In the past decades, an enormous amount of precious information has been collected about molecular and genetic characteristics of cancer. This knowledge is mainly based on a reductionistic approach, meanwhile cancer is widely recognized to be a ‘system biology disease’. The behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. There is not solely a matter how to integrate all available knowledge in such a way that we can still deal with complexity, (...) but we must be aware that a deeply transformation of the currently accepted oncologic paradigm is urgently needed. We have to think in terms of biological networks: understanding of complex functions may in fact be impossible without taking into consideration influences outside of the genome. Systems Biology involves connecting experimental unsupervised multivariate data to mathematical and computational approach than can simulate biologic systems for hypothesis testing or that can account for what it is not known from high-throughput data sets. Metabolomics could establish the requested link between genotype and phenotype, providing informations that ensure an integrated understanding of pathogenic mechanisms and metabolic phenotypes and provide a screening tool for new targeted drug. (shrink)

This article examines Frederick Winslow Taylor’s career, contributions, and influence on management practice. As the father of scientific management, he evokes the most emotional and polarized responses of any management theorist. He is both revered and reviled. There may be disagreement about Taylor’s effect on work and workers, but there is little doubt about his enduring influence. A 2000 survey of the American Academy of Management ranked Taylor first among the twenty-five most influential management thinkers of the twentieth century. He (...) distilled his efforts to increase efficiency into four Principles of Scientific Management: the scientific development of work, new management roles, the scientific selection of workers, and managerial cooperation. Two trends could have a significant bearing on Taylor’s influence in the twenty-first century: the application of lean principles to health care and the use of artificial intelligence adaptive computer programmes for securities trading. (shrink)

This landmark work provides a systematic introduction to systems of modal logic and stands as the first presentation of what have become central ideas in philosophy of language and metaphysics, from the "new theory of reference" and non-linguistic necessity and essentialism to "Kripke semantics.".

Walter Burley was one of the most prominent logicians and metaphysicians of the Middle Ages. This volume, which contain thirteen substantial articles on his philosophy, is aimed to reconstruct the internal evolution of his doctrines and the role they played in the development of Late Medieval philosophy.

In thirteen essays from different aesthetic traditions, Aesthetic Apprehensions: Silences and Absences in False Familiarities problematizes our habituated customs of seeing and reading the familiar to focus on that which cannot easily be comprehended but may be sensed through encounters with the ruptures and gaps that quietly beckon our attention.

No. 93: PAPELES SEMÁNTICOS Estudio de los papeles semánticos a partir de un enfoque tipológico, intentando unificar las distintas propuestas y analizar en profundidad el significado y la utilidad de esta etiqueta.

Este artigo se divide em quatro partes. Inicialmente apresentamos a noção de biopolítica de modo introdutório, considerando a relação entre poder soberano e biopoder. Voltamo-nos para a elaboração foucaultiana do termo de modo a esclarecer, em linhas gerais, seu sentido. Essa breve análise da noção de biopolítica encaminha-nos para o conceito de tanatopolítica, que aparece, na segunda parte do texto, como epíteto da derivação funesta da biopolítica. Na terceira parte, a partir de uma perspectiva biopolítica, lançamos luz sobre a crise (...) que enfrentamos. Trata-se de um esforço de evidenciar o sentido biopolítico da crise atual, considerando o conteúdo das reflexões de Foucault. Finalmente, na quarta parte, atualizamos o debate acerca da biopolítica por meio de uma análise da noção de imunidade formulada por Esposito, a qual fornece uma importante chave interpretativa da pandemia atual. (shrink)

Philosopher of science Bruno Latour defines the image as “any sign, work of art, inscription or painting serving as a mediation to reach something else.” According to this definition, mediation could very well be a synonym for image. In this article, I would like to use Latour’s work to argue for the crucial role that images play in overcoming a certain modern worldview that has divided the world into ontological essences that separate subject and object, nature and culture. It is (...) precisely the erasure of the mediations, the images that connect these different forms of life together, that has led to the positing of the modern constitution of autonomous essences, cut off from the many agencies that give them life. Using the art installations of artist Tomas Saraceno, this article will show that it is precisely this mediating role of art that lends it such an interdisciplinary and phenomenological role in allowing the invisible webs connecting earth and sky, nature and culture, human and non-human, to be seen. (shrink)

Appearing in English for the first time, Schelling’s 1842 lectures develop the idea that many philosophical concepts are born of religious-mythological notions.

