In June 1998 Hans Primas turned 70 y ears old. Although he himself is not fond of jubilees and although he lik es to play the decimal system of numb ers do wn as contingent, this is nev ertheless a suitable o ccasion to re ect on the professional work of one of the rare distinguished contemp orary scientists who attach equal imp ortance to exp erimen tal and theoretical and conceptual lines of researc h. Hans Primas' in terests ha (...) ve covered an enormous range: metho ds and instruments for n uclear magnetic resonance, theoretical c hemistry , C - and W -algebraic formulations of quantum mechanics, the measurement problem and its various implications, holism and realism in quantum theory , theory reduction, the w ork and p ersonality of Wolfgang Pauli, as well as Jungian psychology . In man y of these elds he provided imp ortan t and original fo o d for though t, in some cases going far b eyond the ev eryda y business in the scientic world. As is the case with other scien tists who are conceptually innov ativ e, Hans Primas is read more than he is quoted. His in uence is due to his writings. Even with the current ood of publications, he still p erforms the miracle of ha ving scientists eagerly a waiting his next publication. His external life, by wa y of contrast, is not very sp ectacular. With the exception of a brief p erio d as a guest professor at Washington Univ ersity at St. Louis, he has never b een a wa y from Zuric h for an y length of time. He has nev er b een a warded an y prizes, nev er organized a congress, nev er done any organizational work in a scientic so ciety . He delib erately distanced himself from the hustle and bustle of national and in ternational scien tic business. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The traditional formalism of quantum mechanics is mainly used to describe ensembles of identical systems (with a density-operator formalism) or single isolated systems, but is not capable of describing single open quantum objects with many degrees of freedom showing pure-state stochastic dynamical behaviour. In particular, stochastic 'line-migration' as in single-molecule spectroscopy of defect molecules in a molecular matrix is not adequately described. Starting with the Bohr scenario of stochastic quantum jumps (between strict energy eigenstates), we try to incorporate more general (...) pure-state stochastic dynamical behaviour into the quantum mechanical formalism.Probability distributions of (approximately) pure states, arising through the stochastic pure-state dynamics for long times, give rise to appropriate decompositions of thermal density operators. These decompositions of density operators into pure states mediate between quantum mechanics for ensembles of molecules and quantum theory for single molecules (or single dressed quantum objects). We suggest that such decompositions should be consistent with infinite limits (e.g. the Born-Oppenheimer limit for infinite nuclear masses) in the sense that quantum fluctuations (around classical behaviour in the infinite limit) die out asymptotically. (shrink)

Quantum systems have a holistic structure, which implies that they cannot be divided into parts. In order tocreate (sub)objects like individual substances, molecules, nuclei, etc., in a universal whole, the Einstein-Podolsky-Rosen correlations between all the subentities, e.g. all the molecules in a substance, must be suppressed by perceptual and mental processes.Here the particular problems ofGestalt (shape)perception are compared with the attempts toattribute a shape to a quantum mechanical system like a molecule. Gestalt perception and quantum mechanics turn out (on an (...) informal level) to show similar features and problems: holistic aspects, creation of objects, dressing procedures, influence of the observer, classical quantities and structures. The attribute classical of a property or structure means thatholistic correlations to any other quantity do not exist or that these correlations are considered as irrelevant and therefore eliminated (either deliberately and by declaration or in a mental process that is not under rational control). An example of animposed classical structure is the nuclear frame of a molecule. Candidates for classical properties that arenot imposed by the observer could be the charge of a particle or the handedness of a molecule. It is argued here that at least part of a molecule's shape can begenerated automatically by the environment. A molecular shape of this sort arises in addition to Lamb shift-type energy corrections. (shrink)

The essays in this book provide an excellent introduction to the means by which scientists convey their ideas. While diverse in their subject matter, the essays are unified in asserting that scientists compose and use particular representations in contextually organized and contextually sensitive ways, and that these representations - particularly visual displays such as graphs, diagrams, photographs, and drawings - depend for their meaning on the complex activities in which they are situated.The topics include sociological orientations to representational practice, representation (...) and the realist-constructivist controversy, the fixation of evidence, time and documents in researcher interaction, selection and mathematization in the visual documentation of objects in the life sciences, the use of illustrations in texts (E.0. Wilson's Sociobiology, a field guide to the birds), representing practice in cognitive science, the iconography of scientific texts, and semiotic analysis of scientific, representation. The contributors are K. Amann, Ronald Amerine, Francoise Bastide, Jack Bilmes, K. Knorr, Bruno Latour, John Law, Michael Lynch, Greg Meyers, Lucy A. Suchman, Paul Tibbetts, Steve Woolgar, and Steven Yearley.Michael Lynch is Assistant Professor in the Department of Sociology at Boston University. Steve Woolgar is at the Centre for Research into Innovation Culture, and Technology at Brunel University, Uxbridge, England. (shrink)

E. J. Lowe; The problems of intrinsic change: rejoinder to Lewis, Analysis, Volume 48, Issue 2, 1 March 1988, Pages 72–77, https://doi.org/10.1093/analys/48.2.7.

