Hans Krebs' discovery, in 1932, of the urea cycle was a major event in biochemistry. This article describes a program, KEKADA, which models the heuristics Hans Krebs used in this discovery. KEKADA reacts to surprises, formulates explanations, and carries out experiments in the same manner as the evidence in the form of laboratory notebooks and interviews indicates Hans Krebs did. Furthermore, we answer a number of questions about the nature of the heuristics used by Krebs, in particular: How domain‐specific are (...) the heuristics? To what extent are they idiosyncratic to Krebs? To what extent do they represent general strategies of problem‐solving search?The relative generality of KEKADA allows us to view the control structure of KEKADA and its domain‐independent heuristics as a model of scientific experimentation that should apply over a broad domain. (shrink)

On Ramchandra Dattatraya Ranade, 1886-1957, educationist and Indic philosopher.

Access to energy is essential for our daily lives, economic growth, environment, and sustainability. However, our use of fossil fuels has contributed to global climate change, which poses a significant threat to society and life on this planet. Yet, it has been challenging to reconcile the perceived conflict between economics and climate change, which has created deep divisions in our society. ENERGY 2040: Aligning Innovation, Economics, and Decarbonization provides a holistic and comprehensive analysis of the ongoing energy transition and its (...) underlying causes. It presents a viable path to meet the energy, economic, and climate goals by weaving together science, technology, economics, policy, entrepreneurship, and geopolitics. The book presents a captivating narrative that brings together a range of topics, including new and disruptive technologies with steep learning rates, the challenges of the future power grid, the democratization of energy, and reducing the timeline from science to impact at scale. It also explores the complex role of scientific research, disruptive deep tech, entrepreneurship, and policy in accelerating this energy transformation. This book is a must-read for anyone interested in understanding the future of energy. Whether you're a scientist, energy-industry practitioner, policymaker, investor, student, or concerned citizen, this book offers critical insights into the complex and evolving world of energy, innovation, decarbonization, and climate change. (shrink)

This article reports the findings of a survey examining whether gender differences influence the degree to which individuals recognize unethical conduct in the use and development of information technology. The results show that, on the average, there is a significant gender gap in the recognition of unethical behavior in information systems. Although, women are better able to recognize unethical actions described in information systems scenarios than men, the existence of statistically significant differences varies depending upon the nature of the ethical (...) dilemma. The findings of this study provide both managers and researchers valuable understanding regarding the differences (and similarities) in the reactions of individuals of both genders to unethical situations in information systems. (shrink)

When you gaze out at the night sky with its awe-inspiring display of stars and galaxies, do you ever ask yourself if it could be possible that you are actually looking into a mirror? What if we inhabit a universe that perfectly fits our needs here on Earth -- a truly human universe? That's the bold thesis author Deepak Chopra and physicist Menas Kafatos set out to prove: quite literally, "You are the universe." The startling truth is that the (...) everyday world of physical objects "out there" disguises a hidden dimension. By turning our investigation "in here" to the world of consciousness, the real reality emerges. You Are the Universe guides the reader into a realm in which each of us has the power to transform our personal existence, while at the same time fashioning a new story about how time, space, matter, and energy came into existence. Looking to overturn the traditional model of scientific reality, Chopra and Kafatos hold that each of us is a cocreator of reality and we can uncover the hidden dimensions where consciousness is a field of infinite possibilities. This seemingly impossible proposition follows from the cutting-edge modern thinking of the quantum universe and the great mysteries that must be unriddled before human beings actually know who they are. These include but are not limited to questions such as What came before the big bang? Why does the universe fit together so perfectly? Where did time come from? And do we live in a conscious universe? These mysteries are part and parcel of everyone's life. "All of us live in a participatory universe," the authors write. "Once you decide that you want to participate fully with mind, body, and soul, the paradigm shift becomes personal. The reality you inhabit will be yours to either embrace or change. (shrink)

My artistic inquiries draw from gender and sexuality in public space and use performance as process. In inspiration, the works emerge as aesthetic responses to post-colonial, gendered public identi...