In order to explore some of the divergences within new materialism and elucidate their relationship to actor-network theory, this article will develop Latour’s theory of agency and then compare it to those new materialists who uphold a ‘flat ontology’ that includes technological tools and those who uphold an animate/inanimate distinction. In light of the ecological crisis called the Anthropocene, the dissolution of the animate/inanimate distinction will be defended in order to address both polar bears and glaciers, coral reefs and clown (...) fish. Though Latour himself has defended such a dissolution, his political proposals to address the ecological crisis revert back to the modern and dualist position he has himself critiqued for so long. Using the gains of actor-network theory, while differentiating a new materialist ecological politics from that of Latour, will be shown to be necessary in order to find a solution to the crisis of the Anthropocene. (shrink)

With precision and profundity born of 30 years of devoted study, John Boyle offers an essential introduction to St. Thomas Aquinas on Scripture, shedding helpful light on the goals, methods, and commitments that animate the Angelic Doctor's engagement with the sacred page. Because the genius of St. Thomas's approach to the Bible lies not so much in its novelty but rather in the fidelity and clarity with which he recapitulates the riches of the preceding interpretive Tradition, this initiation into St. (...) Thomas's vision of Scripture is itself an orientation to the Church's vision of Scripture, from the Fathers through and beyond the Middle Ages. St. Thomas's embeddedness within the Church's Tradition and his own historical context is integral to his approach to Scripture, yet it sets him at some distance from modern readers, for whom his interpretive vision may seem perplexing or even impenetrable. In this Primer, Boyle first provides an acclimation to this medieval context through a survey and explanation of pertinent technical terminology used by St. Thomas and characteristic of the scholastic theology of the time. With an eye to the medieval practice of considering Scripture according to the fourfold division of causes, Boyle builds on this initial foundation by exploring in turn St. Thomas's accounts of the end or use of Scripture (final cause), its divine and human authorship (efficient cause), its order and division (material cause), and its literary styles or genres (formal cause). Drawing on writings from across St. Thomas's corpus, but especially his work On the Commendation and Division of Sacred Scripture and the prologues to his biblical commentaries, Boyle masterfully elucidates both the hermeneutical principles and deep wisdom of the Angelic Doctor's approach to Scripture, imparting invaluable guidance not only for reading and understanding St. Thomas and other great masters of the Tradition, but also-and ultimately-for understanding Scripture in light of this Tradition and reading it with greater benefit and joy. (shrink)

Antiretroviral pre-exposure prophylaxis (PrEP) is protective against HIV. Low utilization rates amongst HIV vulnerable populations are due in part to the high cost of PrEP. Generic PrEP offers the potential to improve health at significantly reduced costs. In this study, we examine early utilization patterns and prices for generic PrEP. We discuss the opportunities and challenges for generic PrEP to improve health among HIV vulnerable populations.

Robots are versatile devices that are promising tools for supporting teaching and learning in the classroom or at home. In fact, robots can be engaging and motivating, especially for young children. This paper presents an experimental study with 81 kindergarten children on memorizations of two tales narrated by a humanoid robot. The variables of the study are the content of the tales (knowledge or emotional) and the different social behaviour of the narrators: static human, static robot, expressive human, and expressive (...) robot. Results suggest a positive effect of the expressive behaviour in robot storytelling, whose effectiveness is comparable to a human with the same behaviour and better when compared with a static inexpressive human. Higher efficacy is achieved by the robot in the tale with knowledge content, while the limited capability to express emotions made the robot less effective in the tale with emotional content. (shrink)

Today political theorists and the public generally often associate descriptive representation with democracy. However, in Victorian Britain supporters of descriptive representation tended to be arrayed against democracy. The impression that democracy was incompatible with descriptive representation and a set of related values, primary among which was deliberation, formed one of the great obstacles which democratic theory faced in this period. These values belonged to a traditional theory of representation which held that Parliament ought to be a mirror of the nation (...) in its diversity and which judged democracy, in contrast, to be an illiberal mode of regulating the franchise because it risked handing the representation wholly to one part or class within society. In response to this school of thought, democratic theory developed two conflicting responses: first, that democracy could accommodate social and ideological diversity; second, that democracy was irreconcilable with the goal of mirroring diversity, but that nevertheless democracy had to be preferred on grounds of fairness and non-arbitrariness. (shrink)

According to libertarianism about free will, at least some of the choices we make are free and undetermined. Many libertarians also accept the thesis that, before we make an undetermined choice, there is a nontrivial objective probability that we will make that choice. In the literature on free will, the ascription of objective probabilities is sometimes justified via an “Argument from Motivation,” which adverts to the fact that typically, in situations of choice, we are more motivated to choose some options (...) over others. In this paper, I will examine this argument and I will argue that it is unsound, as one of its premises is at odds with a widely accepted principle governing the evolution of objective probabilities over time. (shrink)

