgment of agency does not necessarily rely on the same mechanisms on which implicit perceptual measures such as sensory attenuation rely. (shrink)

「地獄に落ちても後悔しない」――親鸞が比叡山を捨ててまで求めた、法然の教えとは!? その教えと歩みを探った、著者渾身の一冊。.

本書構畫「忠」概念在中國春秋戰國時代的演變，並嘗試藉此闡明其功能與特質。在春秋到戰國早期的政治思想中，「忠」和「忠信」概念對於國家社稷的生存幾乎是最高價值，而且到戰國中期更具有涵蓋「天下」的普遍性。然 而在戰國中期以後，道家與稷下思想家如慎到等人開始批判「忠」的價值，並且將原本以道德動機為主要內涵的「忠」概念、轉變成以個人利益為主要實踐動機的「忠」概念。面對此趨勢，戰國晚期的《荀子》和《呂氏春秋》都 試圖重新界定「忠」對國家運作的正面價值，而《韓非子》雖然基本上接受稷下學者之「反忠論」，但還是肯定「忠臣」是國家社稷安定的關鍵角色。本書也對中日韓及歐美學者過去研究「忠」概念的成果有詳細評述。.

日常においてはいつも素通りされている豊かな経験の世界がある―。“自明”であるがゆえに眼を向けられることのないこの経験の世界を現象学は精査し、われわれにとっての「現実」が成立する構造を明るみに出す。創始 者フッサール以来続く哲学的営為の核心にあるものは何か。そしていまだ汲みつくせないその可能性とは。本書は粘り強い思索の手触りとともに、読者を生と世界を見つけなおす新たな思考へと誘う。.

Early modern humans developed mental capabilities that were immeasurably greater than those of nonhuman primates. We see this in the rapid innovation in tool making, the development of complex language, and the creation of sophisticated art forms, none of which we find in our closest relatives. While we can readily observe the results of this high-order cognitive capacity, it is difficult to see how it could have developed. We take up the topic of cave art and archeoacoustics, particularly the discovery (...) that cave art is often closely connected to the acoustic properties of the cave chambers in which it is found. Apparently, early modern humans were able to detect the way sound reverberated in these chambers, and they painted artwork on surfaces that were acoustic “hot spots,” i.e., suitable for generating echoes. We argue that cave art is a form of cross-modality information transfer, in which acoustic signals are transformed into symbolic visual representations. This form of information transfer across modalities is an instance of how the symbolic mind of early modern humans was taking shape into concrete, externalized language. We also suggest that the earliest rock art found in Africa may constitute one of the first fossilized proxies for the expression of full-fledged human linguistic behavior. (shrink)

The phylogenetic position of the hagfish remains enigmatic. In contrast to molecular data that suggest monophyly of the cyclostomes, several morphological features imply a more ancestral state of this animal compared with the lampreys. To resolve this question requires an understanding of the embryology of the hagfish, especially of the neural crest. The early development of the hagfish has long remained a mystery. We collected a shallow‐water‐dwelling hagfish, Eptatretus burgeri, set up an aquarium tank designed to resemble its habitat, and (...) successfully obtained several embryos. By observing the histology and expression of genes known to play fundamental roles in the neural crest, we found that the hagfish crest develops as delaminating migratory cells, as in other vertebrates. We conclude that the delaminating neural crest is a vertebrate synapomorphy that seems to have appeared from the beginning of their evolutionary history, before the splitting away of the hagfish lineage. BioEssays 30:167–172, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

◎ 以政治思想使的角度切入，完整剖析荀子的政治思想淵源、構造及特色。 ◎ 闡明荀子如何將早期儒、墨的倫理論辯，提升為分析國家社會原理的禮治論。 ◎ 理解漢朝後中國國家體制的設計藍圖，必須從理解荀子禮治論開始。 本書以「禮治」與「綜合」為切入點，闡明《荀子》書中政治思想的淵源、構造以及特色，並對荀子的生平、其文本的流傳以及戰國時代「禮」概念的發展等問題，進行完整且系統性的說明。 作者將戰國時代的思想演變，分成以孔子至孟子的早期儒家與墨家思想為主要內容的「倫理論辯」階段，和以慎到、田駢等稷下學者與道家等戰國中、晚期思想為主要內容的「分析論述」階段，並主張荀子以「禮」概念綜合了此 兩種思想潮流。經由闡述「禮」概念的各種功能，荀子將當時備受懷疑的倫理工夫之效能，以及過度抽象化的各種政治論辯內容，重新界定為每個人都能夠實踐的倫理準則；早期儒墨的「倫理論辯」，由此提升為富有分析國家社 會原理的「禮治論」。而因為荀子的禮治論兼有豐富的倫理實踐意涵，以及分析國家社會的理論意涵，其後更成為漢朝建立國家制度與倫理基礎時的設計藍圖。 經由作者條分縷析地說明，讀者當能對荀子的禮治思想有更深入的了解，進而掌握其整體面貌。.

