The relations between language and imagery are addressed by cross referencing Lacan and James Hillman, along with Mead, Geschwind, and Gibson. Not only is neither symbolic frame reducible to the other, but neither can be rooted in perceptual capacities that would be distinct from or more "primitive" than the other. Outside of specific theoretical agendas that would analyze one by simplifying the other, word and image are co-emergent and co-dependent expressions of the inherent openness of the human mind.

During meditation, consciousness/awareness is usually enhanced because of higher attention and concentration, which inter-dependently co-arise thru appropriate interactions between neural signals. Nāgārjuna rejects ‘inherent existence’ or ‘essence’ in favor of co-dependent origination (Pratītyasamutpāda), and that is also why he rejects causality; the entities that lack inherent existence dependently co-arise. Causality is a major issue in metaphysical views. The goals of this article are as follows: (I)Which entities lack ‘inherent existence’ or ‘essence’ and which ones inherently exist? (II) Do the entities (...) that lack inherent existence dependently co-arise and hence can we reject causality as in Nāgārjuna’s philosophy? (III) Do the entities that exist inherently cause entities that lack inherent existence? (IV) Do structure, function, experience, and environment cause each other? And (V)We critically analyze, extend, and examine Nāgārjuna’s philosophy of dependent co- origination in the extended Dual-Aspect Monism (eDAM) framework. Our analysis suggests that: (i) All conventional entities lack inherent existence. However, the dual-aspect unmanifested state of the primal entity (unified information field (UIF), emptiness, Śūnyatā, a neutral entity of Neutral Monism, or Brahman) inherently exists. The dual-aspect unmanifested state of UIF has (a) physical unified information field (PUIF, quantum vacuum, ‘zero- point field’/ZPF)as physical aspect and (b) unified potential consciousness information field (UPCIF) as the non-physical aspect. The subjective experiences (SEs) of objects and of the subject (self) are the excitations or modes of the UPCIF, so they are derived entities and hence they lack inherent existence. The dual-aspect unmanifested state of UIF/emptiness/Śūnyatā is fundamental and irreducible, and hence it inherently exists. (ii) The entities that lack inherent existence dependently co-arise, and hence causality for them can be rejected but instead conditions (such as efficient, percept-object, immediate, and dominant conditions) are necessary, as in Nāgārjuna’s philosophy. (iii) It is unclear that the dual-aspect primal entity UIF (Brahman/emptiness/Śūnyatā) that exists inherently cause entities that lack inherent existence. Most likely, all manifested entities inter-dependently co-arise thru natural laws built-in the UIF when necessary conditions for a manifested entity are satisfied thru interaction among relevant entities. (iv) It is unclear that structure, function, experience, and environment cause each other. A cause must, at the same time, be an effect of another cause. This implies that there is no first cause. Therefore, the structure, function, and experience inter-dependently co-arise thru co-evolution, co-development, sensorimotor co-tuning, and the interaction among relevant entities after the necessary conditions of manifestation of a specific entity are satisfied; and they are linked via conditions. (v) In the extended Dual-Aspect Monism (eDAM) framework, the physical aspect of a state of a manifested entity and that of the non-physical aspect (with functional, qualitative, cognitive, and experiential sub-aspects) of the same state of the same entity inseparably co-exist in each state of each entity at all levels. However, the degrees of manifestations of inseparable physical and non-physical aspects vary with the states, levels of entities, and contexts. Moreover, manifested entities lack inherent existence. In other words, the physical aspect and that of the non-physical aspect of manifested entities dependently co- arise, co-evolve, co-develop, and co-tuned for sensorimotor system appropriately depending on the levels of entities and contexts, which along with common “effective”information entail the inseparability of both aspects. In this sense, the symmetry between physical and non-physical aspects of a state of an entity (such as brain-mind system) is maintained, where the physical aspect (from third person perspective) does not cause the inseparable non-physical aspect (from first-person perspective) in living systems or vice- versa. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dependent Co-Origination and Universal IntersubjectivityJoseph A. Bracken, SJTwo essays in a recent issue of Buddhist-Christian Studies dealt with the topic "Buddhist and Christian Views of Community." The first essay, by Rita Gross, was a careful analysis of the way in which the separation of home and workplace in contemporary Western society has tended to reduce effective community life to the nuclear family and thus pose significant disadvantages to everyone (...) involved (not only mothers, fathers, and their children but also non–family members, friends, and neighbors) within the broader civic community.1 A consumer-oriented culture catering to individual needs and desires has arisen to compensate for the pervasive feeling of loneliness and emptiness created by the relative lack of significant interpersonal relationships. In the second essay Donald Mitchell recounted the origin and unexpected growth of the International Focolare movment of which he is a longtime member.2 He noted how the founder of the movement, Chiara Lubich, and her women friends found inspiration for living together and working for the poor and the homeless around them in what they saw as the self-giving love of the three divine persons of the Christian doctrine of the Trinity both for one another and for all their creatures. This movement over time broadened to include first Protestant members, then Jews, Muslims, Buddhists, and Hindus, all drawn by the goal of richer life in community along with group efforts to assist the underprivileged of this world.My own contribution to the topic of Buddhist and Christian views of community will focus on the same communitarian model of the doctrine of the Trinity that originally inspired Lubich and her followers in the years during and after World War II, but my remarks will be more philosophically oriented. Following the lead of the late Colin Gunton in his book The One, the Three and the Many,3 I will analyze the communitarian model of the Trinity for its value in setting forth a new paradigm for the relationship of the One and the Many. As Gunton perceptively notes in the early chapters of his book, Western civilization seems to be still preoccupied with a basically Platonic understanding of the One and the Many in which the One enjoys primacy over the Many as their transcendent principle of order and intelligibility.4 As a result, even though freedom and individual self-expression are theoretically prized in Western societies, in point of [End Page 3] fact there is a great deal of uniformity and even repression of individual differences so as to conform to the cultural standards imposed by some dominant individual or minority group within each society. In the end people seem to fear the threat to personal security represented by wide diversity and plurality more than they value their individual liberty.Looking to the doctrine of the Trinity set forth by the Greek-speaking fathers of the Church, however, Gunton finds a new paradigm for the One and the Many whereby the One is emergent out of the interplay of the Many with one another rather than transcendent over the Many as their necessary principle of order and intelligibility.5 The Many are defined by their internal relations to one another rather than by their common relation to an external One. The community thus achieved is a differentiated unity, not only tolerating differences of the Many among themselves, but even fostering those differences so as to produce in the end a more complex form of community. The application to the Christian doctrine of the Trinity is obvious. The three divine persons are strictly defined with respect to one another; each of them has no self-identity apart from relation to the other two persons. Yet together they co-constitute the reality of the one God, a richly differentiated rather than blandly homogeneous unity.6The application to human beings and their membership in various communities, of course, is not so obvious. But Gunton believes that three principles or "transcendentals" for the understanding of the relation of human beings with one another and with God are at hand, given careful study of this communitarian model of the Trinity: namely, perichoresis, substantiality or... (shrink)

