We provide a formally rigorous framework for integrating singular causation, as understood by Nuel Belnap's theory of causae causantes, and objective single case probabilities. The central notion is that of a causal probability space whose sample space consists of causal alternatives. Such a probability space is generally not isomorphic to a product space. We give a causally motivated statement of the Markov condition and an analysis of the concept of screening-off. 1. Causal dependencies and probabilities1.1Background: causation in branching space-times1.2What are (...) probabilities defined for?2. Basic transitions2.1Basics of basic transitions2.2Sets of basic transitions3. Causal probability theory3.1Some simple cases3.2General causal probabilities3.3Application: probability of suprema of a chain. (shrink)

The well-replicated observation that many people maintain mental health despite exposure to severe psychological or physical adversity has ignited interest in the mechanisms that protect against stress-related mental illness. Focusing on resilience rather than pathophysiology in many ways represents a paradigm shift in clinical-psychological and psychiatric research that has great potential for the development of new prevention and treatment strategies. More recently, research into resilience also arrived in the neurobiological community, posing nontrivial questions about ecological validity and translatability. Drawing on (...) concepts and findings from transdiagnostic psychiatry, emotion research, and behavioral and cognitive neuroscience, we propose a unified theoretical framework for the neuroscientific study of general resilience mechanisms. The framework is applicable to both animal and human research and supports the design and interpretation of translational studies. The theory emphasizes the causal role of stimulus appraisal (evaluation) processes in the generation of emotional responses, including responses to potential stressors. On this basis, it posits that a positive (non-negative) appraisal style is the key mechanism that protects against the detrimental effects of stress and mediates the effects of other known resilience factors. Appraisal style is shaped by three classes of cognitive processes – positive situation classification, reappraisal, and interference inhibition – that can be investigated at the neural level. Prospects for the future development of resilience research are discussed. (shrink)

Das Handbuch bietet einen Überblick über die technischen, historischen, sozialen, medialen, kulturwissenschaftlichen und technikphilosophischen Dimensionen verschiedener Typen von Mensch-Maschine-Interaktion sowie über deren ethische Implikationen. Dabei werden zum einen wissenshistorische Analysen der Diskurse in Philosophie, Literatur und Technik sowie ihrer medialen, apparativen und literalen Praktiken von ca. 1870 bis in die Gegenwart verfolgt. Zum anderen wird das komplexe Verhältnis von Menschen und Maschinen anhand von zentralen Begriffs- und Problemfeldern dargestellt und kritisch befragt.

New forms of artificial intelligence on the one hand and the ubiquitous networking of “everything with everything” on the other hand characterize the fourth industrial revolution. This results in a changed understanding of human–machine interaction, in new models for production, in which man and machine together with virtual agents form hybrid teams. The empirical study “Socializing with robots” aims to gain insight especially into conditions of development and processes of hybrid human–machine teams. In the experiment, human–robot actions and interactions were (...) closely observed in a virtual environment. Robots as partners differed in shape and behavior. Participants were instructed to achieve an objective that could only be achieved via close teamwork. This paper unites different aspects from core disciplines of social robotics and psychology contributing to anthropomorphization with the empirical insights of the experiment. It focuses on the psychological effects on anthropomorphization and mechanization, taking the inter- and transdisciplinary field of social robotics as a starting point. (shrink)

The present article puts forward a behavioral disinhibition hypothesis stating that, often, at least some levels of behavioral disinhibition are needed to overcome people’s inhibition to intervene in dilemmatic situations in which they have to choose between different actions with good reasons for each of the actions involved. Results reported indeed show that people to whom disinhibited behaviors were salient or people with stronger predispositions toward behavioral disinhibition were more likely to intervene in trolley and footbridge dilemmas.

We argue that mathematical knowledge is context dependent. Our main argument is that on pain of distorting mathematical practice, one must analyse the notion of having available a proof, which supplies justification in mathematics, in a context dependent way.

