The potential of the vertebrate limb as a model system to study developmental mechanisms is particularly well illustrated by the analysis of the Hox gene network. These genes are probably involved in the establishment of patterns encoding positional information. Their functional organisation during both limb and trunk development are very similar and seem to involve the progressive activation in time, along the chromosome, of a battery of genes whose products could differentially instruct those cells where they are expressed. This process (...) may be common to all organisms that develop according to an anterior‐posterior morphogenetic progression. The possible linkage of this system to a particular mechanism of segmentation as well as its phylogenetic implications are discussed. (shrink)

The potential of the vertebrate limb as a model system to study developmental mechanisms is particularly well illustrated by the analysis of the Hox gene network. These genes are probably involved in the establishment of patterns encoding positional information. Their functional organisation during both limb and trunk development are very similar and seem to involve the progressive activation in time, along the chromosome, of a battery of genes whose products could differentially instruct those cells where they are expressed. This process (...) may be common to all organisms that develop according to an anterior‐posterior morphogenetic progression. The possible linkage of this system to a particular mechanism of segmentation as well as its phylogenetic implications are discussed. (shrink)

Genetic studies have revealed that the antagonistic interplay between PcG and TrxG/MLL complexes is essential for the proper maintenance of vertebrate Hox gene expression in time and space. Hox genes must be silenced in totipotent embryonic stem cells and, in contrast, rapidly activated during embryogenesis. Here we discuss some recently published articles1-4 that propose a novel mechanism for the induction of Hox gene transcription. These studies report a new family of histone demethylases that remove H3K27me3/me2 repressive marks at Hox promoters (...) during differentiation of stem cells. Though the overall importance of these enzymes for proper embryogenesis was demonstrated, their precise role in Hox gene epigenetic regulation during development still remains to be firmly established. BioEssays 30:199–202, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Molecular and developmental studies of limb pattern formation have recently gained widespread attention. The fact that vertebrate limbs are amenable to both genetic and embryological manipulations has established this model system as a valuable paradigm for studying vertebrate development. Limb buds are polarised along all three major axes and the establishment of the dorso‐ventral (DV) polarity is dependent upon cues localised in the trunk, where a DV ectodermal interface is produced by confrontation of dorsal and ventral identities. By analogy to (...) Drosophila imaginal disc development, this interface has been proposed to determine and position an ectodermal organising centre, the Apical Ectodermal Ridge (AER), controlling limb bud outgrowth. Recent fate mapping studies(1) and studies of genes regulating DV limb polarity(2‐6), AER formation(7,8) and differentiation(9) suggest, however, that DV patterning and AER induction, though coordinately regulated during limb bud outgrowth, may early on be more dissociated than expected. (shrink)

Name der Zeitschrift: Das Mittelalter Jahrgang: 21 Heft: 1 Seiten: 61-82.

An illustrated biography of Confucius (551 BCE-479 BCE), the ancient Chinese teacher, politician, thinker, and philosopher known for his popular aphorisms, his emphasis on education and study, and his models of social interaction. Includes a map and author's sources"--Provided by publisher.

Prologue. Setting up the stage : "beauty is in the street" in Istanbul -- Democratic action, spontaneity, and the intermediating practices of political friendship -- Jean-Jacques Rousseau : from the unsettling reality of the theater to the dream of immediacy -- Antonio Negri : insurgencies, the multitude, and the search for permanence -- Jürgen Habermas : embracing transience, containing unpredictability -- Jacques Rancière : the theatrical paradigm and the messiness of democratic politics -- Enacting political friendship in Gezi -- Epilogue. (...) Fanning the spark of hope. (shrink)

The text which follows was put together from answers given to questions at meetings held by PD Ouspensky in London and New York between 1935 and 1944. ...

The revised translation of the world famous Russian philosopher's work about attempting to understand man and his place in creation.

Studies man in view of what he may become. Describes how a man must work simultaneously on his knowledge and his being to find inner unity.

Three indexes have been compiled: authors of main articles (including our special departments such as ‘Projects in progress’ and ‘Notes and discussions’); essay reviews; and book reviews. Co-author...

