Much of the current research in regenerative medicine concentrates on stem-cell therapy that exploits the regenerative capacities of stem cells when injected into different types of human tissues. Although new therapeutic paths have been opened up by induced pluripotent cells and human mesenchymal cells, the rate of success is still low and mainly due to the difficulties of managing cell proliferation and differentiation, giving rise to non-controlled stem cell differentiation that ultimately leads to cancer. Despite being still far from becoming (...) a reality, these studies highlight the role of physical and biological constraints (e.g., cues and morphogenetic fields) placed by tissue microenvironment on stem cell fate. This asks for a clarification of the coupling of stem cells and microenvironmental factors in regenerative medicine. We argue that extracellular matrix and stem cells have a causal reciprocal and asymmetric relationship in that the 3D organization and composition of the extracellular matrix establish a spatial, temporal, and mechanical control over the fate of stem cells, which enable them to interact and control (as well as be controlled by) the cellular components and soluble factors of microenvironment. Such an account clarifies the notions of stemness and stem cell regeneration consistently with that of microenvironment. (shrink)

Both physiological and evolutionary criteria of biological individuality are underpinned by the idea that an individual is a functionally integrated whole. However, a precise account of functional integration has not been provided so far, and current notions are not developed in the details, especially in the case of composite systems. To address this issue, this paper focuses on the organisational dimension of two representative associations of prokaryotes: biofilms and the endosymbiosis between prokaryotes. Some critical voices have been raised against the (...) thesis that biofilms are biological individuals. Nevertheless, it has not been investigated which structural and functional obstacles may prevent them from being fully integrated physiological or evolutionary units. By contrast, the endosymbiotic association of different species of prokaryotes has the potential for achieving a different type of physiological integration based on a common boundary and interlocked functions. This type of association had made it possible, under specific conditions, to evolve endosymbionts into fully integrated organelles. This paper therefore has three aims: first, to analyse the organisational conditions and the physiological mechanisms that enable integration in prokaryotic associations; second, to discuss the organisational differences between biofilms and prokaryotic endosymbiosis and the types of integration they achieve; finally, to provide a more precise account of functional integration based on these case studies. (shrink)

Although the analogy between macroscopic machines and biological molecular devices plays an important role in the conceptual framework of both neo-mechanistic accounts and nanotechnology, it has recently been claimed that certain complex molecular devices cannot be considered machines since they are subject to physicochemical forces that are different from those of macroscopic machines. However, the structural and physicochemical conditions that allow both macroscopic machines and microscopic devices to work and perform new functions, through a combination of elemental functional parts, have (...) not yet been examined. In order to fill this void, this paper has a threefold aim: first, to clarify the structural and organisational conditions of macroscopic machines and microscopic devices; second, to determine whether the machine-like analogy fits nanoscale devices; and third, to assess whether the machine-like analogy is appropriate for describing the behaviour of some biological macromolecules. Finally, the paper gives an account of ‘machine’ which, while acknowledging the physicochemical and organisational differences between man-made machines and biological microscopic devices, nevertheless identifies a common conceptual core that allows us to consider the latter ‘machines’. (shrink)

Organoids and organs-on-a-chip are currently the two major families of 3D advanced organotypic in vitro culture systems, aimed at reconstituting miniaturized models of physiological and pathological states of human organs. Both share the tenets of the so-called “three-dimensional thinking”, a Systems Physiology approach focused on recapitulating the dynamic interactions between cells and their microenvironment. We first review the arguments underlying the “paradigm shift” toward three-dimensional thinking in the in vitro culture community. Then, through a historically informed account of the technical (...) affordances and the epistemic commitments of these two approaches, we highlight how they embody two distinct experimental cultures. We finally argue that the current systematic effort for their integration requires not only innovative “synergistic” engineering solutions, but also conceptual integration between different perspectives on biological causality. (shrink)

