DNA replication requires the unwinding of the parental duplex, which generates (+) supercoiling ahead of the replication fork. It has been thought that removal of these (+) supercoils was the only method of unlinking the parental strands. Recent evidence implies that supercoils can diffuse across the replication fork, resulting in interwound replicated strands called precatenanes. Topoisomerases can then act both in front of and behind the replication fork. A new study by Sogo et al. [J Mol Biol 1999;286:637–643 (Ref. 1)], (...) using a topological analysis, provides the best evidence that precatenanes exist in negatively supercoiled, partially replicated molecules in vivo. BioEssays 21:805–808, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Higman essentially showed that if A is any language then SUBSEQ(A) is regular, where SUBSEQ(A) is the language of all subsequences of strings in A. Let s1, s2, s3, . . . be the standard lexicographic enumeration of all strings over some finite alphabet. We consider the following inductive inference problem: given A(s1), A(s2), A(s3), . . . . learn, in the limit, a DFA for SUBSEQU). We consider this model of learning and the variants of it that are usually (...) studied in Inductive Inference: anomalies, mind-changes, teams, and combinations thereof. This paper is a significant revision and expansion of an earlier conference version [10]. (shrink)

Do American Christians have hope in community, within their congregations and in the wider society, and should they? Putting my fieldwork in five church communities in dialogue with Thomas Aquinas’s account of hope and with insights from congregational studies, I answer yes to both questions. Christian hope is best understood and lived not simply as a theological virtue but as a social virtue. In this understanding, connections forged with others, both inside and outside a church, can develop a community’s realistic, (...) forward-looking trust in social relationships and in the fate of society. I suggest four guidelines for church practices to build up social hope and make it more effectual. (shrink)

This definitive survey of the hottest issues in inductive logic sets the stage for further classroom discussion.

From Arthur Schopenhauer we can glean a characteristically moody perspective on the primordial condition of speaking and being spoken. Focusing on his dualistic view of the embodied subject as having to contend with the forces of both Will and presentation, in this article I argue that his philosophy construes communication as a sort of weird ventriloquism. Drawing on François Cooren’s proposed method of ‘ventriloqual analysis’, I re-examine Schopenhauer’s subject as a being that both animates and is animated by his strange (...) dark noumena. Bearing witness to this eerie metaphysical stagecraft, his concept of Will becomes synonymous with a will to communicate, which manifests itself through the voice of the speech actor and allows us to think about his ontology and ethics from a different rhetorical perspective. (shrink)

The main claim here is that Aquinas’s theory of natural law is false because it is incompatible with the occurrence of evolution by variation and natural selection. This contradicts the Thomist opinion that there is no conflict between the two. The conflict is deep and pervasive, involving the core elements of Aquinas’s theory. The problematic elements include: 1) the fundamental precept that good should be done and pursued, and evil avoided; 2) the claim that every organism aims at the good (...) and that it is wrong to frustrate nature; 3) the Aristotelian preconception that everything has a single preeminent end; 4) the putative natural inclinations attributed to human beings; 5) the assumption that species essentialism is true; and 6) the notion that God’s intentions are discernible in the natural world. It is concluded that the problems are so extensive that Aquinas’s theory is beyond rescue. (shrink)

This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected on April 27, 1999.

This article argues that, in public and policy contexts, the ways in which many scientists talk about uncertainty in simulations of future climate change not only facilitates communications and cooperation between scientific and policy communities but also affects the perceived authority of science. Uncertainty tends to challenge the authority of chmate science, especially if it is used for policy making, but the relationship between authority and uncertainty is not simply an inverse one. In policy contexts, many scientists are compelled to (...) talk about uncertainty but do not wish to imply that uncertainty is a serious challenge to the authority of scientific knowledge or to its substantial use in policy making. "Boundary-ordering devices, " the contextual discursive attempts to reconcile uncertainty and authority in science, depend critically for their success on their "dual" interpretation: at a general level across a boundary and differently on either side of it. The authors empirically identify a range of such boundary-ordering devices in the climate field. (shrink)