This introduction to the Madhva school of Vedanta is accessible to a wide audience with interest in Hinduism, Indian thought and in the comparative philosophy of religion.Deepak Sarma explores the philosophical foundations of Madhva Vedanta and then presents translations of actual debates between the Madhva and Advaita schools of Vedanta, thus positioning readers at the centre of the 700 year-old controversy between these two schools of Vedanta. Original texts of Madhvacarya are included in an appendix, in translation and in (...) Sanskrit. (shrink)

In light of the recent events of terrorism and publicized cases of mass slayings and serial killings, there have been calls from the public and policy-makers alike for neuroscience and neurotechnology (neuroS/T) to be employed to intervene in ways that define and assess, if not prevent, such wanton acts of aggression and violence. Ongoing advancements in assessment neuroS/T have enabled heretofore unparalleled capabilities to evaluate the structure and function of the brain, yet each and all are constrained by certain technical (...) and practical limitations. In this paper, we present an overview of the capabilities and constraints of current assessment neuroS/T, address neuro-ethical and legal issues fostered by the use and potential misuse of these approaches, and discuss how neuroethics may inform science and the law to guide right and sound applications of neuroS/T to “deliver us from evil” while not being led into temptations of ampliative claims and inapt use. (shrink)

This article analyzes the past, the present, and the future of business institution in society in terms of its management approaches by using the framework of human evolution, and discovers a trend that explains three paradigms in business management that have been witnessed so far. Extending the trend, it projects another two paradigm shifts to take place in future, and establishes that the business management practice is going to evolve further where it will turn from its present status of ‘result-oriented (...) management’to ‘process-oriented management’ in terms of its focus, or in other words, it will evolve from ‘professional management’ to ‘ethical management’ in terms of its underlying philosophy. As a result, the business enterprise will evolve from its present form of economic organization to a humane organization, and further up to a divine organization. Expressed the other way round, the business institution that had kicked off as an industrial organization has got transformed to a human organization by now; however, in the future, it will further evolve to its final level of a divine organization. (shrink)

This paper introduce a new variant of the Genetic Algorithm whichis developed to handle multivariable, multi-objective and very high search space optimization problems like the solving system of non-linear equations. It is an integer coded Genetic Algorithm with conventional cross over and mutation but with Inverse algorithm is varying its search space by varying its digit length on every cycle and it does a fine search followed by a coarse search. And its solution to the optimization problem will converge to (...) precise value over the cycles. Every equation of the system is considered as a single minimization objective function. Multiple objectives are converted to a single fitness function by summing their absolute values. Some difficult test functions for optimization and applications are used to evaluate this algorithm. The results prove that this algorithm is capable to produce promising and precise results. (shrink)

Martin Heidegger’s writings on modern science as well as his stray remarks on communication are important theoretical resources to understand the character and contour of, and our response to the Anthropocene epoch. John Caputo distinguishes between the early hermeneutic account of science in Heidegger’s corpus and the later deconstructive account, claiming that the former would have sufficed to fulfil the critical task of the latter without its pejorative and dismissive reading of modern science. Accepting Caputo’s distinction but rejecting his critique (...) of the deconstructive account, this paper argues that Heidegger’s abandoning of the hermeneutic account was premised on the refusal of the Western metaphysical baggage that still pervades and is endorsed in that account, a baggage which is now leading to the Anthropocene epoch and the consequent ontological communication of distress. The deconstructive approach evokes the communication of scientific phenomena in plural ways such as fictional, poetical and metaphorical narratives, thus undercutting the reductionist and monolithic character of modern science. (shrink)

This paper attempts to show how Martin Heidegger’s phenomenological interpretation of Aristotle’s theory of rhetoric can be interpreted usefully to understand the existential dimension of communication. Heidegger’s treatment of communication as a phenomenon is ontologically broader as he locates it within the existential analytics of Dasein. Taking Heidegger’s 1924 Marburg lecture, Being and Time and other texts dealing with the problem of the being of language as theoretical sources, this study first presents the importance of Heidegger’s conception of rhetoric and (...) then shows how this throws light on the ontological aspects of communication as such. Human beings in their basic mode of existence as being-in-the-world and speaking-with-one-another is always already in communication through language. If rhetoric is a way of having the existential view about how matters present themselves in a particular manner by virtue of speaking about it with-one-another, then it is in the region of the doxa of people. Further, how existential communication works in our concrete life is demonstrated through a rhetorical analysis of the film Blow-Up. (shrink)