In his 2013 monograph on Structure and Method in Aristotle’s Meteorologica, Malcolm Wilson has shown both that Aristotle conceived of meteorological phenomena as analogous to the bodily processes of animals, and that for the Stagirite the sublunar world should not be seen as a single body, but rather as composed of many different individuals. However, Wilson did not articulate the relationship between these two theories—that is, he did not answer the following question: how is it possible for the Earth to (...) behave like an animal if it is not a single body? This paper argues that the answer to this question lies in the Aristotelian statement about the different paschein of the Earth and animals. In fact, in the chapter of Meteorology dedicated to climatic changes (1.14), Aristotle, after comparing such changes to the maturing and ageing of living organisms, states that ‘only, in the case of the bodies of plants and animals being affected does not occur in each part separately, but it is necessary for the being to mature and decay all at once, whereas in the case of the Earth this occurs in each part separately, due to cooling and warming’ (351a.28-31). In his commentary, Alexander of Aphrodisias reiterates that the difference between the changes of the Earth and those of living organisms concern the way in which these different subjects undergo affections (pathê). The concept of paschein/pathos is thus fundamental to understanding how Aristotle conceives of biological analogies, which play a key role in his meteorology: as the affections of maturing and corruption show, parallels with organic processes can be found in meteorological phenomena, but always at the level of the individual parts of the Earth. Although the sublunary world can be understood in organic terms, this world is not a ‘cosmic animal’, but rather a multiplicity of ‘regional animals’. To corroborate this thesis, this paper addresses several related questions, including: the mechanics ofenvironmental changes according to Aristotle; the differences between the regions of the Earth; the lexicon used in Meteorology to refer to the transformations of the Earth; the personal notes that Alexander adds to Aristotle’s discussion. Finally, the first modern translation of the relevant section of Alexander’s commentary is also provided here. (shrink)

This paper lists and examines the explicit references to Aristotle’s Topics in the Greek Neoplatonic commentaries on the Categories. The references to the Topics by Porphyry, Dexippus, Ammonius, Simplicius, Olympiodorus, Philoponus and David are listed according the usual prolegomena to Aristotle’s works. In particular, the paper reconstructs David ’s original thesis about the proponents of the title Pre-Topics for the Categories and compares Ammonius’, Simplicius’ and Olympiodorus’ doxographies about the postpraedicamenta. Moreover, the study identifies two general trends. The first one (...) is that all the commentators after Proclus share the same general view about: the authenticity of the Topics, Aristotle’s writing style in them, the part of philosophy to which they belong, their purpose, their usefulness and their place in the reading order. The second one is that whereas Porphyry, Dexippus and Simplicius use the Topics as an aid to understanding the Categories, Ammonius, Olympiodorus and David do not. (shrink)

Compte rendu de Quentin Hiernaux, Du comportement végétal à l’intelligence des plantes?

The comments in this Note are not exhaustive, but intentionally offer a path ; 4. The sacramental bond) wherein theological interpretation has a privileged place, deeply inscribed in the present commentary in regard to women’s problems and expectations in today’s Church. Although nothing certain and irrefutable emerges from the documentary evidence, in regard to women’s ministry, the situation of the Church has changed, as has the situation of women. The true sacramental bond concerns the theological understanding of ordained ministry. If (...) this bond is reconnected to its original and constitutive character of service, perhaps some of the reasons for excluding women will crumble. For there are women in the Church who continue to live and work within and for the Church. (shrink)

Il volume comprede una serie di saggi sui passi più significativi del commento di Alessandro di Afrodisia al IV libro dei Topici di Aristotele. In particolare, i saggi sono dedicati ai seguenti tre argomenti, su cui Alessandro espone tesi estremamente interessanti. Il primo tratta la dialettica, cioè l'argomento dei Topici; segue poi il genere, che costituisce l'argomento del IL libro in particolare; infine l'anima, le discussioni intorno alla quale costituiscono per il commentatore un esempio privilegiato per illustare i "luoghi" dialettici (...) via via discussi."--Page 2 of cover. (shrink)

This article is about the terms used in the works traditionally ascribed to Alexander of Aphrodisias to mean the process of abstraction through which intellect separates form and matter. The passages are studied in order to identify what nouns and verbs are used. Since in two works of dubious authorship aphaireô and aphairesis are found, the usage of these terms in the works that can be ascribed with certainty to Alexander is studied. The results obtained are examined in the light (...) of the hypotheses about the authorship and chronology of the cited works formulated by scholars so far. (shrink)

