Evidence-based medicine (EBM) has long deemphasized mechanistic reasoning and pathophysiological rationale in assessing the effectiveness of interventions. The EBM+ movement has challenged this stance, arguing that evidence of mechanisms and comparative studies should both be seen as necessary and complementary. Advocates of EBM+ provide a combination of theoretical arguments and examples of mechanistic reasoning in medical research. However, EBM+ proponents have not provided recent examples of how downplaying mechanistic reasoning resulted in worse medical results than would have occurred otherwise. Such (...) examples are necessary to make the case that EBM+ responds to a problem in clinical practice that urgently demands a solution. In light of this, we examine the failed rollout of efavirenz as a first-line HIV treatment in Zimbabwe as evidence of the importance of mechanistic reasoning in improving clinical practice and public health policy decisions. We suggest that this case is analogous to examples commonly given to support EBM. (shrink)

Proposals for how health care ought to be allocated and delivered in the United States have been debated for at least the last 80 years. The last major effort at expanding health-care coverage in the US was the Affordable Care Act, which went into law in 2010. The ACA increased the number of Americans who have medical insurance, but it has nonetheless fallen short of providing universal coverage, and as of 2017, 8.8% of Americans, or 28.5 million, were uninsured. So (...) far, Republican efforts to fully repeal the ACA have failed, but Republican lawmakers have whittled away at crucial elements of the Act (including, importantly, the individual mandate that compels individuals to obtain insurance or... (shrink)

The development of empathy is central to positive social adjustment. However, issues remain with integrating empathy research conducted with children, adolescents, and adults. The current article (...

Empathy is an extensively studied construct, but operationalization of effective empathy is routinely debated in popular culture, theory, and empirical research. This article offers a process-focused approach emphasizing the relational functions of empathy in interpersonal contexts. We argue that this perspective offers advantages over more traditional conceptualizations that focus on primarily intrapsychic features. Our aim is to enrich current conceptualizations and empirical approaches to the study of empathy by drawing on psychological, philosophical, medical, linguistic, and anthropological perspectives. In doing so, (...) we highlight the various functions of empathy in social interaction, underscore some underemphasized components in empirical studies of empathy, and make recommendations for future research on this important area in the study of emotion. (shrink)

I strongly agree with the criticisms of the restrictive isomorphic matching definition of empathy made by Murphy, Lilienfeld, and Algoe, and largely agree with their conceptualization of empathy as a dynamic process best defined by its function. In this commentary, I extend this argument by emphasizing the relational, interpersonal aspects of empathy. It is my view that in order to understand the functions of empathy, we must take into account not only the internal experience of the individual empathizing, but also (...) the individual whose perspective the empathizer is attempting to take. I highlight how the emotional needs of others are dynamic and require flexible adaptation and underscore the role of context in appreciating the function of empathy. (shrink)

It is clear a relational approach to the study of empathy is gaining traction across multiple disciplines. Both commentaries on “A Relational Framework for Integrating the Study of Empathy in Child...

In this article, I draw on historical and conceptual arguments to show, first, that disenchantment and the influential view of the relationship between science and religion to which disenchantment gives rise are rooted in the metaphysics of theism. I then introduce the alternative metaphysical position of panentheism and identify Jungian psychology as an important, if implicit, mid-twentieth-century instance of panentheistic thought. Using the example of Jungian psychology, I demonstrate how the viewpoint of panentheism undoes the implications of disenchantment for the (...) relationship between science and religion, promoting greater opportunities for dialogue and reconciliation between science and religion. I note, however, that these closer relations may depend on understanding science and religion differently from how they are understood under disenchantment. While the original tension between science and religion is eased, another tension—between panentheistic and disenchanted understandings of science and religion—is exposed. I conclude by reflecting on some implications of this discussion for sociology. (shrink)

Consent remains a crucial, yet challenging, cornerstone of clinical practice. The ethical, legal and professional understandings of this construct have evolved away from a doctor-centred act to a patient-centred process that encompasses the patient’s values, beliefs and goals. This alignment of consent with the philosophy of shared decision-making was affirmed in a recent high-profile Supreme Court ruling in England. The communication of information is central to this model of health care delivery but it can be difficult for doctors to gauge (...) the information needs of the individual patient. The aim of this paper is to describe ‘core information sets’ which are defined as a minimum set of consensus-derived information about a given procedure to be discussed with all patients. Importantly, they are intended to catalyse discussion of subjective importance to individuals. The model described in this paper applies health services research and Delphi consensus-building methods to an idea orginally proposed 30 years ago. The hypothesis is that, first, large amounts of potentially-important information are distilled down to discrete information domains. These are then, secondly, rated by key stakeholders in multiple iterations, so that core information of agreed importance can be defined. We argue that this scientific approach is key to identifying information important to all stakeholders, which may otherwise be communicated poorly or omitted from discussions entirely. Our methods apply systematic review, qualitative, survey and consensus-building techniques to define this ‘core information’. We propose that such information addresses the ‘reasonable patient’ standard for information disclosure but, more importantly, can serve as a spring board for high-value discussion of importance to the individual patient. The application of established research methods can define information of core importance to informed consent. Further work will establish how best to incorporate this model in routine practice. (shrink)

