The immune system does not just fight pathogens but also engages in interactions with beneficial microbes and non-immune cells of the body to harmonize their behavior by means of cytokines, antibodies and effector cells (Dinarello, 2007; Moticka, 2015, pp. 217e226, 261e267). However, the importance of these “housekeeping” functions has not been fully appreciated (Cohen, 2000). In his new book Immunity: The Evolution of an Idea Alfred I. Tauber traces the history of fundamental ideas in immunology and refers to recent advances (...) in the field to overturn the notion that immunity is the ability of an autonomous organism to protect itself against pathogens. Indeed, as suggested by the author, the autonomy of the organism is illusive because individuals develop as holobionts: functionally integrated multispecies consortia (p. 98). Similarly, he suggests that pathogenicity also emerges from the lack of subordination of a microbe to social welfare of the holobiont rather than from context-independent properties of this organism (pp. 165, 181). Emphasizing the contextual character of the parasite and the host, Tauber redefines immunity as an active process of coordination of a cellular ecosystem, which allows this collective to navigate through challenges of the environment and to face demands of the communal living (pp. 10e16). From this point of view, the failure to modulate intercellular interactions by the immune system entails mitigating immunity and impairing resistance to infection and disease (pp. 103e104). Immunity is a groundbreaking work establishing a new framework for understanding the function and activity of the immune system. Its value also lies in the fact that it serves as an important stepping-stone towards an integrated philosophical, ecological and immunological study of our embedment in the microbial world. (shrink)

Somatic diversification of antigen receptor genes depends on the activity of enzymes whose homologs participate in a mutagenic DNA repair in unicellular species. Indeed, by engaging error-prone polymerases, gap filling molecules and altered mismatch repair pathways, lymphocytes utilize conserved components of genomic stress response systems, which can already be found in bacteria and archaea. These ancient systems of mutagenesis and repair act to increase phenotypic diversity of microbial cell populations and operate to enhance their ability to produce fit variants during (...) stress. Coopted by lymphocytes, the ancient mutagenic processing systems retained their diversification functions instilling the adaptive immune cells with enhanced evolvability and defensive capacity to resist infection and damage. As reviewed here, the ubiquity and conserved character of specialized variation-generating mechanisms from bacteria to lymphocytes highlight the importance of these mechanisms for evolution of life in general. (shrink)

Philosophy of immunology is a subfield of philosophy of biology dealing with ontological and epistemological issues related to the studies of the immune system. While speculative investigations and abstract analyses have always been part of immune theorizing, until recently philosophers have largely ignored immunology. Yet the implications for understanding the philosophical basis of organismal functions framed by immunity offer new perspectives on fundamental questions of biology and medicine. Developed in the context of history of medicine, theoretical biology, and medical anthropology, (...) philosophy of immunology differs from these related branches of study in its focus on traditional philosophical questions concerning identity, individuality, ecology, cognition, scientific methodology and theory construction. This broad agenda derives from immunology’s multifaceted research program that has developed from its initial clinical challenges of host defense, transplantation, autoimmunity, tumor immunology, and allergy. In addition to these well-established research areas, immunity is now understood to play a central role in other physiological functions, development, ecology, and evolutionary mechanics. Holding together these diverse domains of inquiry lie philosophical commitments oriented by organismal identity. In this regard, pertinent issues are raised concerning cognition (organization of immune perception and information processing), the character of individuality (framed by the ecological context of immune-mediated assimilation and rejection), and the dynamics of complex systems (understood as holistic systems biology). Indeed, immunology, in the context of cognitive science, evolutionary biology, environmental sciences, and development provides multi-focal perspectives for philosophy of science. (shrink)

The extent to which normal (nonmalignant) cells of the body can evolve through mutation and selection during the lifetime of the organism has been a major unresolved issue in evolutionary and developmental studies. On the one hand, stable multicellular individuality seems to depend on genetic homogeneity and suppression of evolutionary conflicts at the cellular level. On the other hand, the example of clonal selection of lymphocytes indicates that certain forms of somatic mutation and selection are concordant with the organism-level fitness. (...) Recent DNA sequencing and tissue physiology studies suggest that in addition to adaptive immune cells also neurons, epithelial cells, epidermal cells, hematopoietic stem cells and functional cells in solid bodily organs are subject to evolutionary forces during the lifetime of an organism. Here we refer to these recent studies and suggest that the expanding list of somatically evolving cells modifies idealized views of biological individuals as radically different from collectives. (shrink)

