Background:Nurses and nursing students appear vulnerable to moral distress when faced with ethical dilemmas or decision-making in clinical practice. As a result, they may experience professional dissatisfaction and their relationships with patients, families, and colleagues may be compromised. The impact of moral distress may manifest as anger, feelings of guilt and frustration, a desire to give up the profession, loss of self-esteem, depression, and anxiety.Objectives:The purpose of this review was to describe how dilemmas and environmental, relational, and organizational factors contribute (...) to moral distress in undergraduate student nurses during their clinical experience and professional education.Research design:The research design was a systematic literature review.Method:The search produced a total of 157 articles published between 2004 and 2014. These were screened with the assessment sheet designed by Hawker and colleagues. Four articles matched the search criteria (one quantitative study and three qualitative), and these were separately read and analyzed by the researchers. The process of review and analysis of the data was supervised by a colleague experienced in moral distress who provided an independent quality check.Ethical consideration:Since this was a systematic review, no ethical approval was required.Findings:From the analysis, it emerged that inequalities and healthcare disparities, the relationship with the mentor, and students’ individual characteristics can all impact negatively on the decisions taken and the nursing care provided, generating moral distress. All these factors condition both the clinical experience and learning process, in addition to the professional development and the possible care choices of future nurses.Conclusion:Few studies dealt with moral distress in the setting of nurse education, and there is a knowledge gap related to this phenomenon. The results of this review underline the need for further research regarding interventions that can minimize moral distress in undergraduate nursing students. (shrink)

Background:Prisons are contexts where nurses are required to have specific skills to ensure that, in a setting designed for the expiation of crime, prisoners receive the same type of care as anyone else. But this is not always the case, giving rise to ethical issues.Research questions:‘How do correctional nurses describe their working experience in prisons? What issues emerged?’Methodology:This is a qualitative descriptive study. Following purposive sampling, we conducted five focus groups. Thematic analysis was used to analyse the data.Participants and research (...) context:Our sample included 31 correctional nurses in seven prisons in Northern Italy.Ethical considerations:The scientific merit of this study was recognized by the Academic Board of the University of Genoa. Approval to conduct the study was obtained from the Liguria Regional Government that funded this study and from the Local Health Authority that was the prison nurses’ employer. Formal consent was obtained from all the nurses who volunteered to participate in this study.Findings:Five themes emerged from the focus groups: prisoners’ healthcare needs, negotiation between custody and care, satisfaction of working in prisons, obstacles to quality care and safety. ‘Manipulation’ was a transversal theme that emerged from all the focus groups.Discussion:The problems generated by the clash between prison security and nursing care priorities did not enable nurses to practice autonomously and provide the best possible to care prisoners, giving rise to ethical issues and moral distress. This in turn causes high nursing turnover rates that negatively impact continuum of care.Conclusion:In Italy, correctional nurses urgently require specific education interventions with the participation of all those who work in prisons. Interventions based on the post-modern concept of restorative nursing could offer prison nurses the opportunity to both resolve ethical issues and reduce moral distress. (shrink)

Ethical concerns in e-social science are often raised with respect to privacy, confidentiality, anonymity and the ethical and legal requirements that govern research. In this article, the authors focus on ethical aspects of e-research that are not directly related to ethical regulatory framework or requirements. These frameworks are often couched in terms of benefits or harms that can be incurred by participants in the research. The authors shift the focus to the sources of value in terms of which benefits or (...) harms are understood in real social situations. A central claim of this paper is that the technologies that are used for research are not value neutral, but serve to reinforce some values at the expense of others. The authors discuss databases, modelling and simulation, network analysis as examples of technologies which affect the articulation of values. A view of e-social science as a techno-scientific constellation of researchers, technologies and society, in which values are always already embedded, is put forward as a basis for a view of ethics as reflexive and active engagement, conducted with awareness. Methodological pluralism and proactive openness are also proposed as responses to this view of the ethical dimensions of e-social science. (shrink)

Since the 1980s, several studies of visual perception have persuasively argued that important aspects of human vision are best accounted for not by recourse to inner mental representations but rather through socially observable actions and behaviors (e.g. Lynch 1985, Latour 1986, Lynch 1990, Goodwin 1994, Goodwin 1997, Sharrock & Coulter 1998). While there are clearly physiological mechanisms required for vision, psychological accounts of perception in terms of inner mental representations have been dislodged from their position as the basic term in (...) the interface between human beings and their environment and replaced with terms such as "social practice," and "vernacular intelligibility." The focus for these .. (shrink)

