Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 − the “plunger” − pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex − the “barrel” − into the matrix of the organelle. Notably, insertion of cargo-loaded receptor into the “barrel” is an ATP-independent process, whereas extraction (...) of the receptor back into the cytosol requires its monoubiquitination and the action of ATP-dependent mechanoenzymes. Here, we review the main data behind this model. The peroxin PEX5 is the peroxisomal matrix protein receptor. It shuttles between the cytosol and the organelle membrane, where it gets inserted into the docking/translocation module, thus pushing the cargo-protein into the peroxisome lumen. Resetting the system involves PEX5 monoubiquitination and its extraction from the membrane by the AAA-ATPases, PEX1/PEX6. (shrink)

O presente artigo objetiva analisar a existência de uma possível contradição entre a _morale par provision_ e o sistema filosófico cartesiano. Para tanto, primeiro analisaremos a imbricação entre a teoria metafísica e a teoria moral de Descartes, buscando situar o local da _morale_ em seu edifício filosófico. Neste primeiro momento, também tentaremos engendrar o problema aqui proposto, configurado a partir da pergunta: ao aderir ao uso da opinião em sua _morale_, Descartes não abriria margem para um possível paradoxo entre o (...) desenvolvimento de seu sistema de Filosofia e a sua _morale par provision?_ Depois, apresentaremos o conteúdo da _morale, _analisando separadamente cada uma das três máximas que a compõem. Isto feito, buscaremos evidenciar a natureza racional da moral cartesiana_. _Ao fim do trabalho, pretendemos dissipar o aparente paradoxo ao defender a tese de que o conteúdo das três máximas da _morale par provision_ (moderação, resolução e felicidade) conferem a ela uma natureza racional, o que torna justificado o uso de opiniões, que, mesmo sem possuir um valor de clareza, distinção e evidência, ainda assim são úteis para o desenvolvimento da investigação filosófica, o que coloca a _morale_ na condição de ser um fator imprescindível ao desenvolvimento da filosofia cartesiana. (shrink)

Para Kant, os jogos desempenham um papel extremamente importante na vida humana, já que são responsáveis por colocarem o espírito em atividade e, ao fazê-lo, avivá-lo na direção da sociabilidade, da moderação e do refinamento. De acordo com suas Lições de pedagogia e de antropologia, os jogos não são uma mera distração, eles são uma ótima ferramenta para se aprender a viver. O objetivo deste artigo é o de, em um primeiro momento, recuperar alguns dados biográficos de Kant para aclarar, (...) à luz dos jogos, a dinamicidade subjacente à austeridade do cumprimento da famosa rotina do filósofo alemão e, em seguida, explorar conceitualmente o destaque que Kant dá aos jogos no processo de moralização da criança e do adulto. (shrink)

RESUMO: O Pragmatismo, como proposto por Charles S. Peirce, deve ser considerado um método para a produção teórica de pensamento que visa à construção de conceitos, a qual assume a forma de uma máxima lógica orientadora da conduta científica. Se um conceito é uma relação sígnica e a sua compreensão, um processo sígnico, encontramos na semiótica peirceana uma estratégia para discriminar as etapas da compreensão conceitual e avaliar os significados de termos e conceitos abstratos. Assim, o objetivo deste trabalho é (...) explicar os princípios lógicos que governam os tipos de Signos que mais diretamente estão relacionados à construção de conceitos, a saber: o Símbolo-Remático, o Símbolo-Dicente e o Argumento. Tais signos correspondem à antiga divisão Termo, Proposição e Argumento, modificada de modo a ser aplicável aos signos em geral. ABSTRACT: Pragmatism, as proposed by Charles S. Peirce, should be considered a method for the theoretical production of thought that aims the construction of concepts, which takes the form of a logical maxim guiding scientific conduct. If a concept is a sign relationship and its understanding a sign process, we find in Peircean semiotics a strategy to discriminate the stages of conceptual understanding and to evaluate the meanings of abstract terms and concepts. Therefore, the aim of this work is to explain the logical principles that govern the types of Signs that more directly are related to the construction of concepts, namely: the Rhematic Symbol, the Dicent Symbol and the Argument. Such signs correspond to the old division between Term, Proposition and Argument, modified in order to be applicable to the signs in general. (shrink)

O pragmatismo, como método formal, nos fornece uma importante arena para discussões a respeito do modo pelo qual conceitos podem ser construídos, independentemente de qualquer posição antropocêntrica ou linguística. O presente trabalho tem por finalidade efetuar uma discussão sobre a máxima pragmática e a tese sobre a indeterminação do significado ( meaning ) que ela traz consigo. Ou seja, busca-se entender o trânsito que há entre o indefinido e o definido, entre o indeterminado e o determinado, bem como algumas fronteiras (...) intermediárias encontradas nos processos de determinação relativa do conceito. (shrink)

