Leg rigidity is associated with frequent falls in people with Parkinson’s disease, suggesting a potential role in functional balance and gait impairments. Changes in the neural state due to secondary tasks, e.g., activation maneuvers, can exacerbate rigidity, possibly increasing the risk of falls. However, the subjective interpretation and coarse classification of the standard clinical rigidity scale has prohibited the systematic, objective assessment of resting and activated leg rigidity. The pendulum test is an objective diagnostic method that we hypothesized would be (...) sensitive enough to characterize resting and activated leg rigidity. We recorded kinematic data and electromyographic signals from rectus femoris and biceps femoris during the pendulum test in 15 individuals with PD, spanning a range of leg rigidity severity. From the recorded data of leg swing kinematics, we measured biomechanical outcomes including first swing excursion, first extension peak, number and duration of the oscillations, resting angle, relaxation index, maximum and minimum angular velocity. We examined associations between biomechanical outcomes and clinical leg rigidity score. We evaluated the effect of increasing rigidity through activation maneuvers on biomechanical outcomes. Finally, we assessed whether either biomechanical outcomes or changes in outcomes with activation were associated with a fall history. Our results suggest that the biomechanical assessment of the pendulum test can objectively quantify parkinsonian leg rigidity. We found that the presence of high rigidity during clinical exam significantly impacted biomechanical outcomes, i.e., first extension peak, number of oscillations, relaxation index, and maximum angular velocity. No differences in the effect of activation maneuvers between groups with clinically assessed low rigidity were observed, suggesting that activated rigidity may be independent of resting rigidity and should be scored as independent variables. Moreover, we found that fall history was more common among people whose rigidity was increased with a secondary task, as measured by biomechanical outcomes. We conclude that different mechanisms contributing to resting and activated rigidity may play an important yet unexplored functional role in balance impairments. The pendulum test may contribute to a better understanding of fundamental mechanisms underlying motor symptoms in PD, evaluating the efficacy of treatments, and predicting the risk of falls. (shrink)

A strong form of representationalism says that every conscious property of every mental state can be identified with some part of the state’s representational properties. A weaker representationalism says that some conscious property of some mental state can be identified with some part of the state’s representational properties. David Papineau has recently argued that all such theories are incorrect since they construe consciousness as consisting in “relations to propositions or other abstract objects outside space and time”, whereas consciousness is “concrete” (...) and “here and now”. Papineau defends instead a kind of “qualia theory” according to which all conscious properties are intrinsic non-relational properties of subjects. He argues that this theory bypasses the difficulties he identifies for representationalism. Similar worries about representationalism, and similar ideas to the effect that some qualia theory, adverbial theory, or sense-datum theory fares better with respect to these worries are relatively wide-spread. I argue that Papineau’s theory does not bypass the difficulties he identifies for representationalism. In fact, Papineau’s theory arguably has no advantage at all over representationalism with regard to these issues. The features that concern Papineau about representationalist views do not derive—or do not derive solely—from the representationalism of these views. They derive from a common-factorism of these views. And this common-factorism is embraced by Papineau as well as by most theories of consciousness and perception. (shrink)

A strong form of representationalism says that every conscious property of every mental state can be identified with some part of the state’s representational properties. A weaker representationalism says that some conscious property of some mental state can be identified with some part of the state’s representational properties. David Papineau has recently argued that all such theories are incorrect since they construe consciousness as consisting in “relations to propositions or other abstract objects outside space and time”, whereas consciousness is “concrete” (...) and “here and now”. Papineau defends instead a kind of “qualia theory” according to which all conscious properties are intrinsic non-relational properties of subjects. He argues that this theory bypasses the difficulties he identifies for representationalism. Similar worries about representationalism, and similar ideas to the effect that some qualia theory, adverbial theory, or sense-datum theory fares better with respect to these worries are relatively wide-spread. I argue that Papineau’s theory does not bypass the difficulties he identifies for representationalism. In fact, Papineau’s theory arguably has no advantage at all over representationalism with regard to these issues. The features that concern Papineau about representationalist views do not derive—or do not derive solely—from the representationalism of these views. They derive from a common-factorism of these views. And this common-factorism is embraced by Papineau as well as by most theories of consciousness and perception. (shrink)

Psychological constructs such as personality dimensions or cognitive traits are typically unobserved and are therefore measured by observing so-called indicators of the latent construct. The Common Factor Model models the relations between the observed indicators and the latent variable. In this article we argue in favor of interpreting the CFM as a causal model rather than merely a statistical model, in which common factors are only descriptions of the indicators. When there is sufficient reason to hypothesize that (...) the underlying causal structure of the data is a common cause structure, a causal interpretation of the CFM has several benefits over a merely statistical interpretation of the model. We argue that a causal interpretation conforms with most research questions in which the goal is to explain the correlations between indicators rather than merely summarizing them; a causal interpretation of the factor model legitimizes the focus on shared, rather than unique variance of the indicators; and a causal interpretation of the factor model legitimizes the assumption of local independence. (shrink)

We examined the hypothesis that a tendency to experience the world in terms of a sense of ‘special’ connection is responsible for the self-transcendent value dimension identified by multi-dimensional scaling and constitutes a common factor for different religious and non-religious interpretations of spirituality. Eight different groups were studied including: six different types of faith leaders in India and the UK, people who self-rated as spiritual but not religious, and those self-rating as neither spiritual nor religious. They completed a (...) questionnaire that assessed the strength of their spirituality irrespective of type and the experience of special connection to the following categories: people, nature, places and the universe, with and without using the term spiritual. For all eight samples the different types of connection were highly inter-correlated, and self-perceived spirituality correlated with the sum of connection items irrespective of whether items included the term spiritual or not. Variation between groups in the size of the latter correlation was consistent with different interpretations of spirituality in those groups. Although the meaning of spirituality is socially constructed, variability within faith leader groups suggests that its interpretation is also affected by personality. (shrink)

We examined the hypothesis that a tendency to experience the world in terms of a sense of ‘special’ connection is responsible for the self-transcendent value dimension identified by multi-dimensional scaling and constitutes a common factor for different religious and non-religious interpretations of spirituality. Eight different groups were studied including: six different types of faith leaders in India and the UK, people who self-rated as spiritual but not religious, and those self-rating as neither spiritual nor religious. They completed a (...) questionnaire that assessed the strength of their spirituality irrespective of type and the experience of special connection to the following categories: people, nature, places and the universe, with and without using the term spiritual. For all eight samples the different types of connection were highly inter-correlated, and self-perceived spirituality correlated with the sum of connection items irrespective of whether items included the term spiritual or not. Variation between groups in the size of the latter correlation was consistent with different interpretations of spirituality in those groups. Although the meaning of spirituality is socially constructed, variability within faith leader groups suggests that its interpretation is also affected by personality. (shrink)