The doctrine of paṭicca samuppāda or dependent co-arising is fundamental to Buddhist ethics. In this vision of radical relativity, reality appears as an interdependent process wherein change and choice, doer and deed, person and community are mutually causative. Morality is grounded in this interdependence, as in the corrollary Buddhist views of anattā and karma. Consequently it reveals a reciprocal dynamic between personal and social transformation, expressed in Buddhist scripture and illustrated in a contemporary Buddhist movement in Sri Lanka.

In discussions of moral responsibility for collectively produced effects, it is not uncommon to assume that we have to abandon the view that causal involvement is a necessary condition for individual co-responsibility. In general, considerations of cases where there is “a mismatch between the wrong a group commits and the apparent causal contributions for which we can hold individuals responsible” motivate this move. According to Brian Lawson, “solving this problem requires an approach that deemphasizes the importance of causal contributions”. Christopher (...) Kutz’s theory of complicitious accountability in Complicity from 2000 is probably the most well-known approach of that kind. Standard examples are supposed to illustrate mismatches of three different kinds: an agent may be morally co-responsible for an event to a high degree even if her causal contribution to that event is a) very small, b) imperceptible, or c) non-existent (in overdetermination cases). From such examples, Kutz and others conclude that principles of complicitious accountability cannot include a condition of causal involvement. In the present paper, I defend the causal involvement condition for co-responsibility. These are my lines of argument: First, overdetermination cases can be accommodated within a theory of coresponsibility without giving up the causality condition. Kutz and others oversimplify the relation between counterfactual dependence and causation, and they overlook the possibility that causal relations other than marginal contribution could be morally relevant. Second, harmful effects are sometimes overdetermined by non-collective sets of acts. Over-farming, or the greenhouse effect, might be cases of that kind. In such cases, there need not be any formal organization, any unifying intentions, or any other noncausal criterion of membership available. If we give up the causal condition for coresponsibility it will be impossible to delimit the morally relevant set of acts related to those harms. Since we sometimes find it fair to blame people for such harms, we must question the argument from overdetermination. Third, although problems about imperceptible effects or aggregation of very small effects are morally important, e.g. when we consider degrees of blameworthiness or epistemic limitations in reasoning about how to assign responsibility for specific harms, they are irrelevant to the issue of whether causal involvement is necessary for complicity. Fourth, the costs of rejecting the causality condition for complicity are high. Causation is an explicit and essential element in most doctrines of legal liability and it is central in common sense views of moral responsibility. Giving up this condition could have radical and unwanted consequences for legal security and predictability. However, it is not only for pragmatic reasons and because it is a default position that we should require stronger arguments (than conflicting intuitions about “mismatches”) before giving up the causality condition. An essential element in holding someone to account for an event is the assumption that her actions and intentions are part of the explanation of why that event occurred. If we give up that element, it is difficult to see which important function responsibility assignments could have. (shrink)

The canonical Buddhist account of the cognitive processes underlying our experience of the world prefigures recent developments in neuroscience. The developments in question are centered on two main trends in neuroscience research and thinking. The first of these involves the idea that our everyday experience of ourselves and of the world consists in a series of discrete microstates. The second closely related notion is that affective structures and systems play critical roles in governing the formation of such states. Both of (...) these ideas are contained within the Buddhist theory of dependent co-origination. This paper explicates the theory of dependent co-origination in light of the aforementioned developments. It examines the role of the theory of dependent co-origination within Buddhism and it draws attention to critical differences with the neuroscientific account of the same process. Finally, it discusses specific ways in which these differences may be usefully applied to neuroscience research and thinking. (shrink)

