Mucopolysaccharidosis type I (MPS I) is a rare lysosomal storage disorder treated with bone marrow transplantation or enzyme replacement therapy with laronidase, a high-cost orphan drug. Laronidase was approved by the US Food and Drug Administration and the European Medicines Agency in 2003 and by the Brazilian National Health Surveillance Agency in 2005. Many Brazilian MPS I patients have been receiving laronidase despite the absence of a governmental policy regulating access to the drug. Epidemiological and treatment data concerning MPS I (...) are scarce. This study aims to present a demographic profile of Brazilian patients with MPS I, describe the routes of access to laronidase in Brazil, and discuss associated ethical issues relating to public funding of orphan drugs. (shrink)

This article aims to make public part of the research on the concept of ‘light’ in the theological and, above all, liturgical tradition of the Greek Orthodox Church, based on its representation of the concept of ‘hypostasis’. Taking as a point of departure the interpretation of the expression ‘light of light’ [φῶς ἐκ φωτός (phôs ek phōtos)] of the text of the Niceno-Constantinopolitan Symbol, the article presents a proposal for the interpretation of the concept of ‘representation’ for this specific case, (...) based on the idea of apomímesis, and applies this concept to a reading of the place of ‘light’ in the Holy Scripture, in the Patrology and in the Greek Eastern Liturgies. (shrink)

Este texto busca levantar reflexões sobre a importância e necessidades da educação para as relações étnico-raciais e promoção da educação antirracista. A partir do uso conceitual de letramento racial crítico e, da análise de legislações que consideramos oportunas para o enfrentamento do racismo, tais como a Lei nº 14.532, de 11 de janeiro de 2023, Lei nº 7.716, de 5 de janeiro de 1989, que visam criminalizar o racismo, e da Lei nº 10.639, de 9 de janeiro de 2003 sobre (...) a obrigatoriedade do ensino de história e cultura da população afro-brasileira e africana, as compreendemos como avanços no combate ao racismo. Em vista de levantarmos possibilidades para o desenvolvimento de um ensino pautado na luta antirracismo a partir e de que promova o letramento racial crítico, levantamos algumas observações sobre a música Bluesman, de Baco Exu do blues, como alternativa para o levantamento reflexivo em sala de aula para a valorização da história e identidade da população negra. (shrink)

Procurou-se, e esse foi o objetivo essencial, que este volume fosse marcado pelo discurso questionador e crítico de historiadores, de filósofos, de especialistas da ciência política, das ideias, do direito, da economia, da educação, da comunicação, da informação, das ciências, das artes. Surgiram assim interpretações, quadros, configurações e reconfigurações, ângulos de análise diversificados que fomentarão, por certo, uma reflexão viva dos leitores. É fundamental — continua a sê-lo — repensar e questionar campos temáticos à luz das análises teóricas e concetuais, (...) mas também dos processos, das dinâmicas, das relações, das potencialidades explicativas da nossa contemporaneidade. É assim que se entende este livro, com muitas contribuições, que vêm propiciar e enriquecer a reflexão sobre Outros Combates pela História. Combates pela História é, como se sabe, o título de um livro famoso de Lucien Febvre dos anos cinquenta. Através de uma recomposição, de novo se deu importância a todas as modalidades da História, mantendo, todavia, o sentido do rigor que era algo perseguido nos «combates pela História». Quer-se, pois, analisar o sentido da História, nas suas várias áreas. Contudo, ao propor-se este tema, não se desejou que os autores apresentassem tanto as suas investigações nas suas áreas próprias — embora elas estivessem subentendidas e devessem ser expressas —, mas que refletissem sobre o seu sentido no âmbito da História entendida como Ciência Social e Humana. Para tal, desejou-se que discutissem o objeto e o método da História das diversas áreas, equacionando os seus vários problemas. Foi isso que também sucedeu — estamos disso convencidos. Mas será o leitor, melhor do que ninguém, a ajuizá-lo. (shrink)

How veridical is perception? Rather than representing objects as they actually exist in the world, might perception instead represent objects only in terms of the utility they offer to an observer? Previous work employed evolutionary modeling to show that under certain assumptions, natural selection favors such “strict‐interface” perceptual systems. This view has fueled considerable debate, but we think that discussions so far have failed to consider the implications of two critical aspects of perception. First, while existing models have explored single (...) utility functions, perception will often serve multiple largely independent goals. (Sometimes when looking at a stick you want to know how appropriate it would be as kindling for a campfire, and other times you want to know how appropriate it would be as a weapon for self‐defense.) Second, perception often operates in an inflexible, automatic manner—proving “impenetrable” to shifting higher‐level goals. (When your goal shifts from “burning” to “fighting,” your visual experience does not dramatically transform.) These two points have important implications for the veridicality of perception. In particular, as the need for flexible goals increases, inflexible perceptual systems must become more veridical. We support this position by providing evidence from evolutionary simulations that as the number of independent utility functions increases, the distinction between “interface” and “veridical” perceptual systems dissolves. Although natural selection evaluates perceptual systems only on their fitness, the most fit perceptual systems may nevertheless represent the world as it is. (shrink)