Central to vaccination-induced responses, antibodies are suggested by Vaz to operate as observer-dependent entities that owe their status to categorization schemes of immunologists. Inspired by color research by Maturana, he argues that antibodies should be distinguished from immunoglobulins, which unlike the former can be considered as constituents of structural dynamics of an organism, products of millions of years of evolution. However, a deeper understanding of the historical roots of the concept of immunoglobulin and associated “languaging” and naming processes reveals that (...) immunoglobulins, as much as antibodies, are contingent on conceptual schemes of immunology. (shrink)

It has long been taken for granted that the immune system’s capacity to protect an individual from infection and disease depends on the power of the system to distinguish between self and nonself. However, accumulating data have undermined this fundamental concept. Evidence against the self/nonself discrimination model left researchers in need of a new overarching framework able to capture the immune system’s reactivity. Here, I highlight that along with the self/nonself model, another powerful representation of the immune system’s reactivity has (...) been developed in the twentieth century immunology. According to this alternative view, the immune system is not a killer of nonself strangers but a peace-maker helping to establish harmony with the environment. The balance view of the system has never become part of the dominant paradigm. However, it is gaining more and more currency as new research develops. Advances in mucosal immunology confirm that instead of distinguishing between self and foreign the immune system reacts to microbial, chemical and self-induced alterations to produce responses that counterbalance effects of these changes. (shrink)

The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

There are philosophers of mind who believe that externalism with regard to mental content leads inevitably to the conclusion, that the mind should be identified with something external to the cognitive system. These philosophers are convinced that contents of our thoughts are not located in our heads on the basis of Putnam's belief that the contents of linguistic expressions are not located in head. The aim of this paper is to show that despite the above widespread convictions, externalism with regard (...) to mental content allows to identify mental states with the states of the cognitive system. If the question regarding the localization of the mind makes any sense, the mind has to be identified with the entity located within the cognitive system of an individual. I will show that an externalist is not in a position to identify the mental with contents of representational states of the cognitive system. She is unable to identify the mind and mental states with physical bearers too. What is the common mistake of these two options is an unacceptable idealization according to which it is possible to separate content from a bearer. The only possible option that externalist could embrace is the one that says that a mental state should be identified with physical bearers bearing content. Such bearers are the physical objects that thanks to the system in which they exist can stand for other objects. Form the externalistic point of view this power of standing for something is determined, at least partially, by external factors. (shrink)

Advocates of the computational theory of mind claim that the mind is a computer whose operations can be implemented by various computational systems. According to these philosophers, the mind is multiply realisable because—as they claim—thinking involves the manipulation of syntactically structured mental representations. Since syntactically structured representations can be made of different kinds of material while performing the same calculation, mental processes can also be implemented by different kinds of material. From this perspective, consciousness plays a minor role in mental (...) activity. However, contemporary neuroscience provides experimental evidence suggesting that mental representations necessarily involve consciousness. Consciousness does not only enable individuals to become aware of their own thoughts, it also constantly changes the causal properties of these thoughts. In light of these empirical studies, mental representations appear to be intrinsically dependent on consciousness. This discovery represents an obstacle to any attempt to construct an artificial mind. (shrink)

Originating in the work of Ernst Haeckel and Wilhelm Preyer, and advanced by a Prussian embryologist, Wilhelm Roux, the idea of struggle for existence between body parts helped to establish a framework, in which population cell dynamics rather than a predefined harmony guides adaptive changes in an organism. Intended to provide a causal-mechanical view of functional adjustments in body parts, this framework was also embraced later by early pioneers of immunology to address the question of vaccine effectiveness and pathogen resistance. (...) As an extension of these early efforts, Elie Metchnikoff established an evolutionary vision of immunity, development, pathology, and senescence, in which phagocyte-driven selection and struggle promote adaptive changes in an organism. Despite its promising start, the idea of somatic evolution lost its appeal at the turn of the twentieth century giving way to a vision, in which an organism operates as a genetically uniform, harmonious entity. (shrink)

To enable microbial colonisation of the gut mucosa, the intestinal immune system must not only react to danger signals but also recognize cues that indicate safety. Safety recognition, paradoxically, is mediated by the same environmental sensors that are involved in signalling danger. Indeed, in addition to their well established role in inducing inflammation in response to stress signals, pattern recognition receptors (PRRs) and a variety of metabolic sensors also promote gut-microbiota symbiosis by responding to "microbial symbiosis factors", "resolution-associated molecular patterns", (...) markers of energy extraction and other signals indicating the absence of pathogenic infection and tissue damage. Here we focus on how the paradoxical role of immune receptors and other environmental sensors define the microbiota signature of the individual. (shrink)