Is it possible to venture beyond daily living and experience heightened states of awareness? Deepak Chopra says that higher consciousness is available here and now. “Metahuman helps us harvest peak experiences so we can see our truth and mold the universe’s chaos into a form that brings light to the world.”—Dr. Mehmet Oz, attending physician, New York–Presbyterian, Columbia University New York Times bestselling author Deepak Chopra unlocks the secrets to moving beyond our present limitations to access a field (...) of infinite possibilities. How does one do this? By becoming metahuman. To be metahuman, however, isn’t science fiction and is certainly not about being a superhero. To be metahuman means to move past the limitation constructed by the mind and enter a new state of awareness where we have deliberate and concrete access to peak experiences that can transform people’s lives from the inside out. Humans do this naturally—to a point. For centuries the great artists, scientists, writers, and many so-called ordinary people have gone beyond the everyday physical world. But if we could channel these often bewildering experiences, what would happen? Chopra argues we would wake up to experiences that would blow open your body, mind, and soul. Metahuman invites the reader to walk the path here and now. Waking up, we learn, isn’t just about mindfulness or meditation. Waking up, to become metahuman, is to expand our consciousness in all that we think, say, and do. By going beyond, we liberate ourselves from old conditioning and all the mental constructs that underlie anxiety, tension, and ego-driven demands. Waking up allows life to make sense as never before. To make this as practical as possible, Chopra ends the book with a 31-day guide to becoming metahuman. Once you wake up, he writes, life becomes transformed, because pure consciousness—which is the field of all possibilities—dawns in your life. Only then does your infinite potential become your personal reality. (shrink)

TRASCIENDE LOS OBSTÁCULOS QUE AFECTAN A TU CUERPO Y A TU ESPÍRITU 15 años después de su gran clásicoCuerpos sin edad, mentes sin tiempo, Deepak Chopra revisa el “milagro olvidado”—la capacidad infinita de renovación y cambio del ...

Arguing against militant atheist thought, the author maintains that faith and spirituality are valuable practices that should be maintained, and outlines a path toward discovering God within intended to transform everyday life.

In photoreceptors of a dark adapted eye, the inward flux of sodium and calcium ions in the outer segment is balanced by the outward flux of potassium ions. But in the presence of light the creation of cyclic guanosine monophosphate in the outer segment decreases. Due to low concentration of cG the channels in the outer segment open relatively less and thus the influx of calcium ion decreases, leading finally to hyperpolarization of the photoreceptors. We have analyzed theoretically the effect (...) of oxidizing iron ions on the photoreceptors. In order to explain the effects of iron-induced oxidative stress, the different molecules and ions involved in phototransduction are quantified leading to a differential equation for calculating the electroretinogram a-wave voltage. The theoretical results are compared with published experimental data. In the presence of light, the iron ions could push outward the similarly charged calcium ions resulting in a small increase in the amount of inward calcium flux. Again, the presence of iron ions generates Reactive Oxygen Species, and ROS could attract the calcium ions which also increases the calcium flux. This will result in a reduction in the amplitude and slope of the a-wave voltage in the electroretinogram. These results are parametrized in terms of calcium ion concentrations. As the amplitude of the a-wave shows how much electrical signal is produced, its reduction indicates reduction in the visual signal. Thus, the increase in iron ions could explain the reduction in the electrical signal due to iron-induced oxidative stress. (shrink)

The proposed study aims to explore the concepts of self and identity in the philosophy of Śamkarāchārya, the Vedantic philosopher. This critical study seeks to foreground Śamkara, the account of the self that overcomes the limitations of the physicalist and the mentalist accounts of the human self. It focuses on the questions of the ownership of the self, the stability of identity despite the change, the consciousness and its relation to the self. It explains the notion of self by equating (...) the self with the body or with the mind, which does not explain our sense of owning or possessing a body or a mind. The idea of self can be philosophically analyzed at two different conceptual levels: 1) one can deal with the notion of self at a metaphysical level attempting to understand the meaning and significance of this notion in general; 2) one could also deal with the notion of self along with its contextualities and particularities where one would want to understand particular conceptualization that the individual self undergoes depending upon its contexts and particularities of its situation. I would try to analyze the notion of self and Identity in Śamkara in both these senses. Other questions that arise with regard to self and identity are as follows: what kind of relationship the self bears with its identity, pre-given or constructed? Is there anything essential about the identity of the individual self? If we take up these questions, then the question of caste and gender also surface in this debate significantly. Conceptually, the self, in Śamkara’s thought, is explained concerning the ‘not self’. He argues that neither the body, nor the senses, nor even the mind can be equated with the self. That is why Brahman has been described negatively as “neti neti-not this not this”. What is the natural self and identity that one is experiencing here and now? How do we identify one self? What does it consist of? These are some of the questions that I will explicate in this paper. (shrink)

