Two recent reports of mice homozygously deleted for cyclin D1 provide unequivocal evidence that the critical G1 cyclin, cyclin D1, is by itself rate‐limiting for growth in some mammalian tissues(1,2). Cyclin D1 knockout mice are small and exhibit behavioral abnormalities. Specific hypoplasias of retinal and mammary tissues suggest an unusual dependence on cyclin D1 function for tissue growth in those organs. The odd coincidences that cyclin D1 functions as the retinoblastoma gene kinase, together with associations between increased cyclin D1 expression (...) and breast cancer, suggest, but do not prove, a special function of cyclin D1 in those tissues. (shrink)

Historical demographic research shows that the factors influencing mortality risk are labile across time and space. This is particularly true for datasets that span societal transitions. Here, we seek to understand how marriage, migration, and the local economy influenced mortality dynamics in a rapidly changing environment characterized by high in-migration and male-biased sex ratios. Mortality records were extracted from a compendium of historical vital records for the Baja California peninsula (Mexico). Our sample consists of 1,201 mortality records spanning AD 1835–1900. (...) Findings from Cox proportional hazard models indicate that (1) marriage was associated with a protective effect for both sexes; (2) residing in a mining town was associated with higher mortality for men, but not women; (3) migration was associated with decreased mortality risk for women, but not men; and (4) the risk of mortality increased in the face of infectious disease, but decreased over time. Despite the early initiation of reproduction for women, marriage had a protective effect, likely because marriage linked women to resources. Although mining boomtowns were associated with elevated risk factors generally, only men experienced greater mortality risk, likely due to dangerous working conditions that women did not experience. Last, female, but not male, migrants experienced greater longevity, possibly because exposure to harsh labor conditions eroded the protective effect of selection bias for men. Together, these results shed light on an understudied historical population and broaden our understanding of demographic dynamics in preindustrial settings. (shrink)

This engaging introduction to the fundamental issues of philosophy will prompt students to think actively about questions such as: Does God exist? Do we have souls? Does human life have meaning? Is there a real difference between right and wrong? and many others. The twelve chapters focus on these key philosophical questions and possible answers to them, and include readings by famous thinkers on each issue.

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.3 (2001) 454-456 [Access article in PDF] Michael Potter. Reason's Nearest Kin: Philosophies of Arithmetic from Kant to Carnap.New York: Oxford University Press, 2000. Pp. x + 305. Cloth, $45.00. This book tells the story of a remarkable series of answers to two related questions:(1) How can arithmetic be necessary and knowable a priori? [End Page 454](2) What accounts for the applicability of (...) arithmetic to matters of empirical fact?These are philosophical questions, part of a "wider puzzle of explaining the link between experience, language, thought, and the world" (18). But answers to them are heavily constrained by technical results in logic and mathematics, and most of Potter's protagonists are either mathematicians (Frege, Dedekind, Ramsey, Hilbert, Gödel) or mathematically trained philosophers (Kant, Russell, Carnap). (Only Wittgenstein fits neither category.) Potter, whose doctorate was in pure mathematics, is an able guide.It is not hard to think of answers to these questions taken singly; what is hard is answering both at the same time. Formalists can easily explain why arithmetic does not depend for its justification on empirical fact—it is just a game with symbols, not responsible to anything beyond its own rules—but they then have trouble explaining why the world of empirical fact is constrained by this game. Empiricists can explain the applicability of arithmetic in just the same way they explain the applicability of physics, but they then must then explain away the apparent a prioricity and necessity of arithmetic. Kant was the first to propose a plausible answer to both questions: arithmetic is both necessary and empirically applicable because it is grounded in the spatio-temporal form of any possible experience.What unites Frege, Dedekind, Russell, Ramsey, Hilbert, and Carnap is that they reject Kant's answer while continuing to seek an answer to his question: how can arithmetic's necessity be reconciled with its applicability? Potter helpfully classifies their projects by the surrogates they substitute for Kant's appeal to the form of spatio-temporal intuition: Frege and Dedekind appeal to thought, Russell to necessary features of the world, Wittgenstein, Ramsey, and Carnap to language, and Hilbert to the necessary structure of our experience of finitary combinations of objects. (Revealingly, the logicists are not grouped together in Potter's taxonomy.) A chapter (or two) is devoted to each of these thinkers, plus Kant and Gödel.This breadth of coverage does not come at the price of superficiality: Potter's chapters are (by and large) accurate, penetrating, and full of interesting insights. I cannot think of another book that offers such clear explanations of the many mathematical concepts and distinctions one must grasp in order to follow debates in the philosophy of arithmetic. The Russell chapters are enhanced by numerous quotations from archival material. The exposition of Hilbert's programme and the implications for it of Gödel's theorems is the best I have seen. The discussions of Wittgenstein's views on arithmetic and of Carnap's syntactical approach also shine. The chapters on Kant and Frege are somewhat weaker; the discussion of Kant, in particular, would have benefited from some engagement with Michael Friedman's views.But the real contribution of Potter's book is its integration of these nine thinkers into a single coherent story. No one will be surprised that Russell's motivations can only be understood in light of Frege's failures, or that many features of Wittgenstein's cryptic work become clearer when seen in light of the specific problems with Russell's system. But there are also some less obvious payoffs: for example, Hilbert's programme is usefully compared with Russell's regressive method (227-8), and Carnap and Russell are shown to face a common dilemma (269, 286).If there is a central theme to Potter's story, it is "how often we have had to reject an [End Page 455] account not for philosophical reasons but for technical ones" (278). Frege's program founders on Russell's paradox, Russell's... (shrink)