This study aimed to investigate the common predictive factors between social media addiction and eating disorder symptoms, in a group of Chinese female college students. A total of 216 students completed the behavioral assessments of cognitive flexibility and sustained attention, as well as the questionnaires on anxiety, social media dependence, and eating disorders. The results indicate that SMA is significantly correlated with EDS. Structural equation modeling was used to test the model in which state anxiety, cognitive flexibility, and sustained (...) attention predicted social gain and EDS. Additionally, the results confirmed the mediating role of cognitive flexibility and sustained attention between state anxiety and SMA/EDS in the participants. The findings revealed that in the sample group, state anxiety was related to SMA and EDS through cognitive flexibility and sustained attention. These proposals reflect the significance of improving cognitive flexibility/sustained attention and reducing state anxiety to prevent EDS and SMA in female college students. (shrink)

While Mindfulness-Based Interventions have been shown to be effective for a range of patient populations and outcomes, a question remains as to the role of common therapeutic factors, as opposed to the specific effects of mindfulness practice, in contributing to patient improvements. This project used a mixed-method design to investigate the contribution of specific and common therapeutic factors to client improvements within an MBI. Participants with mild-severe depression participated in an 8-week MBI. Specific therapeutic factors and social (...) class='Hi'>common factors were entered into multilevel growth curve models to predict changes in depression, anxiety, stress, and mindfulness at six timepoints from baseline to 3-month follow-up. Qualitative interviews with participants provided rich descriptions of how instructor and group related factors played a role in therapeutic trajectories. Findings indicated that instructor ratings predicted changes in depression and stress, group ratings predicted changes in stress and self-reported mindfulness, and formal meditation predicted changes in anxiety and stress, while informal mindfulness practice did not predict client improvements. Social common factors were stronger predictors of improvements in depression, stress, and self-reported mindfulness than specific mindfulness practice-related factors. Qualitative data supported the importance of relationships with instructor and group members, involving bonding, expressing feelings, and instilling hope. Our findings dispel the myth that MBI outcomes are exclusively the result of mindfulness meditation practice, and suggest that social common factors may account for much of the effects of these interventions. Further research on meditation should take into consideration the effects of social context and other common therapeutic factors. (shrink)

The science of Kalām aims to prove the existence and attributes of Allah. For this purpose, the theologians adopted a method that turns from the sensible universe to the unseen universe. This method, named as qiyāṣ al-ğāib alā alā al-shāḥid, created a common ground in the discussions with the dissenters. Because the sensible universe is open to human perception in a way that does not allow for denial. From this point of view, the universe, which is defined as "everything (...) other than Allah" in Ashʿarite Kalām, has been discussed in terms of both structure and functioning. Based on the principles determined by the theologians, the universe is said to be composed of substance, accidents and bodies. The said entities are basically constructed in a way that is dependent on each other and on a higher will. Based on this construct, the Ashʿarite tradition preferred to explain the functioning of the universe with the theory of custom. In fact, their basic assumptions about the universe and Allah necessitated this preference. This is because they envision Allah as a fāil al- mukhtār deity with absolute will and power. Everything in the universe, except for the events or situations deemed impossible by the mind, is within His power. In this respect, the universe is described as an area of possibilities. The Ashʿarite tradition, which is based on the nonpermanent nature of accidents, insists that accidents should be recreated at every moment. This basic defense completely reveals the dependence of the universe on Allah. Built on these basic assumptions, the theory of custom uniquely explains the functioning of the universe without imposing any limitations on Allah, who has absolute will and power. This theory, which reflects the Ashʿarite tradition exactly, enables them to explain all theological issues, especially the relationship between Allah and the universe, in a consistent manner. This study aims to examine the basic principles that led the early Ashʿarite tradition to accept the theory of custom by analyzing them under several headings. For this aim, the views of the early Ashʿarite theologians have been identified through a literature review analyzed and interpreted in the context of the matter. (shrink)

Famously, scientific theories are underdetermined by their evidence. This occurs in the factor analytic model, which is often used to connect concrete data to hypothetical notions. After introducing FA, three general topics are addressed. Underdetermination: the precise reasons why FA is underdetermined illuminates various claims about underdetermination, abduction, and theoretical terms. Uncertainties: FA helps distinguish at least four kinds of uncertainties. The prevailing practice, often encoded in statistical software, is to ignore the most difficult kinds, which are essential to (...) FA's underdetermination. What to do: some suggestions for dealing with these hardest types of uncertainty are offered. (shrink)

BackgroundPhysical activity has a significant health impact worldwide and has been linked to a lower risk of the common cold.ObjectiveThe aim of this study was to estimate the form of PA among Chinese adults and the correlation between PA and number of the common cold in China's eastern, central, and western areas.DesignA cross-sectional study.SettingChina's eastern, central, and western regions from 30 November 2020 to 30 March 2021.PatientsA total of 1,920 healthy participants, who aged over 18 years old, with (...) Internet access, were enrolled, and then self-reported PA behaviors and number of the common cold were collected.MeasurementsThe authors calculated preference, intensity, frequency, and duration of PA in Chinese based on gender, age, and broad occupational categories and explored the potential effect between these factors and the common cold.ResultsApproximately 20.4% of participants reported not participating in sports regularly. Except for gender, there were significant differences in PA preference and intensity among the remaining individuals. However, intensity shows a U-shaped dose-response relationship with colds, whereas the frequency and duration have an inverse dose-response relationship. High intensity combined with high frequency increased colds the most. Nevertheless, non-exercise groups always have the most colds in each comparison.LimitationsThe result may be vulnerable to recall bias.ConclusionIntensity showed that U-shape, frequency, and duration showed inverse response to the number of colds last year, but age, sex, and occupation had no significant effects. High intensity and high frequency mixed increased colds the most, regardless of duration. (shrink)

Origin of seekers: from caveman to cage fighters -- Impulsivity's hidden side: the secret of being directionally correct -- Eat or be eaten: what politicians have learned from primates -- Bubblology: the plague of the $76,000 flower -- Common sense of ownership -- Factoring you into your decisions -- Potential seekers: directing your innovative impulses -- Risk managers: conquering the fear of big cats -- Striking a balance.

