One of the profound changes in cellular morphology during mitosis is a massive alteration in the organization of microfilament cytoskeleton. It has been recently discovered that nonmuscle caldesmon, an actin and calmodulin binding microfilament‐associated protein of relative molecular mass Mr = 83000, is dissociated from microfilaments during mitosis, apparently as a consequence of mitosis‐specific phosphorylation. cdc2 kinase, which is a catalytic subunit of MPF (maturation or mitosis promoting factor), is found to be responsible for the mitosis‐specific phosphorylation of caldesmon. Because (...) caldesmon is implicated in the regulation of actin myosin interactions and/or microfilament organization, these results suggest that cdc2 kinase directly affects microfilament re‐organization during mitosis. (shrink)

Among Japanese nurses ethics is perceived as being distant and unrelated to their practice, although this is filled with ethical concerns and the making of ethical decisions. The reasons for this dissociation are the primacy of western values in modern Japanese health care systems and the suppression of Japanese nurses’ indigenous ethical values because of domination by western ethics. A hermeneutic study was conducted to listen to the ethical voices of Japanese nurses. Seven ethical concerns were revealed. Although some of (...) these concerns may seem to share similar values with western ethical principles, the basis for the concerns was unique and rooted in the Japanese cultural value system. The meanings of each concern are explicated in conjunction with related background meanings. Listening and trying to understand these nurses’ voices in their own context suggests a way of bridging the gap between abstract and universal ethics and practical and local ethics. (shrink)

A psycho-historical framework for the science of art appreciation will be an experimental discipline that may shed new light on the highest capacities of the human brain, yielding new scientific ways to talk about the art appreciation. The recent findings of the contextual information processing in the human brain make the concept of the art-historical context clear for empirical experimentation.

Nurses are obliged to provide quality nursing care that meets the ethical standards of their profession. However, clear descriptions of ethical practice are largely missing in the literature. Qualitative research using a phenomenological approach was conducted to explicate ethical nursing practice in Japanese end-of-life care settings and to discover how ethical practices unfold in clinical situations. Two paradigm cases and contrasting narratives of memorable end-of-life care from 32 Japanese nurses were used to reveal four levels of ethical practice: ethical, distressed, (...) uncertain, and unethical. Having the ability to actualize, justify, and recognize what is the good and/or right differentiated between these levels of ethical practice, empirical descriptions of which are given, followed by discussion of how nurses gain the skilled knowledge necessary for ethical practice. (shrink)

The promised open space of cyber-interaction has its dark side hidden behind its brilliant rhetoric. The danger emerges within the very center of developing this technology (cyber-evolution). That is a more fundamental danger than this dark side seems to have. The possible replacement of our primary reality with virtual reality might erode the significance of our existential reality. This means also that the virtual reality might lose its own ground to be constructed. In order to clarify this fundamental problem at (...) issue I show some results from a questionnaire done on younger generation. The results seem to suggest possible way of facing this problem. (shrink)

We examined amygdala subregion volumes in patients with a first episode of major depression and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differences in amygdala subregion volumes between the healthy and MD groups. Within the MD group, we examined the association between amygdala subregion volume and the 17-item Hamilton Rating Scale for Depression score and the HAMD subscale score, and found (...) no association in the left amygdala. In the right amygdala, however, there was an inverse linear association between the HAMD total and the HAMD core and lateral nucleus and anterior-amygdaloid-regions. Furthermore, an inverse linear association was seen between the HAMD psychic and the lateral nucleus, anterior-amygdaloid-regions, transition, and whole amygdala. The findings of this study suggest that the severity of MD and some symptoms of MD are associated with right amygdala volume. There have been few reports on the relationship between MD and amygdala subregional volume, and further research is needed to accumulate more data for further validation. (shrink)

book 1. Eternal life.--book 2. Ideal society.

閉塞した現在の政治を担う主体を構想できるのか。世界秩序が揺れ動き、従来の国民概念・市民概念が変革を迫られる今、新たな理論的地平を切り開く。.

John Dewey’s stay in Tokyo in early 1919 coincided with the height of the social movement calling for parliamentary democracy in Japan. His lectures at Tokyo Imperial University offered a new way of viewing the world and human actions that emphasizes the importance of communication and the growth of democratic personality. Those who expected to hear from him something else were disillusioned. But the disillusionment was mutual. Dewey was disillusioned by the Japanese intellectuals whose affection for European philosophy led them (...) to an uncritical acceptance of the emperor system and Japan’s imperialism abroad. His criticism toward the Japanese intellectuals grew severe as he saw the Japanese aggression while he was on the continent. Dewey’s lecture on democracy left some impact on a few of intellectuals who modified their view of person’s actions that was eventually to be crashed when Japan fell into the all-out war-making. (shrink)

In this paper we contend that the ability to engage in meta-dialog is necessary for free and exible conversation. Central to the possibility of meta-dialog is the ability to recognize and negotiate the distinction between the use and mention of a word. The paper surveys existing theoretical approaches to the use-mention distinction, and brie y describes some of our ongoing e orts to implement a system which represents the use-mention distinction in the service of simple meta-dialog.