The collaborative ‹Big Science’ approach prevalent in physics during the mid- and late-20th century is becoming more common in the life sciences. Often computationally mediated, these collaborations challenge researchers’ trust practices. Focusing on the visualisations that are often at the heart of this form of scientific practice, the paper proposes that the aesthetic aspects of these visualisations are themselves a way of securing trust. Kant’s account of aesthetic judgements in the Third Critique is drawn upon in order to show that (...) the image-building capability of imagination, and the sensus communis, both of which are integral parts of aesthetic experience, play an important role in building and sustaining community in these forms of science. Kant’s theory shows that the aesthetic appeal of scientific visualisations is not isolated from two other dimensions of the visualisations: the cognitive-epistemic, aesthetic-stylistic and interpersonal dimensions, and that in virtue of these inter-relationships, visualisations contribute to building up the intersubjectively shared framework of agreement which is basic for trust. (shrink)

As data-intensive and computational science become increasingly established as the dominant mode of conducting scientific research, visualisations of data and of the outcomes of science become increasingly prominent in mediating knowledge in the scientific arena. This position piece advocates that more attention should be paid to the epistemological role of visualisations beyond their being a cognitive aid to understanding, but as playing a crucial role in the formation of evidence for scientific claims. The new generation of computational and informational visualisations (...) and imaging techniques challenges the philosophy of science to re-think its position on three key distinctions: the qualitative/quantitative distinction, the subjective/objective distinction, and the causal/non-causal distinction. (shrink)

Pila (2009) has criticised the recommendations made by requirements engineers involved in the design of a grid technology for the support of distributed readings of mammograms made by Jirotka et al. (2005). The disagreement between them turns on the notion of “biographical familiarity” and whether it can be a sound basis for trust for the performances of professionals such as radiologists. In the first two sections, this paper gives an interpretation of the position of each side in this disagreement and (...) their recommendation for the design of technology for distributed reading, and in the third the underlying reasons for this is agreement are discussed. It is argued that Pila, in attempting to make room for mistrust as well as trust, brings to the fore the question of having and reflecting upon reasons for trust or mistrust. Pila holds that biographical familiarity is not a sound reason for trust/mistrust, as it seems to obliterate the possibility of mistrust. In response to her proposal, an analysis is proposed of the forms of trust involved in biographical familiarity. In particular, implicit trust is focused upon — as a form of trust in advance of reasons, and as a form of trust contained (in the logical sense) within other reasons. It is proposed that implicit trust has an important role in establishing an intersubjectively shared world in which what counts as a reason for the acceptability of performances such as readings of X-rays is established. Implicit trust, therefore, is necessary for professionals to enter into a “space of reasons”. To insist upon judgements made in the absence of the form of implicit trust at play in biographical familiarity is to demand that radiologists (and other relevantly similar professionals) make judgements regarding whether to trust or mistrust on the basis of reasons capable of being reflected upon, but at the same time leave them without reasons upon which to reflect. (shrink)

Desde sus inicios, la globalización se ha manifestado como un acontecimiento de alcance extraordinario, sobre todo para la superación de las distancias de relaciones y valores entre los individuos. La globalización ha ampliado los espacios de reglamentación, pero ha puesto de manifiesto también como la hiperproducción normativa se corresponde con una inadecuación de las normas para solucionar los problemas sociales complejos. De ahí el conflicto o la “contradicción” creciente entre derecho y sociedad, así como la incapacidad del derecho para producir (...) justicia o hacer justicia, en el sentido de colmar la distancia entre los individuos y entre los individuos y las instituciones. La respuesta aparentemente resolutiva de dicha problemática ha venido de la praxis, de la multiplicación de instrumentos mediadores, que parecen poder detener la situación de emergencia generalizada que caracteriza hoy el mundo de la justicia. La mediación es, al mismo tiempo, el resultado de un proceso radical de innovación en la regulación y de gestión de la conflictividad, y una modalidad comunicativa de las nuevas expectativas de justicia social e individual. (shrink)