Commensal and pathogenic organisms employ camouflage and mimicry to mediate mutualistic interactions and predator escape. However, the immune mechanisms accounting for the establishment and maintenance of symbiotic bacterial populations are poorly understood. A promising hypothesis suggests that molecular mimicry, a condition in which different organisms share common antigens, is a mechanism of establishing tolerance between commensals and their hosts. On this view, certain bacteria may mimic the structural features of some of their host’s T-cell receptors (TCRs), namely those that survive (...) thymic selection due to their lack of complementarity to self-antigens. With such “holoimmunity” the mimicking micro-organisms avoid immune recognition as the copied TCRs become mirror images of an extended super-organismal self, consisting of symbiotic and host antigens. Accordingly, analysis of genomic and metagenomic data suggests a tripartite mimicry between TCRs, self-antigens, and commensal antigens that would serve as the basis for immune tolerance between these populations. And conversely, in an autoimmune scenario, both symbiotic microbes and the mimicked host tissue would be targeted for immune destruction. (shrink)

Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli (...) influence the course of immune activation. (shrink)

One of the fundamental questions of life sciences is one of whether there are genuinely random biological processes. An affirmative or negative answer to this question may have important methodological consequences. It appears that a number of biological processes are explicitly classified as random. One of them is the so-called somatic hypermutation. However, closer analysis of somatic hypermutation reveals that it is not a genuinely random process. Somatic hypermutation is called random because the exact outcome of this process is difficult (...) to predict in practice. The case of somatic hypermutation suggests that there may be no scientific evidence of a single case of ontologically random process in the biological world. (shrink)

[Przekład] Pogląd głoszący, że układ odpornościowy rozróżnia to, co swoje, od tego, co obce, był jednym z centralnych założeń immunologii w drugiej połowie XX wieku. Pogląd ten miał wpływ na projekty eksperymentalne i interpretowanie danych. Jednakże w obliczu nowych dowodów empirycznych konieczny jest w immunologii nowy aparat konceptualny.

There is a deep-seated neopositivist view which regards the language of science as a neutral medium of communication, radically different from indirect symbolic forms of discourse characteristic of arts and humanities. But naturalists, like poets and social scientists, also draw on the dominant images in their culture to organize their thoughts and simplify complex concepts. By conceptualizing one thing in terms of another, metaphors in science not only aid mutual communication between researchers but also structure their understanding of experience and (...) reality. Too transparent to be noticed and critically analyzed within the framework of science itself, metaphors act as lenses, making selected aspects of complex phenomena visible to study and investigation (Reynolds 2018). By linking two seemingly unrelated ideas, for example, those of a machine and DNA replication, metaphors establish new interactions of meaning evoking shared associated connotations between these interacting concepts (Black 1962). This, in turn, may not only transform the perception of a target domain but also open up new prospects for experimental and interpretative avenues. Understanding Metaphors by Andrew Reynolds draws on this vision of metaphors as indispensable tools of scientific thinking to elucidate their role in the life sciences. (shrink)

Immunity by William Paul is an overview of fundamental principles of immunology and their experimental basis. The book includes not only well- established facts about the immune system but also recent findings (the role of Th17 cells, regulatory T cells, inflammasomes, etc.), which are skillfully incorporated into the framework of immunological understanding. The presentation is clear and emotionally charged, which makes the reading of Immunity enjoyable. Despite the original intentions, though, the book may appear too challenging for a lay reader (...) to serve as a popular introduction to immunology. Instead, it may help to put already acquired immunological knowledge in order benefiting advanced biology students and researchers. At a deeper level, Immunity provokes questions concerning what counts as relevant and what counts as a landmark in immunology. (shrink)

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various (...) types of Leukemia/Blood malignancies. (shrink)

This paper argues, against the prevailing view, that consent to privacy policies that regular internet users usually give is largely unproblematic from the moral point of view. To substantiate this claim, we rely on the idea of the right not to know (RNTK), as developed by bioethicists. Defenders of the RNTK in bioethical literature on informed consent claim that patients generally have the right to refuse medically relevant information. In this article we extend the application of the RNTK to online (...) privacy. We then argue that if internet users can be thought of as exercising their RNTK before consenting to privacy policies, their consent ought to be considered free of the standard charges leveled against it by critics. (shrink)