We present a psychometric test of life history theory as applied to human individual differences using MIDUS survey data (Brim et al. 2000). Twenty scales measuring cognitive and behavioral dimensions theoretically related to life history strategy were constructed using items from the MIDUS survey. These scales were used to construct a single common factor, the K-factor, which accounted for 70% of the reliable variance. The scales used included measures of personal, familial, and social function. A second (...) class='Hi'>common factor, Covitality, was constructed from scales for physical and mental health. Finally, a single general factor, Personality, was constructed from scales for the “Big Five” factors of personality. The K-factor, covitality factor, and general personality factor correlated significantly with each other, supporting the prediction that high K predicts high somatic effort and also manifests in behavioral display. Thus, a single higher-order common factor, the Super-K factor, was constructed that consisted of the K-factor, covitality factor, and personality factor. (shrink)

Exploratory factor analysis is a statistical method widely used in quantitative psychology for the construction of scales and measurement instruments. It aims to reduce the complexity of a data set and explain the common and unique variance using latent variables. In introductory textbooks, exploratory factor analysis is generally presented in contrast to confirmatory factor analysis as a theory- or a hypothesis-generating process that does not require prior background, theory or hypothesis to be performed. The aim of (...) the present paper is to analyze this claim and clarify in which sense exploratory factor analysis is theory-laden. We provide a careful examination of the concepts it involves and thereby establish a clear limitation of the epistemic scope of exploratory factor analysis. (shrink)

Background: Physical restraint is among the commonly used methods for ensuring patient safety in intensive care units. However, nurses usually experience ethical dilemmas over using physical restraint because they need to weigh patient autonomy against patient safety. Aim: The aim of this study was to explore factors behind ethical dilemmas for critical care nurses over using physical restraint for patients. Design: This is a qualitative study using conventional content analysis approach, as suggested by Graneheim and Lundman, to analyze the data. (...) Methods: Seventeen critical care nurses were purposefully recruited from the four intensive care units in Tehran, Iran. Data were collected through in-depth semi-structured interviews and were concurrently analyzed through conventional content analysis as suggested by Graneheim and Lundman. Ethical consideration: This study was approved by the Ethics Committee of Iran University of Medical Sciences, Tehran, Iran with the code: IR.IUMS.REC.1397.795. Before interviews, participants were provided with explanations about the aim of the study, the confidentiality of the data, their freedom to participate, and the right to withdraw the study, and their free access to the study findings. Finally, their consents were obtained, and interviews were started. Results: Factors behind ethical dilemmas for critical care nurses over using physical restraint were categorized into three main categories, namely the outcomes of using physical restraint, the outcomes of not using physical restraint, and emotional distress for nurses. The outcomes of using physical restraint were categorized into the three subcategories of ensuring patient safety, physical damage to patients, and mental damage to the patient. The outcomes of not using physical restraint fell into two subcategories, namely the risks associated with not using physical restraint and legal problems for nurses. Finally, the two subcategories of the emotional distress for nurses main category were nurses’ negative feelings about restraint use and uncertainty over the decision on physical restraint use. Conclusion: Decision-making for restraint use is often associated with ethical dilemmas, because nurses need to weight the outcomes of its use against the outcomes of not using it and also consider patient safety and autonomy. Health authorities are recommended to develop clear evidence-based guidelines for restraint use and develop and implement educational and counseling programs for nurses on the principles of ethical nursing practice, patient rights, physical restraint guidelines and protocols, and management of emotional, ethical, and legal problems associated with physical restraint use. (shrink)

The common law's approach in the law of unjust enrichment is to enumerate specific «unjust factors» as permissible causes of action in claims for restitution. This approach has come under attack, inter alia, for being unnecessarily complicated. The claim is that the civilian approach, with its single ground of absence of legal cause for the transfer, is preferable since the operative unjust factor in any particular case is irrelevant to the restitutionary response. In defence of the common (...) law's approach, this article tenders four aspects of the restitutionary response which, it is claimed, are illuminated by reference to the nature, context, and effect of the operative unjust factor in any particular case. They are: (i) the availability of the defence of change of position; (ii) the justifiability of certain «bars» on rescission and the permissible mode of mutual restitution on rescission; (iii) the appropriate measure of enrichment where restitution is, or must be, effected in money; and (iv) two possible justifications for the controversial remedy of partial rescission. (shrink)

Previous research has investigated factors that contribute to the development of different risk-taking behaviors, such as can occur on lab-based behavioral risky decision making tasks. On several of the most common tasks, participants must develop an adequate understanding of the relative risks and benefits associated with each decision in order to learn to decide advantageously. However, contextual factors can affect the decision making process and one’s ability to weigh the risks and benefits of a decision. The present study investigates (...) the extent to which music may be an additional contextual factor that can disrupt decision making and other executive functions. Across four studies we examine whether having music playing passively in the background or having participants actively listen to music affects performance on measures of risky decision making, working memory, processing speed, and problem solving. Participants reported greater distraction for rock music than classical music in the passive listening studies but did not report any differences in distraction across conditions in the active listening studies. Despite this self-reported increased level of distraction, few significant differences were found in task performance across groups and across studies. The Angling Risk Task was sensitive to differences in risk by condition, with music leading to greater risk-taking in a passive listening study, but less risk-taking in an active listening study, compared to no music. The extent to which music serves as a contextual factor disrupting performance on measures of risky decision making and other executive functions may depend in part on whether individuals are actively versus passively listening to the music. (shrink)

Developing cells acquire mature fates in part by selective (i.e. qualitatively different) expression of a few cell‐specific genes. However, all cells share the same basic repertoire of molecular and subcellular building blocks. Therefore, cells must also specialize according to quantitative differences in cell‐specific distributions of those common molecular resources. Here we propose the novel hypothesis that evolutionarily‐conserved transcription factors called scaling factors (SFs) regulate quantitative differences among mature cell types. SFs: (1) are induced during late stages of cell maturation; (...) (2) are dedicated to specific subcellular domains; and, thus, (3) allow cells to emphasize specific subcellular features. We identify candidate SFs and discuss one in detail: MIST1 (BHLHA15, vertebrates)/DIMM (CG8667, Drosophila); professional secretory cells use this SF to scale up regulated secretion. Because cells use SFs to develop their mature properties and also to adapt them to ever‐changing environmental conditions, SF aberrations likely contribute to diseases of adult onset. (shrink)

To determine factors affecting successful research and publication among medical students, a cross-sectional survey study was carried out at four Thai medical schools during 2018–2022. Medical students who had previously performed research under research advisors’ supervision and their research advisors were included. There were 120 participants, 78 medical students and 42 research advisors. The most common problems reported by the students were student’s lack of knowledge of research design (78%) and research topic (53%), while the most common problems (...) reported by the advisors were student’s lack of knowledge of research topic (55%) and how to prepare documents for ethics committee approval (48%). The promoting factors for research success commonly reported by the students and advisors were “an advisor helps with protocol writing and reviewing the manuscript”, “research teaching in the curriculum”, “provision of an example of a written ethics committee protocol”, and “arranging a special session so that advisors can talk to students about their research of interest”. Among the 78 participating students, 20 (26%) had successfully published their research in journals. These 20 students were more likely than those without publications to be from an institute that had a special research project or conference for medical students (20% vs. 0%,) and to suggest that teaching protocol writing helped in promoting research success (70% vs. 43%). These findings suggest that teaching research, a special research project or conference for medical students, and faculty development of research advising could potentially increase the success rate of students’ research publications. (shrink)

Conceptual congruency effects are biases induced by an irrelevant conceptual dimension of a task (e.g., location in vertical space) on the processing of another, relevant dimension (e.g., judging words’ emotional evaluation). Such effects are a central empirical pillar for recent views about how the mind/brain represents concepts. In the present paper, we show how attentional cueing (both exogenous and endogenous) to each conceptual dimension succeeds in modifying both the manifestation and the symmetry of the effect. The theoretical implications of this (...) finding are discussed. (shrink)

