A structural similarity between deflationism and a certain semantically excessive interpretation of the results of cognitive science is developed. Both views incorporate "two-worlds" accounts of the nature of representation. But two-worlds accounts are committed to what I call quasi-technically “the worst possible theory of truth”. This renders the semantically excessive interpretation committed to the worst possible theory of truth; but it renders deflationism internally inconsistent or incoherent.

Is understanding epistemic in nature? Does a correct account of what constitutes understanding of a concept mention epistemological notions such as knowledge, justification or epistemic rationality? We defend the view that understanding is epistemic in nature – we defend epistemological conceptions of understanding. We focus our discussion with a critical evaluation of Tim Williamson's challenges to epistemological conceptions of understanding in The Philosophy of Philosophy. Against Williamson, we distinguish three kinds of epistemological conceptions and argue that Williamson's arguments succeed against (...) only the most heavily committed kind, and leave the less heavily committed kinds untouched. Further, we argue that Williamson's elaboration of lessons from his arguments point in a direction opposite of his own conclusions and give vivid articulation and support to epistemological conceptions. We suggest also that skepticism about Williamson's larger metaphilosophical conclusions – according to which understanding plays no special role in the epistemology of philosophy – may be in order. (shrink)

Recently, philosophers have put forth views in the epistemology of disagreement that emphasize the epistemic relevance of the first-person perspective in disa- greement. In the first part of the paper, I attempt a rational reconstruction of these views. I construe these views as invoking the first-person perspective to explain why it is rational for parties to a disagreement to privilege their own opinions in the absence of independent explanations for doing so—to privilege without independent explanations. I reconstruct three ways privilege (...) might be thought to arise: by demotion, through self-trust, and through the epistemic immediacy in the first-person perspective. I argue that none of these ways, and none of the views that make use of them, clarify a compelling account of the epistemic relevance of the first-person perspective. In the second part of the paper, I try to discern some lessons and outline an alternative approach. According to this approach, the epistemic relevance of the first-person perspective is not to explain privilege without independent explanations but to explain the epistemic limits of intersubjective understanding. These limits are manifest in reflective disagreement and explain how other minds matter for one’s own mind in the pursuit of knowledge. The resulting view about the epistemology of disagreement is neither skeptical nor dogmatic, but dialectical, involving an active mental state that conceptualizes not only the subject matter but also one’s own and others’ minds in thinking and rational interaction at the epistemic limits of intersubjective understanding. (shrink)

Is knowledge of language a kind of knowledge-that or knowledge-how? Michael Devitt’s Ignorance of Language argues that knowledge of language is a kind of knowledge-how. Devitt’s account of knowledge of language is embedded in a more general account of the nature of language as grounded in thought. The paper argues that Devitt’s view is inconsistent when thought is understood in an externalist or anti-individualist way. A key phenomenon in externalist thought experiments is the possibility of incomplete or mistaken understanding, and (...) its correction. This phenomenon is exhibited in our knowledge of language. Expanding on some brief remarks by Chomsky, it is argued that speakers display incomplete understanding in making mistakes in linguistic judgrnents. These mistakes can be irnproved through reflection on cases. In this process of mistake, reflection, and correction, speakers’ knowledge of language remains stable despite the change in linguistic judgments. This stable knowledge of language cannot be understood as kind of knowledge-how, without making the rational efficacy of reflection a constitutive feature of knowledge-how. But to do this is to obliterate the distinction between knowledge-how and knowledge-that. The conclusion is that if externalism about thought is accepted, then the knowledge in language is a kind of knowledge-that. (shrink)