On ‘Mismatch’ and ‘Metabolic Ghettos:’ The Conceptualization of Global Health Differences in Research on the Developmental Origins of Health and Disease. Epigenetic approaches to human health have received growing attention in the past two decades. They allow to view the development of human organisms as plastic, i.e. as open to influences from the social and material environment such as nutrition, stress, and trauma. This has lent new credence to approaches in biomedicine that aim to draw attention to the importance of (...) development for later life health. Some scholars in the social sciences and humanities have welcomed such approaches as a departure from gene‐centric perspectives and as an opportunity for highlighting the social and political determinants of health and illness. Others have warned that they might lead to new forms of biological reductionisms and determinisms. In this article, we explore how research on developmental plasticity addresses and articulates global health disparities, specifically in the context of postcolonial India. We discuss two prominent approaches from the field of Developmental Origins of Health and Disease (DOHaD) that build on epigenetic perspectives on health and illness and view different global rates of disease susceptibility as the result of developmental processes: first, the ‘mismatch paradigm’ by Peter Gluckman and Mark Hanson and second, the ‘metabolic ghetto’ concept by Jonathan Wells. We highlight how both approaches render historical and social factors meaningful for the development of global health disparities, but emphasize how they at the same time remain prone to determinisms and reductionisms reminiscent of a gene‐centric perspective. DOHaD actors themselves are critical of these tendencies, and in conclusion we explore novel opportunities for interdisciplinary collaborations enabled by this critical potential. (shrink)

Solidarity between generations served as a prominent but controversially discussed normative reference point in public debates about the Coronavirus-pandemic. The aim of this contribution is the empirical reconstruction and ethical evaluation of prominent notions of intergenerational solidarity and their underlying assumptions in the public media discourse on the pandemic in Germany. After a brief introduction to the concept of intergenerational solidarity and the pertinent discourses during the pandemic, we present the results of a comprehensive qualitative content analysis of 149 articles (...) from leading media in Germany. On this basis, we carve out three typical understandings of intergenerational solidarity: (a) communal care, (b) mutual support, and (c) responsible use of freedom. We discuss these understandings and the underlying ‘moral paradigms’ and evaluate their theoretical and practical implications from an ethical point of view, drawing conclusions for discourses on future societal crises. (shrink)

A longitudinal, epidemiological study was carried out in a rural area of Kenya with a population of about 28,000 between 1974 and 1980. Population registration during this time showed that population growth was very high between 1974 and 1978 (4·4% per year) and much lower in 1979 and 1980 (1·1%). Natural increase was nearly as high as in Kenya as a whole (3·7%) in this period. Fertility was somewhat lower than in all Kenya (the crude birth rate was 46 per (...) 1000) while mortality was substantially lower (7 per 1000). Evidence is presented supporting the argument that these low mortality rates are genuine. Levels of temporary and permanent migration are high and probably characteristic for many parts of Kenya. The change in population growth in 1979 and 1980 is probably due to changes in economic conditions leading in particular to less in-migration and to more out-migration. (shrink)

Homeotic genes are subject to transcriptional silencing, which prevents their expression in inappropriate body regions. Here, we shall focus on Drosophila, as little is known about this process in other organisms. Evidence is accumulating that silencing of Drosophila homeotic genes is conferred by two types of cis‐regulatory sequences: initiation (SIL‐I) and maintenance (SIL‐M) elements. The former contain target sites for transient repressors with a highly localised distribution in the early embryo and the latter for constitutive repressors that are likely to (...) be present in all cells. We discuss how SIL‐I elements may cooperate with SIL‐M elements to promote formation of a silencing complex. We propose that this complex consists of specific non‐histone proteins, the so‐called Polycomb group proteins, and that it is anchored at SIL‐M elements and at the promoter. (shrink)

Although the cell is commonly addressed as the unit of life, historians and philosophers have devoted relatively little attention to this concept in comparison to other fundamental concepts of biology such as the gene or species. As a partial remedy to this neglect, we introduce the cell as a major point of connection between various disciplinary approaches, epistemic strategies, technological vectors and overarching biological processes such as metabolism, growth, reproduction and evolution. We suggest that the role of the cell as (...) a nexus forms the basis for a new philosophical and historical appreciation of cell biology. This perspective focuses less on the cell as a well-defined, stable object and places more emphasis on its role as a mediator of fundamental biological processes. (shrink)