In discussions of moral responsibility for collectively produced effects, it is not uncommon to assume that we have to abandon the view that causal involvement is a necessary condition for individual co-responsibility. In general, considerations of cases where there is “a mismatch between the wrong a group commits and the apparent causal contributions for which we can hold individuals responsible” motivate this move. According to Brian Lawson, “solving this problem requires an approach that deemphasizes the importance of causal contributions”. Christopher (...) Kutz’s theory of complicitious accountability in Complicity from 2000 is probably the most well-known approach of that kind. Standard examples are supposed to illustrate mismatches of three different kinds: an agent may be morally co-responsible for an event to a high degree even if her causal contribution to that event is a) very small, b) imperceptible, or c) non-existent (in overdetermination cases). From such examples, Kutz and others conclude that principles of complicitious accountability cannot include a condition of causal involvement. In the present paper, I defend the causal involvement condition for co-responsibility. These are my lines of argument: First, overdetermination cases can be accommodated within a theory of coresponsibility without giving up the causality condition. Kutz and others oversimplify the relation between counterfactual dependence and causation, and they overlook the possibility that causal relations other than marginal contribution could be morally relevant. Second, harmful effects are sometimes overdetermined by non-collective sets of acts. Over-farming, or the greenhouse effect, might be cases of that kind. In such cases, there need not be any formal organization, any unifying intentions, or any other noncausal criterion of membership available. If we give up the causal condition for coresponsibility it will be impossible to delimit the morally relevant set of acts related to those harms. Since we sometimes find it fair to blame people for such harms, we must question the argument from overdetermination. Third, although problems about imperceptible effects or aggregation of very small effects are morally important, e.g. when we consider degrees of blameworthiness or epistemic limitations in reasoning about how to assign responsibility for specific harms, they are irrelevant to the issue of whether causal involvement is necessary for complicity. Fourth, the costs of rejecting the causality condition for complicity are high. Causation is an explicit and essential element in most doctrines of legal liability and it is central in common sense views of moral responsibility. Giving up this condition could have radical and unwanted consequences for legal security and predictability. However, it is not only for pragmatic reasons and because it is a default position that we should require stronger arguments (than conflicting intuitions about “mismatches”) before giving up the causality condition. An essential element in holding someone to account for an event is the assumption that her actions and intentions are part of the explanation of why that event occurred. If we give up that element, it is difficult to see which important function responsibility assignments could have. (shrink)

Co-hyperintensionality, or hyperintensional equivalence, is a relation holding between two or more contents that can be substituted in a hyperintensional context salva veritate. I argue that two strategies used to provide criteria for co-hyperintensionality fail. I argue that there is no generalized notion of co-hyperintensionality that meets plausible desiderata, by showing that the opposite thesis leads to falsity. As a conclusion, I suggest to take co-hyperintensionality as a primitive and I provide a general criterion of co-hyperintensionality whose content depends on (...) each hyperintensional notion we aim to formalize. (shrink)

This paper provides an analysis of the fair trade network in the North through a comparative assessment of two distinctly different fair trade certified roasters: Planet Bean, a worker-owned co-operative in Guelph, Ontario; and Starbucks Coffee Company, the world's largest specialty roaster. The two organizations are assessed on the basis of their distinct visions of the fair trade mission and their understandings of "consumer sovereignty". It is concluded that the objectives of Planet Bean are more compatible with the moral mission (...) of fair trade, even while the network has become increasingly dependent on the market-reach of corporations like Starbucks, raising difficult prospects for the future of fair trade. (shrink)

Interoception, the ability to feel the body’s internal sensations, is an essential aspect of emotional experience. There is mounting evidence that interoception is impaired in common mental health disorders and that poor interoceptive awareness is a major contributor to emotional reactivity, calling for clinical interventions to address this deficit. The manuscript presents a comprehensive theoretical review, drawing on multidisciplinary findings to propose a metatheory of reinforcement mechanisms applicable across a wide range of disorders. We present a reconsideration of operant conditioning (...) through the co-emergence model of reinforcement, which is a neurophenomenological account of the interaction between cognition and interoception, and its consequences on behavior. The model suggests that during memory processing, the retrieval of autobiographical memory (including maladaptive cognition) is dependent upon its co-emerging interoceptive cues occurring at the encoding, consolidation and reconsolidation stages. Accordingly, “interoceptive reinforcement” during emotional distress is a common factor to all emotional disorders and a major cause for relapse. We propose that interoceptive desensitization has transdiagnostic benefits, readily achievable through the cultivation of equanimity during mindfulness training and can be integrated in cognitive and behavioral interventions to permit a transdiagnostic applicability. We summarize the contributions of this approach into 10 specific and testable propositions. (shrink)

