Nuclear pre‐mRNAs must be precisely processed to give rise to mature cytoplasmic mRNAs. This maturation process, known as splicing, involves excision of intron sequences and ligation of the exon sequences. One of the major problems in understanding this process is how splice sites, the sequences which form the boundaries between introns and exons, can be accurately selected. A number of studies have defined conserved sequences within introns which were later shown to interact with small nuclear ribonucleoproteins (snRNPs). However, due to (...) the simplicity of these conserved sequences it has become clear that other elements must be involved and a number of studies have indicated the importance of secondary structures within pre‐mRNAs. Using various examples, we shall show that such structures can help to specify splice sites by modifying physical distances within introns or by being involved in the definition of exons and, lastly, that they can be part of the regulation of alternative splicing. (shrink)

We characterize the collapse of Buss' bounded arithmetic in terms of the provable collapse of the polynomial time hierarchy. We include also some general model-theoretical investigations on fragments of bounded arithmetic.

Perhaps no philosopher is more of a conundrum than Nietzsche, the solitary rebel, poet, wayfarer, anti-revolutionary Aufklärer and theorist of aristocratic radicalism. His accusers identify in his 'superman' the origins of Nazism, and thus issue an irrevocable condemnation; his defenders pursue a hermeneutics of innocence founded ultimately in allegory. In a work that constitutes the most important contribution to Nietzschean studies in recent decades, Domenico Losurdo instead pursues a less reductive strategy. Taking literally the ruthless implications of Nietzsche's anti-democratic (...) thinking - his celebration of slavery, of war and colonial expansion, and eugenics - he nevertheless refuses to treat these from the perspective of the mid-twentieth century. In doing so, he restores Nietzsche's works to their complex nineteenth-century context, and presents a more compelling account of the importance of Nietzsche as philosopher than can be expected from his many contemporary apologists. (shrink)

Despite the burgeoning literature on the governance and impact of cross-sector partnerships in the past two decades, the debate on how and when these collaborative arrangements address globally relevant problems and contribute to systemic change remains open. Building upon the notion of wicked problems and the literature on governing such wicked problems, this paper defines harnessing problems in multi-stakeholder partnerships as the approach of taking into account the nature of the problem and of organizing governance processes accordingly. The paper develops (...) an innovative analytical framework that conceptualizes MSPs in terms of three governance processes harnessing three key dimensions of wicked problems. The Roundtable on Sustainable Palm Oil provides an illustrative case study on how this analytical framework describes and explains organizational change in partnerships from a problem-based perspective. The framework can be used to better understand and predict the complex relationships between MSP governance processes, systemic change and societal problems, but also as a guiding tool in organizing governance processes to continuously re-assess the problems over time and address them accordingly. (shrink)

In this paper we argue that data science is a coherent and novel approach to empirical problems that, in its most general form, does not build understanding about phenomena. Within the new type of mathematization at work in data science, mathematical methods are not selected because of any relevance for a problem at hand; mathematical methods are applied to a specific problem only by `forcing’, i.e. on the basis of their ability to reorganize the data for further analysis and the (...) intrinsic richness of their mathematical structure. In particular, we argue that deep learning neural networks are best understood within the context of forcing optimization methods. We finally explore the broader question of the appropriateness of data science methods in solving problems. We argue that this question should not be interpreted as a search for a correspondence between phenomena and specific solutions found by data science methods; rather, it is the internal structure of data science methods that is open to precise forms of understanding. (shrink)

This paper explores the relationship between business experience in cross-sector partnerships and the co-creation of what we refer to as ‘dynamic capabilities for stakeholder orientation,’ consisting of the four dimensions of sensing, interacting with, learning from and changing based on stakeholders. We argue that the co-creation of dynamic capabilities for stakeholder orientation is crucial for CSPs to create societal impact, as stakeholder-oriented organizations are more suited to deal with “wicked problems,” i.e., problems that are large, messy, and complex. By means (...) of a grounded theory approach of inductive research, we collected and interpreted data on four global agri-food companies which have heterogeneous experience in participating in CSPs. The results of this paper highlight that only companies’ capability of interacting with stakeholders continually increases, while their capabilities of sensing, learning from, and changing based on stakeholders first increase and then decrease as companies gain more experience in CSP participation. To a large extent, this can be attributed to the development of corporate strategies on sustainability after a few years of CSP participation, which entails a shift from a reactive to a proactive attitude towards sustainability issues and which may decrease the need or motivation for stakeholder orientation. These findings open up important issues for discussion and for future research on the impact of CSPs in a context of wicked problems. (shrink)