Does the epistemology of disagreement have significant consequences for theories of conceptual understanding? I argue that it does. I argue that the epistemology of disagreement manifests the existence of a special kind of concept, perspectival modes of metarepresentation, a kind of concept instances of which figure in the thinking about thoughts that occurs in deep disagreement. These perspectival modes of metarepresentation are de re modes of presentation of thoughts themselves – hence de re modes of metarepresentation – in which one (...) and the same thought is presented to higher‐order thinking about thoughts in different ways. These modes or ways are de re and perspectival because they are individuated by facts about whether the thought being thought about is the grasped or understood propositional object of one's own or another's thinking. I outline a broadly Fregean framework for theorizing conceptual understanding and draw out three significant consequences of the existence of perspectival modes of metarepresentation for theories of conceptual understanding: they (1) constitute a new philosophical motivation for a restricted fragment of what Terence Parsons calls a “libertine” hierarchy of Fregean sense; (2) provide, against David Chalmers, examples of a priori equivalences that are nevertheless cognitively significant; and (3) constitute a novel and pervasive example of Kripkean ‘Paderewski’‐type designators. (shrink)

What is the cognitive value of the concept of truth? What epistemic difference does the concept of truth make to those who grasp it? This paper employs a new perspective for thinking about the concept of truth and recent debates concerning it, organized around the question of the cognitive value of the concept of truth. The paper aims to defend a substantively correct and dialectically optimal account of the cognitive value of the concept of truth. This perspective is employed in (...) understanding the critical discussion around what Hartry Field has called “the incorporation model” for extending a deflationary view of truth to foreign sentences. Field's original intentions in discussing the incorporation model were to defend the deflationary view from some counterintuitive consequences concerning the understanding of truth attributions to foreign sentences. However, more recently, philosophers unencumbered by deflationary commitments have taken over the incorporation model for their own inflationary purposes. In particular, and in my terms, these philosophers can be understood as making what I argue is the ultimately too radical suggestion that the cognitive value of the concept of truth is to allow the incorporation not only of the linguistically foreign, but also of the conceptually alien. I clarify this dialectic en route to explaining and arguing for the cognitive inflationary view, according to which the cognitive value of the concept of truth is is to make possible the proprietary kind and quality of knowledge allowed by reflective clarity over the concepts and thoughts that one already has. (shrink)

Emmanuel Lévinas (1906-1995) zählt nicht nur zu den wichtigsten Ethikern im 20. Jahrhundert. Vor allem entwirft er einen anderen Anfang der Ethik, die nicht auf der gesellschaftlichen Ebene oder als grosse Idee und Erzählung entsteht. Ethik entspringt vielmehr in der konkreten Zwischenmenschlichkeit, wenn man vom Anderen in die Verantwortung gerufen wird - und zwar durch die Verletzlichkeit seines nackten Gesichtes wie durch die Anrede. Die ethische Beziehung verdankt sich dabei nicht etwa der Gleichheit, der Nähe oder der Geschwisterlichkeit, sondern der (...) Andersheit des Anderen, seiner Ferne und vor allem seiner Fremdheit, die sich nicht hintergehen lassen. Damit gründet Lévinas die Gesellschaft nicht nur auf die Zwischenmenschlichkeit, sondern auch auf die Pluralität. So wenig wie die Ethik universelle Ansprüche erheben kann, lässt sich Gerechtigkeit als ein allgemeines Prinzip entwerfen. Vielmehr muss sie den Individuen in deren unendlicher Andersheit gerecht werden. In dieser Unendlichkeit blitzt im nackten Gesicht das Antlitz Gottes auf, denkt Lévinas aus der jüdischen Tradition heraus. Das lässt sich auch rein säkular verstehen, dass alle Menschen anders sind. Sie als Gleiche zu behandeln, unterwirft sie totalen politischen Ansprüchen, macht sie zu gehorsamen Untertanen. In Auseinandersetzung mit Sartre entwickelt Lévinas eine individualistische Ethik der Verantwortung, die jeden Menschen betrifft, indem sie aus der Zwischenmenschlichkeit heraus die Mündigkeit konstituiert. So verfolgt der Einzelne nicht primär seine Interessen, sondern übernimmt Verantwortung für den Anderen: Die Wende der Ethik im 20. Jahrhundert - von Sartre, de Beauvoir und Lacan inspiriert, von Derrida und Butler fortgeschrieben, bestehen zudem Parallelen zu Arendt und Foucault. (shrink)