Andrew Webster proposes that science and technology studies align itself more thoroughly with practical policy contexts, actors and issues, so as to become more useful, and thus more a regular actor in such worlds. This commentary raises some questions about this approach. First, I note that manifest influence in science or policy or both should not become-by default, or deliberately-a criterion of intellectual quality for STS research work. I distinguish between reflective historical work, which delineates the contingent ways in which (...) existing policy and technoscientific cultures have become entrenched as such inscribed and perhaps dysfunctional institutional habit; and, work of the kind that Webster's three case studies exemplify, that is, geared to influence policy-decision outcomes. I suggest that many of the important issues facing STS-and "policy"-are not explicit "policy-decision issues" as such, but implicit "policy syndromes" that need naming, diagnosing and open, if enforced, institutional reflection. (shrink)

I perform an economic and ethical analysis on wealth and income inequality. Economists have performed many statistical studies that reveal a number of, often contradictory, findings in connection with the distribution of wealth and income. Hence, the statistical findings leave us with no better knowledge of the effects that inequality has on economic progress. At the same time, the existing theoretical results have not provided us with a definitive answer concerning the effects of inequality on progress. By gaining knowledge of (...) the nature of inequality, and bringing basic economic principles to bear on the subject, we can come to an understanding of what the causal relationship is between inequality and economic progress. Furthermore, I apply a new theory of ethics – rational egoism – to assess economic inequality. I show that, in the right context, economic inequality is both economically and morally desirable. (shrink)

A field K in a ring language $\mathcal {L}$ is finitely undecidable if $\mbox {Cons}(T)$ is undecidable for every nonempty finite $T \subseteq {\mathtt{Th}}(K; \mathcal {L})$. We extend a construction of Ziegler and (among other results) use a first-order classification of Anscombe and Jahnke to prove every NIP henselian nontrivially valued field is finitely undecidable. We conclude (assuming the NIP Fields Conjecture) that every NIP field is finitely undecidable. This work is drawn from the author’s PhD thesis [48, Chapter 3].

In three experiments, subjects attempted to track multiple items as they moved independently and unpredictably about a display. Performance was not impaired when the items were briefly (but completely) occluded at various times during their motion, suggesting that occlusion is taken into account when computing enduring perceptual objecthood. Unimpaired performance required the presence of accretion and deletion cues along fixed contours at the occluding boundaries. Performance was impaired when items were present on the visual field at the same times and (...) to the same degrees as in the occlusion conditions, but disappeared and reappeared in ways which did not implicate the presence of occluding surfaces (e.g. by imploding and exploding into and out of existence, instead of accreting and deleting along a fixed contour). Unimpaired performance did not require visible occluders (i.e. Michotte’s tunnel effect) or globally consistent occluder positions. We discuss implications of these results for theories of objecthood in visual attention. (shrink)

It is morally negligent or reckless to believe without sufficient evidence. The foregoing proposition follows from a rule that is a modified expression of W. K. Clifford's ethics of belief. Clifford attempted to prove that it is always wrong to believe without sufficient evidence by advancing a doxastic counterpart to an act utilitarian argument. Contrary to various commentators, his argument is neither purely nor primarily epistemic, he is not a non-consequentialist, and he does not use stoicism to make his case. (...) Clifford's conclusion is a universal generalisation that is in a precarious position because of potential counterexamples. But the counterexamples do not preclude a rule against going beyond the available evidence and it is worthwhile making a moral case for such a rule. (shrink)