It is a well-known fact that mathematics plays a crucial role in physics; in fact, it is virtually impossible to imagine contemporary physics without it. But it is questionable whether mathematical concepts could ever play such a role in psychology or philosophy. In this paper, we set out to examine a rather unobvious example of the application of topology, in the form of the theory of persons proposed by Kurt Lewin in his Principles of Topological Psychology. Our aim is to (...) show that this branch of mathematics can furnish a natural conceptual system for Gestalt psychology, in that it provides effective tools for describing global qualitative aspects of the latter’s object of investigation. We distinguish three possible ways in which mathematics can contribute to this: explanation, explication and metaphor. We hold that all three of these can be usefully characterized as throwing light on their subject matter, and argue that in each case this contrasts with the role of explanations in physics. Mathematics itself, we argue, provides something different from such explanations when applied in the field of psychology, and this is nevertheless still cognitively fruitful. (shrink)

The following article challenges the traditional reading of the Rural Dionysia scene in Aristophanes’ Acharnians. It is often assumed that the text contains a reference to an animal sacrifice, which is arguably absent from this comedy. Moreover, the vast majority of scholars claim that the lines 244 ff. were uttered after the procession of worshippers reached the altar in the orchestra. However, as I argue, these verses were most probably spoken by the characters in front of the door of the (...) comic hero’s house and only subsequently did the procession form and move towards the altar. (shrink)

The history of relationship between faith and reason is marked by four models of the interaction between science and theology proposed by Ian G. Barbour: conflict, independence, dialogue and integration. Even if nineteenth-century positivism is still present in many scientists’ minds, philosophy of science eventually managed to overcome it in the 1960s. A mutual distrust between faith and reason started to disappear. In this context Fr. Michał Heller presented a project of a new discipline – the theology of science which (...) would look at the boundaries of the natural sciences from the theological point of view. According to Fr. Wojciech Giertych the adequate model of relationship between faith and reason can be based theologically on Chalcedonian Christology of Jesus’ two natures. Since reason and faith come together unconfusedly and inseparably in a human being, a mutual dialogue and even integration between theology and science is by all means possible. (shrink)

The subject of this article in an analysis of the globalisation process in economic and social areas. The author describes the main spheres of globalisation such as economic and political integration, the declining role of nation states, cultural homogenisation and the increasing significance of transnational corporations. The advantages and disadvantages of globalisation are discussed. The author also indicates differences between regions that benefit from globalisation. The article tries to answer questions whether globalisation is a desirable process and what it should (...) be like to bring more benefits than losses. (shrink)

Yuri Gagarin has started the first time in human history the manned mission in space when his Vostok aircraft successfully achieved Earth orbit in 1961. Since his times, human space programs did not develop too much, and the biggest achievement still remain landing on the Moon. Despite this stagnation, there are serious plans to launch manned mission to Mars including human space settlement. In out paper, we are going to identify and discuss a couple of challenges that – in our (...) opinion – will be a domain of every human deep-space program. (shrink)

Having been involved in a slew of recent scandals, many of the world’s largest technology companies embarked on devising numerous codes of ethics, intended to promote improved standards in the conduct of their business. These efforts have attracted largely critical interdisciplinary academic attention. The critics have identified the voluntary character of the industry ethics codes as among the main obstacles to their efficacy. This is because individual industry leaders and employees, flawed human beings that they are, cannot be relied on (...) voluntarily to conform with what justice demands, especially when faced with powerful incentives to pursue their own self-interest instead. Consequently, the critics have recommended a suite of laws and regulations to force the tech companies to better comply with the requirements of justice. At the same time, they have paid little attention to the possibility that individuals acting within the political context, e.g. as lawmakers and regulators, are also imperfect and need not be wholly compliant with what justice demands. This paper argues that such an omission is far from trivial. It creates a heavy argumentative burden on the part of the critics that they by and large fail to discharge. As a result, the case for Big Tech regulation that emerges from the recent literature has substantial lacunae and more work needs to be done before we can accept the critics’ calls for greater state involvement in the industry. (shrink)

Is it wrong to distract? Is it wrong to direct others’ attention in ways they otherwise would not choose? If so, what are the grounds of this wrong – and, in expounding them, do we have to at once condemn large chunks of contemporary digital commerce (also known as the attention economy)? In what follows, I attempt to cast light on these questions. Specifically, I argue – following the pioneering work of Jasper Tran and Anuj Puri – that there is (...) a right to attention, and that its existence underlies some of our claims regarding the wrongness of distractions. However, I depart from both these authors in two respects: first, I present a new way of deriving the right to attention, grounding it in the more fundamental right to mental integrity. Second, I remain agnostic on whether the contemporary business practices of capturing attention in exchange for a variety of digital products and services are plagued by routine violations of the right. (shrink)