According to the Relational View of Propositional Attitude Reports (‘Relational View of Reports’, for short), attitude reports report thinkers as standing in cognitive relations to propositions. One difficult question for the view is: What is the nature of the cognitive relation(s) thinkers stand in to propositions in having propositional attitudes? One promise of The Measure Theory of Mind (sometimes, ‘The Measure Theory’ or ‘Measure Theory’ for short) is that it can avoid having to answer this question by allowing attitude reports (...) to be relational in form without taking the atti- tudes themselves to be relational, and a fortiori without taking propositional attitudes to involve any cognitive relation to propositions. This paper argues that if the propositional attitudes are conceived of in a robust way that emphasizes their normative and perspectival aspects, then this promise of The Measure Theory cannot be realized. If there is a viable Measure Theory for mind conceived of in these robust terms, it must incorporate, rather than dismiss, the notion of a cognitive relation to a proposition. (shrink)

Kit Fine (2007) outlines an account of semantic coordination, an account motivated by the role of semantic coordination in cognition. Actually, Fine outlines two accounts of semantic coordination, one in terms of co-reference and another in terms of synonymy. I argue, first, that Fine's two accounts are not equivalent, with one being logically stronger than the other, but second and more importantly, that neither account is correct. I outline an alternative account of semantic coordination – the epistemic conception of semantic (...) coordination – that links semantic and epistemic aspects of cognition more directly. The most surprising result of my alternative account of semantic coordination is that semantic coordination is a relation that can hold between elements of thought and language of different semantic types. I close the paper by briefly outlining some applications of the idea that semantic coordination is a relation that can hold across semantic types. (shrink)

Mates’s Puzzle has flown below many philosophers’ radar, despite its relations to both Frege’s Puzzle and the Paradox of Analysis. We explain the relations amongst these puzzles on the way to arguing that Mates’s Puzzle suggests a generalization of Frege’s Puzzle, and of the sense-reference distinction itself, in the form of hierarchy of senses. We explain how Mates’s Puzzle and the hierarchy, to different degrees, illuminate each other, and how their connection is missed in the literature. However, we argue that (...) the potential of Mates’s Puzzle to illuminate the hierarchy is yet to be fully actualised. We suggest that in order to do better, we need to formulate Mates’s Puzzle as a puzzle in the philosophy of thought and not as puzzle in the philosophy of language. What is needed, to which the present paper is a precursor, is an account of the cognitive significance of higher-order senses. (shrink)

Quine’s arguments in the final two sections of “Two Dogmas of Empiricism” bring semantic and epistemic concerns into spectacular collision. Many have thought that the arguments succeed in irreparably smashing a conception of a distinctively analytic and a priori philosophy to pieces. In Constructing the World, David Chalmers argues that much of this distinctively analytical and a priori conception of philosophy can be reconstructed, with Quine’s criticisms leaving little lasting damage. I agree with Chalmers that Quine’s arguments do not have (...) the lasting damage some take them to have. However, I do not think that Chalmers has succeeded in explaining why. The core of Chalmers’s error lies in the rational dispositionalism that forms the metasemantics of his Carnapian intensionalism. Responding to Quine requires recognizing conceptions of both concepts and epistemic normativity that go beyond the opposition between irrationality and conceptual change that Chalmers brings to bear on Quine. I explain this expanded conception of concepts and epistemic normativity in terms of another fundamental aim of Constructing the World, namely that of providing an account of Fregean sense, or more generally of defending what Chalmers calls epistemological semantics. (shrink)

