Implications of algorithmic mediation can be studied through the artefact itself, peoples’ practices, and the social/political/economical arrangements that affect and are affected by such interactions. Most studies in Academic social media (ASM) focus on one of these elements at a time, either examining design elements or the users’ behaviour on and perceptions of such platforms. We take a multi-faceted approach using affordances as a lens to analyze practices and arrangements traversed by algorithmic mediation. Following our earlier studies that examined the (...) artefact, this study’s aim is to understand how algorithmic mediation in ASM may shape researchers’ perceptions. We conducted online in-depth interviews with show and tell (n = 11) with ASM users from four countries, about their use of ASM. Data were analyzed using thematic analysis, and the codes were clustered in themes and validated via peer debriefing process. Four themes—related to exposure to content, visibility, ethical or legal infringements, and engagement—are discussed considering implications of datafication and findability. We conclude that algorithmic mediation constructs a narration of the relevant other in ASM, configuring the other as participatory and productive. (shrink)

The tricarboxylic acid (TCA) or Krebs cycle, which takes place in prokaryotic cells and in the mitochondria of eukaryotic cells, is central to life on Earth and participates in key events such as energy production and anabolic processes. Despite its relevance, it is not perceived as tightly regulated compared to other key metabolisms such as glycolysis/gluconeogenesis. A better understanding of the functioning of the TCA cycle is crucial due to mitochondrial function impairment in several diseases, especially those that occur (...) with neurodegeneration. This article revisits what is known about the regulation of the Krebs cycle and hypothesizes the need for large‐scale, rapid regulation of TCA cycle enzyme activity. Evidence of mitochondrial enzyme activity regulation by activation/deactivation of protein kinases and phosphatases exists in the literature. Apart from indirect regulation via G protein‐coupled receptors (GPCRs) at the cell surface, signaling upon activation of GPCRs in mitochondrial membranes may lead to a direct regulation of the enzymes of the Krebs cycle. Hormonal‐like regulation by posttranscriptional events mediated by activable kinases and phosphatases deserve proper assessment using isolated mitochondria. Also see the video abstract here: https://youtu.be/aBpDSWiMQyI. (shrink)

The goal of this paper is to critically examine the objections of John Locke’s contemporaries against the theory of substance or substratum. Locke argues in Essay that substratum is the bearer of the properties of a particular substance. Locke also claims that we have no knowledge of substratum. But Locke’s claim about our ignorance as to what substratum is, is contentious. That is, if we don’t know what substratum is, then what is the point of proposing it as a bearer (...) of properties? This question underlies the criticism Locke’s contemporaries raise against the notion of substratum. In section I, I lay out the context for Locke’s theory of substratum by pointing out his main motivation in proposing his theory. In section II, I give a brief analysis of the theory of substratum. In section III, I discuss the objections of Locke’s contemporaries against the theory of substratum.1 I focus on Edward Stillingfleet, Lee Henry, G. W. Leibniz and John Sergeant. In section IV, I conclude that there is no warrant to dismiss Locke’s theory of substance. (shrink)

Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in (...) particular: How domain‐specific are the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

Since Krebs and Davies’s (1978) landmark publication, it is acknowledged that behavioural ecology owes much to the ethological tradition in the study of animal behaviour. Although this assumption seems to be right—many of the first behavioural ecologists were trained in departments where ethology developed and matured—it still to be properly assessed. In this paper, I undertake to identify the approaches used by ethologists that contributed to behavioural ecology’s constitution as a field of inquiry. It is my contention that the (...) current practices in behavioural biology owe ethology something much subtler than the simple transposition of Tinbergen’s Four Problems for heuristic purposes. Demonstrating what ethology inherited from the long naturalist tradition shows the tensions that strained the field and that later led to the loss of both its unity and its specificity. It also allows for a precise delineating of what behavioural ecology picked up from the ethological practice, and it helps to cast some light on the introduction of economical thinking in behavioural sciences. (shrink)

Engelbert Krebs, a Catholic priest and professor of theology at Freiburg University, was a close friend of her husband, the philosophy lecturer Martin Heidegger. In fact, Krebs was the minister who had officiated at the Heideggers' Catholic wedding in Freiburg Cathedral on March..