John MacFarlane explores how we might make sense of the idea that truth is relative. He provides new, satisfying accounts of parts of our thought and talk that have resisted traditional methods of analysis, including what we mean when we talk about what is tasty, what we know, what will happen, what might be the case, and what we ought to do.

We consider a paradox involving indicative conditionals (‘ifs’) and deontic modals (‘oughts’). After considering and rejecting several standard options for resolv- ing the paradox—including rejecting various premises, positing an ambiguity or hidden contextual sensitivity, and positing a non-obvious logical form—we offer a semantics for deontic modals and indicative conditionals that resolves the paradox by making modus ponens invalid. We argue that this is a result to be welcomed on independent grounds, and we show that rejecting the general validity of modus (...) ponens is compatible with vindicating most ordinary uses of modus ponens in reasoning. (shrink)

As some see it, an impasse has been reached on the mind- body problem between mainstream physicalism and mainstream dualism. So lately another view has been gaining popularity, a view that might be called the 'Russellian theory of mind' (RTM) since it is inspired by some ideas once put forth by Bertrand Russell. Most versions of RTM are panpsychist, but there is at least one version that rejects panpsychism and styles itself as physicalism, and neutral monism is also a possibility. (...) In this paper I will attempt to sort out these different versions with a view to determining which, if any, have a chance of breaking the perceived impasse. The unsurprising conclusion will be that there are a lot of challenges ahead for the RTM theorist. The surprising conclusion will be that it's not clear that pan- psychist RTM holds an advantage over the other versions in this regard. (shrink)

Anyone who is a color eliminativist‐i.e., believes that the physical world is colorless‐must explain how our sense experience of color can be so systematically illusory. As it turns out, it is difficult to do this without committing oneself to dualism. In this paper I explore the options available to the color eliminativist in this regard, and argue that his/her prospects are more promising, though still far from certain, if s/he adopts the position that sense experience is strictly intentional.

Evans’ 1968 ANALOGY system was the first computer model of analogy. This paper demonstrates that the structure mapping model of analogy, when combined with high‐level visual processing and qualitative representations, can solve the same kinds of geometric analogy problems as were solved by ANALOGY. Importantly, the bulk of the computations are not particular to the model of this task but are general purpose: We use our existing sketch understanding system, CogSketch, to compute visual structure that is used by our existing (...) analogical matcher, Structure Mapping Engine (SME). We show how SME can be used to facilitate high‐level visual matching, proposing a role for structural alignment in mental rotation. We show how second‐order analogies over differences computed via analogies between pictures provide a more elegant model of the geometric analogy task. We compare our model against human data on a set of problems, showing that the model aligns well with both the answers chosen by people and the reaction times required to choose the answers. (shrink)

