The similarity of documents in a large database of published Fractals articles was examined for redundancy. Three different text matching techniques were used on published Abstracts to identify redundancy candidates, and predictions were verified by reading full text versions of the redundancy candidate articles. A small fraction of the total articles in the database was judged to be redundant. This was viewed as a lower limit, because it excluded cases where the concepts remained the same, but the text was altered (...) substantially. Far more pervasive than redundant publications were publications that did not violate the letter of redundancy but rather violated the spirit of redundancy. There appeared to be widespread publication maximization strategies. Studies that resulted in one comprehensive paper decades ago now result in multiple papers that focus on one major problem, but are differentiated by parameter ranges, or other stratifying variables. This ‘paper inflation’ is due in large part to the increasing use of metrics (publications, patents, citations, etc) to evaluate research performance, and the researchers’ motivation to maximize the metrics. (shrink)

The similarity of documents in a large database of published Fractals articles was examined for redundancy. Three different text matching techniques were used on publisheds to identify redundancy candidates, and predictions were verified by reading full text versions of the redundancy candidate articles. A small fraction of the total articles in the database was judged to be redundant. This was viewed as a lower limit, because it excluded cases where the concepts remained the same, but the text was altered substantially.Far (...) more pervasive than redundant publications were publications that did not violate the letter of redundancy but rather violated the spirit of redundancy. There appeared to be widespread publication maximization strategies. Studies that resulted in one comprehensive paper decades ago now result in multiple papers that focus on one major problem, but are differentiated by parameter ranges, or other stratifying variables. This ‘paper inflation’ is due in large part to the increasing use of metrics (publications, patents, citations, etc) to evaluate research performance, and the researchers’ motivation to maximize the metrics. (shrink)

The similarity of documents in a large database of published Fractals articles was examined for redundancy. Three different text matching techniques were used on published Abstracts to identify redundancy candidates, and predictions were verified by reading full text versions of the redundancy candidate articles. A small fraction of the total articles in the database was judged to be redundant. This was viewed as a lower limit, because it excluded cases where the concepts remained the same, but the text was altered (...) substantially.Far more pervasive than redundant publications were publications that did not violate the letter of redundancy but rather violated the spirit of redundancy. There appeared to be widespread publication maximization strategies. Studies that resulted in one comprehensive paper decades ago now result in multiple papers that focus on one major problem, but are differentiated by parameter ranges, or other stratifying variables. This ‘paper inflation’ is due in large part to the increasing use of metrics (publications, patents, citations, etc) to evaluate research performance, and the researchers’ motivation to maximize the metrics. (shrink)

Researchers, educators and clinicians have long recognized the profound influence of the mid‐twentieth century focus on interpersonal relations and relationships on nursing. Today, in nursing, as well as in medicine and other social sciences, neuroanatomy, neurobiology and neurophysiology have replaced interpersonal dynamics as keys to understanding human behavior. Yet concerns are being raised that the teaching, research and practice of the critical importance of healing relationships have been overridden by a biological focus on the experiences of health and illness. As (...) a way to move forward, we return to Hildegard Peplau's seminal ideas about the transformative power of relationships in nursing. We propose that Peplau's formulations and, in particular, her seminal Interpersonal Relations in Nursing can provide direction. We do not propose that her formulations or her book be simply transposed from the 1950s to today's classroom and clinic. But we do believe that her ideas and writings are dynamic documents containing concepts and derived operations that can be brought to life in clinical practice. Finally, we explore Peplau's transformative idea that nursing is, at its core, an interpersonal process both to acknowledge an idea that has shaped our past and can guide us into our future. (shrink)

Long-term potentiation (LTP) is operationally defined as a long-lasting increase in synaptic efficacy following high-frequency stimulation of afferent fibers. Since the first full description of the phenomenon in 1973, exploration of the mechanisms underlying LTP induction has been one of the most active areas of research in neuroscience. Of principal interest to those who study LTP, particularly in the mammalian hippocampus, is its presumed role in the establishment of stable memories, a role consistent with descriptions of memory formation. Other characteristics (...) of LTP, including its rapid induction, persistence, and correlation with natural brain rhythms, provide circumstantial support for this connection to memory storage. Nonetheless, there is little empirical evidence that directly links LTP to the storage of memories. In this target article we review a range of cellular and behavioral characteristics of LTP and evaluate whether they are consistent with the purported role of hippocampal LTP in memory formation. We suggest that much of the present focus on LTP reflects a preconception that LTP is a learning mechanism, although the empirical evidence often suggests that LTP is unsuitable for such a role. As an alternative to serving as a memory storage device, we propose that LTP may serve as a neural equivalent to an arousal or attention device in the brain. Accordingly, LTP may increase in a nonspecific way the effective salience of discrete external stimuli and may thereby facilitate the induction of memories at distant synapses. Other hypotheses regarding the functional utility of this intensely studied mechanism are conceivable; the intent of this target article is not to promote a single hypothesis but rather to stimulate discussion about the neural mechanisms underlying memory storage and to appraise whether LTP can be considered a viable candidate for such a mechanism. (shrink)