Mirror neurons may play a role in representing not only signs but also their meaning. Because actions are the only aspect of behavior that are inter-individually accessible, interpreting meanings in terms of actions might explain how meanings can be shared. Behavioral evidence and artificial life simulations suggest that seeing objects or processing words referring to objects automatically activates motor actions.

Legends and stories about fabulous races that dwelt in India or in Africa circulated in Iran probably since the Achaemenid times. Unfortunately, scholarship on this topic has neglected some late Iranian and, especially, Zoroastrian sources, such as Draxt ī āsūrīg, the Bundahišn, the Ayādgār ī Jāmāspīg, and the New Persian epic Šāhnāme. This article examines the aforementioned sources and discusses their accounts of five fabulous races from an Iranian, and especially Zoroastrian, perspective and through a comparative approach to some similar (...) neighboring traditions. (shrink)

The relations between the Iranian, in particular Zoroastrian, and Jewish apocalyptic literature as well as their mutual influences have, since the beginning of the twentieth century, constituted a rich and exciting battlefield for the scholars of these respective traditions. This article aims to present some topics concerning the definition of Iranian apocalyptics and its relation with its Jewish counterpart, as well as to establish an updated starting point for a new scholarly debate.

In this paper the affiliation of Lévi-Strauss with the functional structuralism of Trubetzkoy and Jakobson is defined as “explicit linguistics” and the consonance with the works of Franz Boas is also thrown into relief. As “implicit linguistics” is defined his accurate attention to lexical facts, in the case of questions of nomenclature and in particular of the terminology of kinship. As this regards, Lévi-Strauss perfectly captures not only the differences between linguistic systems and anthropological systems, but also their respective integration. (...) In this way he comes to surmount the model itself of the functional structuralism of a certain linguistics which is too predictive. Finally, in homage to the great scholar, two examples are proposed of the integration of linguistics “without adjectives” and anthropology “without adjectives” in relation to the etymology of gr. anthropos, seen from the point of view of a specific sociolinguistic hierarchy and within the frame of the Indo-Mediterranea area, and of the Indo-European name of the woman of marriageable age (gr. gyné) seen in the perspective of the innovative conditions of exogamous marriage. (shrink)

The contribution examines the notion of occasionalismo sensista, or also known by the expression of formalismo sensista, that the Italian philosopher Adelchi Baratono was proposing in the ’30s and ’40s of the twentieth century. Best known for his dense volume, Il mondo sensibile. Introduzione all’estetica, Baratono is among the first thinkers of his time in Italy to start a confrontation with Kantian criticism in aesthetic context, looking groundwork for an alternative route to the one proposed by the Italian Neo-idealism. In (...) fact, against the absolutization of the subject, which Baratono ascribes, in particular, to the thought of Giovanni Gentile, he affirms the profound otherness of subject and object in front of which philosophy is bound to be wrecked. In this perspective, the “sensible world” for Baratono is in itself, regardless of the knowing subject, because everything is resolved in the “world within and around us”. In this perspective, Baratono affirms that the feeling is all this, that is something without which are neither perception nor the concept and even the idea. The feeling, therefore, far from being considered the first stage of knowledge, is the real existence. (shrink)

The present essay seeks to analyze the reflections on cinematographic art proposed by Jean-Luc Nancy, referring in particular to his L’Évidence du film. Abbas Kiarostami (2001) as well as to other studies where the author reconsiders the concepts of image and gaze. The specifity of films lies in “evidence”, which is a way to affirm the finite character of existence-presence. Cinema addresses the world without any form of realism. It is reality itself to open out to the image. What results (...) is a possible gaze which is no longer on representation and nor can it be a representative gaze. This gaze does not look at any object; the very act of seeing can be seen through it. (shrink)