In Crawford, C. & Krebs, D. (eds.) Foundations of evolutionary psychology: Ideas, issues, applications and findings. (2nd Ed.) Mahwah, NJ: Erlbaum Associates.

Issue is taken with Dawkins and Krebs's (1978) conception of communication as being by nature manipulative and with Cronk's proposals concerning the evolution of morality, both of which are grounded in evolutionary biology. An alternative view, which recognizes that which humanity has in common with other species but which emphasizes humanity's distinctiveness, is offered to account for religion and morality.

Dieser Band formuliert - über den Kontext philosophischer Editionen hinaus - Probleme und Forschungsfragen, die sich in der Edition von Manuskripten zu Vorlesungen, von Nachschriften sowie von Seminarprotokollen ergeben. Der Fokus liegt auf methodischen Lösungsansätzen, die exemplarisch an Editionsvorhaben von Texten des 18. bis 20. Jahrhunderts vorgeführt werden. Damit bildet der Band ein Kompendium, von dem weitere editorische Forschung ausgehen kann. Frank Grunert und Holger Glinka eröffnen den Band, indem sie am Beispiel der Edition einer Nachschrift der Grotius-Vorlesung von Christian (...) Wolff zeigen, dass professionell hergestellte Nachschriften auf eine besondere wissenssoziologische Situation hinweisen: Mit der zunehmenden Emanzipation der Vorlesungen von kanonischen Lehrbüchern hat die Vorlesung selbst Lehrbuchcharakter entwickelt, der den Zugzwang ihrer Hörer noch verstärkt, sich des von Professoren gesprochenen Wortes schriftlich zu vergewissern. Der Handel mit Nachschriften hat hier seinen Grund wie in der Überlieferung besonders elaborierter Manuskripte in den Nachlässen adeliger und vermögender Häuser. Werner Stark stellt die problematische Funktion von Nachschriften als vermeintlicher Stütze für weitgehend ungeschriebene Werke am Beispiel von Kants Physischer Geographie in der Ausgabe Rink heraus und teilt damit spezifische Erfahrungen mit den älteren Editionen von Nachschriften Kantischer Vorlesungen in Königsberg mit. Holden Kelm rekonstruiert im historischen Vergleich, wie unterschiedliche Editionsstandards und v. a. Absichten ihren Autor gerade in der Rekonstruktion seiner Lehre jeweils neu konstitutieren, sodass ein editorisch manifestes theologisches Interesse an Schleiermacher zunehmend von einem philosophischen abgelöst wird. Annette Sell spürt anhand der Edition der Vorlesungsnachschriften zu Hegels Logik der Frage nach Hegels möglicherweise eigenen Überlieferungsabsichten seines in seiner Bewegung vorgetragenen Werkes nach. Johannes Korngiebel nimmt eine Nachschrift zu Friedrich Schlegels Jenaer Vorlesung zur Transcendentalphilosophie von 1800/01 zum Anlass, die Leistungsfähigkeit einer textkritischen Auswertung von Vorlesungsnachschriften für die Edition exemplarisch darzustellen. Christoph Binkelmann teilt aus der Werkstatt Schellings die editorischen Herausforderungen mit, die dessen Vorlesungen über Philosophie der Kunst bedeuten. Daniel Elon beleuchtet Schopenhauers Versuche als Dozent, wie sie sich in den Manuskripten zu dessen Vorlesung von 1820 darstellen. Francisco Arenas-Dolz nimmt Nietzsche als Universitätslehrer ernst und vertieft anhand der Edition der Vorlesung,,Einleitung in das Studium der klassischen Philologie" die Reflexionen über das Verhältnis von Vorlesungen und den sie begleitenden Textarten. Windelbands vor wenigen Jahren in Sendai wiederaufgefundene Manuskripte zur Vorbereitung von Lehrveranstaltungen und Publikationsvorhaben sind Gegenstand von Jörn Bohrs Beitrag. Andrea Leubin und Monika Philippi gewähren einen Einblick in die Edition von Vortragsnachschriften innerhalb der Rudolf Steiner Gesamtausgabe. Max Webers Manuskripte für Vorlesungen dienen Sophia Krebs und Ulrich Rummel als Fallbeispiel für das Ermitteln und Belegen von Krypto-Zitaten und Paraphrasen, einem Hauptgegenstand editorischen Kommentierens. Mit Thomas Kessels Beitrag zu Nicolai Hartmanns Circelprotokollen wird das 20. Jahrhundert in den Blick genommen, als in den Seminaren und Kolloquien die Form des Protokolls Einzug hielt. Dirk Braunstein liefert eingehende Reflexionen über den möglichen Sinn der Begriffe,Autorschaft' und,Authentizität' in der Editionspraxis solcher Seminarprotokolle. - Beigefügt ist eine Bibliographie zum Thema Edition von Kollegheften, Kollegnachschriften und Protokollen. (shrink)