The author analyses the legal culture of our time trying to make explicit the dynamics that form the basis of the present socio-normative order through an examination of the essential changes in the world of norms and of regulations in general. In particular, the analysis focusses on the structural transformation of law and on the loss of the traditional space-time dimension of regulation in the context of globalization. In the second place, she indicates the changes in the forms of communication (...) such as the fundamental presuppositions from which the problem of the new rights is tackled. The conclusion is that the regulating and directive function of pre-global law is losing ground to new resolution techniques such as mediation. (shrink)

This paper is a comparative study based on the linguistic evidence in Vedic Sanskrit and Homeric Greek, aimed at reconstructing the space-time cognitive models used in the Proto-Indo-European language in a diachronic perspective. While it has been widely recognized that ancient Indo-European languages construed earlier events as in front of later ones, as predicted in the Time-Reference-Point mapping, it is less clear how in the same languages the passage took place from this ‘archaic’ Time-RP model or non-deictic sequence, in which (...) future events are behind or follow the past ones in a temporal sequence, to the more recent ‘post-archaic’ Ego-RP model that is found only from the classical period onwards, in which the future is located in front and the past in back of a deictic observer. Data from the Rigveda and the Homeric poems show that an Ego-RP mapping with an ego-perspective frame of reference could not have existed yet at an early Indo-European stage. In particular, spatial terms of front and behind turn out to be used with reference not only to temporal events, but also to east and west respectively, thus presupposing the existence of an absolute field-based FoR which the temporal sequence is metaphorically related to. Specifically, sequence is relative position on a path appears to be motivated by what has been called day orientation frame, in which the different positions of the sun during the day motivate the mapping of front onto ‘earlier’ and behind onto ‘later’, without involving ego’s ‘now’. These findings suggest that early Indo-European still had not made use of spatio-temporal deixis based on the tense-related ego-perspective FoR found in modern languages. (shrink)

In clinical practice, decision-making is not performed by individual knowers but by an assemblage of people and instruments in which no one member has full access to every piece of evidence. This is due to decision making teams consisting of members with different kinds of expertise, as well as to organisational and time constraints. This raises important questions for the epistemology of medicine, which is inherently social in this kind of setting, and implies epistemic dependence on others. Trust in these (...) contexts is a highly complex social practice, involving different forms of relationships between trust and reasons for trust: based on reasons, and not based on reasons; based on reasons that are easily accessible to reflection and others that are not. In this paper, we focus on what it means to have reasons to trust colleagues in an established clinical team, collectively supporting or carrying out every day clinical decision-making. We show two important points about these reasons, firstly, they are not sought or given in advance of a situation of epistemic dependence, but are established within these situations; secondly they are implicit in the sense of being contained or nested within other actions that are not directly about trusting another person. The processes of establishing these reasons are directly about accomplishing a task, and indirectly about trusting someone else’s expertise or competence. These processes establish a space of reasons within which what it means to have reasons for trust, or not, gains a meaning and traction in these team-work settings. Based on a qualitative study of decision-making in image assisted diagnosis and treatment of a complex disease called pulmonary hypertension (PH), we show how an intersubjective framework, or ‘space of reasons’ is established through team members forging together a common way of identifying and dealing with evidence. In dealing with images as a central diagnostic tool, this also involves a common way of looking at the images, a common mode or style of perception. These frameworks are developed through many iterations of adjusting and calibrating interpretations in relation to those of others, establishing what counts as evidence, and ranking different kinds of evidence. Implicit trust is at work throughout this process. Trusting the expertise of others in clinical decision-making teams occurs while the members of the team are busy on other tasks, most importantly, building up a framework of common modes of seeing, and common ways of identifying and assessing evidence emerge. It is only in this way that trusting or mistrusting becomes meaningful in these contexts, and that a framework for epistemic dependence is established. (shrink)

Late archaic lyric poetry tends to obscure all pathetic and tragic elements of Achilles’ destiny present in the Iliad. The offence against his honour, his grief for Patroclus, his yearning for native Phthia, and a painful awareness of being ὠκύμορος – none of these themes play a role in the passages of Pindar, Bacchylides or Simonides where Achilles is mentioned. Yet each of these three poets operates differently with regard to the epic source, and it is worth investigating how they (...) do so. (shrink)