El presente artículo expone brevemente las circunstancias del "redescubrimiento" de la obra de Luciano en la Italia renacentista y el movimiento renovador en las letras que esto trajo consigo en el caso específico del Momus de Leon Battista Alberti. Para tal objetivo, me concentraré en el rol de Manuel Crisoloras; en los aspectos de género literario que Luciano plantea, sobre todo, en el Prometheus es in verbis, y finalmente, en cómo estos son retomados en el Momus, donde Alberti se presenta (...) como innovador de las letras latinas, pero al mismo tiempo como indirecto continuador del quehacer luciánico. (shrink)

Le volume rassemble 25 études concernant la cosmologie médiévale, abordée à travers ses diverses composantes, à l’intérieur d’une fourchette chronologique allant de Calcidius jusqu’au XIVe siècle. Dix contributions sont consacrées à des questions de cosmologie hébraïque et islamique, traitant en particulier de Gersonide (R. Gatti), Maïmonide (L. Pepi), Avicenne (C. Di Martino, O. Lizzini), Sohravardî (I. Panzeca), Qûnawî (P. Spallino), les Frères de la Pureté (C. Baffioni) ainsi qu’aux interférences qui existent entre moyen âge islamique et latin : la grande (...) question de la cosmologie alchimique (M. Pereira), des textes traduits comme le De secretis naturae (P. Travaglia), la doctrine de la grande année dans Thebit et Pietro d’Abano (F. Seller). Les travaux de E.S. Mainoldi et de R. Gambino consacrent une large place à l’influence de la patristique grecque sur la pensée occidentale. D’autres études présentent le développement de la pensée cosmologique et scientique latine à partir de Calcidius (C. Militello), par l’intermédiaire d’Adélard de Bath (P. Palmeri), de Guillaume de Conches (G. Pellegrino) et d’autres documents divers (A. Tarabochia Canavero) jusqu’à l’avènement de l’aristotélisme physique, en particulier dans les commentaires universitaires aux Météorologiques (G. Fioravanti), au De caelo (C.A. Musatti, A. Vella) et chez Dante (M. Gallarino, P. Falzone). Quant à la littérature scientifique en langue vulgaire, elle est représentée par Restoro d’Arezzo (U. Villani-Lubelli) et Raymond Lull (J.Gayà). La communication de G. Alliney est dédiée à des questions de méthode historiographique, tandis que la contribution magistrale de Tullio Gregory sur “Cosmogonie et cosmologies chrétiennes” reconstitue de manière idéale l’ensemble des liens constituant les coordonnées générales de l’ensemble de la problématique abordée sous ses différentes facettes par les auteurs du volume. (shrink)

As Russian influence in Italy grows, Putin’s ‘Trojan horse’ in the EU reflects several societal trends, molding perceptions of a foreign policy appropriate for Italy.

The COVID-19 virus is severely testing the Italian healthcare system, as the requests for intensive treatment are greater than the real capacity of the system to receive patients. Given this emergency situation, it follows that citizens are limited in their freedom of movement in order to limit infection, and that in hospitals a significant number of critical situations must be faced. This brief contribution aims to offer a reflection on the public and clinical role of the bioethicist: a figure able (...) to promote dialogue between the world of medicine and the community, and to face ethical dilemmas even in emergent clinical settings. (shrink)

Summary My paper aims to clarify the subsequent steps of Rome’s encroachment on Etruria in the aftermath of the Pyrrhic War. As is well known, the Latin colony of Cosa was founded in 273 BC on the Tyrrhenian coast to the north of Vulci; moreover, in the years 264–245 BC, four citizen colonies were founded on the Caeretan coast, namely Castrum Novum, Pyrgi, Alsium and Fregenae. Unfortunately, it is not easy to reconstruct precisely what the Roman movements in Etruria were, (...) or how the Etruscans reacted to them. Above all, it is difficult to determine whether a colonial foundation like Cosa – which was contemporary with the establishment of Paestum in Lucania – was part of a broader and coherent strategy that the Romans had been following in their expansion into the Italian peninsula. By evaluating all the available evidence, I will try to demonstrate that the foundation of Cosa depended more upon particular contingencies than upon any preconceived plan for the conquest of Italy. (shrink)