Substrate cycles are ubiquitous structures of the cellular metabolism (e.g. Krebs cycle, fatty acids -oxydation cycles, etc... ). Moiety-conserved cycles (e.g. adenine nucleotides and NADH/NAD, etc...) are also important.The role played by such cycles in the metabolism and its regulation is not clearly understood so far. However, it was shown that these cycles can generate multistationarity (bistability), irreversible transitions, enhancement of sensitivity, temporal oscillations and chaotic motions (Hervagault & Canu, 1987; Hervagault & Cimino, 1989; Reich & Sel'kov, 1981; Ricard (...) & Soulié, 1982). Fig. 1: Scheme of the open binary substrate cycle under study. The substrate S is converted into P with a net rate v2. Substrate P is converted in turn into S with a net rate v3. Step v2 is inhibited by excess of the substrate, S. In addition, the cycle operates under open conditions, that is zero-order input of S at rates \ga0(v1) and first order outputs of S and P at rates \gaS and \gaP(v4), respectively. (shrink)

1施莱尔玛赫 contribution to the development施莱尔玛赫for hermeneutics in the development of Historically hermeneutics In order to make a decisive turn when he made ​​the future "general hermeneutics" , hermeneutics will be applied to all text interpretation. When the traditional hermeneutics contains In order to understand, description and application,施莱尔玛赫the attention is hermeneutics as "the art of understanding." 施莱尔玛赫also introduced the interpretation of psychology, can penetrate the text by means of its author's individuality and flexibility soul. He wanted to become a systematic hermeneutics, (...) and criticism of previous hermeneutics is "the rules of the merger," and the lack of coherence. Wu Ning speaking, they deal with different issues is a combination of methods. 施莱尔玛赫hermeneutics points to avoid misunderstanding of the text. This part is up to the final discussion of施莱尔玛赫criticism of the United States. 2. Dilthey contribution to the philosophical hermeneutics of Dilthey on施莱尔玛赫In order to write the thesis, including In order to Protestant hermeneutics history, from the Reformation to the future as a second reference books. He was a learned scholar and has been on many topics regardless above. For our purposes, Dilthey is a philosopher with a passion for life, he was placed In order to humanities and social sciences and natural sciences in an established full equality of points, by the foundation on the hermeneutics In order to develop a basic methodology. But in the science competition, he was seeking "Allgemeingultigkeit", a universal validity, to do so In order to give him too much towards the foundation to the scientific methods of thought. He is still a major development of the character of philosophical hermeneutics. 3 Heidegger before and on philosophical hermeneutics, "and there is time" contribution to the development of philosophical hermeneutics is the decisive shift in Heidegger, born with the future, there are original philosopher The early works. He Freiburg Hu plugs Seoul assistant, and in the phenomenological Hu stopper Seoul In order to create a useful set up beyond the traditional methods of philosophy, but he is still too dependent on science Hu stopper Marco effectiveness. Part I: description of the evolution of the early Heidegger: "ontology - the fact of hermeneutics," the book published after the death of Heidegger was published in 1999, English translation, Heidegger in this series by the fact that the ontology of hermeneutics In order to give us a hermeneutic understanding of his meaning. In order to avoid the traditional hermeneutics of his meaning, In order to return to the ancient hope臘hermeneueinc and hermeneia idiom. He attempts to go beyond the limits of contemporary objects, through the period of return to the ancient hope臘general language idioms. Hermeneutic encounter with the interpretation of Homer's description of the mouth, publish, translate and interpret. His description of historical hermeneutics in the pull-down maps and sub ​​Lane Park after a groundbreaking Aristotle hope臘idioms in the loss of richness and decline. But the hermeneutics of Heidegger speaking the method is close to something, such as early speech hermeneutics In order to approach closer to the truth of it is understandable the former interpretation of this domain as there face life. For this last hermeneutics as the method of self-understanding, but in a letter to his students Engelbert Kerbs letter, Heidegger also emphasizes the history In order to recognize the character. Us from our understanding of historical context, our understanding of the structure is formed by shaping the concept of history and even our language. In Dilthey's hermeneutics, he also stressed that understanding the historical basis. From Dilthey to Heidegger this view. Heidegger in his speech defines hermeneutics as "the fact of participation, close, and descriptions of the same interrogation methods." Hermeneutics is the