Childhood obesity has become a public health epidemic, and currently a battle exists over how to frame and address this problem. This paper explores how public policy approaches can be employed to address obesity. We present the argument that obesity should be viewed as the consequence of a “toxic environment” rather than the result of the population failing to take enough “personal responsibility.” In order to make progress in decreasing the prevalence of obesity, we must shift our view of obesity (...) away from the medical model to a public health model . At the same time, we must be sensitive to the problem of weight bias.Potential obstacles to taking a public policy approach are identified, as well as suggestions on how to overcome them. (shrink)

After years of near total neglect, the problem of childhood obesity is now in the limelight. Terms like “epidemic,” “crisis,” and “emergency” are used frequently when describing the trend. Progress is defined with strong language and fueled by statistics such as the observation that this generation of children will be the first to live shorter lives than their parents. Multi-disciplinary journals such as the Journal of Law, Medicine & Ethics have dedicated symposiums to the issue, and conferences have been convened (...) not only by health professionals but by government agencies, the food industry, and even professionals who market to children. The seriousness of childhood obesity is no longer in doubt, and finally attention has turned to the more complex question – what must be done? (shrink)

The moral distress of psychologists working in psychiatric and mental health care settings was explored in an interdisciplinary, hermeneutic phenomenological study situated at the University of Alberta, Canada. Moral distress is the state experienced when moral choices and actions are thwarted by constraints. Psychologists described specific incidents in which they felt their integrity had been compromised by such factors as institutional and interinstitutional demands, team conflicts, and interdisciplinary disputes. They described dealing with the resulting moral distress by such means as (...) silence, taking a stance, acting secretively, sustaining themselves through work with clients, seeking support from colleagues, and exiting. Recognizing moral distress can lead to a significant shift in the way we perceive moral choices and understand the moral context of practice. (shrink)

Name der Zeitschrift: Frühmittelalterliche Studien Jahrgang: 36 Heft: 2 Seiten: 432-435.

Scholars have long asserted that public relations (PR) professionals should play the role of organizational conscience, but little research has focused on why and how they play this role effectively. We found that PR professionals who played the role of organizational conscience had broadened conceptions of their roles and responsibilities, including a fervent duty to the public interest. This often put them in the position of providing criticism to powerful organizational players. Rather than raising their ethical concerns as persuasive orators, (...) they used subtle, resourceful, and experiential approaches to persuasion. Playing the role of organizational conscience typically necessitated gaining access to informal coalitions since access to dominant power coalitions often was limited or late. Organizations with participative cultures supported the role of organizational conscience. (shrink)

Bergson définit le temps par la succession, qui est création de nouveauté. Mais il prend des exemples qui relèvent non de la succession mais de la simultanéité, garante d’une autre différence, entre deux choses qui coexistent en même temps, c’est-à-dire l’individualité. Dans Le Rire, on trouve en outre un type de comique qui joue sur la duplication simultanée du même. Ces cas de comique engagent la différence entre la simultanéité naturelle d’individus différents et la simultanéité artificielle d’êtres identiques. Si la (...) simultanéité mécanique du même fait rire, c’est bien que la simultanéité naturelle fonde les différences. Cet oubli de Bergson est d’autant plus surprenant que sa conception du temps repose sur une critique de celle de Kant, lequel avait précisément inclus la simultanéité dans le temps comme un de ses modes ; garant du « divers simultané ». Finalement, Bergson est contraint par sa controverse avec Einstein à réintégrer la simultanéité dans le temps. (shrink)

Beginnings : a Russian émigré's first interviews (1932-1949) -- Russian girl jeers at U.S. for depression complaint, Oakland Tribune, 1932 -- True picture of Russian girls' love life tragic, Boston Post, 1936 -- The woman of tomorrow, WJZ radio, 1949 -- On campus : Ayn Rand talks with future intellectuals (1962-1966) -- Objectivism versus conservatism -- The campaign against extremism -- The robber-barons -- Myths of capitalism -- The political structure of a free society -- The American Constitution -- Objective (...) law -- The role of a Free Press -- Education -- Romantic literature -- Romanticism versus naturalism -- The visual arts -- Cyrano de Bergerac -- Favorites in art -- The nature of humor -- The foundations of morality -- Altruism -- Individual rights -- The ethics of objectivism -- On television and radio : Ayn Rand in America's living rooms (1959-1981) -- The Mike Wallace interview, ABC-TV, 1959 -- For the intellectual, University of Michigan television, with Professor James McConnell, 1961 -- The Tonight Show with Johnny Carson, NBC-TV, August 1967 -- The Tonight Show with Johnny Carson, NBC-TV, October 1967 -- Speaking freely with Edwin Newman, NBC-TV, 1972 -- Day and Night, a television program hosted by James Day, 1974 -- Focus on youth, a radio show hosted by Garth R. Ancier, 1976 -- The Raymond Newman Journal, a radio show, 1980 -- Louis Rukeyser's Business Journal, 1981. (shrink)

Brian C. Ribeiro’s _Sextus, Montaigne, Hume: Pyrrhonizers_ invites us to view the Pyrrhonist tradition as involving all those who share a commitment to the activity of Pyrrhonizing and develops fresh, provocative readings of Sextus, Montaigne, and Hume as radical Pyrrhonizing skeptics.