Not so long ago, the idea that analytic philosophers would be taking panpsychism seriously would have been hard to believe. That is because in its early, logical positivist, stage, the analytic movement earned the reputation of being militantly anti-metaphysical. But analytic philosophy has come a long way since the heyday of logical positivism; and, in fact, the dialectic of recent debates on the mind–body problem among analytic philosophers has pushed many of them in the direction of panpsychism. In this paper, (...) I want to explain how this has come about and take a look at some of the versions of panpsychism that have emerged. This will involve running through a quick history of debates on the mind–body problem since about 1960, focusing on how panpsychism has been proposed as a promising, though not unproblematic, way of breaking an apparent impasse that has emerged between more standard physicalist and dualist theories of mind. Along the way, I will also have occasion to comment on the prospects of panpsychism as a respectable scientific theory and how a number of scientists stand on this. (shrink)

A popular defense of physicalist theories of consciousness against anti-physicalist arguments invokes the existence of ‘phenomenal concepts’. These are concepts that designate conscious experiences from a first person perspective, and hence differ from physicalistic concepts; but not in a way that precludes co-referentiality with them. On one version of this strategy phenomenal concepts are seen as (1) type demonstratives that have (2) no mode of presentation. However, 2 is possible without 1-call this the ‘bare recognitional concept’ view-and I will argue (...) that this avoids certain recent criticisms while retaining the virtue of finessing the ‘mode of presentation’ problem for phenomenal concepts. But construing phenomenal concepts this way seems to not do justice to the phenomenology of conscious experience. In this paper I examine whether or not this impression can be borne out by a good argument. As it turns out, it is harder to do so than one might think. It can be done, but it involves somewhat more convoluted reasoning than one might have supposed necessary. Having shown that, I will end with a few brief remarks on what my argument means for attempts to preserve a physicalist account of consciousness. (shrink)

We reflect, using a vignette, on conceptual tensions and the value judgements that lie behind difficult decisions about whether or not the older person with dementia should return home or move into long-term care following hospital admission. The paper seeks, first, to expose some of the difficulties arising from the assessment of residence capacity, particularly around the nature of evaluative judgements and conceptual tensions inherent in the legal approach to capacity. Secondly, we consider the assessment of best interests around place (...) of residence, which demonstrates significant conceptual tensions. In addition, ‘best interests’ raise issues around the perception of risk and the perceptions of the family and crucially involve the notions of autonomy and trust. Finally, we not only gesture at some practical considerations based on insights from values-based medicine, but also make the suggestion that we require tighter functional assessments of residence capacity coupled with broader judgements about best interests. (shrink)

Frank Jackson formulated his knowledge argument as an argument for dualism. In this paper I show how the argument can be modified to also establish the irreducibility of the secondary qualities to the properties of physical theory, and ultimately "secondary quality eliminativism"- the view that the secondary qualities are physically uninstantiated.

The relativist's central objection to contextualism is that it fails to account for the disagreement we perceive in discourse about "subjective" matters, such as whether stewed prunes are delicious. If we are to adjudicate between contextualism and relativism, then, we must first get clear about what it is for two people to disagree. This question turns out to be surprisingly difficult to answer. A partial answer is given here; although it is incomplete, it does help shape what the relativist must (...) say if she is to do better than the contextualist in securing genuine disagreement. (shrink)

The goal of this paper is to make sense of relativism about truth. There are two key ideas. (1) To be a relativist about truth is to allow that a sentence or proposition might be assessment-sensitive: that is, its truth value might vary with the context of assessment as well as the context of use. (2) Making sense of relativism is a matter of understanding what it would be to commit oneself to the truth of an assessment-sensitive sentence or proposition.

If it is not now determined whether there will be a sea battle tomorrow, can an assertion that there will be one be true? The problem has persisted because there are compelling arguments on both sides. If there are objectively possible futures which would make the prediction true and others which would make it false, symmetry considerations seem to forbid counting it either true or false. Yet if we think about how we would assess the prediction tomorrow, when a sea (...) battle is raging (or not), it seems we must assign the utterance a definite truth-value. I argue that both arguments must be given their due, and that this requires relativizing utterance-truth to a context of assessment. I show how this relativization can be handled in a rigorous formal semantics, and I argue that we can make coherent sense of assertion without assuming that utterances have their truth-values absolutely. (shrink)

