In the present study, we have demonstrated hysteresis phenomena in the excitability of single, enzymatically dissociated guinea pig ventricular myocytes. Membrane potentials were recorded with patch pipettes in the whole-cell current clamp configuration. Repetitive stimulation with depolarizing current pulses of constant cycle length and duration but varying strength led to predictable excitation (1:l) and non-excitation (1:0) patterns depending on current strength. In addition, transition between patterns depended on the direction of current intensity change and stable hysteresis loops were obtained in (...) stimulus:response pattern vs. current intensity plots in 14 cells. Increase of pulse duration and decrease of stimulation rate contributed to a reduction in hysteresis loop areas. Changes in amplitude and shape of the subthreshold responses during the transitions from one stable pattern to the other, suggested that activity led to an increase in membrane resistance, particularly in the voltage domain between resting potential, and threshold. Therefore, we modelled the dynamic behaviour of the single cells as a function of diastolic membrane resistance, using previously published analytical solutions. Numerical iteration of the analytical model equations closely reproduced the experimental hysteresis loops in both qualitative and quantitative ways. In particular, the effect of stimulation frequency on the model was similar to the experimental findings. The overall study suggests that the excitability pattern of guinea pig ventricular myocytes accounts for hysteresis and bistabilities when current intensity is allowed to fluctuate around threshold levels. (shrink)

Dentro del epistolario de Francisco Romero, que permanece inédito, se analizan las cartas que intercambió con el filósofo personalista Edgar S. Brightman (1884-1953), como así también se alude a otros representantes dentro del movimiento en EEUU. Este escrito se apoya en la hipótesis del interés compartido por esta corriente de ideas dentro de los años que van desde la II Guerra Mundial hasta los inicios de la llamada Guerra Fría. Se alude también al propósito de ambos corresponsales por acercar la (...) filosofía estadounidense y la desarrollada en América Latina. Las cartas en el repositorio se extienden entre 1939 y 1952. Se incluye como anexo la nota necrológica sobre Brightman redactada por José Vasconcelos con el fin de mostrar que su filosofía interesaba también en otros países latinoamericanos. Within the unpublished epistolary collection of Francisco Romero, this work analyses the letters that were exchanged with the personalist philosopher Edgar S. Brightman (1884-1953), and it also refers to others representative philosophers inside the American Personalist movement. The hypothesis is that both maintain a mutual interest for these ideas during World War II until the beginnings of the so called Cold War. It also refers to the purpose of both correspondents to come closer American and Latin American philosophy. The letters in the collection were written between 1939 and 1952. This paper includes as appendix the obituary authored by José Vasconcelos about Brightman to show that his philosophy was of interest in other Latin American countries. (shrink)

SPANISH: Se analiza la revista Nosotros (1907-1943) en la década de 1930. Dentro de su variedad de temas, el eje de la investigación rastrea las contribuciones de autores nacionales que cuestionaron la propia identidad argentina. Dentro del período se estudian las opiniones que, como respuestas, aparecieron ante los artículos de Ortega y Gasset referidos "al hombre a la defensiva" y a "la pampa, promesas"; la discusión sobre el rol de los intelectuales; los interrogantes sobre una supuesta "nueva generación"; las tipologías (...) de un imaginario "ser argentino"; el vínculo entre arte y política, como la función del deporte. Igualmente el artículo recoge las reflexiones suscitadas por las diferentes encuestas lanzadas por la Revista; el suicidio de Lugones, y aquellos aspectos que nos acercan a miradas en busca de un sí mismos, donde los protagonistas se debatían en la encrucijada intelectual y política, tal como aparecieron en esta emblemática publicación. ENGLISH: This article analyses the Journal Nosotros (1907-1943) during the 1930's. The main focus of the research is to identify the contributions by national authors that questioned the Argentinean identity. In particular, this study explores the opinions that were published in response to articles from Ortega y Gasset about "el hombre a la defensiva" and "la pampa, promesas"; discussions on the role of intellectuals; inquiries about a supposed "new generation"; the typologies of an imaginary "Argentinean being"; the links between art and politics; and the role of sports. The article also discusses the ideas raised by different surveys launched by the Journal; the suicide of Lugones, and views on the search of the self, in which the protagonists debated the intellectual and political crossroads that were presented by Nosotros. (shrink)

This book explores the epistemic side of racial and sexual oppression. It elucidates how social insensitivities and imposed silences prevent members of different groups from listening to each other.