The increasing interest in online shopping in recent years has increased the importance of understanding customer engagement valence in a virtual service network. There is yet a comprehensive explanation of the CEV concept, particularly its impact on multi-actor networks such as web stores. Therefore, this study aims to fill this research gap. In this study, past literature in the marketing and consumer psychology field was critically reviewed to understand the concept of CEV in online shopping, and the propositional-based style was (...) employed to conceptualize the CEV within the online shopping context. The outcomes demonstrate that the valence of customer engagement is dependent on the cognitive interpretation of signals that are prompted by multiple actors on a web store service network. If the signals are positively interpreted, positive outcomes such as service co-creation are expected, but if they are negatively interpreted, negative outcomes such as service co-destruction are predicted. These notions create avenues for future empirical research and practical implications. (shrink)

The economic theory of contract is being reshaped in ways which resonate with the findings of socio-legal contract scholars and of industrial economists and sociologists in the Marshallian tradition, who emphasise the 'embeddedness' of organizations within their social and cultural environment. Contractual co-operation is seen as depending on institutional factors which serve to enhance 'trust', and arrangements which in the past were criticized as the product of collusion are being reassessed as potentially efficient responses to market failure. An active debate (...) has begun on how instruments of public policy can best be deployed to arrive at an effective balance between co-operation and competition. This affects both the competitiveness of private sector organizations and the success of deregulatory reforms in the public sphere. These issues are explored within four main areas: developments in private-sector contracting; contract and organization in the public sector; the economics of contract law; and competitiveness and competition policy. (shrink)

The overall objective of the study was to examine the pros and cons of the participatory approach adopted in natural resource management in the ecologically protected areas of the Sundarbans mangrove of Bangladesh. A comparative study was done between the people who are involved and non-involved in this approach. Empirical data was collected through personal interviews with a structured questionnaire. The Gini coefficient was measured first and then embedded with the Lorenz curve to draw a line between perfect equality and (...) inequality vis-a-vis. The study revealed that the co-management built awareness in favor of biodiversity conservation and the efficient use of natural resources. Contradictorily, a segment of different hierarchical committees was involved in destructive activities like poisoning the wetlands for fishing. Therefore, a mixed outcome was found. The findings will help the policymakers in identifying the pitfalls and bottlenecks rooted in co-management. Hence, the study recommends revising the approach to ensure the community’s active participation on an equal basis and take action against them who degrade those resources. Exploring profitable alternative income-generating activities is warranted to narrow down the dependency on the Sundarbans mangrove’s natural resources. In order to address the tragedy of the commons, the study advocates for the unity of all knowledge ranging from science to humanistic scholarship for sound policymaking. (shrink)

Teaching is hypothesized to be a species-typical behavior in humans that contributed to the emergence of cumulative culture. Several within-culture studies indicate that foragers depend heavily on social learning to acquire practical skills and knowledge, but it is unknown whether teaching is universal across forager populations. Teaching can be defined ethologically as the modification of behavior by an expert in the presence of a novice, such that the expert incurs a cost and the novice acquires skills/knowledge more efficiently or that (...) it would not acquire otherwise. One behavioral modification hypothesized to be an adaptation for teaching is ostensive communication—exaggerations of prosody and gesture that signal intent to transmit generalizable knowledge and indicate the intended receiver. On this view, the use of ostensive communication in conjunction with the transmission of generalizable knowledge constitutes evidence of teaching. Oral storytelling appears to meet these criteria: Indigenous peoples regard their traditions as important sources of ecological and social knowledge, and oral storytelling is widely reported to employ paralinguistic communication. To test this hypothesis, descriptions of performed narrative in forager societies were coded for the use of 14 ostensive-communicative behaviors and the presence of generalizable knowledge. Although biased toward North America, the study sample comprised 53 forager cultures spanning five continents, 34 language families, and diverse biomes. All cultures evinced the predicted behaviors. Results suggest that foragers use storytelling as a mode of instruction, thus providing cross-cultural evidence of teaching in forager populations. (shrink)

Small human complex systems, here called co-present groups, are found across all fields of human social life. Complexity thinking suggests why this is so: that these groups, irrespective of formal content, have a meta-function of providing maximum complexity to manage the indeterminacy or uncertainty that characterises the most complex of human social issues. This claim depends on an understanding of the functioning of these groups as being characterised by irreducibly complex intersubjective (person to person) relations, which are involved in the (...) processing of raw human experience (‘affective processing’), to produce shared meaningfulness. An example of the use of co-present groups in medical continuing professional development (CPD) is given. (shrink)

This book investigates the unresolved issue of democratic legitimacy in contexts of pervasive disagreement and contributes to this debate by defending a relational version of political liberalism that rests on the ideal of co-authorship. According to this proposal, democratic legitimacy depends upon establishing appropriate interactions among citizens who ought to ascribe to one another the status of putative practical and epistemic authorities. To support this relational reading of political liberalism, the book proposes a revised account of the civic virtue of (...) reasonableness along with an investigation of the epistemic-specific dimension of political equality. By engaging with political epistemology and social theory, this book explores ways to address inherent tensions within the liberal paradigm, using the following strategies of addressing these tensions: first, it defends a twofold model of legitimacy that distinguishes the goals, methodologies, and justificatory tasks of both ideal and nonideal phases of the two-level justificatory framework; second, it contends that democratic legitimacy requires an engaged and contextual critical appraisal of the injustices that characterize our daily social lives, illustrating how structural forms of injustice represent a profound betrayal of the liberal ideal of democratic legitimacy. (shrink)