Fascist Italy and Nazi Germany: Comparisons and Contrasts, Edited by R. Bessel, (Cambridge University Press, 1996) 242 pp. £35 cloth, £12.95 paper. The Sacralization of Politics in Fascist Italy. By E. Gentile (Cambridge, Mass: Harvard University Press, 1996). 208 pp. $49.95 cloth.

Cet article constitue l'un des éléments d'un dossier comparatif international sur le traitement médiatique de l'attentat survenu à la gare d'Atocha à Madrid en mars 2004. Centré sur l'Italie et basé sur l'étude d'un corpus des quatre principaux quotidiens, il analyse les orientations du discours développé par cette presse dans les jours qui ont suivi cet événement. Il montre, qu'après un moment de compassion devant les conséquences dramatiques de l'attentat, ces titres se sont déterminés sur la base d'une analogie entre (...) la situation politique espagnole et la situation italienne et ceci en raison des positions identiques de leurs gouvernements quant au conflit en Irak. Des divergences de tons et d'attitude sont observables entre ces différents journaux, mais on assiste globalement à une forme de banalisation et de «nationalisation» de l'événement progressivement replié sur la scène nationale.This article is one of a comparative study on the international media coverage of the attack in Atocha train station in Madrid in March 2004. Centered on Italy and based on the study of a corpus of four major dailies, it analyzes the stand taken by the press in the days following the event. It shows, after a moment of compassion for the tragic consequences of the attack, these securities are determined on the basis of an analogy between the Spanish political situation and the situation in Italy and this because of the identical positions of their governments about the conflict in Iraq. Differences of tone and attitude are observable between these newspapers, but there is generally a form of trivialization and "nationalization" of the event gradually declined on the national scene. (shrink)

La fin du xviiie siècle et le début du xixe coïncident en Italie non seulement avec de grandes mutations politiques et juridiques liées aux guerres napoléoniennes, mais aussi avec de profondes transformations des rôles familiaux. À travers l’analyse d’une série de correspondances épistolaires échangées dans cette période entre des frères et des sœurs membres de familles de l’aristocratie, l’article examine la manière dont l’interprétation du rôle des individus a pu se modifier et les attentes que ces derniers ont entretenues quand (...) au comportement des autres membres de leur fratrie. Les arguments des lettres, leur ton, les références à des épisodes de la vie familiale et les notices sur la gestion du patrimoine permettent de définir la substance de la relation entre frères et sœurs à la fin de l’Ancien Régime, et de saisir en quoi elle différait des rapports noués par leurs pères et leurs oncles ou de ceux entretenus par des frères et sœurs appartenant à d’autres familles aristocratiques d’Italie dans la seconde moitié du xviiie siècle. (shrink)

La fin du xviiie siècle et le début du xixe coïncident en Italie non seulement avec de grandes mutations politiques et juridiques liées aux guerres napoléoniennes, mais aussi avec de profondes transformations des rôles familiaux. À travers l’analyse d’une série de correspondances épistolaires échangées dans cette période entre des frères et des sœurs membres de familles de l’aristocratie, l’article examine la manière dont l’interprétation du rôle des individus a pu se modifier et les attentes que ces derniers ont entretenues quand (...) au comportement des autres membres de leur fratrie. Les arguments des lettres, leur ton, les références à des épisodes de la vie familiale et les notices sur la gestion du patrimoine permettent de définir la substance de la relation entre frères et sœurs à la fin de l’Ancien Régime, et de saisir en quoi elle différait des rapports noués par leurs pères et leurs oncles ou de ceux entretenus par des frères et sœurs appartenant à d’autres familles aristocratiques d’Italie dans la seconde moitié du xviiie siècle. (shrink)