interpretation of not only understanding knowledge as a negative process, but active participation, interrogation and close. Fact of itself is interpreted, it is through understanding the questions and answers something. Heidegger back to the necessary conditions for our understanding of factors, understanding of "the former structure." He describes some part of the former, is awareness and understanding of nature, we understand something "to" something, and we understand it in a specific historical context. Further more, we expect to understand it in the presence of a sight, not a determining sexual arousal by the sight, by the basic problems of the future horizon, it is "the possibility of there," the sight, for there is a special special possible time horizon. These early works of Heidegger has been found there the possibility of meaning. We all都leadership to a new concept of the humanities. In addition, as a rational animal, as Aristotle said sub-Lane, who is of a future there may not be included, including the timing of there. People are looking to understand their own there. Instructions to Heidegger, hermeneutics offers a new concept for the person's point of view. Part II: there and time hermeneutics is first mentioned in the "there and the time," Section VII, Heidegger phenomenology has been interpreted as if it is. In order that he found "the meaning of phenomenological description as a way to rely on hermeneutics, phenomenology of this and some of the logos have hermeneuein the characteristics of this phenomenology is to use some basic meaning of the word hermeneutics, it indicates the work In order to interpret . "In the second sense, Heidegger found in hermeneutics裡are there for the meaning of this method of exposing the shield. The third meaning is the interpretation of this promising continuous manner so that its future is possible, it's future there. Section 31 of hermeneutics is important, because there is some understanding that is. Understanding the process is the center of human existence, in Section 32 entitled "interpretation and understanding," understanding the interpretation built on. Visit the world around it and understand things as this or that, always never as pure consciousness. As Heidegger said, "always had to watch as the ability to understand and interpret", in other words, there is no precedence in the interpretation of pure consciousness, there is always ask questions and interpretation of the visual field. Section 44, regardless Heidegger also true about management, in its modern form as a true statement, is always carried a deeper understanding and interpretation of the export process. But the really right is defined as the management there has been an associate of knot, so it access to basic ontology of sight. It is obvious that there's open, this hole is to guide him toward the police point of view of the artistic part of the next lecture will be discussed. This lecture primarily presents the two early works of Heidegger in which hermeneutics plays a definitive role. As background, the contributions of Schleiermacher and Dilthey are presented briefly before going into Heidegger's contribution. Ⅰ. Schleiermacher's Contribution to the Development of a Philosophical Hermeneutics Schleiermacher made a decisive turn in the history of hermeneutics when he proposed a "Universal Hermeneutics," a hermeneutics that would apply to all kinds of text interpretation. While traditional hermeneutics included moments of understanding, explication and application, Schleiermacher focused on hermeneutics as the "art of understanding . "Schleiermacher also introduced psychological interpretation whereby one tried to penetrate the individuality and soul of the author of a text. He wanted hermeneutics to be systematic, and he criticized previous hermeneutics for being only an" amalgam of rules "and lacking systematic coherence. Rather , they were methods for dealing with an array of different kinds of problems. Schleiermacher's hermeneutics was directed at avoiding misunderstanding of the text. At the end of this section Gadamer's criticisms of Schleiermacher will be discussed. Ⅱ. Dilthey's Contribution to Philosophical Hermeneutics Dilthey wrote his dissertation on Schleiermacher and included a history of Protestant hermeneutics since the Reformation as a second companion volume. He was a broadly educated professor and wrote on many topics. For our purposes, Dilthey was a life-philosopher with a passion for placing the Humanities and Social Sciences on an equal footing with the Natural Sciences by developing a basic methodology for them based on hermeneutics. But in competing with the sciences, he sought an "Allgemeingultigkeit," a universal validity, and in doing so he tended to give too much ground to the way of thinking in the sciences. Still, he is a major figure in the development of philosophical hermeneutics. Ⅲ. The Contribution of Martin Heidegger to Philosophical Hermeneutics before and in Being and Time