In Brazil, the CNPq (National Council for Scientific and Technological Development) provides grants, funds and fellowships to productive scientists to support their investigations. They are ranked and categorized into four hierarchical levels ranging from PQ 1A (the highest) to PQ 1D (the lowest). Few studies, however, report and analyse scientific productivity in different sub-fields of Biomedical Sciences (BS), e.g., Biochemistry, Pharmacology, Biophysics and Physiology. In fact, systematic comparisons of productivity among the PQ 1 categories within the above sub-fields are lacking (...) in the literature. Here, the scientific productivity of 323 investigators receiving PQ 1 fellowships (A to D levels) in these sub-fields of BS was investigated. The Scopus database was used to compile the total number of articles, citations, h-index values and authorship positions (first-, co- or last-listed author) in the most cited papers by researchers granted CNPq fellowships. We found that researchers from Pharmacology had the best performance for all of the parameters analysed, followed by those in Biochemistry. There was great variability in scientific productivity within the PQ 1A level in all of the sub-fields of BS, but not within the other levels (1B, 1C and 1D). Analysis of the most cited papers of PQ 1(A–D) researchers in Pharmacology revealed that the citations of researchers in the 1C and 1D levels were associated with publications with their senior supervisors, whereas those in the 1B level were less connected with their supervisors in comparison to those in 1A. Taken together, these findings suggest that the scientific performance of PQ 1A researchers in BS is not homogenous. In our opinion, parameters such as the most cited papers without the involvement of Ph.D. and/or post-doctoral supervisors should be used to make decisions regarding any given researcher’s fellowship award level. (shrink)

In Brazil, the CNPq provides grants, funds and fellowships to productive scientists to support their investigations. They are ranked and categorized into four hierarchical levels ranging from PQ 1A to PQ 1D. Few studies, however, report and analyse scientific productivity in different sub-fields of Biomedical Sciences, e.g., Biochemistry, Pharmacology, Biophysics and Physiology. In fact, systematic comparisons of productivity among the PQ 1 categories within the above sub-fields are lacking in the literature. Here, the scientific productivity of 323 investigators receiving PQ (...) 1 fellowships in these sub-fields of BS was investigated. The Scopus database was used to compile the total number of articles, citations, h-index values and authorship positions in the most cited papers by researchers granted CNPq fellowships. We found that researchers from Pharmacology had the best performance for all of the parameters analysed, followed by those in Biochemistry. There was great variability in scientific productivity within the PQ 1A level in all of the sub-fields of BS, but not within the other levels. Analysis of the most cited papers of PQ 1 researchers in Pharmacology revealed that the citations of researchers in the 1C and 1D levels were associated with publications with their senior supervisors, whereas those in the 1B level were less connected with their supervisors in comparison to those in 1A. Taken together, these findings suggest that the scientific performance of PQ 1A researchers in BS is not homogenous. In our opinion, parameters such as the most cited papers without the involvement of Ph.D. and/or post-doctoral supervisors should be used to make decisions regarding any given researcher’s fellowship award level. (shrink)

In this paper, I present the difficulty in the phenomenology of explaining the constitution of objectivities in consciousness. In the context of phenomenological reduction, constitution has to be understood as unveiling the universal and necessary essences. Recognized by Husserl in Ideas I and named as functional problems, the constitution of objectivities refers at first to individual consciousness, and then to an intersubjective one. In Ideas II, the phenomenologist explains how the constitution of nature, psyche, and spirit occurs. This process begins (...) by assuming three premises: the ontological realism, the regularity of nature, and the transcendental idealism. In this process, the ego, apart from constituting objects (the body, the psyche, and the others), constitutes itself. The objects of material reality are constituted through aesthetic synthesis which unifies singularities and contextualizes the lived experience. The body, as a perceptive organ, perceives the exterior, and the location of the sensory stimulus is the soul. The soul is a real and transcendent object, which is linked to physical things that are constituted in a solipsistic way or intersubjectively. Empathy allows the subject to recognize the consciousness of the alter ego as capable of spontaneous movements and actions, a co-presence sharing the same horizons. Thus, through the theoretical attitude, the physical world is perceived, and through the spiritual attitude the spiritual world is perceived, a living world shared by free intelligent beings. For this, intersubjectivity fulfills a fundamental role, because only in the relationship with the other does the identity of the objects, of the other, and of the self become evident. (shrink)

Na filosofia de Gilles Deleuze, há uma ontologia, que é apresentada por meio da tese da univocidade do ser. Na história da filosofia ocidental, Deleuze destaca três momentos da univocidade do ser: com Duns Scot, o ser é pensado como unívoco ; com Espinosa, o ser é afirmado como unívoco ; com Nietzsche, o ser é realizado como unívoco. Em todo caso, a univocidade é uma alternativa à analogia, e a principal discordância entre essas duas teses é que a analogia (...) insere uma hierarquia e uma negatividade no cerne do ser, ao passo que a univocidade põe o ser como igual e isento de negatividade.Neste artigo, não se trata de apresentar a teoria da univocidade do ser em Deleuze, mas de explorar a leitura que ele faz da univocidade do ser em Espinosa, e sobretudo a variação a ela imposta entre o primeiro e o segundo livros dedicados ao filósofo holandês, Espinosa e o problema da expressão e Espinosa: filosofia prática. Constata-se que, no primeiro estudo, Espinosa é tido principalmente como herdeiro de Duns Scot, e no segundo, ademais, como aliado de Nietzsche. Tem-se como hipótese que Espinosa é arrastado, nesse ínterim, do segundo para o terceiro momento da univocidade do ser, na vassoura de bruxa de Deleuze. A consequência é que a imanência e a afirmação se conciliam com a diferença. A afirmação do ser passa a ser afirmação da própria diferença. Ou, dito de outro modo, o ser deixa de serapenas afirmado para ser realizado como diferença. Chega-se, assim, a uma ontologia construtivista, que tem a ética como sua condição prática. (shrink)

“ZurKritik der Gewalt”, publicado em agosto de 1921, nos ArchivfurSozialwissenschaftundSozialpolitik, tratará da tentativa de demarcação de uma violência exterior ou para além do direito: uma“violência pura”,que romperia a dialética da violência mítica que instauraria e conservaria a ordem jurídica. Este artigo pretende estabelecer algumas problematizações sobre esse conceito na filosofia de Walter Benjamin e de alguns intérpretes contemporâneos,buscando conjugar o conceito de reine Gewalt com as reflexões benjaminianas sobre o tempo e a história.

