Abnormalities in the ability of cells to properly degrade proteins have been identified in many neurodegenerative diseases. Recent work has implicated synaptojanin 1 (SynJ1) in Alzheimer's disease and Parkinson's disease, although the role of this polyphosphoinositide phosphatase in protein degradation has not been thoroughly described. Here, we dissected in vivo the role of SynJ1 in endolysosomal trafficking in zebrafish cone photoreceptors using a SynJ1‐deficient zebrafish mutant, nrca14. We found that loss of SynJ1 leads to specific accumulation of late endosomes and (...) autophagosomes early in photoreceptor development. An analysis of autophagic flux revealed that autophagosomes accumulate because of a defect in maturation. In addition we found an increase in vesicles that are highly enriched for PI(3)P, but negative for an early endosome marker in nrca14 cones. A mutational analysis of SynJ1 enzymatic domains found that activity of the 5'phosphatase, but not the Sac1 domain, is required to rescue both aberrant late endosomes and autophagosomes. Finally, modulating activity of the PI(4,5)P2 regulator, Arf6, rescued the disrupted trafficking pathways in nrca14 cones. Our study describes a specific role for SynJ1 in autophagosomal and endosomal trafficking and provides evidence that PI(4,5)P2 participates in autophagy in a neuronal cell type. -/- . (shrink)

_The Promise of Happiness_ is a provocative cultural critique of the imperative to be happy. It asks what follows when we make our desires and even our own happiness conditional on the happiness of others: “I just want you to be happy”; “I’m happy if you’re happy.” Combining philosophy and feminist cultural studies, Sara Ahmed reveals the affective and moral work performed by the “happiness duty,” the expectation that we will be made happy by taking part in that which (...) is deemed good, and that by being happy ourselves, we will make others happy. Ahmed maintains that happiness is a promise that directs us toward certain life choices and away from others. Happiness is promised to those willing to live their lives in the right way. Ahmed draws on the intellectual history of happiness, from classical accounts of ethics as the good life, through seventeenth-century writings on affect and the passions, eighteenth-century debates on virtue and education, and nineteenth-century utilitarianism. She engages with feminist, antiracist, and queer critics who have shown how happiness is used to justify social oppression, and how challenging oppression causes unhappiness. Reading novels and films including_ Mrs. Dalloway_, _The Well of Loneliness_, _Bend It Like Beckham_, and _Children of Men_, Ahmed considers the plight of the figures who challenge and are challenged by the attribution of happiness to particular objects or social ideals: the feminist killjoy, the unhappy queer, the angry black woman, and the melancholic migrant. Through her readings she raises critical questions about the moral order imposed by the injunction to be happy. (shrink)

A welcome addition to the Routledge Critical Thinkers series, Judith Butler is the first guidebook on this renowned feminist and queer theory scholar, which will help not only students of literary criticism but also students of law, sociology, philosophy, film and cultural studies. Examining Butler's work through a variety of contexts, including the formation of gender performativity, identity and subjecthood, Sarah Salih address Butler's crucial ideas on the gender agenda, the body, pornography, race, gay self-expression and power and psychoanalysis. Concluding (...) with an annotated bibliography, this book will be the ideal starting point for all new to Butler. (shrink)

Violating the human status : the evil of genocide and crimes against humanity -- Superfluous humanity : the evil of global poverty -- Citizens of nowhere : the evil of statelessness -- Effacing the political : the evil of neoliberal globalization.

What is philosophy of education? This question has been answered in as many ways as there are those who self-identify as philosophers of education. However, the questions our field asks and the research conducted to answer them often produce papers, essays, and manuscripts that we can read, evaluate, and ponder. This paper turns to those tangible products of our scholarly activities. The titles, abstracts, and keywords from every article published from 2000 to 2010 in four journals of educational philosophy were (...) analyzed to find out what kind of research is being published in the field of philosophy of education. Over 143 different concepts were identified and analyzed from 1,572 articles. The data suggests that philosophy and education, while primarily concerned with theory, teaching, and learning, tackles a diversity of subjects in a slightly narrowing band of thematic topics. (shrink)