The decisive turn in the development of a philosophical hermeneutics came in the early writings of Martin Heidegger, a radical and original philosopher. He was in Freiburg an assistant to Husserl and found in Husserl's phenomenology a useful way of overcoming traditional philosophy, but he still found Husserl too preoccupied with scientific validity. Part Ⅰ: Heidegger's Early Lectures: Ontology-the Hermeneutics of Facticity A posthumously published and translated set of Heidegger's lectures on ontology in terms of a hermeneutics of facticity gives us a sense of his understanding of hermeneutics. He bypassed the traditional sense of hermeneutics and went back to the Greek usage of hermeneuein and hermeneia. He attempted to overcome the limitations of modern objectivity by returning to the usages current in ordinary language in ancient Greece. There hermeneutics meant orally interpreting Homer, announcing, translating, and explaining. His account of the history of hermeneutics after Plato and Aristotle is a history of decline and loss of the richness found in Greek usage. But hermeneutics for Heidegger meant a means of access to something, and in these early lectures hermeneutics became an interpretive means of access to facticity, to the realm of pre-interpretive understanding as Dasein faces life. Ultimately hermeneutics became a means for the self-understanding for Dasein. But in a letter to his student, Engelbert Krebs, Heidegger also emphasizes the historical character of cognition. We understand from our situation in history, and our understanding is structured by historically shaped concepts and even our language. Dilthey, too, emphasized the historical matrix for understanding in his hermeneutics, and Heidegger took this up from Dilthey. Heidegger defined hermeneutics in the opening lines of the lectures as "the unified manner of the engaging, approaching, accessing, interrogating, and explication of facticity." Hermeneutics as interpretation is not just understanding as a passive process of cognition but an active engaging, interrogating, and accessing. Facticity itself is interpretive in that it sees what something is through question and answer. Heidegger is stepping back into the factors that precondition our understanding, the "forestructure" of understanding. This forehaving, he says, belongs to the very nature of knowing and understanding. We see something "as "something, and we see it in a specific historical situation. Furthermore, we see it in an existential horizon of expectation, a horizon haunted by uncertainty, by the" fundamental questionability of the future, that is of "possible being," of what is possible for this particular being at this particular time and place. Already in these early works Heidegger finds in the sense of what is possible being, a sense of "ontic questionability, care, restlessness, anxiety, temporality." All of this leads to a new conception of humanity. Instead of being an animal endowed with reason, as in Aristotle, a human being is a being with a possible future, a being with temporality. Humans are beings seeking to know themselves. Hermeneutics, Heidegger says, offers the standpoint for a new conception of the human being. Part Ⅱ: Being and Time The first mention of hermeneutics is in section 7 of Being and Time, where Heidegger is already interpreting phenomenology as letting what is show itself. He finds that " the meaning of phenomenological description as a method lies in interpretation. The logos of the phenomenology of Dasein has the character of hermēneúein. The phenomenology of Dasein is a hermeneutic in the original signification of the word, where it designates the work of interpreting. "In a second sense, Heidegger finds in hermeneutics a means of uncovering the meaning of being for Dasein. And the third sense is the interpretation Dasein as continually making its future possibilities, its future being. Section 31 is important to hermeneutics because there the being of Dasein is said to be understanding. Understanding is the central process of an existing human being. In section 32, titled "Understanding and Interpretation," interpretation builds on understanding. It looks around at the surrounding world and sees things as this or that, always already , never as pure perception. As Heidegger puts it, "The seeing of this sight is always already understanding and interpreting." In other words, there is no pure perception prior to interpretation; there is always the horizon of questioning and interpreting. In section 44, Heidegger argues that truth, too, in its modern forms as statements which are true, is derivative from the deeper processes of understanding and interpreting that are always already going on. But when truth is rightfully defined in connection with being, then it moves into the horizon of fundamental ontology. It is the disclosure of being. This insight is part of what leads him to his view of art, which we will discuss in the next lectur. (shrink)