We provide a detailed description of an interleaved and heavily annotated copy of Florae Berolinensis Prodromus, a flora of Berlin published by the German apothecary and botanist Karl Ludwig Willdenow in 1787, which today is preserved at the Staatsbibliothek zu Berlin – Preußischer Kulturbesitz. We demonstrate that this is the copy that the author himself used and carried with him during his botanical excursions in and around Berlin to prepare a second edition of the work. By analyzing this document as (...) paper technology, we reveal that even seemingly trifling aspects of its material organization enabled far-reaching biological research agendas that were not originally intended. The hybrid form of manuscript and printed book, used in field excursions, enabled a kind of natural-historical observation that was at once detailed and bound by strict convention, a combination that inadvertently opened new research questions and suggested new objects of research. We thereby contribute to an understanding of the history of natural history that goes beyond the history of ideas and the intended uses of techniques, giving an example of how routine work on paper within a scientific tradition could generate innovation. (shrink)

Κατά τη διάρκεια της δεύτερης επιφανειακής αρχαιολογικής έρευνας που καλύπτει την πεδιάδα των Μαλίων, βρέθηκαν δυό ενεπίγραφες μαρτυρίες σε κρητική ιερογλυφική γραφή : η άκρη μιας ράβδου από άργιλο με τέσσερεις όψεις (σώζονται οι τρείς) όπου αναγνωρίζονται τέσσερα σημεία και ένα θραύσμα λαβής από αμφορέα που φέρει τρία σημεία. Το πρώτο εύρημα επιβεβαιώνει την ύπαρξη στα Μάλια τουλάχιστον και ενός άλλου αποθέτη αρχείων σε ιερογλυφική γραφή, εκτός από αυτούς του Ανακτόρου και της συνοικίας Μ.

Alguns autores têm afirmado que o externalismo semântico de Putnam implica em um tipo de essencialismo que não descreve adequadamente a prática científica, já que as referências dos termos que designam espécies naturais seriam determinadas por características essenciais dos exemplares que compõem cada uma daquelas espécies. Essas essências seriam as verdadeiras responsáveis pela identidade das espécies naturais. Uma vez conhecidas tais essências, estaríamos aptos a identificar tais espécies em qualquer mundo possível, visto que suas essências permaneceriam estáveis mesmo diante de (...) mudanças nas descrições de outros de seus atributos. Logo, o externalismo semântico parece inadequado para explicar o desenvolvimento da ciência. Ademais, os critérios de identificação de espécies químicas e biológicas não são fixados da maneira proposta por Putnam. Este artigo apresenta essas objeções ao externalismo semântico de Putnam e formula uma resposta, afirmando que Putnam não postulou uma tese própria sobre critérios de identidade para espécies naturais. Sustenta-se que as menções de Putnam a postulados científicos são melhor compreendidas se interpretadas como elementos adicionais para a determinação das referências de termos que designam espécies naturais.Abstract:Some authors have argued that Putnam’s semantic externalism entails a kind of essentialism which does not describe scientific practice adequately, since the references of the terms that designate natural kinds would be determined by essential traits of the specimens which make up those natural kinds. Those essences would account for the identity of natural kinds. Once such essences are known, we would be able to identify natural kinds in anypossible world, since such essences would remain stable even in the face of abrupt changes in the descriptions of other kinds’ attributes. Therefore, semantic externalism seems inadequate for accounting the development of science. Furthermore, the identification criteria for chemical and biological species are not determined in the mannerproposed by Putnam. This paper presents those criticisms to Putnam’s semantic externalism and formulates a reply, stating that Putnam did not posit a thesis on identity criteria for natural kinds. His Putnam’ references to scientific postulates are better understood when interpreted as additional elements for the determination of thereferences of natural kind terms.Keywords: Essentialism; Reference; Necessity; Natural kinds; Meaning; Hilary Putnam. (shrink)