Although the philosophical literature on social institutions has been insightful for social scientific studies, the application of its core concepts, such as collective intentionality, to real inst...

Although finance is ubiquitous in modern life, its ontological foundation is rarely discussed. This essay considers some key characteristics of finance from a social ontological perspective. It initially argues that money requires some sort of representation, and that financial institutions rely on various forms of cognition as well as documents anchoring representations. From that standpoint, one of the crucial aspects of finance is that it provides reference points through the process of quantification. These reference points are numerical representations that allow (...) people to make comparisons. Comparing numbers inevitably creates different hierarchies. However, a specific hierarchy can become outdated or less significant. In such situations, a heterarchy can be created outside the hierarchy. This essay illustrates the appearance of heterarchy in the recent shift toward impact finance, in which financial hierarchies encompass heterarchical systems that are finally replaced by quantifiable hierarchical metrics. With this example, the present research demonstrates that finance tends to convert heterarchical systems into hierarchical ones by quantification through monetary units. (shrink)

Although social ontology (SO) has attracted the attention of scholars in various disciplines, how it is applied to social scientific studies is still under-researched. To tackle this issue, this paper initially considers major streams of research on SO. It then argues that one of the aims of SO in the social sciences is to identify the rhetorical expression of social dynamism. To support this argument, the present study introduces a perspective of performativity and proposes that generic performativity should be identified (...) by social scientists. Finally, such an attempt is demonstrated with reference to the global pursuit of financialization. (shrink)