Tucked away in the foothill of a mountain in the Kathmandu Valley, Mātā Tirtha defies the description of a sacred tirtha. It is neither situated between the confluences of two rivers nor is it dedicated to the God Viṣṇu, as are most of the tirthas in India. And yet, Mātā Tirtha continues to become popular within the valley among citizens of all faiths. What is unique about Mātā Tirtha? This paper sets out to trace its origins by examining its history, (...) folklore, and the myths that surround the sacred site. Positioned as a tirtha, it is dedicated specifically to the mother—the mothers of all men and women whose mothers have passed away. For that reason, Mātā Tirtha stands out as unique. Nothing similar is to be found in India. In terms of geography, Mātā Tirtha has a unique place in the religious landscape of the Kathmandu Valley, while its historic sanctity dates back to the seventeenth century during the reign of King Pratapa Malla. Legend, however, pushes it back to an even earlier existence. Today, visitors of all religious persuasions come to Mātā Tirtha to honor their mothers who have passed away. (shrink)

In _Reliable Reasoning_, Gilbert Harman and Sanjeev Kulkarni -- a philosopher and an engineer -- argue that philosophy and cognitive science can benefit from statistical learning theory, the theory that lies behind recent advances in machine learning. The philosophical problem of induction, for example, is in part about the reliability of inductive reasoning, where the reliability of a method is measured by its statistically expected percentage of errors -- a central topic in SLT. After discussing philosophical attempts to evade (...) the problem of induction, Harman and Kulkarni provide an admirably clear account of the basic framework of SLT and its implications for inductive reasoning. They explain the Vapnik-Chervonenkis dimension of a set of hypotheses and distinguish two kinds of inductive reasoning. The authors discuss various topics in machine learning, including nearest-neighbor methods, neural networks, and support vector machines. Finally, they describe transductive reasoning and suggest possible new models of human reasoning suggested by developments in SLT. (shrink)

Do you have to be one to know one? Madhvàcàrya, the founder of the thirteenth century school of Vedànta, answered this question with a resounding 'yes!' Madhvàcàrya's insistence that one must be a Màdhva to study Màdhva Vedànta led him to employ various strategies to exclude outsiders and unauthorized readers from accessing the root texts of his tradition and from obtaining oral commentary from living virtuosos. Deepak Sarma explores the degree to which outsiders can understand and interpret the doctrine (...) of the Màdhva school of Vedànta. The school is based on insider epistemology which is so restrictive that few can learn its intricate doctrines. This book reveals the complexity of studying traditions based on insider epistemologies and encourages its audience to ponder both the value and the hazards of granting any outsider the authority and opportunity to derive important insights into a tradition as an insider. The first analysis of the Màdhva tradition, this work contributes to the ongoing controversies regarding epistemic authority and voice in religious studies. (shrink)

Selections and accompanying materials inspire a reassessment of long-held presuppositions and modes of thought, and accessible translations prove the modern relevance of these enduring works.

The article focuses on the ‘meaningfulness in work’ concept and addresses three theoretical gaps by investigating ‘meaningfulness in work’ from the perspective of Heidegger’s ‘authenticity’ and ‘Dasein’ constructs as well as virtue ethics. First, it adapts Heideggerian phenomenology and argues that meaningfulness in work may be revealed to an ‘authentic’ employee, while they performs everyday activities by ‘existing’ in their world and discovers their Dasein. Second, it emphasizes the normative, as opposed to instrumental implications of meaningfulness and invokes virtue ethics (...) towards this end. Third, it integrates the Heideggerian approach with virtue ethics to describe how an ‘authentic’ and ‘virtuous’ employee may achieve meaningfulness in work (conceptualized as ‘eudaimonia’). An ‘authentic virtuous employee’ ‘exists in their world’ and discovers what is truly meaningful in work to them. They also displays temperance and courage in terms of closing the gaps between current and desired levels of meaningfulness in work, and continually contemplates it. We describe a ‘professional’ as an example of an ‘authentic virtuous employee’. (shrink)