David Steen and co-authors in this journal offer a philosophical argument to support an “Evolutionary Community Concept” to identify what they call “evolutionary communities.” They describe these as “unique collections of species that interact and have co-evolved in a given geographic area” and that include “co-evolved dependencies between different parts of a community.” Steen et al. refer to the coevolution of assemblages, collections, communities, dependencies, interspecific and abiotic interactions, and traits, but they do not define “co-evolution” or provide an example (...) in which co-evolution has been demonstrated. There may be as many ways to explain interactions among species as these interactions themselves; they may result, for example, from ecological fitting and phenotypic plasticity. In this paper, I argue that standard Darwinian Theory explains intraspecific microevolution or descent with modification within an interbreeding and potentially continuous population. The power, mechanism, or force that causes interspecific co-evolution, especially at the community scale, requires further explanation. (shrink)

An influential view of the nature of the language system is that of an evolved biological system in which a set of rules is combined with a lexicon that contains the words of the language together with a representation of their context. Alternative views, usually based on connectionist modeling, attempt to explain the structure of language on the basis of complex associative processes. Here, I put forward a third view that stresses experience-dependent structural development of the brain circuits supporting language (...) as a core principle of the organization of the language system. In this view, embodied in a recent neuroconstructivist neural network of past tense development and processing, initial domain-general predispositions enable the development of functionally specialized brain structures through interactions between experience-dependent brain development and statistical learning in a structured environment. Together, these processes shape a biological adult language system that appears to separate into distinct mechanism for processing rules and exceptions, whereas in reality those subsystems co-develop and interact closely. This view puts experience-dependent brain development in response to a specific language environment at the heart of understanding not only language development but adult language processing as well. (shrink)

The health co-benefits of CO2 mitigation can provide a strong incentive for climate policy through reductions in air pollutant emissions that occur when targeting shared sources. However, reducing air pollutant emissions may also have an important co-harm, as the aerosols they form produce net cooling overall. Nevertheless, aerosol impacts have not been fully incorporated into cost-benefit modeling that estimates how much the world should optimally mitigate. Here we find that when both co-benefits and co-harms are taken fully into account, optimal (...) climate policy results in immediate net benefits globally, overturning previous findings from cost-benefit models that omit these effects. The global health benefits from climate policy could reach trillions of dollars annually, but will importantly depend on the air quality policies that nations adopt independently of climate change. Depending on how society values better health, economically optimal levels of mitigation may be consistent with a target of 2 °C or lower. (shrink)

We challenge the proposal that partner-choice ecology explains the evolutionary emergence of ostensive communication in humans. The good fit between these domains might be because of the opposite relation (ostensive communication promotes the evolution of cooperation) or because of the dependence of both these human-specific traits on a more ancient contributor to human cognitive evolution: the use of technology.

Each of us has a story which we can think of as a set of beliefs, hopefully consistent. We make our decisions in view of our beliefs which may be probabilistic, in the general case, but simple yes or no as in this paper. Our beliefs are our envelope just as the shell of a tortoise is its envelope. Decision theory—or single agent game theory tells us when to make the best choice in a game of us against nature. But (...) nature has no desire to further or frustrate our efforts. Nature is mysterious but not malign. Things change when there are other agents involved. Then the best thing for us to do will depend on what they do. And they will think the same. And we predict their actions in terms of what we think their beliefs are. But how do we coordinate with others whose beliefs are different? This paper addresses the issue of working together despite different beliefs. (shrink)

Various arguments have been provided for drawing non-humans such as animals and artificial agents into the sphere of moral consideration. In this paper, I argue for a shift from an ontological to a social-philosophical approach: instead of asking what an entity is, we should try to conceptually grasp the quasi-social dimension of relations between non-humans and humans. This allows me to reconsider the problem of justice, in particular distributive justice . Engaging with the work of Rawls, I show that an (...) expansion of the contractarian framework to non-humans causes an important problem for liberalism, but can be justified by a contractarian argument. Responding to Bell’s and Nussbaum’s comments on Rawls, I argue that we can justify drawing non-humans into the sphere of distributive justice by relying on the notion of a co-operative scheme. I discuss what co-operation between humans and non-humans can mean and the extent to which it depends on properties. I conclude that we need to imagine principles of ecological and technological distributive justice. (shrink)

Complexes of two or more proteins form many, if not most, of the intracellular “machines” that execute physical and chemical work, and transmit information. Complexes can form from stochastic post‐translational interactions of fully formed proteins, but recent attention has shifted to co‐translational interactions in which the most common mechanism involves binding of a mature constituent to an incomplete polypeptide emerging from a translating ribosome. Studies in yeast have revealed co‐translational interactions during formation of multiple major complexes, and together with recent (...) mammalian cell studies, suggest widespread utilization of the mechanism. These translation‐dependent interactions can involve a single or multiple mRNA templates, can be uni‐ or bi‐directional, and can use multi‐protein sub‐complexes as a binding component. Here, we discuss benefits of co‐translational complex assembly including accuracy and efficiency, overcoming hidden interfaces, localized and hierarchical assembly, and reduction of orphan protein degradation, toxicity, and dominant‐negative pathogenesis, all serving to improve cell fitness. (shrink)