The neurophysiological phenomenon of LTP (long term potentiation) is considered by many to represent an adequate mechanism for acquiring or storing memories in the mammalian brain. In our target article, we reviewed the various arguments put forth in support of the LTP/memory hypothesis. We concluded that these arguments were inconsistent with the purported data base and proposed an alternative interpretation that we suggested was at least as compatible with the available data as the more widely held view. In doing so, (...) we attempted to illustrate that the inadequacy of present experimental designs did not permit us to distinguish between equally viable hypotheses. In the four years since we wrote the first draft of our target article, hundreds of additional studies on LTP have been published and their results have been incorporated into current theories about memory. A diverse group of commentators responded to our target article with their own theories of how memories might be stored in the brain, some of which rely on LTP. Some commentators doubted whether memories can be stored through modifications of synaptic strength. Some assert that it will never be possible to understand the neural mechanisms of memory; still others remain hopeful that we will accomplish some semblance of a resolution, provided we appreciate LTP's role in a subset of seemingly amorphous memory systems. In summary, although it is commonly written that “LTP is a memory storage device,” the divergence of views among the commentators suggests, at least as strongly as our target article, that such conviction is unwarranted and fails to acknowledge both the lack of consensus regarding the role of LTP in memory and the complexity of the phenomenon of memory itself. (shrink)

Long-term potentiation (LTP) is a long-lasting increase in synaptic efficacy that many consider the best candidate currently available for a neural mechanism of memory formation and/or storage in the mammalian brain. In our target article, LTP: What's learning got to do with it?, we concluded that there was insufficient data to warrant such a conclusion. In their commentaries, Jeffery and Zhadin raise a number of important issues that we did not raise, both for and against the hypothesis. Although we agree (...) with a number of these issues, we maintain that there remains insufficient evidence that LTP is a memory mechanism. (shrink)

NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, (...) functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones. (shrink)

The growing academic literature on ‘food sovereignty’ has elaborated a food producer-driven vision of an alternative, more ecological food system rooted in greater democratic control over food production and distribution. Given that the food sovereignty developed with and within producer associations, a rural setting and production-side concerns have overshadowed issues of distribution and urban consumption. Yet, ideal types such as direct marketing, time-intensive food preparation and the ‘family shared meal’ are hard to transcribe into the life realities in many non-rural, (...) non-farming households, and it is unclear, in turn, how such realities can fit into models of food sovereignty. A particular practical and research gap exists in how to engage the overwhelming need for food options served under time constraints and (often) outside of the home or a full-service restaurant. The over-generalized vilification of ‘fast food’ should be replaced by a framework that allows us to distinguish between unhealthy, corporate fast foods and both traditional and emerging alternatives that can serve to extend the tenets of food sovereignty further into food processing, distribution and consumption. This article analyzes existing conceptualizations of fast food, explores fast food historically, and studies how food sovereignty can operationalize its tenets and priorities in situations where fast food is an unquestionable necessity. (shrink)

This is a book that attempts to propose itself as a new trigger in the wide world of anorexia nervosa. The originality of its proposal consists in approaching anorexia nervosa, not only by endocrinological and psychological perspectives, but also by anthropological, philosophical and ethical point of view. In this way it's not only an update of specific literature, but also an integration with a new method to study this condition. The purpose of the book is to approach anorexia nervosa from (...) different points of view, to reach a new interpretation which involves notions from biological and human sciences interpreted in a unique model and which could allow a new method of treatment. (shrink)

Philosophe et penseur du politique, intellectuel marxiste et militant communiste, enseignant, directeur de collection... : à travers le rayonnement de son oeuvre et de sa personne, Louis Althusser a renouvelé la théorie politique et la philosophie de l'histoire, de Machiavel à Marx. Parmi ses contemporains, Michel Foucault exhorte : " Ouvrez les livres d'Althusser! ", Jacques Derrida évoque " la force rayonnante et provocante de sa pensée ", Gilles Deleuze salue l'" Althusser's Band ", et pour Roland Barthes, " (...) le seul modèle acceptable de la science est celui mis au jour par les études d'Althusser sur Marx ". Aliocha Wald Lasowski converse avec vingt écrivains et philosophes qui ont lu, rencontré, parfois travaillé avec Althusser, quand ils n'ont pas fait partie de ses proches. Où l'on mesure à quel point la pensée d'Althusser demeure d'une actualité brûlante. (shrink)

No presente trabalho é examinado o conceito de "representação" em duas obras de Nicolau de Oresme. No De maneta, o pensador medieval faz pequenas referências ao poder de decisão do povo em questões monetárias. Anos mais tarde, ao traduzir e comentar a Política de Aristóteles, retoma a noção de Marsílio de Pádua a respeito da multidão como legislador, mas define a multidão não como o povo, mas como a congregação de todos os príncipes ou oficiais, entre os principais cidadãos.