"An imposing edifice of thought. Every one of its twenty chapters will richly repay careful reading. Those passages dealing with ethics, love, the significance of knowledge, and the meaning of life are hard to surpass." - New York Evening Post The title of this book, Tertium Organum, boldly refers no less to a reorganization of all knowledge, but it is primarily a study of psychology, more specifically the psychology of our higher mind. For Ouspensky what we can call the higher (...) mind represents, within a single person, the development of an entirely new way of understanding. In short, psychology is the art of self-study. With remarkable scope and sophistication, Ouspensky shows us in this book, which has been hailed as "a work of genius," just how vast and strange our universe really is. P. D. [PETYR DEMIANOVICH] OUSPENSKY (1878-1947) was a Russian mathematician and philosopher turned mystic, who combined geometry and psychology in his discussion of higher dimensions of existence. After traveling through Europe and the East, seeking unsuccessfully the world's centers where ancient esoteric knowledge and wisdom are not only preserved, but taught to initiates, he returned to Russia where he met and studied under G.I. Gurdjieff. Ouspensky is today best known for his expositions of the early work of this famous Russian mystic. (shrink)

This edition of The Psychology of Man's Possible Evolution includes a lecture, not previously published, in which Ouspensky givers some details of the "School of the Fourth Way," with which he was connected, and an account of some of its fundamental principles, methods, and rules. The psychology Ouspensky sets forth in this introductory lectures has existed in one form or another for thousands of years and, unlike modern psychology, studies man from the point of view of what he may become. (...) Once a man realizes how little control he has over his reactions to external circumstances and internal stimuli, he may wish to find a way to becomoe free of this mechanical way of living. Ouspensky describes how a man must work simultaneously on his knowledge and his being to find inner unity and why although his development depends on his own efforts, this is very difficult to achieve without guidance from a "School.". (shrink)

El presente estudio tiene por objetivo demostrar lo siguiente: que no es posible comprender suficientemente, al menos en un aspecto, el método de ejecución(Methode der Ausführung) de la Fenomenología del espíritu como “la exposición del saber que aparece” (die Darstellung des erscheinenden Wissens), si es que no se comprende la relación que tiene dicho método de ejecución con la temática del auto-engaño. Este objetivo se lleva a cabo de la siguiente manera: 1) se propone el tipo de relación que se (...) busca establecer entre el concepto de “auto-engaño” y el método de ejecución, 2) se presentan las notas que les corresponden a ambos y 3) se argumenta en orden a demostrar que el método de ejecución no se puede comprender rectamente sino en relación con la temática del auto-engaño. (shrink)

We suggest that the emerging field of the conservation humanities can play a valuable role in biodiversity protection in Papua New Guinea (PNG), where most land remains under collective customary clan ownership. As a first step to mobilising this scholarly field in PNG and to support capacity development for PNG humanities academics, we conducted a landscape review of PNG humanities teaching and research relating to biodiversity conservation and customary land rights. We conducted a systematic literature review, a PNG teaching programme (...) review, and a series of online workshops between the authors (10 PNG-based, 7 UK-based). We found a small but notable amount of PNG research and teaching focused on biodiversity conservation or customary land rights. This included explicit discussion of these topics in 8 of 156 PNG-authored humanities texts published 2010-2020 and related teaching content in the curricula of several different humanities-based programmes. We discuss current barriers to PNG academic development. The growth of fully fledged in-country conservation humanities will require a joint collaborative effort by PNG researchers, who are best placed to carry out such work, and researchers from abroad who can access resources to support the process. (shrink)

A selection from the correspondence of the logician Wilhelm Ackermann (1896?1962) is presented in this article. The most significant letters were exchanged with Bernays, Scholz and Lorenzen, from which extensive passages are transcribed. Some remarks from other letters, with quotations, are also included.

Translation of Kant's 1768 short treatise: Von dem ersten Grunde des Unterschiedes der Gegenden im Raum (Περί του πρώτου θεμέλιου λόγου της διάκρισης των διευθύνσεων στον χώρο). Athens: PRiNTA-Ροές (2024).

Summary This short article goes back to the problem of the authenticity of the document found at Dem. 24.20–23, with wide implications for the reconstruction of Athenian nomothesia. Without providing a comprehensive response to M. H. Hansen’s recent KLIO article on the topic (M. H. Hansen, The Inserted Document at Dem. 24.20–23. Response to Mirko Canevaro, KLIO 101, 2019, 452–472; itself a response to a previous KLIO article by M. Canevaro), it clarifies some key issues and clears up some important (...) misunderstandings, also providing new evidence against the authenticity of the document. (shrink)