Insight experiences are sudden, persuasive, and can accompany valuable new ideas in science and art. In this preregistered experiment, we aim to validate a novel visceral and continuous measure of insight problem solving and to test whether real-time and embodied feelings of insight can predict correct solutions. We report several findings. Consistent with recent work, we find a strong positive relationship between Aha moments and accuracy for problems that demand implicit processing. We also found that the intensity of the insight (...) experience further predicted the accuracy of solutions and participants naturally embodied the intensity of their insight experiences by squeezing the dynamometer more tightly. Intriguingly, this unintentional embodiment further predicted the accuracy of solutions. We suggest that the dynamometer complements previous measures by (1) simultaneously capturing both process and feeling in real-time, (2) highlights the value of measuring Aha moments on a continuum of intensity, and (3) firmly establishes that the impulsive feeling of Aha can carry information about the veracity of an idea. We discuss the findings in light of a recent theoretical account of how feelings of insight may act as a heuristic to select ideas from the stream of consciousness. (shrink)

The responses to the questions of why? when?, how?, where?, and in what ways? business ethics should be taught in the BusinessEthics classroom inundate the scholarly literature. Yet, to date, despite some very interesting ideas, with respect to the answers givento the above question, not only has nothing even close to consensus been reached, but this particular area of pedagogy is instagnation—authors still challenge both the very idea of teaching business ethics as well as the practical value of such courses (...) for ourstudents once they graduate to the corporate world.In this paper I will suggest that the reason for this lack of pedagogical progress is that there has been a serious oversight regarding the most important teaching question of all: Who? I will show that the pedagogical issue of whom should be teaching Business Ethics has been largely ignored, skirted or answered incorrectly. I will then boldly argue that the only necessary condition for successful courses inBusiness Ethics is that they be taught by experts in ethics, i.e., Ph.D.s in philosophy. (shrink)

The responses to the questions of why? when?, how?, where?, and in what ways? business ethics should be taught in the BusinessEthics classroom inundate the scholarly literature. Yet, to date, despite some very interesting ideas, with respect to the answers givento the above question, not only has nothing even close to consensus been reached, but this particular area of pedagogy is instagnation—authors still challenge both the very idea of teaching business ethics as well as the practical value of such courses (...) for ourstudents once they graduate to the corporate world.In this paper I will suggest that the reason for this lack of pedagogical progress is that there has been a serious oversight regarding the most important teaching question of all: Who? I will show that the pedagogical issue of whom should be teaching Business Ethics has been largely ignored, skirted or answered incorrectly. I will then boldly argue that the only necessary condition for successful courses inBusiness Ethics is that they be taught by experts in ethics, i.e., Ph.D.s in philosophy. (shrink)

A partir da concepção de um racionalismo integral, em que vigora o ideal da plena demonstrabilidade segundo o paradigma identitário da verdade, configura-se em Leibniz a questão da universalidade, que seria enunciada com mais pertinência como a do determinismo universal. São dois aspectos de uma mesma questão: em primeiro lugar, a universalidade no sentido arquitetônico, correspondente à totalidade; em segundo lugar, a determinação absoluta do indivíduo singular. Tanto num caso quanto no outro, a plena determinação é inalcançável para a mente (...) humana. Mas as operações simbólicas de determinação, permitem, de alguma maneira, contornar a impossibilidade de uma visão simultânea e articulada de todos os elementos de um composto e, assim, nos encaminham na direção de uma universalidade determinante. Os fundamentos, os procedimentos e os riscos aí envolvidos constituem o tema desse texto. (shrink)

Cet article est un nouvel examen des objections soulevées par Leibniz dans la controverse avec Clarke contre la théorie absolutiste de l'espace et du temps. Or la plupart de ces objections sont fondées sur le principe de raison suffisante; mais Leibniz utilise aussi le principe de l'identité des indiscernables, qu'il prétend déduire du principe de raison suffisante . Ce qui m'intéresse c'est que Leibniz présente parfois deux versions de la même objection: l'une reposant uniquement sur le principe de raison suffisante, (...) l'autre uniquement sur le principe de l'identité des indiscernables. Se pose alors la question suivante: Leibniz aurait-il pu soulever toutes les objections qu'il voulait contre la théorie absolutiste, en utilisant seulement le principe de l'identité des indiscernables? Il me semble qu'il aurait certainement pu le faire. Et de plus, je crois que si Leibniz avait suivi cette voie, son raisonnement contre la théorie absolutiste aurait été beaucoup plus convaincant. Ainsi donc, je me propose de mener l'attaque de Leibniz contre la théorie absolutiste, en isolant, reformulant, et exposant systématiquement sept arguments dont il se servait ou dont il aurait pu se servir, qui sont tous fondés sur le principe de l'identité des indiscernables. (shrink)