Excerpt from Erkennen und Wissen nach Gregor von Rimini: Ein Beitrag zur Geschichte der Erkenntnistheorie des Nominalismus Krebs engelbert, Theologie und Wissenschaft nach der Lehre der Hoch scholastik (beitrage XI, 3 Munchen 1912. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in (...) the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Intersection of Heidegger's Philosophy and His Politics as Reflected in the Views of His Contemporaries at the University of FreiburgRichard DetschThere has been so much speculation in the last ten years or more about the reasons for and the extent of Heidegger's involvement in the Nazi movement that another attempt to come to grips with this important problem might seem superfluous. Amidst the weighty arguments advanced in what (...) has become a multitude of treatises and tomes, however, there has thus far been little interest in dealing with Heidegger's simple statement in his Spiegel interview that he was moved by the "confusion of opinions... from 22 parties... to adopt a political stance that was national and above all social."1 If we suspend our suspicion for the moment that Heidegger is here again manipulating the facts to fit his postwar predicament, as has been amply demonstrated [End Page 407] regarding other details, and examine the evidence we will find that there are indeed indications of the predominance of Heidegger's social concerns with respect to the political situation of the early '30s as well as of his leaning toward an authoritarian form of government an inclination shared, to be sure, by a significantly large number of his compatriots, academic and otherwise. There is one approach in particular toward answering the question of why Heidegger became a Nazi which the present attempt hopes to put in question: the emphasis on his abandonment of his Christian religious origins. The following statement by Theodore Kisiel expresses this line of reasoning most succinctly: "It will take a decade, but it will be not just an anti-Catholic, nor an anti-Christian, but the full-blown anti-religious attitude of the German Geist ripened from German Idealism that sweeps Heidegger into National Socialism, with all the romantic fervor of another religious conversion."2 John Caputo argues, based on the work of Kisiel and van Buren, that the Heidegger of the early twenties was drawing from two "equiprimordial" sources, "the Aristotelian and the Christian." "It was only in the 1930's, in the period of Heidegger's active political engagement with National Socialism, that the twofold root of the tradition was pruned to a single root... a Great Greek beginning from which everything Jewish and Christian, everything Roman, Latin, and Romance, was to be excluded as fallen, derivative, distortive, and inauthentic."3 This shift in perspective, this rejection by Heidegger of earlier Christian impulses in his work led to "fatal" lapses in the ethical realm: "... by leaving behind Kierkegaard and Luther... and by treating Aristotle as a fading echo of the primordially early Greek, Heidegger left the question of Being in a state of utter mystification about ethico-political matters, about the matter of our concrete responsibilities to one another."4 David Farrell Krell makes this lack of respect for and attention to the "other" the centerpiece of an entire study attempting to show Heidegger's propensity for the inhuman ideology of Nazism.5 These arguments derive perhaps from the rhetorical question posed by the Freiburg historian Hugo Ott in 1988: "Didn't this pseudo-religious expectation of salvation [through the mission of the Führer] conceal a monstrous hubris, wasn't the thinking of Heidegger in its radically contained, i.e., in its elementary [End Page 408] simplicity really a surrogate for the Christian view of life thrown overboard?"6 The problem with all such arguments is that "the Christian view of life" did not prevent others of a background similar to Heidegger's from an enthusiastic acceptance of Nazism without an abandonment of their religious faith. In this regard, let the case of Engelbert Krebs, Heidegger's one-time friend and mentor, the Jesuit priest who officiated at his marriage ceremony, serve as an example. Ott deals with Krebs fairly extensively in his Heidegger biography, stressing Krebs's chagrin when Heidegger turned his back on the Catholic Church, but fails to mention at all the enthusiasm for the Nazi movement that Krebs shared with his former friend.During his tenure as dean of the Theological Faculty at the University of Freiburg, Krebs delivered an address in a university lecture... (shrink)