Les textes rassembles ici marquent un tournant decisif de la philosophie biranienne: apres avoir developpe sa pensee dans les Memoires couronnes (tomes II, III, IV, VI), Maine de Biran, revenant sur ses pas, estime qu'il a laisse sans solution les problemes de la metaphysiques classiques. Il s'efforce d'y repondre a partir de son propre point de vue et elabore a cet effet ses theories de la croyance et de l'absolu: l'etre ne se reduit pas au phenomene qui le manifeste; (...) etre, ce n'est pas etre percu. C'est dans les Rapports des sciences naturelles avec la psychologie que Biran traite pour la premiere fois ces questions de maniere detaillee, ce qui l'oblige a reprendre sa distinction du sujet et de l'objet, et a revoir sa critique de Condillac et des cartesiens. On trouvera aussi dans ce volume plusieurs opuscules de la meme epoque abordant ces questions, et notamment des discours prononces a la societe philosophique qu'il animait alors. (shrink)

Ces deux tomes de la Correspondance decoupent la litterature epistolaire de Maine de Biran en deux periodes: avant la correspondance echangee avec Ampere sur la periode 1766-1804, de 1805 a 1824 les lettres se multiplient alors que commencent les echanges avec Ampere. Le volume des pieces publiees est double par rapport a ce que l'on connaissait. Des correspondants inconnus apparaissent alors que les echanges connus sont completes et revises. L'ensemble est refere a ses sources originales et a ses traditions (...) editoriales. Chaque document est accompagnes de notes historiques qui ouvrent aux commentaires. Ces pieces ont ete presentees comme une biographie epistolaire continue relative aux episodes des fonctions publiques de Maine de Biran. Elles constituent ainsi le pendant des ecrits politiques. (shrink)

On trouvera dans ce volume des textes qui refletent certains aspects de la dernieres philosophies de Maine de Biran, ainsi que de nombreux temoignages de ses lectures entre 1818 et 1823. Sa pensee se developpe selon trois perspectives: une redefinition de la philosophie a l'occasion d'une critique detaillee de Bonald (sur l'origine du langage et la definition de l'homme, notamment), une reflexion sur la morale (qui s'efforce de trouver une troisieme voie a partir de Condillac et Kant), et une (...) reprise de la tradition religieuse (Lamennais, Bossuet, Fenelon, commentaire de l'Evangile de saint Jean). Son evolution vers un platonisme de plus en plus marque, la presence croissante du christianisme peuvent se lire a travers de nombreux textes et appendices - tous inedits (sur Plotin, Proclus, saint Augustin) - ou s'elabore plus nettement le theme de la troisieme vie. (shrink)

Entre 1805 et 1819, Maine de Biran et Ampere echangerent une correspondance si abondante, si riche, si coherente, qu'il a paru souhaitable de consacrer un volume autonome a ces documents, pour une large part restes inedits. Pour Maine de Biran, Ampere est un interlocuteur consistant, qui permet de mettre a l'epreuve les principes philosophiques elabores dans les grands textes de la maturite; il est de plus le grand artisan de la conversion a l'ontologie, operee par le philosophe autour (...) de 1813: c'est dans ces lettres que la question du noumene est posee et discutee longuement. En Maine de Biran, Ampere dispose d'un partenaire de choix, qui lui offre l'occasion de tester les diverses classifications des operations psychiques auxquelles il attache une si grande importance. (shrink)

Since the 1980s, microenterprise development programs have proliferated in the United States, where they are widely praised as strategies for economic development and poverty alleviation, especially for low-income women and welfare mothers. Based on research in a highly respected urban center for women, this article argues that microenterprise development is more detrimental and problematic than it is purported to be. Two reasons are isolated. First, gender constraints mean women tend to choose small-scale, undercapitalized, and barely profitable “pink-collar” businesses, largely home-based (...) operations based on work women are already doing as part of their gender-specific role. Second, microenterprise training programs reinforce this business segregation by discounting the sociocultural conditions women bring with them to business and instead emphasizing the personal growth of individuals. The result is that women are encouraged to maintain their economic vulnerability and social peripheralization rather than become part of the mainstream business world. (shrink)