Certain strands of modern literature and philosophy have laid pronounced emphasis upon the impossibility of sharing the experience of dying: in the face of death, all social bonds dissolve and the human being finds himself in the deepest and most inescapable of solitudes. Greek myth, however, depicts stories in which death is physically shared by two individuals, or magically transferred from one individual to another: such stories provide a fascinating starting point for comparing ancient and modern views on the same (...) problem, or, rather, for exploring ancient perspectives on a modern problem. This article takes as its premise the idea that ‘death’ as an abstract notion is a human construct, and argues that feelings and questions associated with death, such as that of its inexorable power to isolate the dying person psychologically from the rest of mankind, are not intrinsic to the phenomenon, but instead determined by culture. (shrink)

Knowledge does not float free of the technologies available for its production and presentation. The intimate connection between ideas and praxis - embodied, technological, social - exemplified in any knowledge practice is, in the terms of Ihde & Selinger (2004), an 'epistemology engine'. This refers to the material-semiotic connections that obtain for any specific rendering of an idea. Often this material-semiotic connection is easier to recognise in the case of art than in that of knowledge, where it appears more-or-less obvious (...) that the rendering of an idea in poetic rather than prose form, in musical rather than linguistic form, in plastic rather than digital form, makes a difference to the idea. However, it is also recognisable (if not always actually recognised) in science, where there is a keen awareness of visual media alongside or instead of discursive media. -/- Ideas on the Internet shift and change as they pass through different networks of meaning production and communication, in different media and modalities. Different disciplines and modes of knowledge have either embraced these possibilities of transmogrification or remained aloof. Philosophy is one of the latter, and seems still steadily rooted to the discursive world. However, as a discipline, it overlaps in interesting ways both with science and with art. What are the epistemology-engines that apply to philosophy, and are there specific philosophy-engines? This is the background against which the applications to e-learning in philosophy will be considered. -/- In previous work, I claimed that the nature of philosophical argument cannot simply be assumed to remain constant even in the use of relatively simple discursive technologies such as discussion boards (Carusi 2006). In the present paper I consider a range of other technologies that form the technological culture of philosophy, or which mediate it. The paper aims to open a line of enquiry into these underlying technologies and the kinds of philosophy-engine that emerge from them, individually or by way of a convergence of a set of technologies. In particular, I focus on text-mining techniques, visualisations, and modeling showing what potential they have for disturbing, derailing, re-shaping or transforming the mode, form or substance of philosophy. -/- . (shrink)

Most of the essential cellular components, like nucleic acids, lipids and sugars, are phosphorylated. The phosphate equilibrium in Escherichia coli is regulated by the phosphate (Pi) input from the surrounding medium. Some 90 proteins are synthesized at an increased rate during Pi starvation and the global control of the cellular metabolism requires cross‐talk with other regulatory mechanisms. Since the Pi concentration is normally low in E. coli's natural habitat, these cells have devised a mechanism for synthesis of about 15 proteins (...) to accomplish two specific functions: transport of Pi and its intracellular regulation. The synthesis of these proteins is controlled by two genes (the phoB‐phoR operon), involving both negative and positive functions. PhoR protein is a histidine protein kinase, induced in Pi starvation and is a transmembrane protein. It phosphorylates the regulator protein PhoB which is also Pi starvation‐induced. The PhoB phosphorylated form binds specifically to a DNA sequence of 18 nucleotides (the pho Box), which is part of the promoters of the Pho genes. The genes controlled by phoB constitute the Pho regulon.The repression of phoA (the gene encoding alkaline phosphatase) by high Pi concentrations in the medium requires the presence of an intact Pst operon (pstS, pstC, pstA, pstB and phoU) and phoR. The products of pstA and pstC are membrane bound, whereas the product of pstS is periplasmic and PstB and PhoU proteins are cytoplasmic. The function of the PhoU protein may be regulated by cofactor nucleotides and may be involved in signaling the activation of the regulon via PhoR. (shrink)