. Analitic Map where explained factors and conditions to facilitate and inhibit the supply development process as well as purchasing strategies, in integrated companies with supply chain management. The research explores the advantages of a supply development straegy in the business world. All common practices in supply development are identified for a succesful implementation, as well as inhibitors to cause failure. Finally comparing theses strategies according to comanies´wealth generating strategies.Keywords. Supplier development, supply chain management, logistics, value chainResumen. El estudio (...) propone un esquema analítico único e integrador, que busca explorar los principales factores que condicionan, facilitan e inhiben el desarrollo de proveedores como estrategia de compras en empresas integradas en una cadena de valor, a fin de que, en una segunda etapa, sea contrastado empíricamente. En este sentido, el estudio pretende explorar las ventajas del desarrollo de proveedores proponiendo un conjunto de variables de análisis fundamentales para una mejor comprensión de los beneficios y alcances de ésta práctica. Para ello se busca identificar en la literatura académica los principales factores que generan la necesidad de recurrir al desarrollo de proveedores, las prácticas de abastecimiento que favorecen una implementación exitosa y sostenible, y los factores inhibidores que limitan el logro de los objetivos esperados, convirtiéndose en un mecanismo válido de generación de valor.Palabras claves. desarrollo de proveedores, cadena de abastecimiento, compras estratégicas, cadena de valor. (shrink)

My Ph.D. dissertation written under the supervision of Prof. Tomasz Placek at the Institute of Philosophy of the Jagiellonian University in Kraków. In one of its most basic and informal shapes, the principle of the common cause states that any surprising correlation between two factors which are believed not to directly influence one another is due to their common cause. Here we will be concerned with a version od this idea which possesses a purely probabilistic formulation. It was (...) introduced, in the form of a general principle, by Hans Reichenbach in his posthumously published book "The Direction of Time". The central notion of the principle in Reichenbach's formulation, and of the current essay, is that of screening off: two correlated events are screened off by a third event if conditioning on the third event makes them probabilistically independent. Reichenbach's principle marks also the beginning of a new field of philosophy: namely, that of ``probabilistic causality''. For the most part, the current essay can be seen as an effort at checking how far one can go with the purely statistical notions revolving around Reichenbach's idea of common cause. In short, the answer is ``surprisingly far''; in some classes of probability spaces all correlations between ``interesting'' events possess explanations of such sort. However, this fact lends itself to opposing interpretations; more on that in the conclusion. Chapters 6 and 7 contain mathematical results concerning these issues. The screening-off condition requires an equality of a probabilistic nature to hold; chapter 8 is a short discussion of slightly weakened versions of the condition, which hold if the sides of the above mentioned equality differ to a small degree. In chapter 2, after some mathematical preliminaries, we study the various formulations of the principle which might be said to stem from the original idea of Reichenbach. We also examine a few of the most salient counterarguments, which undermine at least some of the formulations. Chapter 3 is of a formal nature, dealing with various probabilistic notions which can be thought of as generalizations of Reichenbach's concept of common cause. The next chapter concerns the relationship between the idea of common causal explanation and the Bell inequalities. In chapter 5 we briefly present the form of Reichenbach's principle which can be found in the field of representing causal structures by means of directed acyclic graphs. (shrink)

The common cause principle says that every correlation is either due to a direct causal effect linking the correlated entities or is brought about by a third factor, a so-called common cause. The principle is of central importance in the philosophy of science, especially in causal explanation, causal modeling and in the foundations of quantum physics. Written for philosophers of science, physicists and statisticians, this book contributes to the debate over the validity of the common cause (...) principle, by proving results that bring to the surface the nature of explanation by common causes. It provides a technical and mathematically rigorous examination of the notion of common cause, providing an analysis not only in terms of classical probability measure spaces, which is typical in the available literature, but in quantum probability theory as well. The authors provide numerous open problems to further the debate and encourage future research in this field. (shrink)

An important distinction is that between selective abductions, which select an optimal candidate from given multitude of possible explanations, and creative abductions, which introduce new theoretical concepts and models. The article focuses on creative abductions, which are essential for scientific progress, although they are rarely discussed in the literature. Scientifically, fruitful creative abductions are demarcated from purely speculative abductions by means of three virtues which are possessed by the former but not by the latter: (i) providing unification, (ii) detecting (...) class='Hi'>common causes and (iii) generating novel predictions by means of which they can be independently tested. Based on historical examples it is demonstrated that common cause abduction from correlated dispositions is the fundamental abductive operation by which new theoretical concepts and models are scientifically generated. Statistical factor analysis can be regarded as a statistical generalization of common cause abduction. (shrink)

Apoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cell proliferation, have now been shown to inhibit death in many cell types. Deprivation of growth factors leads to the induction of apoptosis, i.e. condensation of chromatin and degradation in oligonucleosomesized fragments, formation of plasma and nuclear membrane blebs and cell fragmentation into (...) apoptotic bodies which can be taken up by neighbouring cells. Here we discuss the mechanism(;s) by which growth factors may inhibit apoptosis. (shrink)

The ultimate focus of the current essay is on methods of “creative abduction” that have some guarantees as reliable guides to the truth, and those that do not. Emphasizing work by Richard Englehart using data from the World Values Survey, Gerhard Schurz has analyzed literature surrounding Samuel Huntington’s well-known claims that civilization is divided into eight contending traditions, some of which resist “modernization” – democracy, civil rights, equality of rights of women and minorities, secularism. Schurz suggests an evolutionary model of (...) modernization and identifies opposing social forces. In a later essay, citing Englehart’s work as an example, Schurz identifies factor analysis as an example of “creative abduction”. The theories of Englehart and his collaborators are reviewed again in the current essay. Published simulations and standard statistical desiderata for causal inference show the methods Englehart used, factor analysis in particular, are not guides to truth for the kind of data Schurz recognizes as common in political science. Recent work in statistics, philosophy and computer science that makes advances towards such methods is briefly reviewed. (shrink)