The Marquis de Sade has been labeled everything from a sadomasochistic pornographer to the fiction writer responsible for the ideas that led to the Nazi death camps. Must We Burn Sade? peels away the negative legacy that has shrouded Sade for too long. Deepak Narang Sawhney points out that "Sade's legacy has been neglected, recreated, fictionalized, and venerated by medical guilds, literary hacks, religious detractors, and intellectual movements. In the past two centuries, Sade has come to represent many things (...) for many people.... It is unclear whether we know Sade the writer or the apparatus which has been set up to either condemn or to sanctify his life and work." By contrast, this intriguing collection of essays seeks to examine Sade for what he was—a writer of novels and letters, a creator of plays and stories, and an author of essays and political manifestos. The contributors examine the literary, theatrical, political, social, and philosophical aspects of Sade's work, acquitting him of the false accusations and trials that have plagued his name by revealing his influences and motivations, and by providing an understanding of society's fear of Sade. What is so alarming about Sade's books that civilized society has felt compelled to disassociate itself from his works? This volume forces us to rethink Sade. Included are essays by Kathy Acker, David Allison, Georges Bataille, Catherine Cusset, Lucienne Frappier-Mazur, Annie Le Brun, Alphonso Lingis, Stephen Pfohl, Deepak Narang Sawhney, Philippe Sollers, and Alistair Welchman. (shrink)

The author offers a commentary on the question, “Are there Hindu bioethics?” After deconstructing the term “Hindu,” the author shows that there are indeed no Hindu bioethics. He shows that from a classical and Brahminical perspective, medicine is an inappropriate and impure profession.