Decolonial/anti-colonial Black, Indigenous and Mestiza feminist movements and scholar-activists foreground how the oft-touted apocalypse that the Covid-19 pandemic heralds is not new, nor does it signify the great rupture into chaos that those from within modernity-coloniality often claim it to be. Rather Covid-19 is preceded by and will be out-lived by the apocalyptic anti-life onto-epistemological logics that are foundational to the production of hetero-patriarchal capitalist- coloniality. However, one would commit the violence of reproduction of the epistemological logics and rationalities constitutive (...) of the current system if the story ended there. We have survived and our survival points to the urgent necessity and responsibility of social theory to listen to the story of the pandemic from a Black/Indigenous genealogy and to begin the sense-making of the Covid-19 pandemic, from prior to this particular virus, outside, against and beyond the politics of knowledge of critical social theory itself. Thus, I invite you to journey to an affirmative re-enfleshment of reason and theory-making in relation to and dialogue with Black, Indigenous, and subaltern Mestiza feminist movements in southwest Colombia and in southeast so-called Australia in the unceded lands of the Awabakal and the Worimi. I explore this through the metaphor, the materiality, the cosmology and the herstory of the mangrove swamps a knowing-being otherwise visible to the dehumanising gave of Whiteness and bring to thought three stories of a politics of knowledge of/as the Black/racialised and feminised body/flesh. To do this is to suggest that the co-creation of pathways which are life affirming and life making beyond and out of the post-Covid 19 conjuncture involves an epistemological-political project which decolonises and feminises the containments of reason and knowing being of coloniality/modernity. (shrink)

A relation between two secrets, known in the literature as nondeducibility , was originally introduced by Sutherland. We extend it to a relation between sets of secrets that we call independence . This paper proposes a formal logical system for the independence relation, proves the completeness of the system with respect to a semantics of secrets, and shows that all axioms of the system are logically independent.

The Philosophy of Human Rights brings together an extensive collection of classical and contemporary writings on the topic of human rights, including genocide, ethnic cleansing, minority cultures, gay and lesbian rights, and the environment, providing an exceptionally comprehensive introduction. Sources include authors such as Aristotle, Cicero, Thomas Aquinas, Confucius, Hobbes, Locke, rant. Marx, Gandhi. Hart, Feinberg, Nussbaum, the Dalai Lama, Derrida, Lyocard and Rorty. Ideal for courses in human rights, social theory, ethical theory, and political science, each reading; begins with (...) a brief introduction, and is followed with study questions and suggested further readings. (shrink)

The article proposes Logic of Secrets in Collaboration Networks, a formal logical system for reasoning about a set of secrets established over a fixed configuration of communication channels. The system’s key feature, a multi-channel relation called independence, is a generalization of a two-channel relation known in the literature as nondeducibility. The main result is the completeness of the proposed system with respect to a semantics of secrets.

Cosmopolitan education aims to transmit cosmopolitan forms of life in order to participate morally in the world community. The primary characteristics of this cosmopolitan education are its acceptance of the shared humanity of all persons as a fact of human existence and as a motivating guide for human interaction, and the requirement of democratic inclusion in deliberations of the governance of those interactions, including morality. Such an education in cosmopolitan morality requires means that befit its core components. This paper contrasts (...) the concepts of strict and moderate cosmopolitanism, empirical and deliberative morality, and structural and dispositional cosmopolitanism to show that the moderate, inclusive and deliberative processes of deliberative dispositional cosmopolitanism are more suited to cosmopolitan education in morality than strong, empirical-focused structural cosmopolitan efforts. Though strong, structural and empirically based forms may be more likely to guarantee preferred outcomes in the learning of specific morals or the implementation of institutional norms, they are also more likely to run afoul of the core components of cosmopolitanism because they will privilege outcomes over processes, and are thus more likely to be less inclusive and more coercive. In contrast, and even though they are less certain to guarantee preferred moral outcomes or actions, moderate, deliberative dispositional forms of cosmopolitan education embody the morality they seek to inform, and are more likely to find sustained internalised support over time. (shrink)