We formalize the notion of isolated objects, and we build a consistent theory to describe their evolution and interaction. We further introduce a notion of indistinguishability of distinct spacetime paths of a unit, for which the evolution of the state variables of the unit is the same, and a generalization of the equivalence principle based on indistinguishability. Under a time reversal condition on the whole set of indistinguishable paths of a unit, we show that the quantization of motion of spinless (...) elementary particles in a general potential field can be derived in this framework, in the limiting case of weak fields and low velocities. Extrapolating this approach to include weak relativistic effects, we explore possible experimental consequences. We conclude by suggesting a primitive ontology for the theory of isolated objects. (shrink)

In this contribution I wish to address the question whether, and how, the global cosmological expansion influences local physics, like particle orbits and black hole geometries. Regarding the former I argue that a pseudo Newtonian picture can be quite accurate if “expansion” is taken to be an attribute of the inertial structure rather than of “space” in some substantivalist sense. This contradicts the often-heard suggestion to imagine cosmological expansion as that of “space itself”. Regarding isolated objects in full General Relativity, (...) like black holes, I emphasise the need for proper geometric characterisations in order to meaningfully compare them in different spacetimes, like static and expanding ones. Examples are discussed in some detail to clearly map out the problems. A slightly extended version of this contribution may be found at philsci-archive.pitt.edu/10033. (shrink)

The essay aims at interpreting some aspects of Machiavelli’s thought in the light of Benjamin’s philosophy. The topic of the origin of politics is the red thread of the arguments therein developed. In particular the essay focuses on the immanent origin in the becoming of history, which is the absolute beginning of an era; such immanent origin is not separated from time, but rather a remote and identifiable point in the time itself: a first cause which determines the path ahead. (...) Such origin has to do with the idea of absolute politics, with the idea of conflict and freedom in politics, which the essay carries to its point of catastrophe, whose vortex ruins any possible order. A final reference is made to the messianic splinters scattered in Machiavelli’s work and to Machiavelli’s idea of redemption. (shrink)

Il presente numero di “Rivista di estetica” raccoglie diversi contributi che intendono riflettere oggi sui limiti e sulle possibilità di un approccio estetico-filosofico alle nuove istanze (sia tecniche che narrative) che ci giungono da questo oggetto sempre da identificare chiamato film. Come si sa, il cinema, fin dalle sue origini, ha generato un complesso insieme di discorsi intorno a sé. Il cinema è stato cioè continuamente trattato, discusso, analizzato, fatto oggetto di studio, dalla st...

We present a simple and completely model-theoretical proof of a strengthening of a theorem of Ajtai: The independence of the pigeonhole principle from IΔ0. With regard to strength, the theorem proved here corresponds to the complexity/proof-theoretical results of [10] and [14], but a different combinatorics is used. Techniques inspired by Razborov [11] replace those derived from Håstad [8]. This leads to a much shorter and very direct construction.

Let be a saturated model of inaccessible cardinality, and let be arbitrary. Let denote the expansion of with a new predicate for. Write for the collection of subsets such that ≡. We prove that if the VC-dimension of is finite then is externally definable.

O objetivo deste artigo é refletir sobre o mecanismo da negação como uma estratégia psicopolítica que articula o movimento bolsonarista. Como método de trabalho, realizamos uma discussão teórica sobre alguns aspectos do movimento bolsonarista que são estruturados pelo negacionismo. Empregamos os conceitos da psicologia política, da esquizoanálise e da psicanálise de grupo para analisar este fenômeno. Para discutir os mecanismos de negação, constatamos quatro características principais: (i) a negação como estratégia discursiva, (ii) a lógica cognitiva da negatividade, (iii) a produção (...) do antagonismo coletivo e (iv) a micropolítica do ódio, que é anterior à necessidade de um líder. PALAVRAS-CHAVE: Psicologia Política. Extremismo político. Esquizoanálise. Grupo. (shrink)