Se analizan algunos aspectos del pensamiento filosófico de Carlos Astrada y Arturo Andrés Roig. La hipótesis es que existen ciertas afinidades que permiten acercar las ideas de ambos al menos sobre dos cuestiones fundamentales: el conocimiento y la praxis en sus dimensiones antropológicas y sociales. El análisis se circunscribe a algunos textos importantes de ambos, sin ser excluyentes de otros a ser considerados en otra oportunidad. The article compares some philosophical views of Carlos Astrada and Arturo Andrés Roig. The conclusion (...) proposed is that both authors present similarities in the treatment of knowledge and praxis, particularly in their anthropological and social aspects. The analysis is based on important texts by both authors without excluding further texts to be considered in the future. (shrink)

En la siguiente exposición se propone un comentario de la obra del filósofo cubano Pablo Guadarrama González, denominada Pensamiento filosófico latinoamericano. Humanismo, método e historia. La perspectiva humanista que es postulada contiene una serie de precisiones que son analizadas en sus implicaciones teóricas y prácticas. Asimismo, se extiende su estudio de las ideas filosóficas a distintos momentos del desarrollo particular seguido en América Latina, al igual que está acompañada esta tarea historiográfica de consideraciones metodológicas que resultan significativas. Desde el conjunto (...) de temas planteados por el autor se retoman sus aportes en relación a debates que se inscriben en el cruce disciplinario de la filosofía y la historia de las ideas, que se ubican inicialmente en el contexto latinoamericano pero aspiran a una proyección con alcances universales. We comment the Cuban philosopher Pablo Guadarrama González’s Latin American philosophical thinking. Humanism, method and history. The humanistic perspective posited therein contains some assumptions that we analyze in their theoretical and practical implications. Furthermore, we extend his study of philosophical ideas to different moments of Latin America’s particular development, being this historiographic task accompanied by significant methodological considerations. Of all the themes posed by this author, we take his contributions to the debates raised in the interdisciplinary intersection of philosophy and the history of ideas, initially located in a Latin American context but with universal projection. (shrink)

El libro de Alex Ibarra, Filosofía chilena. La tradición analítica en el periodo de la institucionalización de la filosofía, plantea la discusión sobre las líneas filosóficas, demostrando la existencia de cierta tradición analítica en Chile. A partir de allí, reflexionamos en torno a los procesos de constitución del campo de la filosofía en Chile como una historia atravesada por la necesidad de préstamos y cruces que impiden una delimitación clara de sus límites, lo que tornaría necesaria la atención a ciertas (...) políticas de la lectura que el libro soslaya. La productividad de la filosofía producida en Chile surgiría gracias -y no pese- a su inscripción en sus tiempos y espacios, a partir de recepciones cuya ausencia de retraso no impide el gesto de cierto re-trazo de lo leído. Alex Ibarra's exposition in his book Filosofía chilena. La tradición analítica en el periodo de la institucionalización de la filosofía, places the discussion on the philosophical traditions, showing the existence of a certain kind of analytical tradition in Chile. From there, we expose the processes of constitution of the field in Chile as a history crossed by the need of importations and intersections that contest the clear delimitation of its boundaries, what makes necessary the attention of the politics of readings that the book avoid. The productivity of the philosophic production in Chile, arises thanks to -but not in spite of- its inscription in its age/times and spaces, coming from its receptions and its differences. (shrink)

This paper defends a contextualist approach to epistemic injustice according to which instances of such injustice should be looked at as temporally extended phenomena (having developmental and historical trajectories) and socially extended phenomena (being rooted in patterns of social relations). Within this contextualist framework, credibility excesses appear as a form of undeserved epistemic privilege that is crucially relevant for matters of testimonial justice. While drawing on Miranda Fricker's proportional view of epistemic justice, I take issue with its lack of attention (...) to the role that credibility excesses play in testimonial injustices. I depart from Fricker's view of the relation between credibility excesses and credibility deficits, and I offer an alternative account of the contributions that undeserved epistemic privileges make to epistemic injustices. Then, through the detailed analysis of To kill a mockingbird, I elucidate the crucial role played by the social imaginary in creating and sustaining epistemic injustices, developing an analysis of the kind of social blindness produced by an oppressive social imaginary that establishes unjust patterns of credibility excesses and deficits. (shrink)