Cosmopolitan education aims to transmit cosmopolitan forms of life in order to participate morally in the world community. The primary characteristics of this cosmopolitan education are its acceptance of the shared humanity of all persons as a fact of human existence and as a motivating guide for human interaction, and the requirement of democratic inclusion in deliberations of the governance of those interactions, including morality. Such an education in cosmopolitan morality requires means that befit its core components. This paper contrasts (...) the concepts of strict and moderate cosmopolitanism, empirical and deliberative morality, and structural and dispositional cosmopolitanism to show that the moderate, inclusive and deliberative processes of deliberative dispositional cosmopolitanism are more suited to cosmopolitan education in morality than strong, empirical-focused structural cosmopolitan efforts. Though strong, structural and empirically based forms may be more likely to guarantee preferred outcomes in the learning of specific morals or the implementation of institutional norms, they are also more likely to run afoul of the core components of cosmopolitanism because they will privilege outcomes over processes, and are thus more likely to be less inclusive and more coercive. In contrast, and even though they are less certain to guarantee preferred moral outcomes or actions, moderate, deliberative dispositional forms of cosmopolitan education embody the morality they seek to inform, and are more likely to find sustained internalised support over time. (shrink)

Political friendship is typically portrayed as a dyadic relationship. In this traditional model, friendship is conceived as a positive intersubjective experience of relation-to-self and relation-to-other, assuming the reciprocity and equality characteristic of symmetrical relations of recognition. This essay explores an alternative, triadic model of political friendship, suggested by the work of Hannah Arendt. Arendt makes the claim, at odds with most modern accounts, that “politics is not so much about human beings as it is about the world that comes into (...) being between them and endures beyond them.” I suggest that the dyadic model of political friendship is incomplete; a more adequate paradigm would foreground triadic relations of interest, concern and care for the phenomenal world itself, conceived as the quasi-objective intermediary of human artifice. As a “public thing,” a shared world is a necessary condition for intersubjective friendship and therefore is deserving of a properly political mo.. (shrink)

Hannah Arendt is one of the most prominent thinkers of modern times, whose profound influence extends across philosophy, politics, law, history, international relations, sociology, and literature. Presenting new and powerful ways to think about human freedom and responsibility, Arendt's work has provoked intense debate and controversy. 'Hannah Arendt: Key Concepts' explores the central ideas of Arendt's thought, such as freedom, action, power, judgement, evil, forgiveness and the social. Bringing together an international team of contributors, the essays provide lucid accounts of (...) Arendt's fundamental themes and their ethical and political implications. The specific concepts Arendt deployed to make sense of the human condition, the phenomena of political violence, terror and totalitarianism, and the prospects of sustaining a shared public world are all examined. 'Hannah Arendt: Key Concepts' consolidates the disparate strands of Arendt's thought to provide an accessible and essential guide for anybody who wishes to gain a deeper understanding of this leading intellectual figure. (shrink)

Jones (1991) has proposed an issue-contingent model of ethical decision making by individuals in organizations. The distinguishing feature of the issue was identified as its moral intensity, which determines the moral imperative in the situation. In this study, we adapted three scenarios from the literature in order to examine the issue-contingent model. Findings, based on a student sample, suggest that (1) the perceived and actual dimensions of moral intensity often differed; (2) perceived moral intensity variables, in the aggregate, significantly affected (...) an individual''s moral judgments; and (3) some dimensions of moral intensity (namely, perceived social consensus and perceived magnitude of consequences) mattered more than others. (shrink)

BACKGROUND: Serotonin transporter promoter genotype appears to increase risk for depression in the context of stressful life events. However, the effects of this genotype on measures of stress sensitivity are poorly understood. Therefore, this study examined whether 5-HTTLPR genotype was associated with negative information processing biases in early childhood. METHOD: Thirty-nine unselected seven-year-old children completed a negative mood induction procedure and a Self-Referent Encoding Task designed to measure positive and negative schematic processing. Children were also genotyped for the 5-HTTLPR gene. (...) RESULTS: Children who were homozygous for the short allele of the 5-HTTLPR gene showed greater negative schematic processing following a negative mood prime than those with other genotypes. 5-HTTLPR genotype was not significantly associated with positive schematic processing. LIMITATIONS: The sample size for this study was small. We did not analyze more recently reported variants of the 5-HTTLPR long alleles. CONCLUSIONS: 5-HTTLPR genotype is associated with negative information processing styles following a negative mood prime in a non-clinical sample of young children. Such cognitive styles are thought to be activated in response to stressful life events, leading to depressive symptoms; thus, cognitive styles may index the "stress-sensitivity" conferred by this genotype. (shrink)

The model of feminism as humanist in practice and postmodern in theory is inadequate. Feminist practice and theory directly inform each other to displace both humanist and postmodern conceptions of the subject. An examination of feminism's use of rights discourse suggests that feminist practice questions the humanist conception of the subject as a self-identity. Likewise, feminist theory undermines the postmodern emphasis on the constitutive instability and indeterminacy of the subject.