Perceptual disjunctivism is a controversial thesis about perception. One familiar characterization of the thesis maintains that there is no common epistemic kind that is present in both veridical and non-veridical cases of perception. For example, the good case, in which one sees a yellow lemon, and the bad case, in which one hallucinates a yellow lemon, share a specific first-person phenomenology, being indistinguishable from the first-person point of view; however, seeing a yellow lemon and hallucinating a yellow lemon do (...) not, according to the disjunctivist, share a common epistemic kind. There are two types of disjunctivism: epistemological vs. metaphysical. John McDowell, 243–255, 2011, Philosophical Explorations, 16, 259–279, 2013) has articulated, refined, and defended one kind of disjunctivism. Tyler Burge, 1–78, 2005, Philosophical Explorations, 13, 43–80, 2011) has objected to many forms of disjunctivism, arguing that they are all inconsistent with the proximality principle in the vision sciences. PP requires an ability-general kind in common between relevantly similar perceptual states, such as seeing a yellow lemon and hallucinating a yellow lemon, which disjunctivism denies. Against the background of this debate some analytic epistemologists, such as Michael Martin, Alan Millar, 176–198, 2007), Berit Brogaard, 46–73, 2011), Duncan Pritchard, and Heather Logue, 105–133, 2013) remain attracted to some version of disjunctivism. Brogaard and Pritchard each have gone on to articulate and defend a version. Pritchard’s, for example, defends epistemological disjunctivism. Martin, Millar, and Logue, by contrast, have defended the idea that the disjunctivist is right about something, but perhaps not wholly correct about the nature of perception. In what follows, I articulate and defend the view that an interesting kind of disjunctivism is to be found through a reading of the Nyāya School of classical Indian philosophy. I articulate a version of perceptual disjunctivism informed by Nyāya perceptual theory that is not derivable from any single Nyāya philosopher. The view I offer is inspired by work on disjunctivism both in Anglo-analytic philosophy and in Nyāya scholarship, such as by Dasti and Phillips, 535–540, 2010), Ganeri, 541–550, 2010), Dasti, 1–15, 2012), Phillips, Vaidya, 562–585, 2013), and Schiller, 1–18, 2019). Importantly, the causal account I offer is distinct from Grice’s single-factor causal theory of perception by crucially involving a multi-factor causal theory of perception. My work on Nyāya perceptual theory derives primarily from Jaysankar Shaw’s account of Nyāya on the sources of knowledge, which is distinct from Stephen Phillips’ well-known account of Nyāya epistemology. Shaw’s theory has been developed and refined through textual analysis and dialectical engagement with the twentieth century Nyāya Pundit Philosopher, Viśvabandhu Tarkatīrtha. Like other modern Nyāya scholars, such as B. K. Matilal, A. Chakrabarti, 1–8, 2010), M. Chadha, J. Ganeri, and S. Phillips, 104–113, 2001, 2012), J. Shaw’s account shows how Nyāya epistemology is a living and continuing form of Indian philosophy. My goal here is twofold. On the one hand, I articulate multi-factor causal disjunctivism and show how it can be applied to the McDowell-Burge debate over the viability of disjunctivism and naïve realism. On the other hand, I aim to start a cross-cultural epistemological conversation with those that have contributed to the Anglo-analytic debate in anthologies, such as Haddock and Macpherson, Byrne and Logue, and introductions, such as Soteriou. The hope is that a cross-cultural epistemological investigation into disjunctivism will lead to better epistemic theorizing about the nature of perception. (shrink)

As frequently pointed out in this discussion, one of the most characteristic features of Mayr's approach to the history of biology stems from the fact that he is dealing to a considerable degree with his own professional history. Furthermore, his main criterion for the selection of historical episodes is their relevance for modern biological theory. As W. F. Bynum and others have noted, the general impression of his reviewers is that “one of the towering figures of evolutionary biology has now (...) written a towering history of his discipline.”138 Bynum is here referring to The Growth of Biological Thought, but this observation holds equally true for Mayr's other historical writings: One must surely read this book [One Long Argument] not only for its content in itself, but for what it tells of its author. And certainly as one does so, one comes away full-handed. Many, if not all, of the disputes and controversies that have driven Mayr through his long intellectual life reappear, stated as forcefully and elegantly as ever.139Up to this point, most reviewers agree; the bone of contention is, rather, how to evaluate Mayr's historical work, considering this observation. The two related characteristics of his work-I will call them subjectivity and presentism-stand in opposition to a widespread approach in the history of science exemplified by Kuhn's suggestion that “insofar as possible..., the historian should set aside the science that he knows. His science should be learned from the textbooks and journals of the period he studies.”140 There are, however, historians who consider the close connection between Mayr and the subject matter of his historical studies to be an advantage.141On the other hand, it is assumed that the connection between past and present must result in a distortion of the historical truth and lead to a historiographical fallacy, commonly referred to as “Whig history”. Herbert Butterfield, who in 1931 gave the term its now generally accepted meaning, believed that “real historical understanding is not achieved by the subordination of the past to the present, but rather by our making the past our present and attempting to see life with the eyes of another century than our own”142. Unfortunately, Butterfield's definition of what he considers Whig history remains somewhat vague, and modern authors have emphasized what they consider most important. Butterfield's “subordination of the past to the present” is referred to in respect to the selection of subjects (there are more biographies of Charles Darwin than of, let's say, Louis Agassiz),143 to the evaluation of historical authors,144 or, more generally, to all kinds of histories “with one eye, so to speak, upon the present.”145 The underlying tendency of Whig historians is to produce a “historical account told from the viewpoint of those in power,”146 leading to a “glorification of the present.”147 It is obvious that Mayr's strongly presentist approach to the history of biology can be called Whiggish, if we apply the criteria of “selection” or “reference.” However, it might be worth mentioning that the program of writing a strictly historicist account of the history of science is challenged by various authors.148 For Mayr, it is not only legitimate but necessary to compare the present situation with the past. “Whiggish” is only the evaluation of an author in terms of our time.149I cannot discuss the Whit/anti-Whig controversy in any detail here, apart from saying that Mayr has defended himself rather extensively against the charges of being Whiggish.150 Nevertheless, it may be useful to touch on some of the criticisms that are predominant in reviews of his writings. First, we encounter the notion that historians can write a true and convincing historical account only if they have no personal interest or interpretation of their own; Mayr, on the other hand, because he “has such strong interpretations of his own, ... cannot possibly convince everyone that he is right about everything.”151 It makes one wonder, what historian has ever been able to convince everyone that he or she is right about everything? But apart from this peculiar idea, it unquestionably poses certain dangers if the subject matter of historical scrutiny and the author are identical. At the same time, this identity brings certain advantages with it, especially firsthand experiences of the period in discussion. Whether these personal memories ultimately result in a distorted picture of the past has to be decided in every particular instance. The notion that a scientific study can be conducted by a completely detached observer from a neutral standpoint has been shown to be impossible in physics, and it is also an illusion in historiography. The question is not whether, but which kind of interest are the underlying motivation for a historian. At this point, Mayr is ahead of his critics when he suggests that our understanding of the past always has a subjective component: The main reason, however, why histories are in constant need of revision is that at any given time they merely reflect the present state of understanding; they depend on how the author interpreted the current zeitgeist of biology and on his own conceptual framework and background. Thus, by necessity the writing of history is subjective and ephemeral.152Second, the temporal proximity between the event and the historical analysis makes difficulties inevitable and will finally result in certain false assessments. But this applies to all historians when they discuss recent problems, regardless of whether they are personally involved or not: As long as the battle between Darwinism and Lamarckism was raging, it was quite impossible to undertake an unbiased evaluation of Lamarck. ...[The] definite refutation of Lamarck's theory of evolutionary causation clears the air. We can now study him without bias and emotion and give him the attention that this major figure in the history of biology clearly deserves.153Third, Mayr is primarily interested in biological problems and not, for instance, historiographical, sociological, or psychological questions. Several authors have remarked that since the beginning of the professionalization of the history of science in the 1960s, a rift between two groups has developed, resulting from the heterogeneous professional backgrounds and interests of the people involved: the authors who were originally biologists and became interested in the history of their discipline only later on, and the authors who were trained as historians.154 Whereas the first group, the “biologists,” tend to be laymen in history proper, the “historians” are in most cases laymen in biology. Different professional backgrounds obviously shape the historical perspective in both groups, but neither approach is necessarily superior. The great number of important books in the history of biology written by “biologist” documents how valuable this point of view can be. On the other hand, it cannot be denied that the writings of biologists in the history of science tend to have a strong “internalist” tendency and often neglect the professional, cultural, and political context of science. Mayr's approach is that of a “biologist”; it is “internalist,” and typical for scientists who turn to the history of their discipline.I want to conclude my analysis with a quotation from a review by Douglas J. Futuyma, which gives a perceptive glimpse of Mayr's personality and style: One cannot help standing in awe of the germanic capacity for vast, allembracing synthesis: consider the lifelong devotion of Goethe to Faust, or Wagner's integration of the arts into a Gesamtkunstwerk in which all of human history and experience is wrought into epic myth. It is perhaps in this tradition that Ernst Mayr's The Growth of Biological Thought stands: a history of all of biology, a Ring des Nibelungen complete with leitmotivs such as the failures of reductionism, the struggle of biology for independence from physics, and the liberation of population thinking from the bounds of essentialism.155 Within this style of thinking Mayr has “to offer...nothing less than a vision of biology that places neodarwinian evolutionary theory firmly at the centre.”156 There may be other visions of biology, but few of them have as indefatigable and able representatives as Darwinism has in Ernst Mayr. (shrink)