Philosophers on all sides of the contextualism debates have had an overly narrow conception of what semantic context sensitivity could be. They have conflated context sensitivity (dependence of truth or extension on features of context) with indexicality (dependence of content on features of context). As a result of this conflation, proponents of contextualism have taken arguments that establish only context sensitivity to establish indexicality, while opponents of contextualism have taken arguments against indexicality to be arguments against context sensitivity. Once these (...) concepts are carefully pulled apart, it becomes clear that there is conceptual space in semantic theory for nonindexical forms of contextualism that have many advantages over the usual indexical forms. (shrink)

By “epistemic modals,” I mean epistemic uses of modal words: adverbs like “necessarily,” “possibly,” and “probably,” adjectives like “necessary,” “possible,” and “probable,” and auxiliaries like “might,” “may,” “must,” and “could.” It is hard to say exactly what makes a word modal, or what makes a use of a modal epistemic, without begging the questions that will be our concern below, but some examples should get the idea across. If I say “Goldbach’s conjecture might be true, and it might be false,” (...) I am not endorsing the Cartesian view that God could have made the truths of arithmetic come out differently. I make the claim not because I believe in the metaphysical contingency of mathematics, but because I know that Goldbach’s conjecture has not yet been proved or refuted. Similarly, if I say “Joe can’t be running,” I am not saying that Joe’s constitution prohibits him from running, or that Joe is essentially a non-runner, or that Joe isn’t allowed to run. My basis for making the claim may be nothing more than that I see Joe’s running shoes hanging on a hook. (shrink)

BackgroundConcerns about decision making related to resuscitation have led to two important challenges in the courts resulting in new legal precedents for decision-making practice. Systematic research investigating the experiences of doctors involved in decisions about resuscitation in light of the recent changes in law remains lacking.AimTo analyse the practice of resuscitation decision making on hospital wards from the perspectives of doctors.DesignThe data presented in this paper were collected as part of a wider research study of end-of-life care in an acute (...) hospital setting. Data collection comprised ethnographic non-participant observation on two acute hospital wards and individual interviews with patients, relatives and healthcare professionals caring for patients thought to be approaching the end of life. Data were analysed using a constructivist grounded theory approach.ResultsDiscussions and decision making about resuscitation present many challenges for those involved on acute medical wards. The data highlight the potential for multiple interpretations of legal precedents, creating misunderstandings that may impact patient care in less positive ways.ConclusionsThis paper provides unique insights into how doctors respond to the changing medico-legal culture and the subsequent effects on patient care. It demonstrates how the juridification of medical practice can occur. It highlights the potential benefit of a structure to support clinicians, patients and relatives in discussing and navigating decisions around care at the end of life in line with the patient’s wishes and preferences. Recommendations for future research are made and legal ramifications are discussed. (shrink)

Recent years have seen an explosion of interest in the semantics of knowledge-attributing sentences, not just among epistemologists but among philosophers of language seeking a general understanding of linguistic context sensitivity. Despite all this critical attention, however, we are as far from consensus as ever. If we have learned anything, it is that each of the standard views—invariantism, contextualism, and sensitive invariantism—has its Achilles’ heel: a residuum of facts about our use of knowledge attributions that it can explain only with (...) special pleading. This is not surprising if, as I will argue, there is a grain of truth in each of these views. (shrink)

Much philosophy of logic is shaped, explicitly or implicitly, by the thought that logic is distinctively formal and abstracts from material content. The distinction between formal and material does not appear to coincide with the more familiar contrasts between a priori and empirical, necessary and contingent, analytic and synthetic—indeed, it is often invoked to explain these. Nor, it turns out, can it be explained by appeal to schematic inference patterns, syntactic rules, or grammar. What does it mean, then, to say (...) that logic is distinctively formal? (shrink)

To assert something is to perform a certain kind of act. This act is different in kind both from other speech acts, like questions, requests, commands, promises, and apologies, and from acts that are not speech acts, like toast buttering and inarticulate yodeling. My question, then is this: what features of an act qualify it as an assertion, and not one of these other kinds of act? To focus on a particular example: in uttering “Bill will close the window,” one (...) might be practicing English pronunciation, asserting that Bill will close the window, or requesting that Bill close the window. What makes it the case that one is doing one of these and not another? (shrink)

(1981). Intension, identity, and the Colourless Physical World: A revision and further discussion. Australasian Journal of Philosophy: Vol. 59, No. 2, pp. 203-205.