Harry Frankfurt's conception of care and love has largely been considered a seductive theory of personality, but an untenable and irresponsible theory of moral normativity. Contrary to that interpretation, this article aims at showing that it is possible to remain faithful to Frankfurt's metaphysical premises while not falling into some moral relativism. First, by comparing Frankfurt's and Heidegger's conceptions of care, I show that Frankfurt's subordination of ethics to carology apparently commits him to a neutral foundationalism. In the next step, (...) I argue that his calling into question of the relation between rationality and morality does indeed subject moral normativity to some subjective and contingent limits. And finally, I show that the objections raised against such a conclusion can be answered by shifting Frankfurt's frontier between contingency and necessity and by exploiting his concept of wholeheartedness. (shrink)

The author- following his own research on the subject- argues that Wittgenstein ignores argumentation theory and in general, the problems of rhetoric and argumentation. From this point of view, he frames Stephen Toulmin’s reading of Wittgenstein, arguing that the British philosopher- who was a student of the Austrian- advocates precisely the same thesis. He explains that this happens in a very peculiar (rhetorical) context on Toulmin’s part; a context in which, in essence, Wittgenstein’s philosophy is being rehabilitated.

Traditionally, ontology, or at least western ontology, bas been an anthropocentric enterprise, that takes only human experiences into account. In this paper I argue that a prolific biocentric ontology can be based on UexkülI's Umwelt theory. UexkülI offers the basis of an ontology according to which the study of experiences is a much wider field than it is as depicted by classical ontology and contemporary philosophy of consciousness. Based on the thoughts of the contemporary philosopher Thomas Nagel I claim that (...) there might very well be Iifeforms that are totally unimaginable to us. I argue that this view is compatible with the Umwelt theory, and that it should be adopted by biosemioticians. Furthermore, I argue that a biosemiotic possibilism should be implemented. Followingly, one should not claim to know which characteristics of living beings are universally and necessarily valid, but restrict oneself to statements about life as we know it. (shrink)

The 2017 Commission on Public Relations Education report found new professionals are not meeting employers’ expectations regarding ethics knowledge, skills and abilities. This mixed-method s...

‘Culturology’ is an integral, often compulsory, part of Russian university courses; the discipline has largely replaced chairs in Marxist-Leninism and dialectical materialism, and bookshops are full of texts on the subject. This article is based on analysis of more than ten university textbooks recommended to first-year students. Marlène Laruelle examines why culturology has become so important, the place claimed for it within the human sciences, and what it means for changing Russian ideas of identity and nation.

This paper explores the relationship between people's mental imagery for their experiences of paths and roads and the metaphorical use of path and road in discourse. We report the results of two studies, one a survey examining people's mental imagery about their embodied experiences with paths and roads, with the second providing a corpus analysis of the ways path and road are metaphorically used in discourse. Our hypothesis is that both people's mental imagery for path and road, and speakers' use (...) of these words in metaphorical contexts are strongly guided by their embodied understandings of real-world events related to travel on paths and roads. The results of these studies demonstrate how bodily experiences with artifacts partly constrains not only how specific conceptual metaphors emerge, but how different metaphorical understandings are applied in talk about abstract entities and events. (shrink)

Perceptual experience and visual imagination both offer a first-person perspective on visible objects. But these perspectives are strikingly different. For it is distinctive of ordinary perceptual intentionality that objects seem to be present to the perceiver. I term this phenomenal property of experience ‘presence’. This paper introduces a positive definition of presence. Dokic and Martin (2017) argue that presence is not a genuine property of perceptual experience, appealing to empirical research on derealisation disorders, Parkinson’s disease, virtual reality and hallucination. I (...) demonstrate that their arguments fall short of establishing that presence is not perceptual. (shrink)

El propósito de este ensayo es mostrar que el fenómeno globalizador impulsado desde Occidente, ha venido configurando un escenario, que amenaza reducir lo identitario a una lógica de guerra entre lo propio y lo ajeno. Además, se muestra a Occidente desde otras voces, cuyos argumentos de resistencia a toda visión reduccionista de la experiencia humana cuestionan la universalización monologizante de Occidente, y nos instan a revalorizar nuestros legados culturales e identitarios más próximos, y a redescubrir lo comunitario como un espacio (...) de encuentro y potenciación de aquellas necesidades y expresiones más constitutivas de lo humano. (shrink)