© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Ouvrages Le supplément au voyage de Bougainville et autres œuvres morales de Diderot, édition présentée et commentée, avec un dossier, Paris, Agora, Presses Pocket, 1992. Le trésor perdu. Hannah Arendt, l’intelligence de l’action politique, Paris, Payot, 1999. Un monde commun. Pour une cosmo-politique des conflits, Paris, Seuil, 2003. Le maléfice de la vie à plusieurs. La politique est-elle vouée à l’échec?, Paris, Bayard, 2012. Ouvrages collectifs Avec J. Message et J. Roman, À quoi p...

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

Toujours, les révolutions s'inversent en terreur, la libération fait naître la domination, le pouvoir abuse, ment, échoue... Pourquoi continue-t-on pourtant à croire que le gouvernement des hommes a pour but de transformer la société alors qu'il se réduit souvent à une gestion de la situation? C'est cette question qui résonne singulièrement en ces temps de changement de gouvernance que lance ici Etienne Tassin, se reposant sur une formule de Merleau-Ponty : "On veut oublier un problème que l'Europe soupçonne depuis (...) les Grecs : n'y a-t-il pas un maléfice de la vie à plusieurs?" Les Grecs seront donc nos guides pour éclairer notre démocratie contemporaine, Oreste pour appréhender la question de la justice, Oedipe celle du maléfice, Antigone la dissidence, Socrate l'utopie, Caton les révolutions, Gygès les oubliés du régime libéral, Achille le courage, Diogène la question des migrants... Ils nous aideront à affronter cette idée tragique : il n'y a pas de bonne solution, la politique n'est pas une affaire de réussite ou d'échec mais de risque, celui de vivre à plusieurs. Elle est la condition humaine. (shrink)

Al iniciar con la discusión suscitada por la redacción de los artículos 10 y 11 de la Declaración de los derechos humanos y del ciudadano de 1789, Etienne Tassin establece la diferencia entre la tolerancia como principio de cortesía democrática y la laicidad como principio de ciudadanía republicana. El autor sugiere que la laicidad es la política de la tolerancia cuando la tolerancia es la ética de la política, y que la forma republicana del poder político es la condición (...) de posibilidad de una sociedad democrática. Se puede, entonces, entender que la intransigencia política de la laicidad es como la condición trascendental de la tolerancia civil en el seno de las sociedades democráticas, o incluso que la intransigencia cívica es la única manera de garantizar la tolerancia civil. (shrink)

AU cœur de la vie politique des hommes gît un trésor, aujourd'hui perdu. Les révolutionnaires du XVIIIe siècle pouvaient encore le nommer. En Amérique on l'appelait " bonheur public ", dans la France des Lumières son nom était " liberté publique ". EN certaines circonstances, rares et précaires, ce trésor sans âge ressurgit dans l'action politique conduite à plusieurs, lorsqu'elle se crée un espace public où la liberté peut paraître. Alors un lien se noue, qui déploie entre les hommes un (...) monde commun. Tel est le bien public. En évoquant ce trésor perdu, la philosophie d'Hannah Arendt nous invite à retrouver, à l'écart de tout pragmatisme comme de tout moralisme, le sens instituant de l'action politique qui a le monde comme condition et comme fin. C'est dans la mesure où les actions sont politiques que le monde peut être partagé ; et dans la mesure où elles visent un monde commun que ces actions sont proprement politiques. Toute politique s'apprécie au regard du monde qu'elle est susceptible d'instaurer. N'est-ce pas pourtant à l'aliénation du monde que la politique moderne nous condamne au contraire? Le trésor serait-il pour nous définitivement perdu? Ce livre suggère que, loin de proposer une philosophie politique parmi d'autres, la réflexion arendtienne inaugure une intelligence de l'action politique qui redonne sens au " vivre-ensemble ". En son cœur se tient l'analyse originale et décisive de ce qu'on peut nommer l'acosmisme du monde moderne, cette perte du monde éprouvée aussi bien dans le système totalitaire que dans la prétention technoscientifique de nos sociétés à maîtriser les conditions de l'existence. (shrink)

Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} It has been said that the man whose rights are given through the Declaration of human rights is nothing but a formal abstraction driven by an irresolvable antinomy: either this man is taken prior to any political (...) institution in a kind of state of nature and the so-called human rights are not the rights of the citizen, or this man is seen according to the social determinations that result from the historic community to which he belongs. This antinomy has led to interpret the Declaration from an individualistic and liberal perspective, or to the negation of any political value to Human Rights. These theses that oppose man and citizen ignore another paradox that Hanna Arendt made evident when she underlined that human and citizenship rights only have any consistency because of a more fundamental right to have rights which surpasses the antinomy that grounds most criticisms against human rights and that allows for the actually political dimension of the humanity of beings to appear. (shrink)

L'ouvrage rend hommage au travail de Miguel Abensour et met en évidence les apports et innovations dans le domaine de la philosophie politique critique. Différents chercheurs de nombreux pays prolongent par leurs travaux les perspectives ouvertes par Miguel Abensour.

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.