In recent years, the contribution of various disciplines and professionals (i.e. from marketing, computer science, psychology and pedagogy) to museum management has encouraged the development of a new conception of museology. Specifically, psychology has affected the overall conception of museum and the visitors towards a more holistic vision of the museum experience as a complexity of memory, personal drives, group identity, meaning-making process, as well as leisure preferences. In this regard, psychological research contributes to advance the scientific knowledge about psychological (...) and social phenomena related to the visitor experience, as well as to design innovative technologies and future tourism services. The present contribution discusses the Socio-Cultural Activity Theory as a theoretical framework to conceptualize the museum visit as an activity mediated by the technology, and to better identify the factors shaping the interaction between the visitors and the technologies. To do so, a case study is presented: a qualitative research performed at the Ara Pacis Museum in Rome (Italy) to analyze the visitor experience of a tour that integrates augmented and virtual reality. Information derived from applying Activity Theory on visitors’ experience highlight the value of technology as mediating tool between the museum mission and the visitor experience, considering the interaction between visitors’ characteristics, museum environmental dimensions and technology’s features. (shrink)

In recent years a growing number of scholars in science studies and related fields are developing new ontologies to displace entrenched dualisms. These efforts often go together with a renewed interest in the roles played by symbolisms and tools in knowledge and being. This article brings Maurice Merleau-Ponty into these conversations, positioning him as a precursor of today’s innovative recastings of technoscience. While Merleau-Ponty is often invoked in relation to his early work on the body and embodiment, this article focuses (...) on his later work, where the investigation of perception is integrated with an ontological exploration. The resulting approach revolves around the highly original idea of the body as a standard of measurement. We further develop this idea by coining the term ‘the measuring body’, which to a greater extent than did Merleau-Ponty accentuates the relative autonomy of symbolisms and tools and their capacity to decentre the perceiving body. (shrink)

How is time framed in corporate social responsibility (CSR) talk? The literature mostly fails to analyze how multiple CSR activities are framed from a temporal perspective. Moreover, those researchers who undertake temporal framing tend to overlook the role of home-country cultural characteristics. Using a mixed-method analysis of 2,720 CSR reports from developing country companies, we show that CSR talk is mostly framed in the future tense when firms communicate complex human rights issues such as slavery or child labor, while the (...) past and present tenses are more frequent when they report on philanthropy and other cause-related activities. We find that these effects are stronger when firms are from countries characterized by greater uncertainty avoidance. We contribute to the CSR communication literature by showing that temporal references in CSR talk tend to differ, depending on the company-level control of CSR activities, and by highlighting uncertainty avoidance’s role as a boundary condition for aspirational talk’s performativity. (shrink)

This paper discusses the fallacies of combination and division as they are presented by Aristotle in chapter 4 of his Sophistici Elenchi. Aristotle's examples are concise, their discussion is unclear, and it is difficult to distinguish the cases of combination from those of division. I analyse the Aristotelian examples and the interpretations offered so far. I show that these interpretations suffer from a major defect: they fail to identify a common characteristic whereby the Aristotelian examples can be classified as instances (...) of combination or division. In my reconstruction of the examples, I repair this deficiency: I give a single pattern of explanation for the fallacy of combination and another (similar) pattern for the fallacy of division. Thus, it is possible to free Aristotle from the following charges: (i) he did not clearly distinguish between combination and division, and (ii) he reduced combination and division to a single fallacy. My explanation of the fallacies uses the notion of scope of an expression: in modern terminology, the fallacy of combination can be described as ?fallacy of the wide scope?, the fallacy of division as ?fallacy of the narrow scope? (shrink)

The article is an exploration of online reading from the perspective of theories of reading and interpretation based on literary theory and the phenomenology of reading literary text. One of its aims is to show that such theories can make a contribution to our understanding of reading and to our design of online reading spaces. The precursor of this stance is the form of hypertext theory originally proposed by George Landow, which predicted radical changes in reading practices with an impact (...) not only on literature but on education in general. The prediction has been slow to be verified and has been criticized by empirical and psychological studies. In this article, hypertext theory is compared to the phenomenology of reading linear literary text, with particular attention paid to the role played by the notion of a text, work or ‘whole’ which is constructed or produced during the course of reading. I show that the active and engaged reading predicted by hypertext theory is available in reading linear literary text, and to a higher degree than in reading hypertext, and consider ways in which the kinds of reading process which occur in reading literature can be generalized to reading for other higher education purposes. Finally, I speculate as to the range of online technologies that could be used to encourage these reading processes, and propose an alternative online reading space. (shrink)