The psychological factors influencing a return to sport has gained increased research attention. In the current investigation, we explored professional basketball players’ perceptions of the psychological factors facilitating a return to performance equal to or exceeding previous performance standards. We also sought to describe athletes’ experiences – both positive and negative – of returning to sport following injury recovery. Ten Italian professional male basketball players (age range 22-36 years), were retrospectively interviewed in relation to three time-periods: (1) from the commencement (...) of rehabilitation to their first official competition, (2) the first official competition, and (3) the six-months following the initial competition. Hierarchical content analysis of the data revealed numerous themes across the three time periods. In regards to Period 1, participants indicated that social support, investment in rehabilitation and training programs, coping skills and motivation were fundamental in reaching pre-injury performance levels. During their first official game (i.e. Period 2), athletes reported that realistic performance expectations, focusing on the performance, positive emotions, motivation, arousal and social support facilitated their return to sport. Athletes however, also described a predominance of factors that hindered their return to pre- injury levels (i.e., low confidence in personal abilities, decrements in skill execution and dysfunctional physical sensations). Moreover, participants typically described a substandard level of performance during their first competition back following injury. In recounting experiences during the six months following their first official game, basketballers reported improvements in skill execution and highlighted the importance of coping skills, motivation and social support. The process of restoring self-confidence in one’s ability to successfully perform was perceived as crucial in enabling participants to move beyond a mere return to sport to a return to high performance ─ that is, to reach a level of proficiency equal to or exceeding previous performance standards. Findings support the relevance of cognitive, emotional and behavioral responses highlighted in the Integrated Model and suggest the importance of addressing psychological factors throughout the return-to-sport process. Finally, results from the present study hold a number of practical implications for athletes’ aiming to achieve a return to pre-injury levels. (shrink)

Panpsychism, the view that the material elements of the universe have mental properties, has until quite recently remained in the periphery of the philosophical mainstream due to its blatant contradiction of normative Cartesian dualities, which divided the world into mental properties and material properties, that are devoid of value and sentience. The recent geological shift to the Anthropocene Age, in which human culture can be found in pesticide resistant mosquitoes and the ozone heavens, has undermined the foundations of Cartesian dualism, (...) making panpsychism a credible alternative. Yet some panpsychists go too far by conflating all distinctions between living and nonliving, human and nonhuman, evolved and made entities. Using Whitehead's process philosophy, this article will defend panpsychism and develop the philosophical criteria of causation, relationality, unity and intentionality to differentiate between natural living forms, natural nonliving forms, and human artifacts. (shrink)

Though responses to the Anthropocene have largely come from the natural and social sciences, religious responses to the Anthropocene have also been gaining momentum and many scholars have been calling for a religious response to complement scientific responses to climate change. Yet because Genesis 1:28 does indeed tell human beings to 'subdue the earth' monotheistic religions have often been understood as complicit in the human exceptionalism that is thought to have created the conditions for the Anthropocene. In distinction to such (...) Biblical traditions, indigenous animistic cultures have typically respected all forms of life as 'persons' and such traditions have thus become a source of inspiration for ecological movements. After discussing contemporary Christian efforts to integrate the natural sciences and the environment into their responses to the Anthropocene, this article will turn to animism and seek to evaluate the risks and benefits that could ensue from a postmodern form of animism that could provide a necessary postsecular response to the Anthropocene. (shrink)

For many environmental philosophers, the dualisms intrinsic to Modernity that separate body from mind and nature from culture must be deconstructed in order to develop an inclusive ecology that might respond to the Anthropocene Age. In seeking alternatives to human exceptionalism and humans as exclusive owners of souls to the exclusion of other animals, many scholars have turned to Asian philosophies founded in presuppositions that are far more eco-centric. Focusing on Buddhism, this article will outline some eco-centric aspects of Buddhist (...) dogma, focusing on the idea of co-dependent origination and the Buddhist idea that all things are empty of inherent existence and are constituted through relationality. Then we will show how such Buddhist ideas have been used to develop an ecology that instead of abstracting itself from place, as modern theories are wont to do, seeks to develop an intrinsic relationship to place, and even to locate subjectivity there. This is the Japanese theory of Fudo, developed by twentieth century philosopher Tetsuro Watsuji, a theory that is able to move beyond the dualisms of Western ideology to provide a promising response to the Anthropocene Age. If the being of being human is co-determined and co-dependent upon its milieu and upon the community of others living in such a milieu, we should be focusing on finding ways to re-claim and re-value such milieu as constitutive of human development and flourishing. In this way, we can replace Western universals and intrinsic essence with ontological specificity and the shared inter-dependent experience of community. (shrink)

We question the idea that the mirror neuron system is the substrate of social affordances perception, and we suggest that most of the activity seen in the parietal and premotor cortex of the human brain is independent of mirroring activity as characterized in macaques, but rather reflects a process of one's own action specification in response to social signals.