Introduction: The effect of promoting a physical reaction by the described action is called the action-sentence compatibility effect. It has been verified that physical motion changes depending on the time phase and grammatical expression. However, it is unclear how adverbs and onomatopoeia change motion simulations and subsequent movements.Methods: The subjects were 35 healthy adults. We prepared 20 sentences each, expressing actions related to hands and feet. These were converted into 80 sentences, with the words “Slow” or “Quick” added to the (...) words related to the speed of movement, and 80 sentences with the words “Fast” and onomatopoeia “Satto” added. Additionally, 20 unnatural sentences were prepared for each stimulus set as pseudo sentences. Choice reaction time was adopted; subjects pressed the button with their right hand only when the presented text was correctly understood. The reaction time and the number of errors were recorded and compared.Results: As a result of a two-way repeated ANOVA, an interaction effect was observed in RTs and NoE in set A. “Hand and Fast” had significantly faster RTs than “Hand and Slow” and “Foot and Fast.” Furthermore, “Hand and Fast” had a significantly higher NoE than others. In set B, the main effects were observed in both RTs and NoE. “Hand” and “Satto” had significantly faster RTs than “Foot” and “Quick,” respectively. Additionally, an interaction effect was observed in NoE, wherein “Foot and Satto” was significantly higher than “Hand and Satto” and “Foot and Quick.”Conclusion: In this study, the word “Fast” promoted hand response, reaffirming ACE. The onomatopoeia “Satto” was a word that conveys the speed of movement, but it was suggested that the degree of understanding may be influenced by the body part and the attributes of the subject. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.4 (2003) 26-32 [Access article in PDF] A Sense of Reality In the current highly information-oriented society, electronic media have entered into our daily lives ever so naturally, even unnoticeably, yet their great influence on us is beyond measure. In addition to the many ways that information surrounds us in our everyday lives, we are also exposed to information from outer space via television; (...) computer networks; the surveillance satellite, Landsat; and the weather satellite, Himawari. The means ofunderstanding the "world" no longer come through our own bodies or through immediate involvement with phenomena. Instead, our experience via technologies of information is now mainly indirect. The changes in the [End Page 26] structure of experience have effectuated diverse influences on people, raising problems both within individuals and in society.This essay was written as an introduction to the exhibition "A Sense of Reality," held at the Utsunomiya Museum of Art in the summer of 1999. The purpose of this exhibition was to question the new relationship betweenmedia art and today's society, and the relationship between electronic media and human beings.For this exhibition, based on "sense" and "language," our objective was to examine the transformation of our bodily sensations and the state of "the self," including the changing relations between the two and in the present computerized society. The exhibition has been constructed to have the viewers interact directly with the exhibited works. The works by four artists and two groups cover a wide range of expression, from an installation using a video projector, to digital prints of a virtual space using a computer. Body Absorbed into Media "Lovers," a collaboration by Teiji Furuhashi and Artlab, was first exhibited in 1994 at Hillside Plaza in Tokyo, and has since traveled to various countries. This work can be seen as a work depicting the present state of "information" and "body" with the strongest determination, while also superbly revealing the present-day problems in relation to these. When the viewers entered the virtual space constructed by the electronic media, their living bodies were projected as images. Through intertwining and assimilating sensations both through and about the body, the feeling of merging into an imaginary world at some point creates a sense of bodily unification.This world, originated as a vessel for the "mother of electronics," thatblessed us with "eternal love," was the last device created by Teiji Furuhashi, who had a premonition of his own death. Except for the floor, which was made of white linoleum, the dark space was covered with a black cloth, ten meters in length and width, and six meters in height. A tower-shaped object was installed in the center of the floor. On the tower were video and slide projectors with sensors, which continuously showed the images of nine women and men on the walls and ceiling. The viewers encountered the life-size images that appeared from nowhere, and were compelled to interact with these images. The incidents that took place inside the dark, rectangular space enabled the viewers to actualize various encounters and partings with the images of naked bodies.Though the viewers felt as if they were dreaming or hallucinating, they had an uncanny sensation that the memory of this experience would become manifest deep inside their bodies. "Lovers" was an extraordinary interactive work that fully utilized electronic media, but was uncommon in that the technology was hardly noticeable. This work signified the future state of "the body and media," or "the body absorbed into media." The [End Page 27] work also urged us to recreate a humanistic relationship with the electronic media. Neutral Mind-Body Today, we are surrounded by a variety of electronic media, most of which are beyond the world of art. Many have already become essential devices in our daily lives. The widespread proliferation of electronic media such as video products, CDs, mobile phones, and devices which use information from satellites, have brought about convenient changes in our living environment and in communication. Real-time information, bi-directional information, and other electronic networks circle the globe.Electronic media have... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 37.4 (2003) 26-32 [Access article in PDF] A Sense of Reality In the current highly information-oriented society, electronic media have entered into our daily lives ever so naturally, even unnoticeably, yet their great influence on us is beyond measure. In addition to the many ways that information surrounds us in our everyday lives, we are also exposed to information from outer space via television; (...) computer networks; the surveillance satellite, Landsat; and the weather satellite, Himawari. The means ofunderstanding the "world" no longer come through our own bodies or through immediate involvement with phenomena. Instead, our experience via technologies of information is now mainly indirect. The changes in the [End Page 26] structure of experience have effectuated diverse influences on people, raising problems both within individuals and in society.This essay was written as an introduction to the exhibition "A Sense of Reality," held at the Utsunomiya Museum of Art in the summer of 1999. The purpose of this exhibition was to question the new relationship betweenmedia art and today's society, and the relationship between electronic media and human beings.For this exhibition, based on "sense" and "language," our objective was to examine the transformation of our bodily sensations and the state of "the self," including the changing relations between the two and in the present computerized society. The exhibition has been constructed to have the viewers interact directly with the exhibited works. The works by four artists and two groups cover a wide range of expression, from an installation using a video projector, to digital prints of a virtual space using a computer. Body Absorbed into Media "Lovers," a collaboration by Teiji Furuhashi and Artlab, was first exhibited in 1994 at Hillside Plaza in Tokyo, and has since traveled to various countries. This work can be seen as a work depicting the present state of "information" and "body" with the strongest determination, while also superbly revealing the present-day problems in relation to these. When the viewers entered the virtual space constructed by the electronic media, their living bodies were projected as images. Through intertwining and assimilating sensations both through and about the body, the feeling of merging into an imaginary world at some point creates a sense of bodily unification.This world, originated as a vessel for the "mother of electronics," thatblessed us with "eternal love," was the last device created by Teiji Furuhashi, who had a premonition of his own death. Except for the floor, which was made of white linoleum, the dark space was covered with a black cloth, ten meters in length and width, and six meters in height. A tower-shaped object was installed in the center of the floor. On the tower were video and slide projectors with sensors, which continuously showed the images of nine women and men on the walls and ceiling. The viewers encountered the life-size images that appeared from nowhere, and were compelled to interact with these images. The incidents that took place inside the dark, rectangular space enabled the viewers to actualize various encounters and partings with the images of naked bodies.Though the viewers felt as if they were dreaming or hallucinating, they had an uncanny sensation that the memory of this experience would become manifest deep inside their bodies. "Lovers" was an extraordinary interactive work that fully utilized electronic media, but was uncommon in that the technology was hardly noticeable. This work signified the future state of "the body and media," or "the body absorbed into media." The [End Page 27] work also urged us to recreate a humanistic relationship with the electronic media. Neutral Mind-Body Today, we are surrounded by a variety of electronic media, most of which are beyond the world of art. Many have already become essential devices in our daily lives. The widespread proliferation of electronic media such as video products, CDs, mobile phones, and devices which use information from satellites, have brought about convenient changes in our living environment and in communication. Real-time information, bi-directional information, and other electronic networks circle the globe.Electronic media have... (shrink)

Insulin is synthesized in pancreatic B‐cells of islets of Langerhans. Understanding the mechanisms of action of B‐cytotoxins on pancreatic islets seems to be important for elucidating not only the causes of diabetes mellitus but also its prevention.