Entrevue avec Michel MaffesoliEntrevista com Michel Maffesoli.

The main objective of this research is to identify the current panorama of scientific production associated with governance in university institutions. A bibliometric analysis was developed in Scopus using R Core Team 2022-Bibliometrix and Vosviewer software. The results highlight the countries with the highest productivity in the topic of study, with the most representative authors favoring the understanding of governance. The main thematic clusters stand out. It recognizes the role of university governance and its migration to direct spaces and the (...) transition from a face-to-face model. (shrink)

A agricultura industrial usa muitos xenobióticos que afetam o microbioma humano, desencadeia disbiose e compromete o desenvolvimento neurológico e neuropsiquiátrico. Em contrapartida, hábitos alimentares ancestrais indicam que a diversificação alimentar, incluindo vegetais e proteínas, isentos de agroquímicos, promovem a saúde mental e física além que viabilizar o equilíbrio no meio ambiente. Como solução deve-se unir o saber ancestral com a Agroecologia para resgatar a saúde humana.

(Spanish) RESUMEN: La libertad absoluta postulada por Viktor Emil Frankl y Jean-Paul Sartre, la Shoah y la creencia en un dios omnipotente, bueno y justo parecen contradecirse. La pregunta por el sentido del sufrimiento de las víctimas del Holocausto (la verdadera catástrofe, el mayor crimen contra la humanidad), simbolizado por Auschwitz, y como punto de inflexión en la historia, es terriblemente dolorosa y parece no tener una respuesta filosófica ni teológica. A mi juicio, es importantísimo distinguir entre las víctimas inocentes (...) de la Shoah que perecieron y las víctimas inocentes que sufrieron un verdadero infierno y perdieron a sus seres queridos, pero que lograron sobrevivir. Ambas son víctimas, por supuesto, pero así como encontrarle un posible sentido al sufrimiento de las víctimas masacradas y gaseadas podría suponer un insulto a su sufrimiento y agonía –en especial, al horror que sufrieron los niños–, el horrible sufrimiento de los supervivientes pudo dar, tal vez, de alguna manera, un sentido a sus vidas después de la liberación de los campos de concentración y exterminio, ya fuera como voz, como protesta o como simple supervivencia. Frankl apuesta por un sentido último (que abraza el sentido del sufrimiento de las víctimas), y Sartre, aunque parezca no apostar por sentido alguno, volcó su vida al compromiso político después de la Segunda Guerra Mundial, y ello parece vislumbrar una minúscula pizca de sentido después de la barbarie. La filosofía de Frankl es un sí a la vida incluso en las situaciones más extremas, un grito casi nietzscheano que exalta el valor de la vida más allá de cualquier sufrimiento. Frankl, padre de la logoterapia y superviviente del Holocausto, abre una puerta a Dios al hablar de un dios inconsciente, una dimensión suprahumana y una fe incondicional, y define la religión como espiritualidad y como la búsqueda del hombre por el sentido último. Según Frankl, la libertad no se contradice con Dios, y la religión existe no a raíz de la barbarie, sino a pesar de la barbarie. El existencialismo sartreano es una filosofía de la libertad radical y de la responsabilidad. El hombre está condenado a ser libre. El ser humano es un ser en el que la existencia precede a la esencia. Somos totalmente responsables de lo que somos. Sartre afirma que la libertad humana es incompatible con Dios. En un mundo sin Dios, la moral la construyen los hombres, con sus propias decisiones y sus acciones, y la existencia y el sufrimiento de las víctimas no tienen sentido alguno. Sartre define al hombre como libertad, responsabilidad, angustia y contingencia. Frankl define al hombre como libertad, responsabilidad, espiritualidad y búsqueda de sentido. Con esta tesis me propongo entrar en la resbaladiza dimensión del dolor, la desesperación, el sentido y sinsentido del sufrimiento de las víctimas (teniendo presente los horrores de Auschwitz, que en teología y filosofía ha simbolizado desde la liberación de los campos la muerte de Dios y la muerte de la moral). Es verdad que no solo los hombres, mujeres y niños judíos fueron víctimas de la barbarie alemana, pero, como reza el mensaje de Elie Wiesel en la exposición permanente del Block 27 del Auschwitz-Birkeanu State Museum: "Not all victims were Jewish in this place, but all Jews were victims". La Shoah no es un episodio dentro de la Segunda Guerra Mundial, sino un punto de inflexión en la historia de la humanidad, y es una catástrofe que nos concierne a todos, hombres y mujeres judíos y no judíos, religiosos e irreligiosos, creyentes e increyentes, como seres libres, responsables y morales que somos –o que deberíamos ser. Muchas de las víctimas del Holocausto, en medio de la desesperación, entraron en las cámaras de gas orando, aferrándose a la esperanza de que ese final espeluznante no era un punto final. Con esta tesis no me propongo de ninguna manera responder a la eterna pregunta de si Dios existe o no, sino que propongo interpretar ese grito hacia Dios como un desesperado anhelo de esperanza. También me propongo encontrar una coherencia en las posturas de estos dos grandes pensadores para quienes la libertad y la responsabilidad definen al hombre: Frankl (quien apuesta por una dimensión suprahumana donde existe un sentido último en el que el sufrimiento de las víctimas tiene que tener algún sentido, aunque ese sentido sea completamente incomprensible en la dimensión humana) y Sartre (el existencialista ateo por excelencia, para quien el mundo, la existencia y el sufrimiento son absolutamente contingentes). En el primer capítulo expongo la logoterapia y el existencialismo sartreano: describo las tres dimensiones del hombre y las tres búsquedas de sentido propuestas por Frankl, y expongo las cinco consecuencias de "l'existence précède l'essence", centrándome en la libertad y la responsabilidad, y hablo del suicidio. El segundo capítulo está dedicado al dios inconsciente frankleano, la dimensión suprahumana, la búsqueda por el sentido último y la fe incondicional. En el tercer capítulo ilustro la libertad sin Dios sartreana, la ontología sartreana, el ateísmo sartreano y el humanismo sartreano, y hablo sobre la responsabilidad, la mauvaise foi, la contingencia, la situation y la angustia. El cuarto capítulo es necesariamente histórico (sin dejar de ser filosófico): me pregunto por la muerte de Dios después de Auschwitz, argumento y defiendo la unicidad del Holocausto (la Shoah es un punto de inflexión en la historia de la humanidad), describo las masacres antes de los campos de exterminio (Einsatzgruppen, Ordnungspolizei y Wehrmacht), el gigantesco complejo de Auschwitz (Stammlager, Auschwitz-Birkenau y Monowitz-Buna), reflexiono sobre Dios y el mal (centrándome en los niños de Auschwitz), describo los días de Frankl en Auschwitz, hablo de Dios como esperanza, de la inmortalidad y la escatología, de la crueldad de Dios, de la relación entre el cristianismo y el antisemitismo, del islam y el antisemitismo, critico el silencio de Dios, hablo de la muerte de Dios y del juicio contra Dios. En el quinto capítulo expongo la moral frankleana (una moral que atañe al hombre y no a Dios), basándome en su teoría del amor y en su única obra de teatro (Synchronisation in Binkerwald), y la moral sartreana (una moral que atañe a una humanidad sin Dios), recordando a Dostoyevsky, analizando