The purpose of this text is to draw attention to eight forgotten heroes: William C. Bagley, Charles DeGarmo, David Felmley, William Torrey Harris, Isaac L. Kandel, Charles McMurry, William C. Ruediger, and Edward Austin Sheldon. They have been marginalized from our profession, and drawing upon their legacy is the best hope for restoring the profession of teaching today. This work also includes a chapter at the end of the book entitled "John Dewey's Forgotten Essays." The audience for this book includes: (...) 1) classroom teachers, 2) school administrators, 3) teacher educators, 4) deans and other university administrators, 5) college and university presidents, 6) legislators, 7) historians of education, 8) curriculum specialists, 9) specialists in teacher training, and 10) the general public. (shrink)

Knowledge, like other things of value, can be faked. According to Hawley (2011), know-how is harder to fake than knowledge-that, given that merely apparent propositional knowledge is in general more resilient to our attempts at successful detection than are corresponding attempts to fake know-how. While Hawley’s reasoning for a kind of detection resilience asymmetry between know-how and know-that looks initially plausible, it should ultimately be resisted. In showing why, we outline different ways in which know-how can be faked even when (...) a given performance is successful; and in doing so, we distinguish how know-how can be faked (no less than know-that) via upstream and downstream indicators of its presence, and within each of these categories, we’ll distinguish (in connection with detection resilience) both faking symptoms and (various kinds of) criteria. The unappreciated resilience of faked knowledge-how to successful detection highlights a largely overlooked dimension of social-epistemic risk – risk we face not just in our capacity as recipients of testimony, but in our capacity as both (would-be) apprentices and clients of knowledge-how. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

This new edition of Law and Medical Ethics continues to chart the ever-widening field that the topics cover. The interplay between the health caring professions and the public during the period intervening since the last edition has, perhaps, been mainly dominated by wide-ranging changes in the administration of the National Health Service and of the professions themselves but these have been paralleled by important developments in medical jurisprudence.

Cette biographie de référence éclaire d'un jour nouveau tout un pan de la vie intellectuelle du XXe siècle, celui de ces universitaires juifs allemands obligés de fuir le IIIe Reich et qui, d'étape en étape, finirent par trouver refuge aux Etats-Unis. Le livre associe la présentation des grandes étapes de la pensée et de l'œuvre de Hannah Arendt aux événements historiques qui la sollicitent et au tableau des amitiés et des cercles successifs. Si la liaison qu'elle eut brièvement au début (...) des années 30 avec Heidegger est désormais bien connue, d'autres aspects de son existence, pourtant du plus haut intérêt, le sont moins : son rapprochement avec le sionisme sous l'égide de Kurt Blumenfeld avant et pendant la guerre, son mariage avec Günther Stern, puis avec Heinrich Blücher, sa longue amitié aux Etats-Unis avec la romancière Mary McCarthy ou avec le poète W.H. Auden. Polémiste redoutable et critique cinglante, constante dans ses fidélités, et en premier lieu dans sa relation avec cette grande conscience allemande que fut Karl Jaspers, Arendt a traversé tous les débats du siècle, sans jamais céder ni sur son indépendance d'esprit ni sur sa lucidité : face au totalitarisme, dont elle forge le concept, mais aussi face au racisme et aux mouvements pour les droits civils aux Etats-Unis, face à la création de l'Etat d'Israël et au devenir du sionisme, face à l'engagement américain dans la guerre du Vietnam, face à la révolte de la jeunesse des années 60. Ne s'abandonnant jamais à la tentation aristocratique du retrait, elle accomplit une œuvre de pensée sans avoir besoin de décrier le monde, mais en prônant l'amour de la réalité, donnant ainsi l'image rare d'une vie de penseur à la hauteur de ses accomplissements spéculatifs. Indisponible depuis une dizaine d'années, cet ouvrage a été mis à jour et enrichi d'une nouvelle préface de l'auteur. (shrink)

The phenomenon of ambivalence is an important one for any philosophy of action. Despite this importance, there is a lack of a fully satisfactory analysis of the phenomenon. Although many contemporary philosophers recognize the phenomenon, and address topics related to it, only Harry Frankfurt has given the phenomenon full treatment in the context of action theory - providing an analysis of how it relates to the structure and freedom of the will. In this paper, I develop objections to Frankfurt's account, (...) all revolving around the charge that his account contains a serious ambiguity between willing and identifying. With such objections in place, I then develop an analysis that avoids the difficulties and ambiguities that Frankfurt's analysis is prey to. I briefly distinguish ambivalence from other types of internal conflict. This paper aims to offer conceptual clarification on the phenomenon of ambivalence, which will then allow for discussions about the normative merits and demerits of ambivalence, the effects of ambivalence on autonomous action, and methods of resolution of ambivalence. (shrink)

In this era of increased polarization of opinion and contentious disagreement, CRITICAL REASONING presents a cooperative approach to critical thinking and formation of beliefs. CRITICAL REASONING emphasizes the importance of developing and applying analytical skills in real life contexts. This book is unique in providing multiple, diverse examples of everyday arguments, both textual and visual, including hard to find long argument passages from real-life sources. The book provides clear, step-by-step procedures to help you decide for yourself what to believe--to be (...) a consumer of information in our contemporary "world of experts.". (shrink)