Multinational corporations (MNCs) are increasingly judged not only on their own social impacts but also on those of their supply chain partners. To reduce this environmental dependence, many MNCs implement social evaluations and codes of conduct which suppliers must follow. But how do MNCs legitimise and implement social evaluations in their supply chains? To address this, we draw on and augment resource dependence and legitimacy theories, to analyse a multinational grocery retailer’s implementation of labour standards for its fruit (...) and vegetable suppliers. The case study utilises interviews, analysis of a database of audits, internal documents, and observational data. It provides the basis for theorizing corporate reputation as a resource dependency, with social evaluations a distinct means to co-opt external actors to preserve the focal organization’s autonomy while reducing environmental contingencies. The legitimacy of social evaluations of supply chain partners depends on processes that reconcile both moral and pragmatic concerns, allowing the focal organization to mitigate resource dependencies without ceding control over enforcement and enabling actions. (shrink)

Standards for farm animal welfare are variously managed at a national level by government-led regulatory control, by consumer-led welfare economics and co-regulated control in a partnership between industry and government. In the latter case the control of research to support animal welfare standards by the relevant industry body may lead to a conflict of interest on the part of researchers, who are dependent on industry for continued research funding. We examine this dilemma by reviewing two case studies of research published (...) under an Australian co-regulated control system. Evidence of unsupported conclusions that are favourable to industry is provided, suggesting that researchers do experience a conflict of interest that may influence the integrity of the research. Alternative models for the management of research are discussed, including the establishment of an independent research management body for animal welfare because of its public good status and the use of public money derived from taxation, with representation from government, industry, consumers, and advocacy groups. (shrink)

Nikos K. Logothetis University of Manchester, Manchester, UK In binocular rivalry, the visual percept alternates stochastically between two dichoptically presented stimuli. It is established that both processes related to the eye of origin and binocular, stimulus-related processes account for these fluctuations in conscious perception. Here we studied how their relative contributions vary over time. We applied brief disruptions to rivalry displays, concurrent with an optional eye swap, at varying time intervals after one stimulus became visible (dominant). We found that early (...) in a dominance phase the dominant eye determined the percept by stabilizing its own contribution (regardless of the stimulus), with an additional yet weaker stabilizing contribution of the stimulus (regardless of the eye). Their stabilizing contributions declined in parallel with time so that late in a dominance phase the stimulus (and in some cases also the eye-based) contribution turned negative, favoring a perceptual (or ocular) switch. Our findings show that depending on the time, first processes related to the eye of origin and then those related to the stimulus can have a greater net influence on the stability of the conscious percept. Their co-varying change may be due to feedback from image- to eyeof-origin representations. (shrink)

Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

Purpose Underlying much recent development in data science and artificial intelligence (AI) is a dependence on the labour of precarious crowdworkers via platforms such as Amazon Mechanical Turk. These platforms have been widely critiqued for their exploitative labour relations, and over recent years, there have been various efforts by academic researchers to develop interventions aimed at improving labour conditions. The aim of this paper is to explore US-based crowdworkers’ views on two proposed interventions: a browser plugin that detects automated (...) quality control “Gold Question” (GQ) checks and a proposal for a crowdworker co-operative. Design/methodology/approach The authors interviewed 20 US-based crowdworkers and undertook a thematic analysis of collected data. Findings The findings indicate that US-based crowdworkers tend to have negative and mixed feelings about the GQ detector, but were more enthusiastic about the crowdworker co-operative. Originality/value Drawing on theories of precarious labour, this study suggests an explanation for the findings based on US-based workers’ objective and subjective experiences of precarity. The authors argue that for US-based crowdworkers “constructive” interventions such as a crowdworker co-operative have more potential to improve labour conditions. (shrink)

All people are vulnerable to having their self-concepts shaped by others. This article investigates that vulnerability using a theory of narrative self-constitution. According to narrative self-constitution, people depend on others to develop and maintain skills of self-narration and they are vulnerable to having the content of their self-narratives co-authored by others. This theoretical framework highlights how vulnerability to co-authoring is essential to developing a self-narrative and, thus, the possibility of autonomy. However, this vulnerability equally entails that co-authors can undermine autonomy (...) by contributing disvalued content to the agent’s self-narrative and undermining her authorial skills. I illustrate these processes with the first-hand reports of several women who survived sexual abuse as children. Their narratives of survival and healing reveal the challenges involved in developing the skills required to manage vulnerability to co-authoring and how others can help in this process. Finally, I discuss some of the implications of co-authoring for the healthcare professional and the therapeutic relationship. (shrink)