世界的ベストセラーの問いかけに私たちはどう答えるのか。分子生物学の黎明期に、初めて人間と生命の神秘にせまったジャック・モノー。その思想を原典から読み解き、40年後のいま、モノーに答える。.

人間であること、これを問う政治哲学の徹底。その先に見えるのは、果たして平和的共存の根源性か、戦いのそのとき、自分以外ではありえない人間の生々しさか。.

Many functional glycoproteins are expressed on the lymphocyte cell surface. Some of them carry O-linked oligosaccharides (O-glycans), which are conjugated through serine or threonine residues. During various biological processes, including T-cell activation, a tetrasaccharide on the T-cell surface is dramatically converted to a branched hexasaccharide, called core2 O-glycan. The same structural change in O-glycans is also found on the lymphocytes from patients with immunodeficiency conditions such as Wiskott-Aldrich syndrome and AIDS. Several studies revealing the roles of core2 O-glycans in immune (...) responses show that this is a biologically significant change. In particular, core2 O-glycans expressed on the cell surface reduce cell–cell interactions, thereby regulating immune responses. Furthermore, core2 O-glycan is a key backbone structure in forming selectin ligands. Thus, O-linked oligosaccharides, in particular those containing core2 branches, play vital roles in immune responses and may play dual roles in certain situations. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes. BioEssays 23:46–53, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Many functional glycoproteins are expressed on the lymphocyte cell surface. Some of them carry O-linked oligosaccharides (O-glycans), which are conjugated through serine or threonine residues. During various biological processes, including T-cell activation, a tetrasaccharide on the T-cell surface is dramatically converted to a branched hexasaccharide, called core2 O-glycan. The same structural change in O-glycans is also found on the lymphocytes from patients with immunodeficiency conditions such as Wiskott-Aldrich syndrome and AIDS. Several studies revealing the roles of core2 O-glycans in immune (...) responses show that this is a biologically significant change. In particular, core2 O-glycans expressed on the cell surface reduce cell–cell interactions, thereby regulating immune responses. Furthermore, core2 O-glycan is a key backbone structure in forming selectin ligands. Thus, O-linked oligosaccharides, in particular those containing core2 branches, play vital roles in immune responses and may play dual roles in certain situations. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes. BioEssays 23:46–53, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

本書の第1部は近代日本の思想家がグリーンの理想主義をどのように受容し、それをどう批判し、日本の伝統的思想とどのように融合させ、独自の思想を展開してきたかを中心問題とする。とりあげられる思想家・学者は中 島力造・高山樗牛、綱島梁川、西田幾多郎、河合榮治郎の五人である。第2部はグリーンの形而上学、道徳哲学、政治哲学、宗教思想の中心問題を永遠意識の視点から体系的に再検討することを目的とした。.

Pockett has drawn an alternative conclusion from the data of Libet, Alberts, Wright, and Feinstein , and suggested that it takes 80 ms, rather than 500 ms, for the sensation evoked by a stimulus to enter awareness. Here, I suggest that our conscious sensation evolves over time, during the period from 80 to 500 ms after a stimulus, until the sensation is stably localized in space.

Proposes a provocative reinterpretation of poststructuralist theory of power The “structuralist” theories of power show that the subject is produced and reproduced by the investment of power: but how then can we then think of the subject’s resistance to power? Based on this fundamental question, Power and Resistance interprets critically the (post-)structuralist theory of power and resistance, i.e., the theories of Foucault, Deleuze and Guattari, Derrida and Althusser. It analyses also the mechanism of power and the strategies of resistance in (...) the era of neoliberalism. This meticulous analysis that completely renewed the theory of power is already published in French, Japanese, and Korean with success. (shrink)

Using artificially synthesized stimuli, previous research has shown that cotton-top tamarin monkeys easily learn simple AB grammar sequences, but not the more complex AnBn sequences that require hierarchical structure. Humans have no trouble learning AnBn combinations. A more recent study, using similar artificially created stimuli, showed that there is a neuroanatomical difference in the brain between these two kinds of arrays. While the simpler AB sequences recruit the frontal operculum, the AnBn array recruits the phylogenetically newer Broca’s area. We propose (...) that on close inspection, reported vocal repertoires of Old World Monkeys show that these nonhuman primates are capable of calls that have two items in them, but never more than two. These are simple AB sequences, as predicted by previous research. In addition, we suggest the two-item call cannot be the result of a combinatorial operation that we see in human language, where the recursive operation of Merge allows for a potentially infinite array of structures. In our view, the two-item calls of nonhuman primates result from a dual-compartment frame into which each of the calls can fit without having to be combined by an operation such as Merge. (shrink)

We revisit the EPR problem and make clear what is a correct comprehension of its problem. When one applies the quantum mechanics correctly, it will be shown that there is no paradox. According to these lines of thought, a quantum teleportation scheme without resort to the von Neumann projection postulate is presented.

美と芸術が人に及ぼす力の観点から、「侘び」「寂び」「幽玄」という古来の美的概念の関係性を解明し、日本的美の特質を捉え直す.