In this article we present a conjecture regarding the biology of subjectivity and feeling, based on biophysical and phenomenological considerations. We propose that feeling, as a subjective phenomenon, would come to life as a process of resistance to variance hypothesized to occur during the unfolding of cognition and behaviours in the wakeful and emoting individual. After showing how the notion of affect, when considered from a biological standpoint, suggests an underlying process of resistance to variance, we discuss how vigilance, emotional (...) arousal and attentional behaviours reflect a dynamics of controlled over-excitation related to cognitive integration and control. This can be described as a form of resistance to variance. We discuss how such a dynamics objectively creates an internal state of tension and affectedness in the system that could be associated with subjective states. Such a dynamics is shaped by the system's need to cope with its own inertia, to engage in intentional behaviours, attend, preserve coherence, grapple with divergent cognitive, emotional and motivational tendencies, and delayed auto-perturbations of the brain-body system. More generally, it is related to the need to respect the hierarchy of the various influences which affect its internal dynamics and organization. (shrink)

The integration of artificial intelligence into bioethics education represents a new pedagogical approach that addresses complex moral issues in healthcare. The use of AI-driven platforms like ChatGPT in bioethics education can enhance critical thinking and decision-making skills among students by providing a diverse range of perspectives and solutions. To assess the ability of ChatGPT-4 to understand and resolve ethical dilemmas using validated clinical case vignettes, thereby determining its suitability as a teaching aid in bioethics. Ten clinical scenarios, each with inherent (...) ethical issues, were presented to ChatGPT-4. These scenarios were expert-validated to ensure relevance and complexity. ChatGPT's responses were evaluated by two blinded external raters to eliminate bias. The assessment criteria included identification of bioethical principles, recognition of stakeholders and their outcomes, and comprehension of ethical and legal frameworks. Additionally, the quality of responses was scored on a scale of 1–10. ChatGPT showed proficiency in identifying the pertinent bioethical principles and stakeholders involved in the ethical dilemmas presented. It achieved an overall score of 84.5%, with high marks for its analytical capabilities in complex scenarios. However, the study identified areas for improvement, particularly in proposing comprehensive solutions and alternative actions. ChatGPT demonstrates potential as an effective tool for bioethics education, capable of guiding learners through the resolution of ethical issues in clinical practice. However, to fully integrate ChatGPT into bioethics education, it requires enhancements in delivering detailed, actionable guidance in ethical decision-making. Future development should focus on refining ChatGPT’s ability to offer nuanced solutions aligned with patient values and clinician needs. (shrink)

Dag Prawitz’s theory of grounds proposes a fresh approach to valid inferences. Its main aim is to clarify nature and reasons of their epistemic power. The notion of ground is taken to denote what one is in possession of when in a state of evidence, and valid inferences are described in terms of operations that make us pass from grounds we already have to new grounds. Thanks to a rigorously developed proof-as-chains conception, the ground-theoretic framework permits Prawitz to overcome some (...) conceptual difficulties of his earlier proof-theoretic explanation. Though from different points of view, anyway, the two accounts share an issue of recognizability of relevant operational properties. (shrink)

Prawitz has recently developed a theory of epistemic grounding that differs in many respects from his earlier semantics of arguments and proofs. An innovative approach to inferences yields a new conception of the intertwinement of the notions of valid inference and proof. We aim at singling out three reasons that may have led Prawitz to the ground-theoretic turn, i.e.: a better order in the explanation of the relation between valid inferences and proofs; a notion of valid inference based on which (...) valid inferences and proofs are recognisable as such; a reconstruction of the deductive activity that makes inferences capable of yielding justification per se. These topics are discussed by Prawitz with reference to a very general and ancient question: why and how correct deduction has the epistemic power to compel us to accept its conclusions, provided its premises are justified? We conclude by remarking that, in spite of some improvements, the ground-theoretic approach shares with the previous one a problem of vacuous validity which, as Prawitz himself points out, blocks in both cases a satisfactory explanation of epistemic compulsion. (shrink)