Is relativism a coherent thesis? The paper argues for a new view of relativism that opposes both classic and contemporary views. On this view, the thesis of relativism is coherent even if the key notions in the standard apparatus of relativism—of alternative conceptual schemes, relative truth, perspectival content—are all incoherent. The view defended here highlights issues about attitude attribution and explanation in formulating the thesis of relativism and it proposes a surprising connection between relativism and nonsense. The paper argues further (...) that the thesis of relativism, so understood, is coherent, by considering different accounts of the semantics of attitude attributions in their application to the attribution of nonsensical thinking. (shrink)

In The City of God , XI, 10, St Augustine claims that the divine nature is simple because ‘it is what it has’ . We may take this as a slogan for the Doctrine of Divine Simplicity , a doctrine which finds its way into orthodox medieval Christian theological speculation. Like the doctrine of God's timeless eternality, the DDS has seemed obvious and pious to many, and incoherent, misguided, and repugnant to others. Unlike the doctrine of God's timeless eternality, the (...) DDS has received very little critical attention. The DDS did not originate with Augustine, but I am not primarily concerned with its pedigree. Nor am I concerned to ask how the doctrine interacts with trinitarian speculation. I will have my hands full as it is. In Section I of this paper I shall provide a rough characterization of the DDS, indicate its complexity, and focus on a particular aspect of the doctrine which will exercise us in the remainder of the paper, namely, the thesis that the divine attributes are all identical with each other and with God. In section n I shall discuss Alvin Plantinga's recent objections to Aquinas' version of the DDS. I shall then offer a more detailed presentation of what I take to be Aquinas' version , and recast it in terms of a theory of attributes which is significantly different from Plantinga's . Although the recasting of the doctrine will enable me to rebut Plantinga's objections , it by no means solves all the problems of the DDS. In section vi I shall discuss the chief lingering problem facing a defender of the DDS. (shrink)

The 2023 doctors’ strikes in the UK have elicited a familiar moral outcry that such strikes are morally wrong. We consider five arguments that might be thought to show doctors’ strikes are morally impermissible but show that they all fail. The most we can conclude from such arguments is that doctors’ strikes are morally permissible in a narrower range of circumstances than strikes in other sectors.We then outline two independent but compatible justifications for doctors’ strikes, one that appeals to doctors’ (...) interests in fair pay and working conditions and one that appeals to doctors’ duty to protect public health. We also suggest that doctors’ strikes can be supererogatory when they aim to correct a government failing in its own duty to protect public health. Finally, we assess the 2023 UK doctors’ strikes. We conclude that they are justified and there is a case for considering them supererogatory. (shrink)

Generative AI programs can produce high-quality written and visual content that may be used for good or ill. We argue that a credit–blame asymmetry arises for assigning responsibility for these outputs and discuss urgent ethical and policy implications focused on large-scale language models.

Down Girl is a broad, original, and far ranging analysis of what misogyny really is, how it works, its purpose, and how to fight it. The philosopher Kate Manne argues that modern society's failure to recognize women's full humanity and autonomy is not actually the problem. She argues instead that it is women's manifestations of human capacities -- autonomy, agency, political engagement -- is what engenders misogynist hostility.

Significant issues remain for understanding and evaluating the Quinean critique of the analytic/synthetic distinction. These issues are highlighted in a puzzling mismatch between the common philosophical attitude toward the critique and its broader intellectual legacy. A discussion of this mismatch sets the larger context for criticism of a recent tradition of interpretation of the critique. I argue that this tradition confuses the roles and relative importance of indeterminacy, a priority, and analyticity in the Quinean critique.