la famosa cita de Garcin en Huis clos "L'enfer, c'est les Autres", criticando el marxismo de Sartre y cuestionando (con la mirada de Frankl y Sartre) el verso de Brecht "Erst kommt das Fressen, dann kommt die Moral"; al final del capítulo incluyo una reflexión propia y las críticas frankleana y sartreana sobre la impunidad de los verdugos y colaboradores después del Holocausto (con el permiso de Dios). Después de la Conclusión, añado un Apéndice sobre las vidas de Frankl y Sartre, para poder entender mejor su obra. PALABRAS CLAVE: logoterapia, existencialismo sartreano, búsqueda de sentido, libertad, responsabilidad, moral, angustia, sufrimiento, supervivientes, víctimas, contingencia, espiritualidad, religión, Dios, esperanza, antisemitismo, culpa, Auschwitz, Holocausto, Shoah. /// (English) ABSTRACT: The absolute freedom defended by Viktor Emil Frankl and Jean-Paul Sartre, the Shoah and the belief in an omnipotent, benevolent and just God seem to contradict each other. The question of the meaning of the victims' suffering of the Holocaust (the true catastrophe, the biggest crime against humanity), simbolised by Auschwitz and as a turning point in History, is terribly painful and doesn't seem to have an answer. In my opinion, it's crucial to distinguish between the innocent victims of the Shoah who perished and the innocent victims who sufferend a real hell and lost their loved ones, but managed to survive. Both are victims, of course, but just as finding a possible meaning to the suffering of the massacred and gassed victims could result in an insult to their suffering and agony –especially to the horror that the children suffered– the gigantic suffering of the survivors could, maybe, somehow, give a meaning to their lives after the liberation of the concentration and extermination camps, either as a voice, as a protest, or as a simple survival. Frankl believes in an ultimate meaning (that embraces the meaning of the victims' suffering), and Sartre, even if it appears not to embrace any meaning, turned his life to political engagement after War World II, and that attitude seems to give a tiny glimpse of meaning after the barbarity. Frankl's philosophy says yes to life even in the most extreme situations, and it's a Nietzschean-like scream that exalts the value of life beyond any monstrous suffering. Frankl, the father of logotherapy and a Holocaust survivor, opens a door to God when he talks about an unconscious God, a supra-human dimension and an unconditional faith; he defines religion as spirituality and as man's search for ultimate meaning. According to Frankl, freedom is not contradictory with God, and religion exists not because of the barbarity but in spite of the barbarity. Sartrean existentialism is a philosophy of radical freedom and responsibility. Men are condemned to be free. We are beings where the existence precedes the essence. We are completely responsible of what we are. Sartre argues that human freedom is incompatible with God. In a godless world, morality is constructed by people, with their own choices and actions, and human existence and the suffering of the victims don't have any meaning. Sartre defines man as freedom, responsibility, Angst and contingency. Frankl defines man as freedom, responsibility, spirituality and search for meaning. With this dissertation I attempt to enter in the slippery dimension of the pain, despair, meaning and meaninglessness of the victims' suffering (having in mind the horrors of Auschwitz, that in theology and in philosophy have simbolised, since the liberation of the camps, the death of God and the death of morality). It's true that not only Jewish men, women and children were victims of the German barbarity, but, as Elie Wiesel's message from the permanent exhibition from Block 27 of the Auschwitz-Birkeanu State Museum reads: "Not all victims were Jewish in this place, but all Jews were victims". The Shoah is not an episode inside War World II, but a turning point in the history of humankind, and a catastrophe that embraces us all, Jewish and not not Jewish men and women, religious and not religious, believers and not believers, as the free, responsible and moral beings that we all are –or that we should be. A lot of the victims, in the midst of their desperation, entered into the gas chambers praying, holding to the hope that their horrifying end was not the ultimate end. With this dissertation I do not attempt to answer the eternal question of the existence of God, rather, I will try to interpret that scream to God as a longing for hope. I also intend to find a coherence between the thought of these two great thinkers for whom freedom and responsibilty define man: Frankl (who argues that there is a suprahuman dimension where an ultimate meaning exists and where the victims' suffering has to have a meaning, even if this meaning is completely incomprehensible in the human dimension) and Sartre (the atheist existentialist par excellence, for whom the world, human existence and suffering are absolutely contingent). In the first chapter I expose logotherapy and Sartrean existentialism: I describe the three dimensions of man, the three searches for meaning, the five consequences of "l'existence précède l'essence" and I speak about suicide. The second chapter delves into the unconscious God, the supra-human dimension, the ultimate meaning and the unconditional faith. In the third chapter I expose the freedom without God defended by Sartre, Sartre's ontology, Sartre's atheism, Sartre's humanism, and his ideas about responsibility, mauvaise foi, contingency, situation, and Angst. The fourth chapter is necessarily historical (while being philosophical too): I wonder about the death of God after Auschwitz, I argue and defend the uniqueness of the Holocaust (the Shoah is a turning point in the history of humankind), I describe the massacres before the extermination camps (Einsatzgruppen, Ordnungspolizei y Wehrmacht), the gigantic Auschwitz camp complex (Stammlager, Auschwitz-Birkenau y Monowitz-Buna), I reflect on God and evil (focusing on the children of Auschwitz), I describe Frankl's days in Auschwitz, I talk about God as hope, about immortality and escathology, I discuss God's cruelty, the relationship between Christianity and antisemitism and Islam and antisemitism, I question the silence of God, and I talk about the death of God and about the trial against God. In the fifth chapter I talk about the Franklean morality (a morality that concerns man and not God), on the basis of his love theory and his only work of theater (Synchronisation in Binkerwald), and the Sartrean morality (a morality that concerns a humanity without God), remembering Dostoyevsky, analysing Garcin's famous quote in Huis clos "L'enfer, c'est les Autres", crticizing Sartre's marxism and questioning (with Frankl's and Sartre's eyes) Brecht's verse "Erst kommt das Fressen, dann kommt die Moral"; at the end of the chapter I include my own reflection (and Frankl and Sartre's critique) about the impunity of the executioners and collaborators after the Holocaust (with God's permission). After the Conclusion, I add an Appendix about the lives of Frankl and Sartre, which helps understanding better their work. KEYWORDS: logotherapy, existentialism, search for meaning, freedom, responsibility, morality, Angst, suffering, survivors, victims, contingency, spirituality, religion, God, hope, antisemitism, guilt, Auschwitz, Holocaust, Shoah. (shrink)