The article aims to analyse the thought of Edward Abramowski – a Polish philosopher, pioneer of psychology and theorist of the socialist cooperative movement. It attempts to reconstruct the impact that his social thought and his philosophical anthropology have had on the political activity of Polish cooperativism. In keeping with Michael Freeden’s thesis that an ideologist translates philosophical concepts into political practice, the author sees Abramowski as a thoroughly modern thinker who opened an alternative ideological path to the great political (...) narratives of the day. The article points out the originality of the Polish philosopher’s proposition for the socialist movement, the goal being to achieve the political emancipation of the popular classes through economic activity undertaken by grassroots cooperatives operating outside state structures. The philosophical-sociological concept of ‘fraternity’ or ‘pure socialization’ leads Abramowski to formulate a doctrine of ‘stateless socialism’, in which popular political organizations use primordial, human-based cooperation to create new opportunities for community life. The last parts of the article show links between Abramowski's concepts and the modern school of commoning. The aim of this comparison is to show the doctrine of cooperativism can make a contribution to determining the political stakes of contemporary conflicts regarding biopolitical subjectivity. (shrink)

Streszczenie: Idea sacrum w lirycznej twórczości Dariusza Dekańskiego to konglomerat wielu składowych. Zarówno rzeczywistości konsystencjalnej, jak i tej sensytywnej – wyobrażonej, percypowanej na drodze synestezji. W prezentowanym artykule, pełniącym rolę asumptu do dalszych badań nad poetycką aktywnością autora Saudade, zwrócono szczególną uwagę na więź człowieka z Bogiem, kontakt z sacrum, przejawiającymi się w wewnętrznych przeżyciach podmiotu lirycznego, bezustannie szukającego swojego miejsca w świecie. Aby zbliżyć się do zrozumienia działań bohatera tej poezji wykorzystano przede wszystkim instrumentarium oferowane przez metodologie badań sacrum.

Poetycka twórczość Zdzisława Dębickiego to przykład pisarstwa korzystającego z różnych poetyk, co przejawiało się w wielorakim charakteryzowaniu składających się na nią przestrzeni. Autor Nocy bezsennych, uważany za poetę minorum gentium, umiejętnie wykorzystywał literackie dokonania ówczesnych poetów, powołując do istnienia obszary, pełniące jednocześnie funkcję ekspresji własnej podmiotowości artystycznej. Czytanie liryków Dębickiego pozwala na zestawienie intymnych zwierzeń podmiotu lirycznego z ogołoconą z bogactwa opisu pustą przestrzenią. Przestrzeń, jako jedna z kategorii epistemologiczno-ontologicznych, nie jest dla poety jedynie narzędziem służącym tworzeniu atrakcyjnego obrazka, ale (...) przede wszystkim stanowi asumpt do dociekań poznawczych. (shrink)

Abstractabstract:The aim of this article is to analyze the close relation between social theory (“sociological phenomenalism”) and the political ideology of the Polish thinker Edward Abramowski. Abramowski’s “applied sociology” involved: (1) the sociology of “fraternity,” examining basic forms of socialization; (2) combining social revolution with ethical self-improvement; and (3) the dissemination of “social laboratories” through the development of a network of cooperatives. As “experiments of the will,” the cooperatives allowed Abramowski to combine science, imagination, and ethics in a coherent project (...) of political utopia-building, extending the possible forms of community. Finally, the article shows that in Abramowski’s case, the meaning of utopia as an element embedded in a wide range of political practices derives from his vision of social science. Due to the influence that Abramowski’s thought had on political reality in Poland, the concept of “experimental” utopia entered the vocabulary of modern social sciences in Poland for good. (shrink)

Abstract:Non-anthropocentric approaches to environmental ethics face problems that cannot be resolved within a holistic framework of natural value since such frameworks posit abstract and general properties as the bearers of intrinsic value and thus ignore the moral claims of individual organisms. Two paradigm examples of such approaches, Aldo Leopold's Land Ethic and Arne Neass' Deep Ecology suffer from this problem. Christine Korsgaard's argument for the conceptual separation of intrinsic and instrumental valuing, however, serves as a strong theoretical grounding for a (...) reconceptualization of the value of nature, which can best be described as an enlightened anthropocentrism, while preserving the spirit of Leopold's and Naess' proposals. (shrink)