Background The Regional Committee for Africa of the World Health Organization (WHO) in 2001 expressed concern that some health-related studies undertaken in the Region were not subjected to any form of ethics review. In 2003, the study reported in this paper was conducted to determine which Member country did not have a national research ethics committee (REC) with a view to guiding the WHO Regional Office in developing practical strategies for supporting those countries. Methods This is a descriptive study. The (...) questionnaire was prepared and sent by diplomatic pouch to all the 46 Member States in the WHO African Region, through the WHO country representatives, for facilitation and follow up. The data were entered in Excel spreadsheet and subsequently exported to STATA for analysis. A Chi-Squared test (χ 2) for independence was undertaken to test the relationship between presence/absence of Research Ethics Committee (REC) and selected individual socioeconomic and health variables. Results The main findings were as follows: the response rate was 61% (28/46); 64% (18/28) confirmed the existence of RECs; 36% (10/28) of the respondent countries did not have a REC (although 80% of them reported that they had in place an ad hoc ethical review mechanism); 85% (22/26) of the countries that responded to this question indicated that ethical approval of research proposals was, in principle, required; and although 59% of the countries that had a REC expected it to meet every month, only 44% of them reported that the REC actually met on a monthly basis. In the Chi-Squared test, only the average population in the group of countries with a REC was statistically different (at 5% level of significance) from that of the group of countries without a REC. Conclusion In the current era of globalized biomedical research, good ethics stewardship demands that every country, irrespective of its level of economic development, should have in place a functional research ethics review system in order to protect the dignity, integrity and safety of its citizens who participate in research. (shrink)

This Article shows how three modern English thinkers — Hobbes, Locke and Bentham — construe the law as an intersection of secular eternity on the one one hand and transience in modernity on the other, allowing for immovability and movement at the same time, combining stability with change. It details how these theorists, who undoubtedly have earned themselves places of honor in the canon of modern political thought, tried to solve the problem of self-grounding in three different and yet paradigmatically (...) modern ways, each of them intertwining law and time in a different fashion, and each of them connecting both law and temporality to happiness. Thus this Article shows not only that these three British thinkers claim in one way or another that while natural desires may provide pleasure, only the law can bring happiness, but also emphasizes that, in their view, the transformation of the former into the latter entails a transformation of temporal consciousness. Thereby this Article foregrounds two elements that are crucial to an understanding of how seventeenth and eighteenth century British thinkers envisaged the transformation of pleasure into happiness by means of the law: first, the notion that the law creates or reinforces duration in social life, and second, the idea that the law can harness the immediacy of desires by assuring the legal protection of enduring pleasures, which lead to happiness. (shrink)

A partir del reto axiológico que presupone el hecho de que sea el propio ser humano el creador de los principales peligros que amenazan su supervivencia, tanto en sus efectos naturales como sociales, en el trabajo se argumenta por qué ello es indicador del extravío de los valores fundamentales que debe guiar el accionar humano y cómo el rescate de una confiable brújula axiológica debe partir por asumir a la vida como el criterio último de lo valioso.

El ensayo tiene como tema central el desarrollo de la capacidad valorativa y la participación que en este proceso tienen lo genético y lo sociocultural. Nos interesa mostrar las premisas biológicas generales de esa relación y enfatizar en la especificidad cualitativamente humana de su desarrollo, todo ello sobre todo desde el ángulo del vínculo entre las influencias genéticas y del medio y sus respectivos papeles en la determinación del desarrollo de aquella capacidad que a nivel humano identificamos como valoración. -/- (...) . (shrink)

Este artículo aborda el antiguo problema de la diferencia entre filosofía y poesía partiendo de una interpretación del arte narrativo personificado por Ulises en la Odisea. Una lectura del episodio de las Sirenas permite reconstruir la trama de voces diversas que compone el relato homérico y comprender la significación de esta estructura polifónica en el imaginario odiseico. Frente a la neta oposición entre autofonía y alofonía que propone la filosofía platónica, la poesía homérica implica una idea de heterofonía que apunta (...) más allá de una lógica binaria y sugiere la irreductibilidad de la voz poética a un juego entre extremos contrarios. La heterofonía consiste más bien en una voz figural que crea la «lógica difusa» del mundo ficcional mediante la neutralización de las diferencias entre sujetos enunciativos. (shrink)