Not much work has been done on Hindu bioethics other than by a select few scholars and medical doctors. Professor Cromwell Crawford, author of Dilemmas of Life and Death: Hindu Ethics in a North American Context and Hindu Ethics for the Twenty-first Century, for example, is well known in the field of Hindu bioethics. Others scholars include Dr. Uma Mysorekar, who is a gynecologist as well as the president of the board of trustees of the Ganesha Temple of Flushing New (...) York. She has published several short pieces on Hindu bioethics, and has even been interviewed by PBS for their “Religion and Ethics” program. Dr. H. L. Trivedi, director of the Institute of Kidney Diseases and Research Center at the Civil Hospital Campus in Ahmedabad, India, is also prominent. His pithy paragraph in Transplant Proceedings on Hinduism and organ transplantation is cited with enormous frequency on the Internet and elsewhere. These thinkers, however, are unequivocally wrong in their position that Hinduism supports organ transplantation, and, more importantly, that it offers any coherent or systematic bioethics whatsoever. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Response to Robert Zydenbos' Review of An Introduction to Mādhva VedāntaDeepak SarmaIntroductionI am grateful to the editors of Philosophy East and West for asking me to write a response to Zydenbos' review of my book, An Introduction to Mādhva Vedānta. To this end, I will address four issues: typographical errors, unfounded claims about my translations, content and problems of method and theory, and the future of scholarship in Mādhva (...) Vedānta.Typographical DoṣasFirst, I wish to thank Zydenbos for pointing out the typographical errors. I take full responsibility for them and I intend to correct them in future editions. These are unintentional mistakes and should not be taken as an accurate indicator of my academic ability. I invite readers to examine my other publications on Mādhva Vedānta and to decide for themselves. Jayatīrtha (1365-1388 C.E.), a renowned Mādhva commentator, explained the reasons for such errors in his Pramāṇapad-dhati. He held that defective eyes, whether from cataract, jaundice, or the like,1 [End Page 670] can give rise to defective knowledge, and further, that if an object is too far away, too near, too small, obstructed, or even mixed with similar things, then this will give rise to incorrect knowledge.2 I knew that such errors were likely to occur (especially given the size of the fonts in the page proofs!), which is why I wrote the following in my acknowledgments: "Errors that remain in this text are entirely my own responsibility. If any are found I beg your forgiveness and hope that they inspire you to further study Mādhva Vedānta!" (p. xi). Perhaps all of the undue attention paid by Zydenbos to typographical errors (he devoted a significant portion of his review to them) will inspire further study!TranslationsI am delighted that Zydenbos found my translations to be "not badly done" and disappointed that he incorrectly "assumes" that they are not my own. Rest assured that they are mine. I was assisted by Professor Lawrence McCrea and scholars of the Pūrṇaprajña Saṃśodhana Mandiram (PPSM) and have dutifully acknowledged all of them in my book (p. xii). Zydenbos should know better than to speculate about matters he has no knowledge of.Content and Methodological IssuesThe typographical errors and accusations of plagiarism are far less interesting than the points that were raised about the content of my book. Disputes in the West about interpretations of Mādhva Vedānta are recent; it has been largely ignored in favor of Buddhism and the crypto-Buddhist school, namely Advaita Vedānta. There have been very few books on Mādhva Vedānta written by outsiders, and those few are no longer in print, are poorly written, use dated language, or are in a language that is not available to most lay Mādhvas. Interpretations of Mādhva doctrines made by their authors have remained unquestioned by Western readers given the relative novelty and obscurity of Mādhva Vedānta, while Mādhva insiders have ignored most of them. It is wonderful, then, that Zydenbos doubts my interpretations. After all, his disputes are among the first ones published by an outsider concerning the interpretation of Mādhva doctrines.3Zydenbos' skepticism is reason for celebration for it indicates that Western scholarship on Mādhva Vedānta has come of age. There are now enough scholars of Mādhva Vedānta (or, rather, scholars who claim knowledge of Mādhva Vedānta) in the West that such a debate can occur. I invite others to investigate the points of dispute and to join this expanding community!Zydenbos has also faulted me on the organizational principles of my introductory text. I have, as he correctly notes, intentionally ignored issues of contemporary politics, a topic that he finds essential. Although some historical and political issues are relevant, I find that philosophical discourse sans context is far more intellectually appealing. I am well aware of my biases and have acknowledged the limitations of my historical analysis: [End Page 671]... the history presented here is not intended to be comprehensive. Instead, it is intended... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Response to Robert Zydenbos' Review of An Introduction to Mādhva VedāntaDeepak SarmaIntroductionI am grateful to the editors of Philosophy East and West for asking me to write a response to Zydenbos' review of my book, An Introduction to Mādhva Vedānta. To this end, I will address four issues: typographical errors, unfounded claims about my translations, content and problems of method and theory, and the future of scholarship in Mādhva (...) Vedānta.Typographical DoṣasFirst, I wish to thank Zydenbos for pointing out the typographical errors. I take full responsibility for them and I intend to correct them in future editions. These are unintentional mistakes and should not be taken as an accurate indicator of my academic ability. I invite readers to examine my other publications on Mādhva Vedānta and to decide for themselves. Jayatīrtha (1365-1388 C.E.), a renowned Mādhva commentator, explained the reasons for such errors in his Pramāṇapad-dhati. He held that defective eyes, whether from cataract, jaundice, or the like,1 [End Page 670] can give rise to defective knowledge, and further, that if an object is too far away, too near, too small, obstructed, or even mixed with similar things, then this will give rise to incorrect knowledge.2 I knew that such errors were likely to occur (especially given the size of the fonts in the page proofs!), which is why I wrote the following in my acknowledgments: "Errors that remain in this text are entirely my own responsibility. If any are found I beg your forgiveness and hope that they inspire you to further study Mādhva Vedānta!" (p. xi). Perhaps all of the undue attention paid by Zydenbos to typographical errors (he devoted a significant portion of his review to them) will inspire further study!TranslationsI am delighted that Zydenbos found my translations to be "not badly done" and disappointed that he incorrectly "assumes" that they are not my own. Rest assured that they are mine. I was assisted by Professor Lawrence McCrea and scholars of the Pūrṇaprajña Saṃśodhana Mandiram (PPSM) and have dutifully acknowledged all of them in my book (p. xii). Zydenbos should know better than to speculate about matters he has no knowledge of.Content and Methodological IssuesThe typographical errors and accusations of plagiarism are far less interesting than the points that were raised about the content of my book. Disputes in the West about interpretations of Mādhva Vedānta are recent; it has been largely ignored in favor of Buddhism and the crypto-Buddhist school, namely Advaita Vedānta. There have been very few books on Mādhva Vedānta written by outsiders, and those few are no longer in print, are poorly written, use dated language, or are in a language that is not available to most lay Mādhvas. Interpretations of Mādhva doctrines made by their authors have remained unquestioned by Western readers given the relative novelty and obscurity of Mādhva Vedānta, while Mādhva insiders have ignored most of them. It is wonderful, then, that Zydenbos doubts my interpretations. After all, his disputes are among the first ones published by an outsider concerning the interpretation of Mādhva doctrines.3Zydenbos' skepticism is reason for celebration for it indicates that Western scholarship on Mādhva Vedānta has come of age. There are now enough scholars of Mādhva Vedānta (or, rather, scholars who claim knowledge of Mādhva Vedānta) in the West that such a debate can occur. I invite others to investigate the points of dispute and to join this expanding community!Zydenbos has also faulted me on the organizational principles of my introductory text. I have, as he correctly notes, intentionally ignored issues of contemporary politics, a topic that he finds essential. Although some historical and political issues are relevant, I find that philosophical discourse sans context is far more intellectually appealing. I am well aware of my biases and have acknowledged the limitations of my historical analysis: [End Page 671]... the history presented here is not intended to be comprehensive. Instead, it is intended... (shrink)