The user data mining was introduced into the model construction process, and the user behavior was decomposed by analyzing various influencing factors through the factorization machine learning method. In the recommendation screening stage, the collaborative filtering recommendation is combined to screen the recommendation candidate set. The idea of user-based collaborative filtering is used for reference to obtain music works favored by similar users. On the other hand, we learn from item-based CF, which ensures that the candidate set covers user preference. (...) Firstly, the user’s interest value is predicted by using dynamic interest model. Then, the common problems such as cold start and hot items processing are fully considered. The frequent pattern growth algorithm is compared with the association rule algorithm based on the collaborative filtering recommendation algorithm and the content-based recommendation algorithm, which proves the superiority of the algorithm and its role in solving the recommendation problem after applying the recommendation. The music data in the database data conversion effectively improve the efficiency and accuracy of mining. According to the implementation of the algorithm described in this article, the accuracy of the music recommendation results used to recommend user satisfaction is proved. And the recommended music is indeed feasible and practical. (shrink)

Background and rationale Several factors that motivate individuals to participate in non-therapeutic studies have been identified. This study was conducted as limited data is available regarding these motivations from developing countries. Methods This was a single-centre study conducted over 4 months in which a questionnaire was administered to 102 healthy participants and 16 patient participants who had earlier taken part in non-therapeutic studies at our centre. Descriptive statistics and univariate analysis were used to analyse data. Results The most common (...) motivation among healthy participants was financial reward (65%) followed by altruism, free medical check up, curiosity and personal health benefit. Patient participants, however, most commonly said they consented to take part in the trial as they were ‘invited to participate by the treating physician’ (88%). In comparison with the patient participants, healthy participants were more likely to be satisfied with the financial reward (p=0.02), and recommend participation in studies to friends or relatives (p=0.0013). Conclusions The most common motivating factor to participate in non-therapeutic studies appears to be different for healthy participants (financial reward) and patient participants (invitation to participate by the physician). Participants also felt that adequate information and care was given to them during the trial, and that they would participate in future clinical studies, and would also recommend such studies to their friends. (shrink)

At present, customers’ low satisfaction and loyalty to city express service have restricted the development of city express. It is particularly important to analyze the factors causing customers’ low satisfaction and loyalty, which will promote the development of city express industry effectively. Based on SERVQUAL model and CCSI model, this paper constructs a new evaluation index system from the perspective of service quality. Through this new system, this paper first explores the factors that affect customers’ satisfaction and loyalty, respectively, by (...) fuzzy analytic hierarchy process and hierarchical regression analysis, taking the expected and perceived service quality as conversion variables. And then it analyzes the common factors that affect customers’ satisfaction and loyalty comprehensively. These two analyses will provide reference for solving the problem of low customer satisfaction and loyalty of city express enterprises. The results show that popularity and credibility, delivery time commitment, and mailing security are the common main factors affecting customer satisfaction and loyalty. Easy-to-understand receipts, the three-level index corresponding to the empathy dimension, is the most significant factor affecting customers’ loyalty in city express industry; Delivery time commitment, the three-level index corresponding to the reliability dimension, is the most significant factor affecting customers’ loyalty in city express industry. (shrink)