Every year, the Vietnamese people reportedly burned about 50,000 tons of joss papers, which took the form of not only bank notes, but iPhones, cars, clothes, even housekeepers, in hope of pleasing the dead. The practice was mistakenly attributed to traditional Buddhist teachings but originated in fact from China, which most Vietnamese were not aware of. In other aspects of life, there were many similar examples of Vietnamese so ready and comfortable with adding new norms, values, and beliefs, even contradictory (...) ones, to their culture. This phenomenon, dubbed “cultural additivity”, prompted us to study the co-existence, interaction, and influences among core values and norms of the Three Teachings –Confucianism, Buddhism, and Taoism–as shown through Vietnamese folktales. By applying Bayesian logistic regression, we evaluated the possibility of whether the key message of a story was dominated by a religion (dependent variables), as affected by the appearance of values and anti-values pertaining to the Three Teachings in the story (independent variables). Our main findings included the existence of the cultural additivity of Confucian and Taoist values. More specifically, empirical results showed that the interaction or addition of the values of Taoism and Confucianism in folktales together helped predict whether the key message of a story was about Confucianism, β{VT ⋅ VC} = 0.86. Meanwhile, there was no such statistical tendency for Buddhism. The results lead to a number of important implications. First, this showed the dominance of Confucianism because the fact that Confucian and Taoist values appeared together in a story led to the story’s key message dominated by Confucianism. Thus, it presented the evidence of Confucian dominance and against liberal interpretations of the concept of the Common Roots of Three Religions (“tam giáo đồng nguyên”) as religious unification or unicity. Second, the concept of “cultural additivity” could help explain many interesting socio-cultural phenomena, namely the absence of religious intolerance and extremism in the Vietnamese society, outrageous cases of sophistry in education, the low productivity in creative endeavors like science and technology, the misleading branding strategy in business. We are aware that our results are only preliminary and more studies, both theoretical and empirical, must be carried out to give a full account of the explanatory reach of “cultural additivity”. (shrink)

The ideas of philosopher John Rawls should be appropriated for the information age. A literature review identifies previous contributions in fields such as communication and library and information science. The article postulates the following neo-Rawlsian propositions as co-ordinates for the development of a normative theory of the information society: that political philosophy should be incorporated into information society studies; that social and technological circumstances define the limits of progressive politics; that the right is prior to the good in social morality; (...) that the nation state should remain in sharp focus, despite globalization; that liberty, the first principle of social justice, requires updating to deal with the growth of surveillance and other challenges; that social wellbeing is a function of equal opportunities plus limited inequalities of outcome, in information as well as material resources; and that political stability depends upon an overlapping consensus accommodating both religion and secularism. Although incomplete, such co-ordinates can help to guide policy-makers in the twenty-first century. (shrink)

In general, we know that gesture accompanying spoken instruction can help children learn. The present study was conducted to better understand how gesture can support children’s comprehension of spoken instruction and whether the benefit of teaching though speech and gesture over spoken instruction alone depends on differences in cognitive profile – prior knowledge children have that is related to a to-be-learned concept. To answer this question, we explored the impact of gesture instruction on children’s analogical reasoning ability. Children between the (...) ages of 4 and 11 years solved scene analogy problems before or after speech alone or speech and gesture instruction while their visual attention was monitored. Our behavioral results suggest a marginal benefit of gesture instruction over speech alone, but only 5-year-old children showed a distinct advantage from speech+gesture instruction when solving the post-instruction trial, suggesting that at this age, children have the cognitive profile in place to utilize the added support of gesture. Furthermore, while speech+gesture instruction facilitated effective visual attention during instruction, directing attention away from featural matches, and towards relational information, was pivotal for younger children’s success post instruction. We consider how these results contribute to the gesture-for-learning literature and consider how the nuanced impact of gesture is informative for educators teaching tasks of analogy in the classroom. (shrink)

Establishing and maintaining reference is a crucial part of discourse. In spoken languages, differential linguistic devices mark referents occurring in different referential contexts, that is, introduction, maintenance, and re-introduction contexts. Speakers using gestures as well as users of sign languages have also been shown to mark referents differentially depending on the referential context. This article investigates the modality-specific contribution of the visual modality in marking referential context by providing a direct comparison between sign language and co-speech gesture with speech in (...) elicited narratives. Across all forms of expression, we find that referents in subject position are referred to with more marking material in re-introduction contexts compared to maintenance contexts. Furthermore, we find that spatial modification is used as a modality-specific strategy in both DGS and German co-speech gesture, and that the configuration of referent locations in sign space and gesture space corresponds in an iconic and consistent way to the locations of referents in the narrated event. However, we find that spatial modification is used in different ways for marking re-introduction and maintenance contexts in DGS and German co-speech gesture. The findings are discussed in relation to the unique contribution of the visual modality to reference tracking in discourse when it is used in a unimodal system with full linguistic structure versus in a bimodal system that is a composite of speech and gesture. (shrink)

CHAMELEON is a computational melodic harmonization assistant. It can harmonize a given melody according to a number of independent harmonic idioms or blends between idioms based on principles of conceptual blending theory. Thus, the system is capable of offering a wealth of possible solutions and viewpoints for melodic harmonization. This study investigates how human creativity may be influenced by the use of CHAMELEON in a melodic harmonization task. Professional and novice music composers participated in an experiment where they were asked (...) to harmonize two similar melodies under two different conditions: one with and one without computational support. A control group harmonized both melodies without computational assistance. The influence of the system was examined both behaviorally, by comparing metrics of user-experience, and in terms of the properties of the artifacts that were created between the two experimental conditions. Results suggest that appreciation of the system was expertise-dependent. At the same time, users seemed to adopt more explorative strategies as a result of interaction with CHAMELEON based on the fact that the harmonizations created this way were more complex, diverse, and unexpected in comparison to the ones of the control group. (shrink)