In Computer Science stepwise refinement of algebraic specifications is a well-known formal methodology for rigorous program development. This paper illustrates how techniques from Algebraic Logic, in particular that of interpretation, understood as a multifunction that preserves and reflects logical consequence, capture a number of relevant transformations in the context of software design, reuse, and adaptation, difficult to deal with in classical approaches. Examples include data encapsulation and the decomposition of operations into atomic transactions. But if interpretations open such a new (...) research avenue in program refinement, (conceptual) tools are needed to reason about them. In this line, the paper’s main contribution is a study of the correspondence between logical interpretations and morphisms of a particular kind of coalgebras. This opens way to the use of coalgebraic constructions, such as simulation and bisimulation, in the study of interpretations between (abstract) logics. (shrink)

Skipper and Millstein (2005) argued that existing conceptions of mechanisms failed to "get at" natural selection, but left open the possibility that a refined conception of mechanisms could resolve the problems that they identified. I respond to Skipper and Millstein, and argue that while many of their points have merit, their objections can be overcome and that natural selection can be characterized as a mechanism. In making this argument, I discuss the role of regularity in mechanisms, and develop an account (...) of stochastic (i.e., probabilistic) mechanisms. Explaining the phenomenon of adaptation through the mechanism of natural selection illustrates the power and flexibility of using mechanistic strategies to explain natural phenomena. (shrink)

Resumo: O objetivo deste texto é refletir sobre a produção de anormalidades. de um ponto de vista histórico-hermenêutico. Partindo do marco teórico proposto por Michel Foucault, será possível ver como o binômio normalidade-anormalidade, seja de modo disciplinar, seja biopolítico, serve à produção de indivíduos mediante relações de saber-poder. Nesses termos, observa-se como se dá a produção de anormalidades na obra de Foucault. Na segunda seção, verifica-se como a discussão sobre o biopoder pode ser utilizada no intuito de problematizar situações e (...) casos ocorridos neste continente. Trata-se de relacionar a produção de anormalidades com o desenvolvimento do Higienismo na América Latina, dando a perceber algumas estratégias adotadas na normalização e produção de corpos higiênicos. (shrink)

Aurora P. Jackson and Richard Scheines. Single Mother's Efficacy, Parenting in the Home Environment, and Children's Development in a Two-Wave Study.