Entre 1805 et 1819, Maine de Biran et Ampere echangerent une correspondance si abondante, si riche, si coherente, qu'il a paru souhaitable de consacrer un volume autonome a ces documents, pour une large part restes inedits. Pour Maine de Biran, Ampere est un interlocuteur consistant, qui permet de mettre a l'epreuve les principes philosophiques elabores dans les grands textes de la maturite; il est de plus le grand artisan de la conversion a l'ontologie, operee par le philosophe autour (...) de 1813: c'est dans ces lettres que la question du noumene est posee et discutee longuement. En Maine de Biran, Ampere dispose d'un partenaire de choix, qui lui offre l'occasion de tester les diverses classifications des operations psychiques auxquelles il attache une si grande importance. (shrink)

La carriere de Maine de Biran, homme public, se poursuit durant toute son existence et s'il se plaint frequemment de ne pas disposer du temps indispensable pour la redaction de ses ouvrages philosophiques, c'est parce qu'il est accapare par ses taches dans la fonction publique ou dans les assemblees representatives. Il surmontera les sept regimes auquel il jura fidelite et en vint, avec la Restauration, au regime politique qui s'accordait avec ses pensees relatives a sa troisieme vie. Pour la (...) premiere fois, on disposera de ces ecrits de philosophie politique qui permettent de constater que le philosophe n'est pas un simple executant au service des gouvernements illegitimes puis legitimes. Penser son existence politique, c'est faire entrer ce large champ public dans le domaine philosophique. (shrink)

In this title the author explores the time-tested practice and philosophy using modern examples from more than a decade of experience with this ancient practice. He brings the principles of yoga into focus and makes them user-friendly for yogis living in the post modern era.

Philosophisch gelangte Maine de Biran (1766-1824) über den Sensualismus von Condillac, Helvétius, La Mettrie und Cabanis hinaus, war dem Idealismus Kants und Fichtes zugeneigt und bereitete einen neuen Spiritualismus in der französischen Metaphysik vor. Seine Tagebuchaufzeichnungen zeigen ihn auch als Psychologen und politisch unorthodoxen Menschen.

Frequently referred to as the 'French Kant', Maine de Biran was dubbed the greatest metaphysician to have been produced in France since Descartes and Malebranche by Henri Bergson, indicating the huge impact that Biran's work had during the nineteenth century and beyond. His philosophical vocabulary and key conceptual distinctions still play an undeniably central role in contemporary continental philosophy. This volume situates Biran within the development of modern French, German and British philosophy and illustrates the deep influence he had (...) on major figures such as Maurice Merleau-Ponty, Michel Henry, and Paul Ricoeur. His work also had a huge impact on philosophical understandings of the distinction between the virtual and the actual, as well as the concepts of effort and puissance, that were enormously important to Deleuze and Foucault. The notion of corps propre, so important to phenomenology in the twentieth century, in fact originates in the work of Maine de Biran. Appearing in translation for the first time, this key work and accompanying essays makes the mature thought of this vastly important philosopher available to English speaking audiences, and is an imperative background for students studying modern continental philosophy. (shrink)

This chapter contains sections titled: Introduction The Nature and Extent of Children’s Involvement in ‘the Other Half’ of Education Some Problems with Jung's Account of ‘the Other Half’ of Education Conclusion Notes References.

Cell communication is crucial for many aspects of growth and differentiation during the development of the nematode Caenorhabditis elegans. Two genes, glp‐1 and lin‐12, mediate a number of known cell–cell interactions. Genetic and molecular analyses of these two genes lead to the conclusion that they are structurally and functionally related. We summarize these studies as well as those involving the identification of other genes that interact with glp‐1 and / or lin‐12.

Ideas about child education are inevitably underpinned by particular views of children, including their nature and development. The purpose of this paper is to discuss C. G. Jung's account of child education in relation to his psychological theory and view of children. However, as Jung's theory predominantly concerns the psychological development of adults and not children, the current paper makes selective use of Jung's texts that focus on children, and examines what Jung calls ‘the other half’ of education that works (...) through the teacher's personality indirectly affecting the student's development of personality. From a close study of Jung's texts, the paper discusses the nature and the extent of children's involvement in ‘the other half’ of education and considers some problems with Jung's account of unconscious education. The paper identifies the active and autonomous roles played by children in unconscious education and suggests that Jung's account of ‘the other half of education’ could provide fresh insights about the meaning and quality of education. (shrink)

Toward the close of the nineteenth century, just as American pragmatism began to approach its classic form, Frederick Jackson Turner penned what was to become the single most famous definition of the American character. In the lead essay of his book The Frontier in American History, Turner tells us that "the frontier is the line of most rapid and effective Americanization". What he means is that the idea of the frontier—not the confrontation of slavery or the experience of European colonization—was (...) the most significant factor in the formation of what has come to be seen as uniquely American.By "frontier," Turner means that curious zone in which "wilderness" and "civilization" meet and exercise a. (shrink)