Cet article expose une analyse sémique d’un ensemble de mots, diffusé par le biais du discours religieux, censé présenter une définition des « non-musulmans ». Il s’agit, essentiellement, de montrer en quoi des mots (polythéiste, idolâtre, mécréant, athée, protégé, Nazaréens, chrétiens, Juifs, égaré), figurant dans le discours d’un prédicateur musulman, façonnent, d’une manière systémique, des images, des imaginaires, et peuvent potentiellement véhiculer une représentation altérée de l’Autre. Ces occurrences, généralement spécifiques à un balisage exégétique ou canonique, débordent de leurs contextes (...) et s’utilisent comme concepts génériques dans la prédication contemporaine. En circulation sur le Web et employés hors de leur contexte historique, ces discours sur l’Altérité, révèlent l’ambiguïté qu’engendre une assimilation d’un ensemble de mots, sémantiquement différents, sous l’hyperonyme de « non-musulmans ». (shrink)

Se reflexiona sobre la reprobabilidad moral de la Gestación por Sustitución a través del debate en torno a la autonomía de la gestante y los derechos reproductivos. En primer lugar, se contrastan las posturas liberal y feminista en países del Norte. Asimismo, se consideran las implicaciones para el debate de los intereses económicos de la industria de las Nuevas Técnicas de Reproducción Humana Asistida. Por último, se examina el fenómeno desde una perspectiva transnacional a través de un análisis interseccional y (...) teniendo en cuenta los estudios etnográficos realizados por investigadoras en la India y sus implicaciones para el debate. (shrink)

La Antropología filosófica es el ámbito que enmarca el tema que convoca esta presentación. En el terreno filosófico el marco teórico se apoya, primeramente, en el pensamiento de Nietzsche teniendo en cuenta el estatuto que asigna al cuerpo. En segundo lugar, Rancière ofrece aportes en lo que se refiere a la relación polémica entre lo representable y lo irrepresentable. En tercer término, la guía es proporcionada por la crítica cultural de Walter Benjamin, quien procura revelar la influencia del cine en (...) la masa que puede verse a sí misma en la pantalla. Desplazo el tratamiento del cine como recurso útil al plano educativo. Con este fin escojo escenas fílmicas donde intento aplicar las categorías y las determinaciones analizadas para ofrecerlas como herramienta de reflexión sobre la condición humana. (shrink)

In their 2010 article ‘Research Integrity in China: Problems and Prospects’, Zeng and Resnik challenge others to engage in empirical research on research integrity in China. Here we respond to that call in three ways: first, we provide updates to their analysis of regulations and allegations of scientific misconduct; second, we report on two surveys conducted in Hong Kong that provide empirical backing to describe ways in which problems and prospects that Zeng and Resnik identify are being explored; and third, (...) we continue the discussion started by Zeng and Resnik, pointing to ways in which China's high‐profile participation in international academic research presents concerns about research integrity. According to our research, based upon searches of both English and Chinese language literature and policies, and two surveys conducted in Hong Kong, academic faculty and research post‐graduate students in Hong Kong are aware of and have a positive attitude towards responsible conduct of research. Although Hong Kong is but one small part of China, we present this research as a response to concerns Zeng and Resnik introduce and as a call for a continued conversation. (shrink)

France’s 35-hour workweek is one of the boldest progressive reforms in recent years. Drawing on existing survey and economic data, supplemented by interviews with French informants, this article examines the 35-hour week’s evolution and impacts. Although commonly dismissed as economically uncompetitive, the policy package succeeded in avoiding significant labor-cost increases for business. Most 35-hour employees cite quality-of-life improvements despite the fact that wage moderation, greater variability in schedules, and intensification of work negatively impacted some—mostly lower-paid and less-skilled—workers. Taking into account (...) employment gains, the initiative can be considered a qualified success in meeting its main aims. (shrink)