I defend the non-cognitivist outlook on knowledge of grammar from the criticisms levelled against it by Jonathan Knowles. The first part of the paper is largely critical. First, I argue that Knowles's argument against Christopher Peacocke and Martin Davies's non-cognitivist account of the psychological reality of grammar fails, and thus that no reason has been given to think that cognitivism is integral to an understanding of Chomskyan theoretical linguistics. Second, I argue that cognitivism is philosophically problematic. In particular, I argue (...) (a) that Knowles misunderstands Stephen Stich and Gareth Evans's points about inferential integration; and (b) that Knowles misunderstands the philosophical status and demands of Evans's Generality Constraint. In the final, non-critical part of the paper, I try to show that the Stich and Evans's constraints, together with a Self-Knowledge Constraint, are genuine constitutive constraints by showing how they have rationality as their underlying organizing principle. I argue further that recognizing the constitutive character of these constraints allows one to distinguish two kinds of psychological explanation; in this sense, the constraints mark a genuine boundary in our theorizing about the mind. (shrink)

The science underlying global warming, climate change, and the connections between these phenomena are reviewed. Projected future climate changes under various plausible scenarios of future human behavior are explored, as are the potential impacts of projected climate changes on society, ecosystems, and our environment. The economic, security, and ethical considerations relevant to determining the threat posed by climate change are subsequently assessed. The article then discusses the various means available for climate change mitigation, focusing on the relative strengths and weaknesses (...) of various societal alternatives including ‘geoengineering’ and transitioning to less carbon intensive energy sources. The article concludes with the author's views as to what steps might most profitably be taken to avert dangerous anthropogenic interference with Earth's climate, and the ramifications if such steps are not taken. (shrink)

In a time of genetic editing, global warming, and a worldwide pandemic, the question of how freely science is and should be conducted is one that has significant practical consequences. Drawing on rigorous interdisciplinary methods, this book develops a model of scientific freedom as a human right.

This paper analyzes the concept of truth in terms of an account of Fregean sense as cognitive value. The account highlights the importance of understanding-based knowledge of co-reference for the individuation of senses. Explicit truth attributions, like ‘that I smell the scent of violets is true’ involve an inter-level version of understanding-based knowledge of co-reference in the that-clause concepts of thoughts that they employ: one cannot understand the that-clause concept of the thought in the truth attribution without understanding the thought (...) the that-clause concept is a concept of. This is not a redundancy that eliminates or deflates cognitive value, but an exploitation, by the concept of truth, of the inter-level version of understanding-based knowledge of co-reference in critical reflective thinking. The cognitive value of the concept of truth is to combine semantically with explicit ways of thinking of thoughts to make critical reflective thinking possible. This account of the cognitive value of the concept of truth assigns cognitive value not by construing the concept of truth as a way of thinking about some thing, but by articulating its broader cognitive role. (shrink)

The thought that truth is valuable for its own sake is obvious, yet difficult to explicate in a precise and vindicating way. The paper tries to explicate and vindicate this thought with an argument for the conclusion that truth is an epistemic value. Truth is an epistemic value in the sense that a commitment to the value of truth plays a role in the justification and explanation of a fundamental aspect of our epistemic practice, namely, critical reflection. The paper also (...) argues that this feature of truth is inconsistent with deflationary accounts of truth. The ideas are set against the backdrop of criticism of some recent work by Paul Horwich. (shrink)

My discussion of the prospects for a contemporary republicanism will revolve around, primarily, Philip Pettit’s Republicanism and, secondarily, Jürgen Habermas’s The Structural Transformation of the Public Sphere. Pettit and Habermas may be understood as describing how the conceptions of certain central concepts in political philosophy, in particular, conceptions expressing ideals associated with the republican tradition, were transformed with the expansion of the citizenry in the late eighteenth and early nineteenth centuries. Their interest in the matter is more than historical. For (...) both Pettit and Habermas, the pre-transformation world espoused attractive ideals which were lost in the post-transformation world, and indeed are lost in our contemporary world. Beyond their historical interest is a concern for the viability of reinstating republican conceptions of those ideals in our contemporary political culture. (shrink)