Clinical decisions are expected to be based on factual evidence and official values derived from healthcare law and soft laws such as regulations and guidelines. But sometimes personal values instead influence clinical decisions. One way in which personal values may influence medical decision-making is by their affecting factual claims or assumptions made by healthcare providers. Such influence, which we call ‘value-impregnation,’ may be concealed to all concerned stakeholders. We suggest as a hypothesis that healthcare providers’ decision making is sometimes affected (...) by value-impregnated factual claims or assumptions. If such claims influence e.g. doctor–patient encounters, this will likely have a negative impact on the provision of correct information to patients and on patients’ influence on decision making regarding their own care. In this paper, we explore the idea that value-impregnated factual claims influence healthcare decisions through a series of medical examples. We suggest that more research is needed to further examine whether healthcare staff’s personal values influence clinical decision-making. (shrink)

The sixteenth-century Reformation remains a fascinating and exciting area of study. The revised edition of this distinguished volume explores the intellectual origins of the Reformation and examines the importance of ideas in the shaping of history. Provides an updated and expanded version of the original, highly-acclaimed edition. Explores the complex intellectual roots of the Reformation, offering a sustained engagement with the ideas of humanism and scholasticism. Demonstrates how the intellectual origins of the Reformation were heterogeneous, and examines the implications of (...) this for our understanding of the Reformation as a whole. Offers a defence of the entire enterprise of intellectual history, and a reaffirmation of the importance of ideas to the development of history. Written by Alister E. McGrath, one of today’s best-known Christian writers. (shrink)

Because corporate social responsibility (CSR) is potentially beneficial for companies, it is important to understand the factors that improve a company’s CSR practice. Scholars hypothesize that facilitating learning organization characteristics, which are divided in characteristics at the organizational and the operational level, may improve CSR implementation. These characteristics stimulate companies and their members to be critical, learn from the past, and embrace change, but there is limited empirical evidence of this approach. This study addresses this gap by surveying 280 CSR (...) professionals and performing bootstrap mediation analyses to test multiple hypotheses. Learning organization characteristics at the organizational level, play a key role in supporting CSR implementation: leadership for learning, system connection, and group learning show a direct relationship with CSR implementation. It is striking that the role of the learning organization characteristics at the operational level is only indirect; the organizational characteristics mediate their relationship with CSR implementation. (shrink)

Little is known about how employees on husbandry farms perceive animal welfare and the factors influencing the relationship between them and the animals they engage with in their daily work. Reporting the findings of qualitative interviews with 23 employees on five Danish farms (mink, dairy and pig production), this paper describes how the employees viewed animal welfare, and discusses how they dealt with animal welfare issues in their daily work. Four distinct rationales for animal welfare were identified. 1) Animal welfare (...) was supported by concerns about production and health, and could be negotiated – especially when it came to the ability of the animals to perform natural behaviour. 2) Animal welfare was connected with the working conditions on the farm. 3) The employees’ views about animal welfare were affected by working conditions over which they had no influence. 4) An awareness of the condition of the animals was seen as obviously needed in relation to production, but a deeper attachment to some animals was also seen. A specific challenge is presented by the increasingly diverse workforce in farming, with one third of the employees on Danish farms coming from abroad. If farm owners are not able to integrate these employees, there is a risk of creating a second-tier of foreign workers who are isolated. Furthermore, it was seen that negative working conditions can be taken out on the animals, or that animal welfare can come to be seen as unimportant as compared with human welfare. (shrink)

Soeurs ennemies ou soeurs jumelles, servante et maîtresse ou compagnes de labeur, s'ignorant l'une l'autre ou unies au point de presque s'identifier, la foi et la raison entretiennent à l'évidence une relation intense et tumultueuse. N'est-ce pas justement au coeur du mouvement qui tantôt les rapproche tantôt les oppose que s'ajuste leur rapport? Plus que d'un état stable acquis une fois pour toutes il s'agit bien d'une dynamique, d'un processus. C'est cc que visent à montrer les essais réunis dans cc (...) livre, qui rassemble les fruits d'un colloque de théologie et de philosophie tenu à l'initiative du Studium de Philosophie de Chartres et de l'Institut de Théologie des Dombes, centres de formation de la Communauté du Chemin Neuf. (shrink)

Presenta a grandes rasgos su tesis doctoral. Dentro del marco de la teoría de los afectos, Spinoza sostiene una tesis sobre la alienación a partir de la imaginación y del tiempo, para ello produce una teoría del tiempo y, fundamentalmente, una teoría de las intensidades que sirve para explicar la ilusión.

In this chapter, I focus on the experience of torture and, more specifically, on Jean Améry's account of it in his book *At the Mind's Limits*. There he claims that the loss of confidence in the world is the most devastating effect he experienced as a victim of torture. I thus explore what cosmopolitan aspiration may be revealed by this loss and also discuss whether it is to be discredited as an irrational reaction on the victim's side or instead as (...) proportional to the facts and, consequently, as relevant to the conditions under which a certain cosmopolitan aspiration could be achieved or, at least, favored. (shrink)

Appeal to experience for rational justification of religious belief is probably as old as the question whether religious belief has any rational support. The issues relevant to such appeal range widely, and I will have to be content to deal with only a few of them.