Kyrgyz people lived under the control of Soviet Union for about 70 years. During this time, they were forbidden to practice any kinds of religious duties. Their religious schools and mosques were closed or used for other aims rather than religious needs. In short, all kinds of religious freedom and practices were forbidden strictly. The aim was to bring up an atheistic people during the days of Soviet Union. However, when Kyrgyz people won their independence and established a new country, (...) all kinds of restrictions in terms of religion were abrogated and people began to establish their religious schools and mosques. While during the first years of independency of the country in 1991, there were only 39 mosques, as of 2018 there are nearly 3,000 mosques in the country. In addition to the increase of mosques, the number of people going to mosques also increases day by day. This article examines mainly the development of religious freedom in terms of legal aspect from the beginning of the establishment of the country to our time; the legal statues, functions, and duties of State Commission for Religious Affairs and Religious Office of Kyrgyzstan Muslims, and as common religious educational places mosques, religious activities done at mosques, the factors effecting these activities negatively.Summary: Kyrgyz Turks are one of the most ancient tribes in Central Asia. Although there are various views and knowledge about the religious life and the process of Islamization of them in various sources, there is no doubt that one of the most important elements which shapes Kyrgyz culture and social life is Islam. Even though they continued the activities of Islamic education and training under the rule of many nations thorough the history, all activities of religious education were tried to be forgotten and religion was removed from daily life under the Soviet communist regime. However, with the establishment of the Republic of Kyrgyz based on the secular and democratic bases on 31 August 1991, Muslim people showed a great effort and endeavor to open some institutions where they could live their religion, perform their religious duties, and teach religious and moral values for people. After the declaration of independence, with the enacting of “Freedom of Faith and Religious Institutions” on 16 December 1991 which was one of the first enacting laws, very important developments happened in terms of both formal and informal education. Some knowledge concerning Islam is given in some culture courses and “Religious Office of Kyrgyzstan Muslims” was created for meeting all kinds of religious needs of Muslims in the country in 1993. With the establishment of the “State Commission for Religious Affairs” in 1996, some new legal regulations were made. Thus the state’s policy about religious education and teaching gained a new dimension. During this process, the state faced some problems concerning developments in religious education. Although some of these problems have been solved legally, there are still many problems about religious education today. Since the independency until now, there have been many researches as articles, books, master theses and doctorate dissertations about various fields of religious education, religion-state relations, religious institutions, course books and their curriculums. However, a great majority of these studies belong to religion-state relations and the field of formal religious education. There aren’t any academic studies or research about mosques and imams that concern the great majority of the country population. In fact, from the point of religious education, common or informal religious education is as extremely important as formal religious education. For the mosques that are one of the most important institutions of common religious education are spread to the most remote corner of the country and serve for all people of different ages for the whole year. The effects of common religious education increase day by day. While there were just 33 mosques in 1933, there were 39 mosques in the independency year of 1991, as of 2018 this number has risen to 2830. Relating the imams who work at mosques, it is not possible to speak about a systematic structure. Since imams are generally graduated from madrasas, their educational levels are very low. As they have not enough financial support and highly educated teachers, they cannot give good education to their students and cannot adopt themselves to the modern educational levels in teaching religious issues. In order to solve this problem, Muftiyat either sends students to abroad or gives in service trainings for imams. Another important problem in relation to imams is the way of assignment. There is no criterion for assignment of imams. They are not designated by the Muftiyat, but it just legitimizes those imams who are chosen by congregation. Imams receive neither any salary from the Muftiyat, nor they have any social assurance. They work either voluntary or their incomes are paid by people. Although all of these negative conditions, mosques and imams have a great importance on Kyrgyz people’s education, culture, worship, and moral teaching. It can be said that there are two kinds of education at mosques and masjids. One of these is “moldos”, some men of religion who gather students and give some religious knowledge without following any curriculum. Although some of them take education from some Arabic countries or Pakistan, their educational level is very low and cannot recite even the Qur’an correctly. In addition, they have very little knowledge about pedagogy and religious themes, and they have not enough educational experience. The second type of education at mosques and masjids is carried out through Friday sermons and preaching. However, this is not an effective way in giving religious education. Because the way in which the Friday sermon is given is not appropriate as a good teaching method. As the sermons are done in Arabic, there is no effective communication between the imam and the congregation. However, Friday sermons and preaching are very important for people’s religious education and socialization. This article firstly deals with the developments in religion in the times of freedom of the country, secondly, it examines the institution of Muftiyat to which all mosques are adhered and “State Commission for Religious Affairs” that register the mosques which the Muftiyat approves, and lastly gives information about mosques and their congregations in the country. (shrink)

Long‐range correlation is a general class of coordination pattern found to be common to the intrinsic dynamics of complex systems, including human behavior. Balasubramaniam, Hove, and Médé investigate intrinsic dynamics in repeated finger movements, and they find that different measures of movement dynamics yield different long‐range correlations. Results shed light on the way that coordination patterns are expressed as a function of measurement context.

This article aims to analyze the scope and limits of common cause abduction which is a version of explanatory abduction based on Hans Reichenbach’s Principle of the Common Cause. First, it is argued that common cause abduction can be regarded as a rational inferential mechanism that enables us to accept hypotheses that aim to account for the surprising correlations of events. Three arguments are presented in support of common cause abduction: the argument from screening-off, the argument (...) from likelihood, and the argument from simplicity. Second, it is claimed, that common cause abduction is a defeasible reasoning, i.e., common cause abductive hypotheses are not always more plausible than separate cause abductive hypotheses. Finally, it is outlined what factors should be taken into account in order to use common cause abduction in a reasonable way. (shrink)

The most important property, a distinctive feature of any intelligent system, is its decision-making ability. In this case, the more complex the problem to be solved, the more and more diverse the initial data, and the more critical it is that the decision to be made was comprehensively considered and evaluated. In many cases, simultaneously arriving various initial data, if considered separately, and decisions based on such consideration lead to completely different results, often contradicting each other. Therefore, in the process (...) of development and implementation of artificial intelligence (AI), it is especially important to investigate the “mechanism” of decision-making in conditions of the inconsistency of incoming initial data and the need to establish some generalizing rule, according to which it is possible to find a harmonizing solution taking into account various influencing factors. It is evident that when establishing the rules of decision-making, it is necessary to strive for a “positive” result from the point of view of the problem being solved. This undoubtedly requires analyzing the consequences of the decision made in a set time scale, which can be provided by appropriate feedback that will allow us to make the necessary corrective actions. Artificial intelligence in modern forms of practical realization has, as a rule, a digital embodiment. It should be taken into account that the digital representation of data inevitably shows an inaccurate display of initial values when processes of a continuous nature are considered and analyzed. Since a digital model has certain limitations and characteristic properties when analyzing and processing initial data, it is logical to assume that for this reason, there can be some general approach, some general rule, according to which a decision is made in the conditions of diverse initial data and the need to take into account the relevant consequences after the decision is made. This paper attempts to find a decision-making mechanism, harmonizing it according to the incoming external and available internal input data. (shrink)

It is often assumed that the reaction time of a saccade toward visual and/or auditory stimuli reflects the sensitivities of our oculomotor-orienting system to stimulus saliency. Endogenous factors, as well as stimulus-related factors, would also affect the saccadic reaction time. However, it was not clear how these factors interact and to what extent visual and auditory-targeting saccades are accounted for by common mechanisms. The present study examined the effect of, and the interaction between, stimulus saliency and audiovisual spatial congruency (...) on the SRT for visual- and for auditory-target conditions. We also analyzed pre-target pupil size to examine the relationship between saccade preparation and pupil size. Pupil size is considered to reflect arousal states coupling with locus-coeruleus activity during a cognitive task. The main findings were that the pattern of the examined effects on the SRT varied between visual- and auditory-auditory target conditions, the effect of stimulus saliency was significant for the visual-target condition, but not significant for the auditory-target condition, Pupil velocity, not absolute pupil size, was sensitive to task set, and there was a significant correlation between the pre-saccade absolute pupil size and the SRTs for the visual-target condition but not for the auditory-target condition. The discrepancy between target modalities for the effect of pupil velocity and between the absolute pupil size and pupil velocity for the correlation with SRT may imply that the pupil effect for the visual-target condition was caused by a modality-specific link between pupil size modulation and the SC rather than by the LC-NE system. These results support the idea that different threshold mechanisms in the SC may be involved in the initiation of saccades toward visual and auditory targets. (shrink)

In this article I argue for rule-based, non-monotonic theories of common law judicial reasoning and improve upon one such theory offered by Horty and Bench-Capon. The improvements reveal some of the interconnections between formal theories of judicial reasoning and traditional issues within jurisprudence regarding the notions of the ratio decidendi and obiter dicta. Though I do not purport to resolve the long-standing jurisprudential issues here, it is beneficial for theorists both of legal philosophy and formalizing legal reasoning to see (...) where the two projects interact. (shrink)