The connection between theories of truth and meaning is explored. Theories of truth and meaning are connected in a way such that differences in the conception of what it is for a sentence to be true are engendered by differences in the conception of how meanings depend on each other, and on a base of underlying facts. It is argued that this view is common ground between Davidson and Dummett, and that their dispute over realism is really a dispute in (...) the theory of meaning over holism and molecularism. The view offered is contrasted with influential pragmatist and modest views. (shrink)

Different ideas of the normative relevance of autonomy can give rise to profoundly different action-guiding principles in healthcare. If autonomy is seen as a value rather than as a right, it can be argued that patients’ decisions should sometimes be overruled in order to protect or promote their own autonomy. We refer to this as paternalism in the name of autonomy. In this paper, we discuss different elements of autonomy (decision-making capacity, efficiency, and authenticity) and arguments in favor of paternalism (...) for the sake of autonomy that have been proposed in the bioethical debate. We argue that if autonomy is valuable, then paternalism for the sake of autonomy may be justified. However, policies allowing paternalism in the name of autonomy may be self-defeating. (shrink)

Recent advances in medical and information technologies, the availability of new types of medical data, the requirement of increasing numbers of study participants, as well as difficulties in recruitment and retention, all present serious problems for traditional models of specific and informed consent to medical research. However, these advances also enable novel ways to securely share and analyse data. This paper introduces one of these advances—blockchain technologies—and argues that they can be used to share medical data in a secure and (...) auditable fashion. In addition, some aspects of consent and data collection, as well as data access management and analysis, can be automated using blockchain-based smart contracts. This paper demonstrates how blockchain technologies can be used to further all three of the bioethical principles underlying consent requirements: the autonomy of patients, by giving them much greater control over their data; beneficence, by greatly facilitating medical research efficiency and by reducing biases and opportunities for errors; and justice, by enabling patients with rare or under-researched conditions to pseudonymously aggregate their data for analysis. Finally, we coin and describe the novel concept of prosent, by which we mean the blockchain-enabled ability of all stakeholders in the research process to pseudonymously and proactively consent to data release or exchange under specific conditions, such as trial completion. (shrink)

In this concluding chapter, we gather the various contributions of this volume and attempt to extract some of the many key insights and challenges raised when it comes to the project of explaining health across the sciences. These insights were distilled down into a selection of the central concepts and issues defended or discussed by the authors, and were organized into a table to see, at a glance, where the attention was given. Reflecting on these insights will go some way (...) towards addressing the question of whether these explanations can be brought together into a coherent or unifying framework or whether we are simply stuck with mutually exclusive views about the multifaceted phenomenon of ‘health’. (shrink)

There are three lines of argument in defence of coercive treatment of patients with mental disorders: arguments regarding (1) societal interests to protect others, (2) the patients' own health interests, and (3) patient autonomy. In this paper, we analyse these arguments in relation to an idealized case, where a person with a mental disorder claims not to want medical treatment for religious reasons. We also discuss who should decide what in situations where patients with mental disorders deny treatment on seemingly (...) rational grounds.We conclude that, in principle, coercive treatment cannot be defended for the sake of protecting others. While coercive actions can be acceptable in order to protect close family and others, medical treatment is not justified for such reasons but should be given only in the interest of patients. Coercive treatment may be required in order to promote the patient's health interests, but health interests have to waive if they go against the autonomous interests of the patient. We argue that non-autonomous patients can have reasons, rooted in their deeply-set values, to renounce compulsory institutional treatment, and that such reasons should be respected unless it can be assumed that their new predicaments have caused them to change their views. (shrink)

Are we responsible for our misdeeds in dreams? The obvious answer would seem to be ‘No’. Dreams catch us with our defences down: just those critical and discriminative abilities which are distinctive of our waking lives as responsible moral agents seem out of play when we dream; el sueño de la razón produce monstruos . Moreover, if we are responsible for our dreamt misdeeds, then parity of reasoning demands that we be praised for dreaming noble dreams. But that is absurd. (...) Moral credit should not come that easily, and so neither should moral blame. (shrink)