Based on published works and unpublished materials, this article analyses how cybernetics was received by two Spanish thinkers exiled in Mexico: José Gaos (1900–1969) and Eduardo Nicol (1907–1990). This reception is particularly intriguing especially when considering the substantial presence and social impact that Norbert Wiener had in Mexican society because of his friendship with Arturo Rosenblueth. Gaos and Nicol are the first philosophers to develop a complex and original diagnosis of cybernetics in Mexico. It will be shown how the exiled (...) thinkers take on the philosophical implications of this science in the light of their respective theoretical projects, and finally, it will be defended how the critical perspective they develop is particularly significant for Mexico’s political and academic context since it illuminates some negative aspects of cybernetics that Wiener did not foresee and that had not been reported there until then. (shrink)

In this paper I will argue that when Aristotle uses the word ‘ἀρχή’ he is often referring to what we call a condition, whether necessary, sufficient or necessary and sufficient. To this end I will discuss how conditions for being, change, and knowledge, as identified by Aristotle, can be equated to ontological, physical and noetic principles, respectively.

1 Domains of application 2 Formulating the conceptual/nonconceptual distinction 3 Is there such a thing as nonconceptual content? 4 Developing the account of nonconceptual content .

Este livro não é propriamente uma monografia, mas um ajuste de contas. Desde os anos 60, J. A. Giannotti se preocupa com a possibilidade de uma dialética materialista. No seu último livro, Trabalho e reflexão, percebeu que a tentativa de uma "inversão" da dialética hegeliana conduzia a uma investigação lógica sobre esquemas operatórios capazes de ligar normas às condutas que as seguem. No fundo, tocava no conceito wittgensteiniano de jogo de linguagem não-verbal, sem tirar dele as conseqüências devidas. Impunha-se assim (...) uma reflexão mais penetrante sobre questões elementares da lógica. Esta Apresentação do mundo resulta dessa reflexão, de um esforço de dez anos e, se de novo tenta remar contra a maré, é porque nasce mais duma obsessão do que de um diálogo com seus contemporâneos. (shrink)

In this chapter, I outline what philosophers working on the ethics of immigration have had to say with regard to invidious discrimination. In doing so, I look at both instances of direct discrimination, by which I mean discrimination that is explicitly stated in official immigration policy, and indirect discrimination, by which I mean cases where the implementation or enforcement of facially “neutral” policies nonetheless generate invidious forms of discrimination. The end goal of this chapter is not necessarily to take a (...) side, but to outline the terrain and provide the reader with an adequate entryway into these philosophical discussions over discrimination and immigration. (shrink)

This article argues that bodily awareness is a basic form of self-consciousness through which perceiving agents are directly conscious of the bodily self. It clarifies the nature of bodily awareness, categorises the different types of body-relative information, and rejects the claim that we can have a sense of ownership of our own bodies. It explores how bodily awareness functions as a form of self-consciousness and highlights the importance of certain forms of bodily awareness that share an important epistemological property with (...) canonical forms of self-consciousness such as introspection. (shrink)

It is now 25 years since Gareth Evans introduced the distinction between conceptual and nonconceptual content in The Varieties of Reference. This is a fitting time to take stock of what has become a complex and extended debate both within philosophy and at the interface between philosophy and psychology. Unfortunately, the debate has become increasingly murky as it has become increasingly ramified. Much of the contemporary discussion does not do full justice to the powerful theoretical tool originally proposed by Evans (...) and subsequently refined by theorists in the late 1980’s and early 1990’s – most effectively, I think, by Christopher Peacocke (particularly in his 1992). Even worse, significant parts of the discussion are somewhat confused. This paper makes a start on clarifying what I think ought to be the central issues in debates about nonconceptual content. I begin in §1 by pointing out how narrowly focused contemporary discussion is relative to Evans’s original discussion. We are not making as much use as we should of nonconceptual content as a tool for understanding subpersonal information processing and the complexities of its status relative to perception and thought at the personal level. In §2 I turn to what is the central focus of contemporary discussion, namely, the content of perception and identify a “master argument” for nonconceptualism based on the relation between conceptual capacities and capacities for perceptual discrimination. The aim of §3 is to clarify the relation between the claim that perception has nonconceptual content and some superficially similar claims discussed by philosophers of perception. Finally, in §4 I explain why the attention recently focused on what is sometimes called the state version of the nonconceptualist thesis seems to me to be misdirected. (shrink)

Philosophical accounts of self-deception can be divided into two broad groups – the intentionalist and the anti-intentionalist. On intentionalist models what happens in the central cases of self-deception is parallel to what happens when one person intentionally deceives another, except that deceiver and deceived are the same person. This paper offers a positive argument for intentionalism about self-deception and defends the view against standard objections.