The complexity and inefficiency of the U.S. health care system complicates the distribution of life-saving medical technologies. When the public health is at stake, however, there are alternatives. The proposal for a national PrEP program published in this issue of the Journal applies some of the lessons of the national COVID vaccine campaign to HIV prevention. In doing so, it draws on other examples of public health approaches to the financing of medical technology, from vaccines for children to hepatitis C (...) treatment. (shrink)

The recent proliferation of AI scandals led private and public organisations to implement new ethics guidelines, introduce AI ethics boards, and list ethical principles. Nevertheless, some of these efforts remained a façade not backed by any substantive action. Such behaviour made the public question the legitimacy of the AI industry and prompted scholars to accuse the sector of ethicswashing, machinewashing, and ethics trivialisation—criticisms that spilt over to institutional AI ethics boards. To counter this widespread issue, contributions in the literature have (...) proposed fixes that do not consider its systemic character and are based on a top-down, expert-centric governance. To fill this gap, we propose to make use of qualified informed lotteries: a two-step model that transposes the documented benefits of the ancient practice of sortition into the selection of AI ethics boards’ members and combines them with the advantages of a stakeholder-driven, participative, and deliberative bottom-up process typical of Citizens’ Assemblies. The model permits increasing the public’s legitimacy and participation in the decision-making process and its deliverables, curbing the industry’s over-influence and lobbying, and diminishing the instrumentalisation of ethics boards. We suggest that this sortition-based approach may provide a sound base for both public and private organisations in smart societies for constructing a decentralised, bottom-up, participative digital democracy. (shrink)

In Feb. 2022 Sungho Kimlee passed away. In his memory, we present this revised and abridged version of a portion of his dissertation, Factions and Orders: from Machiavelli to Madison. Sungho summarized the work as follows: “Since antiquity, thinkers have held that every society consists of two hostile orders – the few and the many. But they have disagreed on the proper method for defusing this civic divide, and their various proposed remedies can be classified into three approaches. The first (...) approach aims to eliminate the division between the rich and the poor by abolishing private property. Plato’s Republic inaugurated this method, which was later embraced with ambivalence by Thomas More and vigorously defended by Karl Marx. The second approach merely aims to contain the harmful effects of the binary civic divide. Plato proposed two methods for accomplishing this in the Laws: Plutarch championed the first method, and Aristotle the second. My dissertation traces the genealogy of the third approach – the method of supplanting the binary civic divide with more numerous divisions. This oft-neglected method was pioneered by Rousseau, who prescribed the creation of artificial divisions by the state as a remedy for majority factions. (shrink)

Many scholars have understood the Anthropocene as confirming the patient work in the social sciences to deconstruct the nature/culture divide, for the human being is now present in the entire eco-system, from deet-resistant mosquitoes to the ozone hole in the heavens. Scholars like Bruno Latour have claimed that nature and culture have always been co-determined and thus that their separation was a case of modern bad faith with disastrous consequences. Because Latour blames this divide on the human exceptionalism that pitted (...) a human subject against a world of objects, and thus denied agency to other living and nonliving actants, the solution for Latour lies in recognizing their agency in an ‘enlarged democracy.’ Such scholarship has inspired many scholars to adopt a ‘flat ontology’ that treats all forms of agency, whether animate or inanimate, as equivalent and autonomous material forces. This article will elucidate Latour’s ‘democracy of things’ and explore the beneficial consequences for the Anthropocene of attributing autonomous agency to non-human actants, while at the same time discussing the negative repercussions of reifying the agency of technological tools as separate from human agency. Due to such widespread reification of technological agency, it will be shown that causal analysis that traces such agency back to its source in human political organization is required in order to adequately respond to the Anthropocene. (shrink)

SUMMARYDue to his famous conflict with John Stuart Mill, James Fitzjames Stephen is often assumed to have been an opponent of toleration and intellectual freedom and a defender of authoritarian or reactionary principles. These assumptions are misleading. Stephen was, and was known in his time to have been, a champion of toleration. This essay provides a comprehensive overview of his writing on these themes, drawing from a wider array of texts than is usually considered in the study of the Stephen-Mill (...) controversy. Contrary to popular belief, Stephen had a deep and multi-faceted argument in favor of toleration. As a critic of contending theories of toleration and freedom of discussion, Stephen was concerned to defeat what he saw as the resurgence of a priori principles in Victorian political philosophy and to combat the expansion of a proper notion of toleration to include a cluster of beliefs and attitudes of which he disapproved. In his approach to these issues Stephen was, arguably, as representative of Victorian thinking as the author of On Liberty. (shrink)