In a recent article, Grover Maxwell presents a case for a kind of mind-brain identity theory which he claims precludes materialism. His case is based on some views about meaning which I find plausible. However, I will argue that, by adopting certain assumptions about the nature of sensory experience, and extending some of Maxwell's views about meaning in a plausible way, the issue of a materialistic identity theory is reopened. Ultimately, I will agree that such a theory is not true, (...) but more is needed to show this than Maxwell gives us. But the question of materialism is not thereby closed, because it has become axiomatic these days that materialism does not require an identity theory. So I will go on to consider if all forms of materialism have been ruled out by Maxwell's theory, as extended by me. I will end with a tentative affirmative answer but also with a proposal which, if it can be worked out, would reverse the decision. (shrink)

The subjectivity of consciousness is widely regarded as a major stumbling block for materialist theories of mind. In this paper I show how Kripkean arguments against identity theories , and in particular a Kripkean argument against qualia-material property identity developed by Frank Jackson are a way of highlighting this problem. As such, Kripkean arguments are akin to recent discussions of subjectivity by Thomas Nagel and Frank Jackson . I then consider some recent attempts to refute Kripkean arguments or otherwise show (...) that subjectivity is not an insurmountable problem for identity theory. The most promising attempt is one that I myself develop, based on some ideas by Keith Gunderson . But I contend that even it, let alone any of the others, is not without problems. Thus, tentatively, Kripkean arguments against property identity succeed. (shrink)

The subjectivity of consciousness is widely regarded as a major stumbling block for materialist theories of mind. In this paper I show how Kripkean arguments against identity theories (Kripke, 1972), and in particular a Kripkean argument against qualia-material property identity developed by Frank Jackson (1980) are a way of highlighting this problem. (And such arguments are not the quasi-historical curiosities they are sometimes pictured as being, because problems confronting functionalism have led to a modest revival of identity theory.) As such, (...) Kripkean arguments are akin to recent discussions of subjectivity by Thomas Nagel (1965, 1974, 1979) and Frank Jackson (1982). I then consider some recent attempts to refute Kripkean arguments or otherwise show that subjectivity is not an insurmountable problem for identity theory. The most promising attempt is one that I myself develop, based on some ideas by Keith Gunderson (1970). But I contend that even it, let alone any of the others, is not without problems. Thus, tentatively, Kripkean arguments against property identity succeed. (shrink)

The subjectivity of consciousness is widely regarded as a major stumbling block for materialist theories of mind. In this paper I show how Kripkean arguments against identity theories (Kripke, 1972), and in particular a Kripkean argument against qualia-material property identity developed by Frank Jackson (1980) are a way of highlighting this problem. (And such arguments are not the quasi-historical curiosities they are sometimes pictured as being, because problems confronting functionalism have led to a modest revival of identity theory.) As such, (...) Kripkean arguments are akin to recent discussions of subjectivity by Thomas Nagel (1965, 1974, 1979) and Frank Jackson (1982). I then consider some recent attempts to refute Kripkean arguments or otherwise show that subjectivity is not an insurmountable problem for identity theory. The most promising attempt is one that I myself develop, based on some ideas by Keith Gunderson (1970). But I contend that even it, let alone any of the others, is not without problems. Thus, tentatively, Kripkean arguments against property identity succeed. (shrink)

A popular defense of physicalist theories of consciousness against anti-physicalist arguments is the “phenomenal concept strategy”. According to PCS there are phenomenal concepts that designate phenomenal properties, and whose use requires adopting the first person perspective with respect to those properties, thus allowing an epistemic gap between the phenomenal and the physical without requiring a metaphysical gap. One version of PCS is the quotational version, according to which phenomenal concepts are in part constituted by the very properties they designate. The (...) advertising for this version of PCS is that it does better justice to the phenomenology of consciousness than alternative versions. But in doing so, I argue, it threatens to reintroduce dualism. This can be avoided by adopting a Russellian account of physical concepts, but even with this we seem to be committed to a non-physicalist Russellian account of consciousness, and perhaps even a Russellian panpsychism. This can be avoided only by holding that, even though we now cannot see how the phenomenal supervenes on the physical, it does anyway, and perhaps future developments will make this clear. Thus, what starts out as a Type B physicalist strategy becomes a Type C strategy. (shrink)