Transcription factor (TF) signaling regulates gene transcription and requires a complex network of proteins. This network includes co‐activators, co‐repressors, multiple TFs, histone‐modifying complexes, and the basal transcription machinery. It has been widely appreciated that pioneer factors, such as FoxA1 and GATA1, play an important role in opening closed chromatin regions, thereby allowing binding of a secondary factor. In this review we will focus on a newly proposed model wherein multiple TFs, such as steroid receptors (SRs), can function in a pioneering (...) role. This model, termed dynamic assisted loading, integrates data from widely divergent methodologies, including genome wide ChIP‐Seq, digital genomic footprinting, DHS‐Seq, live cell protein dynamics, and biochemical studies of ATP‐dependent remodeling complexes, to present a real time view of TF chromatin interactions. Under this view, many TFs can act as initiating factors for chromatin landscape programming. Furthermore, enhancer and promoter states are more accurately described as energy‐dependent, non‐equilibrium steady states. (shrink)

Theories of cognition and theories of social practices and institutions have often each separately acknowledged the relevance of the other; but seldom have there been consistent and sustained attempts to synthesize these two areas within one explanatory framework. This is precisely what my dissertation aims to remedy. I propose that certain recent developments and themes in philosophy of mind and cognitive science, when understood in the right way, can explain the emergence and dynamics of social practices and institutions. Likewise, the (...) view I construct explains how social practices and institutions shape the character of cognition of their constituent agents. Moreover, I explain both cognitive and social agency under the single explanatory framework provided by Dynamic Systems Theory. Drawing upon the phenomenological tradition, "embodied, "extended", "embedded", "enactive", and "ecological" approaches to cognition, as well as the conceptual resources of Dynamic Systems Theory, I construct a theory of agency that sees cognitive and social agents as far-from-equilibrium, open, recursively self-maintenant dynamic systems. Depending on the specifics of concrete circumstances, such systems, which I call "Dynamic Embodied Agents", may develop and possess emergent capacities for error-detection, flexible learning, normative behavior, representation, self-reflection, various modes of pattern-recognition, a temporal sense of self, and even moral responsibility. Some such systems are also sensitive to perceived social influences ; while reciprocally constituting and causally affecting them. (shrink)

Studies on societal path dependencies tend to focus on mechanisms that anchor and stabilize national trajectories while paying less attention to transnational interactions and multilevel governance. This paper explores processes of path transformation in societies that are presumed to have the characteristics of open systems. Two pairs of case studies are presented and compared. The first illustrates institutional change through collision, when a national path meets with another. The second describes the emergence of transnational institutional paths and the impact of (...) that process on national institutions and their (potential) transformation. The results indicate that path transformation often stems from a gradual succession and combination of incremental steps and junctures – change is gradual but consequential. They also point to increasing co-evolutionary interaction between national path transformation and transnational path creation. This implies a need for analytical tools that are adapted to the analysis of multi-level, nested processes of institutionalization and de-institutionalization. The paper suggests that the concept of path generation allows for a better specification of the conditions for change in existing societal paths and for the emergence of new paths in the case of open systems than the concept of path dependency. (shrink)

China has for almost four decades been experiencing a market transition and an associated tax state transition, leading to the emergence of capitalists who increasingly control economic resources and serve as important sources of tax revenue. Some theories suggest that these changes should give capitalists political power. From the perspective of the taxation institution, using a mechanism-based case study, this article investigates whether China’s emerging capitalists have gained bargaining power with the party-state. Findings suggest that hidden bargaining, patron-clientelism, legislature co-optation, (...) and legal repression constrain their bargaining power. The underinstitutionalized taxation system has co-opted the capitalists through patronage and, more important, deterrence, thereby building an asymmetric mutual dependence between the local state and capital owners. (shrink)

The relation between ethics and social science is often conceived as complementary, both disciplines cooperating in the solution of concrete moral problems. Against this, the paper argues that not only applied ethics but even certain parts of general ethics have to incorporate sociological and psychological data and theories from the start. Applied ethics depends on social science in order to asses the impact of its own principles on the concrete realities which these principles are to regulate as well as in (...) order to propose practice rules suited to adapt these principles to their respective contexts of application. Examples from medical ethics (embryo research) and ecological ethics (Leopold's land ethic) illustrate both the contingence of practice rules in relation to their underlying basic principles and the corresponding need for a co-operation between philosophy and empirical disciplines in judging their functional merits and demerits. In conclusion, the relevance of empirical hypotheses even for some of the perennial problems of ethics is shown by clarifying the role played by empirical theories in the controversies about the ethical differentiation between positive and negative responsibility and the relation between utility maximisation and (seemingly) independent criteria of distributive justice in the context of social distributions. (shrink)