In this paper we study in details a system of two weakly coupled harmonic oscillators from the point of view of Bohm’s interpretation of quantum mechanics. This system may be viewed as a simple model for the interaction between a photon and a photodetector. We obtain exact solutions for the general case. We then compute approximate solutions for the case where one oscillator is initially in its first excited state (a single photon) reaching the other oscillator in its ground state (...) (the photodetector). The approximate solutions represent the state of both oscillators after the interaction, which is not an eigenstate of the individual hamiltonians for each oscillator, and therefore the energies for each oscillator do not exist in the Copenhagen interpretation of Quantum Mechanics. We use the approximate solutions that we obtained to compute Bohmian trajectories and to study the energy transfer between the oscillators. We conclude that, even using the Bohmian view, the energy of each individual oscillator is not well defined, as the nonlocal quantum potential is not negligible even after the coupling is turned off. (shrink)

This article analyses the evolutionist discourses on the senses that emerged in the late 19th century, when theories on the evolution of species were in full sway. Drawing on newspapers, essays and medical literature, this article aims to set face to face the two currents of thought that I have identified regarding sensory evolution: the one that stressed the value of the progressive specialisation of the senses as evidence for human evolution mainly supported by Max Nordau, and the one which (...) regarded the sensory regrouping, exemplified by the phenomenon of synaesthesia, as the true symptom of evolution, strongly supported by Victor Segalen. A close examination of their arguments will provide clues concerning their relative position vis-à-vis the theory that stressed the exceptional nature of humankind among all living beings. Based on newspapers, essays and medical literature, this paper, which straddles several fields (history of science, philosophy, cultural history and aesthetics) aims to set both positions face to face, examining their arguments in detail and establishing their genealogies. This will lead to a better understanding of the scope and range of evolutionist discourses in the fin de siècle culture and on their impact upon artistic practices. (shrink)

This book examines the controversies surrounding biomedical research in the twenty-first century from a human rights perspective, analyzing the evolution and ...

This article assesses the similarity and difference between the Western European style of doing bioethics and the Scandinavian one. First, it reviews the introductory article by the editor, C. Delkeskamp-Hayes in the first issue of Christian Bioethics (2008), devoted to the possibility of a specifically Christian bioethics in Europe. Second, it analyses bioethics debates in Scandinavian today. In light of Delkeskamp-Hayes' article, the main similarity is that both regions are facing secularization as a threat to basic Christian values, for example, (...) to the Christian view of the sanctity and dignity of the human life. But the Scandinavian tends to reduce Christian bioethics to Luther's concept of the worldly kingdom, supposed to foster a dialogue between Christians and non-Christians on controversial ethical issues. Despite the positive value of the dialogue, this strategy renders Christian ethics powerless. Third, from an evangelical theological standpoint, it proposes some strategies for enhancing the influence of Christian commitments on bioethical laws and policies. (shrink)

In this paper we study in details a system of two weakly coupled harmonic oscillators from the point of view of Bohm's interpretation of quantum mechanics. This system may be viewed as a simple model for the interaction between a photon and a photodetector. We obtain exact solutions for the general case. We then compute approximate solutions for the case where one oscillator is initially in its first excited state (a single photon) reaching the other oscillator in its ground state (...) (the photodetector). The approximate solutions represent the state of both oscillators after the interaction, which is not an eigenstate of the individual hamiltonians for each oscillator, and therefore the energies for each oscillator do not exist in the Copenhagen interpretation of Quantum Mechanics. We use the approximate solutions that we obtained to compute Bohmian trajectories and to study the energy transfer between the oscillators. We conclude that, even using the Bohmian view, the energy of each individual oscillator is not well defined, as the nonlocal quantum potential is not negligible even after the coupling is turned off. (shrink)

En este escrito se presentan algunos desarrollos de la teoría política de John Rawls ahondando en aquellas categorías que permitan contrastar aspectos de los planteamientos rawlsianos con spectos del pensamiento utilitarista clásico. El propósito es discernir qué tan grande es la deuda que tienen pensadores contemporáneos como Rawls con autores clásicos del siglo XIX tales como Bentham y Mill.

When and why do we need the indexical ‘I’? Perry (1979) thinks that ‘I’ is an essential ingredient to the explanation and prediction of action. We need ‘I’ to classify the kind of belief that causes an agent to produce a new action. In his view, classifying the agent’s belief in terms of ‘I’ makes sense because, when asked to explain her behavior, the agent will be disposed to say ‘I’. Here, we argue that this dispositional assumption is problematic. The (...) disposition to act according to an essential indexical and the disposition to make a speech act that contains ‘I’ are two very different things that are not always related. The most common circumstances in which we need to say ‘I’ to explain ourselves involve other agents: when we coordinate in joint actions or when we engage in self-talk to save face before the eyes of potential witnesses. Finally, we revisit Perry’s famous messy shopper anecdote to offer a better story about why its main character is disposed to say ‘I’. (shrink)