Some philosophers in recent discussions concerned with current ecological crises have attempted to address and sometimes to utilize poststructuralist thought. Yet few of their studies have delineated the ecological orientation of a specific poststructuralist. In this paper, I provide a discussion of the naturalistic ontology embraced by the contemporary French philosopher Gilles Deleuze, one of the most significant voices in poststructuralism. I interpret Deleuze as holding an ecologically informed perspective that emphasizes the human place within nature while encouraging awareness of (...) and respect for the differences of interconnected life on the planet. I also suggest that this view may be joined with Deleuze’s innovative ethical-political approach, which he refers to as micropolitics, to create new ways of thinking and feeling that support social and political transformation with respect to the flourishing of ecological diversity. Finally, I briefly show how Deleuze’s ecological orientation compares to several versions of ecological theory and politics. (shrink)

SummaryIn this article, I seek to develop a genetic/diachronic approach to the phenomenon of authorial revision, and to the interpretation of texts that exist in multiple versions. In all such cases, the reconstruction of textual meaning cannot be separated from the reconstruction of the process through which the text in its ‘final’ form came into being; furthermore, an understanding of the author's intentions in (re)writing cannot be entirely separated from an understanding of his/her motives for (re)writing. This article is divided (...) into three sections. In the first section, I consider recent trends in editorial and literary theory that aim at characterising texts in terms of processes rather than products, in order to uphold the equal dignity of each version without losing sight of its connectedness to other stages in the history of the text. In the second section, I discuss how Quentin Skinner's views on meaning and context apply to cases of authorial revision, and I suggest that some key aspects of Skinner's contextualism need to be reconsidered. In the concluding section, I focus on a case study in order to demonstrate the operational value of such a genetic and motive-based approach to authorial revision: more particularly, I seek to show how a close examination of Jean Bodin's rewriting practices in the Methodus (1566–1572) and the République (1576) can throw new light on his shift from a concept of limited sovereignty to one of absolute sovereignty. (shrink)

In 2011, Ingmar Riedel‐Kruse's bioengineering laboratory at Stanford University publicized an application that uses paramecia for what the researchers termed “biotic games.” These games make use of living organisms, computer programs, and lab equipment to implement games like Pong, Pac‐man, and soccer. Gamesand related activities are often considered nonserious or trivial, whereas life, biological systems, and science are treated very seriously in moral analysis and public perception. The manipulation of living matter frequently engenders at least some controversy in the marketplace (...) of ideas, and using living things in games is no exception. Some of the objections lodged against biotic games have appeared in the ethics literature on similar topics; however, the addition of an entertainment element introduces some objections distinct from those about similar cases, as the online comments vividly illustrate. We aim to explore and address the objections in this paper, using the comments to organize and launch the discussion. In scientific work, there is typically a presumption of some prospect of translation and application of generated knowledge for public benefit. In the case of biotic games, these applications are not self‐evident. Because of this, a serious analysis of the justifications, limitations, and features of biotic games is warranted. To this end, we outline key ethical limits that ought to be placed on these activities as well as the obligations that these activities generate for researchers, other professionals, and lay people who design, implement, use, and play them. (shrink)

Taking a cue from the appalling incidents of September 2001, these essays explore the ostensible reasons behind the American war on terrorism, apologize for the pre-emptive nature of the war itself and address the concept of terrorism in the moral discourse of humanity.

This article revisits John Wilson’s “first steps” in moral education—a conceptual analysis of morality—and what he calls an education in morality. Education in morality focuses on morality as a form of life with a specific domain in which it aims to initiate students, and on education as a growth-oriented, progressive activity. Arendt’s conception of natality in education is then used to show how it provides a catalyst for growth, discovery, and tradition-trumping newness, and acts as a stepping-stone to public action (...) as morality and recognition of the plurality of human life. It becomes clear that the inherent sociability of morality forces the consideration of it as a public and social act. Education in morality must preserve the potential for the capacity to contribute to the development of morality and concurrently develop that capacity through the production of plurality that follows and the negotiations necessary for its preservation. Morality, then, must not be taught as a static set of immutable principles, but rather as an inclusive, adaptive process by and through which groups govern their associations. (shrink)