Herbert Simon’s work on scientific discovery deserves serious attention by philosophers of science for several reasons. First, Simon was an early advocate of rational scientific discovery, contra Popper and logical empiricist philosophers of science (Simon 1966). This proposal spurred on investigation of scientific discovery in philosophy of science, as philosophers used and developed Simon’s notions of “problem solving” and “heuristics” in attempts to provide rational accounts of scientific discovery (See Nickles 1980a, Wimsatt 1980). Second, Simon promoted and developed many of (...) the crucial techniques and methods used in cognitive science. One is the use of computers to model internal psychological processes, a technique central to his account of scientific discovery. Another is protocol analysis, the use of the verbal reports of experimental subjects in psychology to construct accounts of their psychological processes. Protocol analysis is given a detailed formulation by Simon (Simon and Ericsson 1984), and is modified for use in the study of scientific cognition in the paper on Krebs (Kulkarni and Simon 1988). (shrink)

Hypoxia hampers ATP production and threatens cell survival. Since cellular energetics tightly controls cell responses and fate, ATP levels and dynamics are of utmost importance. An integrated mathematical model of ATP synthesis by the mitochondrial oxidative phosphorylation/electron transfer chain system has been recently published :e36, 2005). This model was validated under static conditions. To evaluate its performance under dynamical situations, we implemented and simulated it . Inner membrane potential and [NADH] were used as indicators of mitochondrial function. Root mean squared (...) error was used to compare simulations and experiments :39155–39165, 2003). Steady-state experimental data were reproduced within 2–6%. Model dynamics were evaluated under: baseline, activation of NADH production, addition of ADP, addition of inorganic phosphate, oxygen exhaustion. In all phases, except the last one, ΔΨ and [NADH] as well as oxygen consumption, were reproduced . Under anoxia, simulated ΔΨ markedly depolarized . In conclusion, the model reproduces dynamic data as long as oxygen is present. Anticipated improvement by the inclusion of ATP consumption and explicit Krebs cycle are under evaluation. (shrink)

Human nature is enigmatic. Are we cruel, selfish creatures or good merciful Samaritans? This book takes you on a journey into the complexities of human mind and kind, from altruism, sharing, and large-scale cooperation, to cheating, distrust, and warfare. What are the building blocks of morality and sociality? Featuring contributions from leading researchers, such as Christophe Boesch, Leda Cosmides and John Tooby, Azar Gat, Dennis Krebs, Ara Norenzayan, and Frans B. M. de Waal, this fascinating interdisciplinary reader draws on (...) evolutionary and comparative perspectives, and is essential reading for any students interested in the unique characteristics that define humanity and society. (shrink)