The phenomenon of cheating in higher education is of overwhelming importance in that the students engaging in these acts are unlikely to have the skills necessary for their future professional life. Despite its relevance, the empirical evaluation of cheating in universities has been almost exclusively focused on the US context. Little is known about cheating at the European level, let alone in Portugal. Even less is explored at the regional level. In this paper we present evidence on the perception of (...) cheating by Portuguese undergraduate students of economics/business degrees. We undertake a large-scale survey, involving 2675 students from all Portuguese mainland public universities. We found that copying-favourable environments are associated with a higher propensity to cheat. Moreover, in universities where ‘codes of honour’ exist, this propensity tends to be lower. Finally, the propensity to copy seems to be highly influenced by the cultural systems and socially-related factors of different regions. (shrink)

RESUMEN: La muerte del hombre anunciada por Foucault está en estrecha relación con la muerte de Dios anunciada por Nietzsche. El retorno del lenguaje conlleva la desaparición del hombre como figura cardinal del saber moderno. La historia es discontinua. Foucault dudó de las verdades de cada época y de las verdades intemporales. En este artículo trazo el recorrido del hombre en Les mots et les choses, mostrando la tensión entre el lenguaje y la desaparición del hombre, hablo de la discontinuidad (...) de la historia y los “jeux de vérité”, y muestro que Foucault se consideraba, por encima de todo, un pensador escéptico. / ABSTRACT: The death of man proclaimed by Foucault is in close relationship with the death of God proclaimed by Nietzsche. The return of language is linked with the disappearance of man. History is discontinuos. Foucault doubted the truths of each era as well as the timeless truths. In this article I present man’s journey in Foucault’s Les mots et les choses, showing the tension between language and the disappearance of man, I talk about historical discontinuity and the “jeux de vérité”, and I argue that Foucault considered himself, above all, a skeptical thinker. (shrink)

El presente escrito se propone mostrar por qué Heidegger, luego del fracaso de su proyecto inicial, presenta la obra de arte como lugar en el que se esencia la verdad. Más específicamente, propone descubrir por qué el arte permite la superación de la idea de mundo propia de la filosofía moderna y de la ciencia. Para esto, se mostrará por qué la noción de tierra es crucial, como sustracción ocultante, y que es neurálgica para que la verdad se esencie, y (...) posibilite, así, la superación de la idea de mundo como objeto. (shrink)

(2002). Missing twins. Philosophy & Geography: Vol. 5, No. 1, pp. 13-17.

O presente texto visa avaliar o estatuto da revolução a partir da obra de dois filósofos franceses, por assim dizer, que empenharam parte considerável de seu trabalho na investigação sobre a história: Voltaire e Jean Bodin. Nossa intenção é entender a relação entre as noções de transformações, revolução e guerra, conflitos, tumultos. Não pretendemos estabelecer uma comparação rígida, porque anacrônica, entre as obras desses filósofos que trabalharam sobre a história. O que intentamos aqui é investigar algumas linhas de força de (...) seus argumentos que visam explicar as revoluções, suas origens e consequências para mostrar como a articulação entre esses elementos possibilita a Voltaire e a Bodin que realizem o que chamaremos de desmistificação de aspectos pertinentes tanto à filosofia quanto à história. Trata-se ainda de mostra em que medida Bodin e Voltaire divergem e se encontram no que tange ao tratamento filosófico desses temas. This paper aims at evaluating the status of the idea of revolution presented by Voltaire and Bodin. Both philosophers' works are mostly directed to the investigation of history. The purpose of this paper is to understand the connection between the ideas of change, revolution, war, turmoil and conflicts. There is no intention of establishing a strict comparison between the two works, as for that would be anachronistic. On the contrary, this paper intends to investigate some of the main arguments used by both authors to explain the revolutions, its origins and consequences, to show how the articulation between those elements enables them to demystify relevant aspects present in both history and philosophy. Finally, it also aims at pointing at the extent to which the authors diverge and converge in their philosophical approach to the referred themes. (shrink)

La filosofía, más que ser una tarea que busca crear e instaurar una teoría absoluta de la verdad, como fue el caso, en la historia de la filosofía misma, del pensamiento cartesiano, el hegeliano,el husserliano, entre otros, es una actividad, es decir, una praxis dialógica que se entiende como introducirse en el medio de un camino que ya otros han recorrido, lo cual presupone, inmediatamente, una concepción de la filosofía como un camino de experiencia siempre abierto. Así, el presente artículo (...) busca analizar el hacer filosófico como una práctica hermenéutica que no sólo se presenta como familiarización con la tradición, la cual se ejemplifica en el texto con la teoría de la reminiscencia platónica, sino también bajo la forma del rompimiento inherente a dicha familiarización. Por tanto, el artículo busca presentar el saber y el hacer filosófico desde una visión hermenéutica, lo que de suyo implica concebirlo como una acción dialógica mediante la cual se estimula el hacer filosófico como recuerdo, es decir, no sólo como mera aprehensión de conceptos e instauración de verdades totalizantes, sino como praxis humana, que es donde la filosofía y, en suma, la experiencia hermenéutica, encuentran su verdadero topos. (shrink)

O artigo discute a questão da redução da existência humana à vida natural no pensamento de Hannah Arendt, analisando as práticas totalitárias de exclusão dos apátridas das esferas jurídica e política e a dominação totalitária nos campos de concentração, quando o governo totalitário operou a transformação da vida humana até atingir a aniquilação da liberdade humana e produzir um resíduo antropológico em que os seres humanos foram reduzidos à elementaridade da vida.