Understanding the phenomenon of health is crucial for ageing research since there is often an implicit view on what constitutes health and how to measure it. We provide some reflections on how we might better understand and measure health, discuss the basic biological principles of survival, ageing, age-related diseases and eventual death, and end by tying these ideas together to rethink the nature of and implications for healthy ageing. We defend a more positive view on health understood in terms of (...) various phenotypic parameters, such as robustness and resilience, and show how it relates to the aim to support these parameters over time to achieve healthy ageing. Together, these ideas suggest that the most effective strategies for healthy ageing may come from the outside-in by altering those aspects of the environment that prevent robust and resilient phenotypic responses and by supporting those aspects which ensure such responses. (shrink)

Drugs used to provide improvement of cognitive functioning have been shown to be effective in healthy individuals. It is sometimes assumed that the use of these drugs constitutes cheating in an academic context. We examine whether this assumption is ethically sound. Beyond providing the most up-to-date discussion of modafinil use in an academic context, this contribution includes an overview of the safety of modafinil use in greater depth than previous studies addressing the issue of cheating. Secondly, we emphasize two crucial, (...) but hitherto nearly overlooked, nuances to the issues: the potential for modafinil to decrease inequality and disadvantage in academic settings, and the fact that how modafinil is used dramatically impacts its effects on health, coercion, fairness, authenticity and effort. Finally, we explicitly defend the position that there are no qualitatively morally relevant differences between modafinil use and other enhancement modalities; any such differences are in degree,... (shrink)

BackgroundInvoluntary treatment is a key issue in healthcare ethics. In this study, ethical issues relating to involuntary psychiatric treatment are investigated through interviews with Swedish psychiatrists.MethodsIn-depth interviews were conducted with eight Swedish psychiatrists, focusing on their experiences of and views on compulsory treatment. In relation to this, issues about patient autonomy were also discussed. The interviews were analysed using a descriptive qualitative approach.ResultsThe answers focus on two main aspects of compulsory treatment. Firstly, deliberations about when and why it was justifiable (...) to make a decision on involuntary treatment in a specific case. Here the cons and pros of ordering compulsory treatment were discussed, with particular emphasis on the consequences of providing treatment vs. refraining from ordering treatment. Secondly, a number of issues relating to background factors affecting decisions for or against involuntary treatment were also discussed. These included issues about the Swedish Mental Care Act, healthcare organisation and the care environment.ConclusionsInvoluntary treatment was generally seen as an unwanted exception to standard care. The respondents’ judgments about involuntary treatment were typically in line with Swedish law on the subject. However, it was also argued that the law leaves room for individual judgments when making decisions about involuntary treatment. Much of the reasoning focused on the consequences of ordering involuntary treatment, where risk of harm to the therapeutic alliance was weighed against the assumed good consequences of ensuring that patients received needed treatment. Cases concerning suicidal patients and psychotic patients who did not realise their need for care were typically held as paradigmatic examples of justified involuntary care. However, there was an ambivalence regarding the issue of suicide as it was also argued that risk of suicide in itself might not be sufficient for justified involuntary care. It was moreover argued that organisational factors sometimes led to decisions about compulsory treatment that could have been avoided, given a more patient-oriented healthcare organisation. (shrink)

The capacity of cells and organisms to respond to external stimuli and to maintain stability in order to survive decreases progressively during ageing. The mitogenic and stimulatory effects of growth factors, hormones and other agents are reduced significantly during cellular ageing. The sensitivity of ageing cells to toxic agents including antibiotics, phorbol esters, radiations and heat shock increases. This failure of homeostasis during cellular ageing does not appear to be due to any quantitative and qualitative defects in the receptor systems. (...) Instead, metabolic defects in the pathways of macromolecular synthesis may be the basis of altered cellular responsiveness during ageing. (shrink)