The Metaphysics of Cooperation presents the intellectual achievements of the Polish associative socialist and pioneer of social sciences, Edward Abramowski. The volume is divided into five sections, each of them contains an analysis of Polish philosopher's work according to the issues he dealt with: sociology, ethics, politics, cooperativism, and psychology. Each part also contains a selection of his writings. Its intention is to show Abramowski's works in the context of global intellectual history and to include them in the current political (...) debates. Abramowski makes fraternity or cooperation the main concepts of his social metaphysics. The Polish version of cooperativism can be inspiring both for contemporary researchers and political activists in the post-economic-crisis Europe. It also opens up a space for creating more democratic political and economic institutions. (shrink)

This paper offers a critical review of the notion of a “singular cognitive role”, which is central to some recent theories of singular thought. According to those theories, whether a thought is singular depends on the role it plays in the subject’s cognitive activity. We compare the two most developed accounts of this type: Crane’s :21–43 2011, The Objects of Thought2013) and Jeshion’s. Both theories aim to capture the notion of a singular cognitive role in terms of mental files. We (...) argue that Jeshion’s theory is much more promising as it provides a more detailed and non-circular characterization of the mental files responsible for singular thinking. We examine the prospects for enhancing that account in light of three major concerns about it present in the literature. First, we discuss whether the weakest aspect of the whole proposal, i.e. the condition for the initiation of mental files, can be replaced without debilitating the rest of the theory. Second, we examine Goodman’s : 437–461 2014, The Philosophical Quarterly2015) argument against mental file theories of singular thought and show that it does not affect Jeshion’s account. Third, we argue against Sawyer :264–283 2012) that Jeshion’s notion of a singular cognitive role is in strong opposition to acquaintance-based theories of singular thought and cannot be incorporated into any of them. Thus, the paper concludes that Jeshion’s proposal, despite its shortcomings, is currently the most promising account of a singular cognitive role. (shrink)

David Lewis cautions that although a no-collapse interpretation of quantum mechanics entails immortality for trans-world selves, the nature of the branching leaves us crippled, lonely, deathly ill, and mentally infirm, meaning that immortal life, on such terms, amounts to an existence in eternal torment. This paper argues that the problem Lewis points to is in fact one of individuation and that a synthesis of Lewis’ own notion of perdurance and Robert Nozick’s closest continuer theory, when cast in the mould of (...) a deterministic multiverse, individuates trans-world selves in such a way as to allow to prune the infinitesimal expectation of a miserable eternal existence from the histories of most trans-world agents. Thus, contrary to Lewis’ warning that if personal identity is a trans-world notion, then we should all shake in our shoes, this paper argues that even if we are trans-world selves, we almost certainly have nothing to worry about. (shrink)

It might become possible to build artificial minds with the capacity for experience. This raises a plethora of ethical issues, explored, among others, in the context of whole brain emulations (WBE). In this paper, I will take up the problem of vulnerability – given, for various reasons, less attention in the literature – that the conscious emulations will likely exhibit. Specifically, I will examine the role that vulnerability plays in generating ethical issues that may arise when dealing with WBEs. I (...) will argue that concerns about vulnerability are more matters of institutional design than individual ethics, both when it comes to creating humanlike brain emulations, and when animal-like emulations are concerned. Consequently, the article contains reflection on some institutional measures that can be taken to protect the sims' interests. It concludes that an institutional framework more likely to succeed in this task is competitive and poly-centric, rather than monopolistic and centralized. (shrink)

Journal of Applied Philosophy, EarlyView.

In “Accepting Moral Responsibility for the Actions of Autonomous Weapons Systems—a Moral Gambit” (2022), Mariarosaria Taddeo and Alexander Blanchard answer one of the most vexing issues in current ethics of technology: how to close the so-called “responsibility gap”? Their solution is to require that autonomous weapons systems (AWSs) may only be used if there is some human being who accepts the ex ante responsibility for those actions of the AWS that could not have been predicted or intended (in such cases, (...) the human being takes what the authors call the “moral gambit”). The authors then propose several institutional safeguards to implement in order to ensure that the moral gambit is taken in a fair and just way. This paper explores this suggestion in the context of the institutional settings within which AWSs are most likely to be deployed. It raises some concerns as to the feasibility of Taddeo and Blanchard’s proposal, in light of the recent empirical work on the incentive structures likely to exist within militaries. It then presents a potential problem that may arise in case the accountability mechanisms are successfully implemented. (shrink)