This paper seeks to explore the processes involved in becoming a teacher in this particular historical moment of global pandemic in Brazil. What are the challenges, limitations, possibilities and opportunities that the pandemic presents to the process of teaching work and teacher formation? A review of the literature that included contributions from Caponi, Kohan, Larrosa, Neuscharank, Vaz, Arroyo and Abramowicz suggests a dialogue between pedagogic theory, philosophy of education and the contemporary experience of political and social events in the pandemic (...) period The discussions reviewed explore the profound extent to which Covid-19 has affected our way of living, working and relating to others, and the psychological effects of social isolation. The situation demands from the Brazilian teacher an attitude of openness to change, specifically in the use of new technologies, and the extent to which they are or are not able to replace face-to-face interactions. The situation also challenges us to reconstruct, beyond the logic of neoliberalism, our notions of the type of school we have and type of school we want, the type of teachers we are and the type of teacher we want to be. We conclude that this process of thinking school again depends, if it is to escape neoliberal logic, on the capacity of understanding the vocation of the teacher to be one of “becoming-child” in the sense of experiencing an openness to and a desire for the new. As such, the “becoming-teacher” is one who allows herself to be addressed by another logic, another more sensitive and more aesthetic temporality, and who finds, in encounter with others, with art, with childhood, with becoming itself, the capacity to think, to resist, to fight for the realization of that logic. (shrink)

This work has its origin in a master's research about Brazilian Education. The approach that we present in this text reveals the perspectives of caring perceived in a five-year-olds classroom in the daily life in a municipal center for Early Childhood Education in Fortaleza. The theoretical discussions on the theme involved a dialogue between Pedagogy and Philosophy of Education based on the contributions of Kramer, Pagni, Foucault, Rancière, Kohan and Boff. It was a qualitative research of phenomenological inspiration, which method (...) of data creation was participant observation. The analysis revealed that: in the interactions occurred in pedagogical practices, teachers and children take care of each other; the meaning of caring for children can be perceived in the minutia of their daily actions, as well as in affective involvement, in playing together, in speaking and listening to others, in sharing life on a daily basis; as for the meaning of caring for the adults, it is influenced by the way they were cared for, by their subjectivation and their choices in their way of being; caring humanizes teaching practices, inspiring emancipation; the policy on results that has aimed at "improving educational indices" may represent a danger to Early Childhood Education by minimizing the sharing of specific childhood experiences to training in order to achieve expected results. The study emphasized the need to reflect on the meaning of education and therefore proposes that caring be valued as an ethical decision and as an option for reflection on the way of living and interacting. (shrink)

Em Ser e Tempo, Heidegger argumenta que o conhecimento primordial do Dasein se dá no manuseio de entes mundanos. Merleau-Ponty, por sua vez, descreve na Fenomenologia da Percepção que o conhecimento é, antes de tudo, uma intencionalidade corporal intraduzível em termos proposicionais. Mais tarde, em What Computers Can’t Do, Hubert Dreyfus usa a obra de ambos para apontar os equívocos do paradigma cognitivista, isto é, a abordagem dominante do então nascente campo da inteligência artificial. Finalmente, em The Embodied Mind: Cognitive (...) Science and Human Experience, a noção de enativismo - elaborada por Francisco Varela, Evan Thompson e Eleanor Rosch - surge como uma tentativa de tomar do cognitivismo e do conexionismo a hegemonia nas ciências cognitivas. Dito isso, o objetivo do artigo consiste em descrever o enativismo e apontar sua herança fenomenológica. (shrink)

No final da década de 1950, Merleau-Ponty desloca seu foco de investigação da fenomenologia à ontologia. Tal transição envolve a articulação de seus estudos prévios acerca da percepção e da corporeidade com os desdobramentos filosóficos dos postulados da física e da biologia da primeira metade do século. A partir de uma reformulação do conceito de natureza, fomentada não só pelas ciências supracitadas como pela metafísica de Whitehead, Merleau-Ponty propõe a admissão da natureza como um fluxo de expressividade temporal autoprodutora de (...) sentido, incorporando ao âmago do ser a temporalidade e a negatividade antes exclusivas ao para-si. A carne de Merleau-Ponty, como veremos, está em harmonia com a noção de processo de Whitehead, apontando assim um certo hilozoísmo pré-socrático na ontologia de ambos. Dito isso, o objetivo do artigo consiste em examinar a ontologia indireta de Merleau-Ponty, indicando sua convergência com a filosofia de Whitehead para, finalmente, introduzirmos uma crítica incipiente a partir da obra de Francisco Varela. Defende-se aqui que o conceito de autopoiesis pode indicar uma alternativa à noção merleau-pontiana de natureza. (shrink)

Therapeutic alliance is a central concept in psychotherapeutic work. The relationship between the therapist and the patient plays an important role in the therapeutic process and outcome. In this article, we investigate how therapists work with disaffiliation resulting from enduring disagreement while maintaining an orientation to the psychotherapeutic project at hand. Data come from a total of 18 sessions of two dyads undergoing psychoanalytic psychotherapy and is analyzed with conversation analysis. We found that collaborative moves deployed amidst enduring disagreement can (...) assist the therapist in furthering the disagreement as part of the ongoing psychotherapeutic project. Relying on their collaborative format, therapists utilize collaborative moves to temporarily mend the disaffiliation without necessarily changing their position and re-affiliating with the patient. We show how the relation between the therapist and the patient gets transformed in the moment-by-moment work accomplished in the psychotherapeutic talk. (shrink)