Ethical principles including autonomy, justice and equality function in the same paradigm of thought, that is, logocentrism - an epistemological predilection that relies on the analytic power of deciphering between binary oppositions. By studying observable behavior with an analytical approach, however, one immediately limits any recognition and possible understanding of modes of thought based on separate epistemologies. This article seeks to reveal an epistemological predilection that diverges from logocentrism yet continues to function as a fundamental component of ethical behavior. The (...) issue of cancer disclosure in Japan is used to exemplify the nature of relative subjectivity (kankeiteki-shukansei), a term I define and believe to be an epistemological predisposition fundamental to ethical behavior. Relative subjectivity denotes an epistemology quintessential to the behavior of individuals who attend to the respective tides of each particular situation, each interpersonal relationship or, in the context of clinical medicine, to the needs and values of each patient. (shrink)

Both the quantity of information and the informational content of a signal are defined in the context of signaling games. Informational content is a generalization of standard philosophical notions of propositional content. It is shown how signals that initially carry no information may spontaneously acquire informational content by evolutionary or learning dynamics. It is shown how information can flow through signaling chains or signaling networks.

Towards thriving communities" demonstrates how developing individual virtue can lead to a vision for collaboratively improving the world at large. It provides an accessible case for the inseparable pursuits of both personal and societal flourishing.

We live in a world of gross inequality. While a minority live in unprecedented wealth, the majority live in considerable poverty. Though much money has been given in aid by the rich countries to the poor, both by secular and Christian institutions, there has been much criticism that much of that aid has been wasted, indeed much of it has been actually harmful. But while there is truth in some of these criticisms, there is also increasing evidence of where community (...) development has been effective, and sustainable. This article considers the strengths and limitations, and examples, of such a church-based, bottom-up, approach to transforming the physical and spiritual needs of the individuals and their communities. We will see that it is, arguably, the only way that truly holistic transformation can be delivered, and consider some of the implications for Western Christians and Christian NGOs. (shrink)

Drawing on interviews and observational work with practicing U.K. plant scientists, this article uses Michel Callon's work as a tool to explore the issue of collaboration between academic science and business, in particular, calls by the Biotechnology and Biological Sciences Research Council for a return to “public good” plant science. In an article titled “Is Science a Public Good?” Callon contributed to the debate about the commercialization of science by suggesting that commercialization and the public good need not be incompatible. (...) Moving away from arguments that center on the effects of business involvement in science, he suggested that analysts use another model, centered on “diversity.” This model allows us to ask what society might want from science, what public good science might look like, and how public good science can be ensured while also recognizing that science cannot be easily separated from the market. (shrink)

When Huxley quotes the famous Jefferson line in Brave New World Revisited—"If a nation expects to be ignorant and free... it expects what never was and never will be"2—there is something, on the face, humorously explicit to it. The state of civilization the brave new world is in seems to speak directly to this point. Brave new worlders are ignorant and conspicuously not free; they "[like] what [they've] got to do"3 because they have been decanted and conditioned by the corporate (...) government, the World State. This cursory assessment, however, obscures another possibility, one that touches on the satirical poignancy and relevance of. (shrink)

Since its publication in 1965 _Political Argument_ has come to be recognized as occupying a key position in the revival of Anglo-American political philosophy. A number of the ideas introduced by Barry have become part of the standard vocabulary, such as the distinction between ideal-regarding and want-regarding principles and the division of principles into aggregative and distributive. _Political Argument_ provided the first precise analysis, still frequently cited, of the conception that political values have trade-off relations; the analysis of the notion (...) of the public interest has also enjoyed wide influence. For this long-awaited reprint, the author has prepared a substantial, new introductory essay in which he recounts the process of writing the book and sets it in the intellectual milieu of its time. He then offers extensive comments on the subsequent fate of some of the leading ideas and assesses the book in light of criticisms and later developments. Finally, Barry evaluates current approaches to political philosophy as they look today. This new edition of _Political Argument_ will interest political theorists, philosophers, economists, and a range of other scholars. Brilliant and incisive, it will engender discussion and debate from many quarters. (shrink)

We show how Richard Jeffrey's The Logic of Decision provides the proper formalism for calculating expected fitness for correlated encounters in general. As an illustration, some puzzles about kin selection are resolved.