On page 1 of his classic text, Millsap states, “Measurement invariance is built on the notion that a measuring device should function the same way across varied conditions, so long as those varied conditions are irrelevant [emphasis added] to the attribute being measured.” By construction, measurement invariance techniques require not only detecting varied conditions but also ruling out that these conditions inform our understanding of measured domains. In fact, measurement invariance techniques possess great utility when theory and research inform their (...) application to specific, varied conditions that, if not detected, introduce measurement biases, and, thus, depress measurement validity. Yet, we see emerging bodies of work where scholars have “put the cart before the horse” when it comes to measurement invariance, and they apply these techniques to varied conditions that, in fact, may reflect domain-relevant information. These bodies of work highlight a larger problem in measurement that likely cuts across many areas of scholarship. In one such area, youth mental health, researchers commonly encounter a set of conditions that nullify the use of measurement invariance, namely discrepancies between survey reports completed by multiple informants, such as parents, teachers, and youth themselves. In this paper, we provide an overview of conceptual, methodological, and measurement factors that should prevent researchers from applying measurement invariance techniques to detect informant discrepancies. Along the way, we cite evidence from the last 15 years indicating that informant discrepancies reflect domain-relevant information. We also apply this evidence to recent uses of measurement invariance techniques in youth mental health. Based on prior evidence, we highlight the implications of applying these techniques to multi-informant data, when the informant discrepancies observed within these data might reflect domain-relevant information. We close by calling for a moratorium on applying measurement invariance techniques to detect informant discrepancies in youth mental health assessments. In doing so, we describe how the state of the science would need to fundamentally “flip” to justify applying these techniques to detect informant discrepancies in this area of work. (shrink)

The principle of common cause asserts that positive correlations between causally unrelated events ought to be explained through the action of some shared causal factors. Reichenbachian common cause systems are probabilistic structures aimed at accounting for cases where correlations of the aforesaid sort cannot be explained through the action of a single common cause. The existence of Reichenbachian common cause systems of arbitrary finite size for each pair of non-causally correlated events was allegedly demonstrated by Hofer-Szabó (...) and Rédei in 2006. This paper shows that their proof is logically deficient, and we propose an improved proof. (shrink)

Objective: To determine the usefulness of Q methodology to locate and describe shared subjective influences on clinical decision making among participant physicians using hypothetical cases containing common ethical issues. Design: Qualitative study using by-person factor analysis of subjective Q sort data matrix. Setting: University medical center. Participants: Convenience sample of internal medicine attending physicians and house staff (n = 35) at one midwestern academic health sciences center. Interventions: Presented with four hypothetical cases involving urgent decision making near the (...) end of life, participants selected one of three specific clinical actions offered for each case. Immediately afterward and while considering their decision, each respondent sorted twenty-five subjective self-referent items in terms of the influence of each statement on their decision-making process. By-person factor analysis, where participants are defined as variates, yielded information about the attitudinal background the physicians brought to their consideration of each hypothetical case. We performed a second-order factor analysis on all of the subjective viewpoints to determine if a smaller core of shared attitudes existed across some or all of the four case vignettes. Factor scores for each item and post-sort comments from interviews conducted individually with each respondent guided the interpretation of ethical perspective used by these respondents in making clinical decisions about the cases. Measurements and Main Results: Second-order factor analysis on seventeen viewpoints used by physicians in the four hypothetical urgent decision cases revealed three moderately correlated (r 2 < 40%) subjective core attitudinal guides used broadly among all the cases and among sixteen of the seventeen original factors. Across all the cases, our participants were guided in general by: (1) patient-focused beneficence, (2) a patient- and surrogate-focused perspective that includes risk avoidance, and (3) best interest of the patient guided by ethical values. Economic impact on the physician, expediency in resolution of the situation, and the expense of medical treatment were not found to be influential determinants in this study. Conclusions: Q sorting and by-person factor analysis are useful qualitative methodological tools to study the complex structure of subjective attitudes that influence physicians in making medical decisions. This study revealed the subjective viewpoints used by our physician participants as they made ethically challenging treatment decisions. The three second-order factors identified here are grounded in current bioethical values as well as the personal traits of physicians. The participants' decision methods appear to resemble casuistry more than principle-based decision making. Generalizability of results will require further studies. (shrink)

PurposeBased on social exchange theory, this study aimed to investigate, from the cost-benefits perspective, the intention to co-create open educational resources.Design/Methodology/ApproachParticipants in the study included 311 undergraduate students selected from those enrolled in a course on the China University MOOC platform. Regression analysis was conducted to examine cost and benefits factors that influenced participants’ intentions to co-create OER.Findings From the perspective of benefits, expected reciprocity, increase in knowledge self-efficacy, and creative self-efficacy were found to significantly and positively impact the intention (...) to co-create OER, while increase in internet self-efficacy was not. From the perspective of cost, perceived effort and perceived privacy were found to significantly and negatively impact the intention to co-create OER, while perceived intellectual property risks were not significant.Originality/ValueThree strategies are recommended to promote the intention to co-create OER based on the findings of this study: focusing on OER communities and developing reciprocity norms; popularizing and promoting knowledge and use of Creative Commons copyright licenses; providing easy-to-use online resource editing tools for use with OER repositories.Research Limitations/ImplicationsFuture research should explore other ages, cultural backgrounds, and types of online learning experience to help broaden the universality of the results. (shrink)

It is commonly hypothesized that scientists are more likely to engage in data falsification and fabrication when they are subject to pressures to publish, when they are not restrained by forms of social control, when they work in countries lacking policies to tackle scientific misconduct, and when they are male. Evidence to test these hypotheses, however, is inconclusive due to the difficulties of obtaining unbiased data. Here we report a pre-registered test of these four hypotheses, conducted on papers that were (...) identified in a previous study as containing problematic image duplications through a systematic screening of the journal PLoS ONE. Image duplications were classified into three categories based on their complexity, with category 1 being most likely to reflect unintentional error and category 3 being most likely to reflect intentional fabrication. We tested multiple parameters connected to the hypotheses above with a matched-control paradigm, by collecting two controls for each paper containing duplications. Category 1 duplications were mostly not associated with any of the parameters tested, as was predicted based on the assumption that these duplications were mostly not due to misconduct. Categories 2 and 3, however, exhibited numerous statistically significant associations. Results of univariable and multivariable analyses support the hypotheses that academic culture, peer control, cash-based publication incentives and national misconduct policies might affect scientific integrity. No clear support was found for the “pressures to publish” hypothesis. Female authors were found to be equally likely to publish duplicated images compared to males. Country-level parameters generally exhibited stronger effects than individual-level parameters, because developing countries were significantly more likely to produce problematic image duplications. This suggests that promoting good research practices in all countries should be a priority for the international research integrity agenda. (shrink)