Background and rationale Several factors that motivate individuals to participate in non-therapeutic studies have been identified. This study was conducted as limited data is available regarding these motivations from developing countries. Methods This was a single-centre study conducted over 4 months in which a questionnaire was administered to 102 healthy participants and 16 patient participants who had earlier taken part in non-therapeutic studies at our centre. Descriptive statistics and univariate analysis were used to analyse data. Results The most common motivation (...) among healthy participants was financial reward (65%) followed by altruism, free medical check up, curiosity and personal health benefit. Patient participants, however, most commonly said they consented to take part in the trial as they were ‘invited to participate by the treating physician’ (88%). In comparison with the patient participants, healthy participants were more likely to be satisfied with the financial reward (p=0.02), and recommend participation in studies to friends or relatives (p=0.0013). Conclusions The most common motivating factor to participate in non-therapeutic studies appears to be different for healthy participants (financial reward) and patient participants (invitation to participate by the physician). Participants also felt that adequate information and care was given to them during the trial, and that they would participate in future clinical studies, and would also recommend such studies to their friends. (shrink)

The problem of induction is sometimes motivated via a comparison between rules of induction and rules of deduction. Valid deductive rules are necessarily truth preserving, while inductive rules are not.

Reviving the Invisible Hand is an uncompromising call for a global return to a classical liberal economic order, free of interference from governments and international organizations. Arguing for a revival of the invisible hand of free international trade and global capital, eminent economist Deepak Lal vigorously defends the view that statist attempts to ameliorate the impact of markets threaten global economic progress and stability. And in an unusual move, he not only defends globalization economically, but also answers the cultural (...) and moral objections of antiglobalizers. Taking a broad cross-cultural and interdisciplinary approach, Lal argues that there are two groups opposed to globalization: cultural nationalists who oppose not capitalism but Westernization, and "new dirigistes" who oppose not Westernization but capitalism. In response, Lal contends that capitalism doesn't have to lead to Westernization, as the examples of Japan, China, and India show, and that "new dirigiste" complaints have more to do with the demoralization of their societies than with the capitalist instruments of prosperity. Lal bases his case on a historical account of the rise of capitalism and globalization in the first two liberal international economic orders: the nineteenth-century British, and the post-World War II American. Arguing that the "new dirigisme" is the thin edge of a wedge that could return the world to excessive economic intervention by states and international organizations, Lal does not shrink from controversial stands such as advocating the abolishment of these organizations and defending the existence of child labor in the Third World. (shrink)

Stochastic forecasts in complex environments can benefit from combining the estimates of large groups of forecasters (“judges”). But aggregating multiple opinions faces several challenges. First, human judges are notoriously incoherent when their forecasts involve logically complex events. Second, individual judges may have specialized knowledge, so different judges may produce forecasts for different events. Third, the credibility of individual judges might vary, and one would like to pay greater attention to more trustworthy forecasts. These considerations limit the value of simple aggregation (...) methods like linear averaging. In this paper, a new algorithm is proposed for combining probabilistic assessments from a large pool of judges. Two measures of a judge’s likely credibility are introduced and used in the algorithm to determine the judge’s weight in aggregation. The algorithm was tested on a data set of nearly half a million probability estimates of events related to the 2008 U.S. presidential election (∼ 16000 judges). (shrink)

Many in both developed and developing countries fear global economic integration. But developing‐country fears of volatile capital flows are unfounded, as are developed‐country fears of pauper wages due to low‐cost imports. Demands for “ethical trading” are as misplaced as the fears of Third‐World cultural nationalists that globalization will destroy their valued ways of life.