The paper reconstructs an emblematic case of the relationship between scientific models and metaphors, showing how it is just a metaphor to shape the new image of the life promoted by Claude Bernard in the context of nineteenth-century biology. In fact, the scientist chooses to map a field that is still little known by transferring properties and relations taken from the domain of the art. Using this heuristic fiction, Bernard can claim the originality of biological science and its independence from (...) the physical and chemical sciences, without putting into question its deterministic system and its status as an experimental science. (shrink)

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...) identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies. (shrink)

This paper aims to focus on the Weberian concept of Weltbild, considered as one of the most important analytic instruments of his sociology. I will argue that Weltbilder have a mainly cognitive function, with a direct practical effect: they are framing devices, that allow men to orient themselves in the world. In this sense, the Weberian concept of Weltbild differs from the notion of Ideology. I will base my argument on two different elements: the peculiar theoretical status of World-images and (...) their relationship with material factors. Unlike ideologies, in fact, Weltbilder do not deal with the distinction true-false: they are conceivable as cultural constructions, the relationship with whom can only take the form of belief. Secondly, they are not simply functional products of material interests: in Weberian analysis, ideal and material factors have a mutual influence, that is not deducible by a rule. (shrink)

In this issue, Pila (2009) has criticised the recommendations made by requirements engineers involved in the design of a grid technology for the support of distributed readings of mammograms made by Jirotka et al. (2005). The disagreement between them turns on the notion of “biographical familiarity” and whether it can be a sound basis for trust for the performances of professionals such as radiologists. In the first two sections, this paper gives an interpretation of the position of each side in (...) this disagreement and their recommendation for the design of technology for distributed reading, and in the third the underlying reasons for this disagreement are discussed. It is argued that Pila, in attempting to make room for mistrust as well as trust, brings to the fore the question of having and reflecting upon reasons for trust or mistrust. Pila holds that biographical familiarity is not a sound reason for trust/mistrust, as it seems to obliterate the possibility of mistrust. In response to her proposal, an analysis is proposed of the forms of trust involved in biographical familiarity. In particular, implicit trust is focused upon—as a form of trust in advance of reasons, and as a form of trust contained (in the logical sense) within other reasons. It is proposed that implicit trust has an important role in establishing an intersubjectively shared world in which what counts as a reason for the acceptability of performances such as readings of X-rays is established. Implicit trust, therefore, is necessary for professionals to enter into a “space of reasons”. To insist upon judgements made in the absence of the form of implicit trust at play in biographical familiarity is to demand that radiologists (and other relevantly similar professionals) make judgements regarding whether to trust or mistrust on the basis of reasons capable of being reflected upon, but at the same time leave them without reasons upon which to reflect. (shrink)

The aim of this work is to show how Edgar Morin chose Vico and Hegel as cultural points of reference while elaborating a new method as an alternative to classical scientific knowledge. The French philosopher did this specifically when he tried to re-propose the problem s of history and the event in human sciences. The origins of sociology arose from the explicit extension of the scientific method to the socio-anthropological world; that is, with the intention of studying society as a (...) natural phenomenon to which the laws of physical and biological sciences must be applied. As a tendency against this, at the end of the 1970s Morin began a process of putting sociology into historical context, which led him to a methodological revolution of sociology itself. (shrink)

Ethical concerns in e-social science are often raised with respect to privacy, confidentiality, anonymity and the ethical and legal requirements that govern research. In this article, the authors focus on ethical aspects of e-research that are not directly related to ethical regulatory framework or requirements. These frameworks are often couched in terms of benefits or harms that can be incurred by participants in the research. The authors shift the focus to the sources of value in terms of which benefits or (...) harms are understood in real social situations. A central claim of this paper is that the technologies that are used for research are not value neutral, but serve to reinforce some values at the expense of others. The authors discuss databases, modelling and simulation, network analysis as examples of technologies which affect the articulation of values. A view of e-social science as a techno-scientific constellation of researchers, technologies and society, in which values are always already embedded, is put forward as a basis for a view of ethics as reflexive and active engagement, conducted with awareness. Methodological pluralism and proactive openness are also proposed as responses to this view of the ethical dimensions of e-social science. (shrink)

En este artículo se revisa la noción jurídica y moral de dignidad personal, más allá de los enfoques realistas y constructivistas tout court, para llegar a colocar de relieve modos de sufrimiento y experiencias del daño. Las herramientas con las que cuentan habitualmente las perspectivas jurídicas y morales al momento de identificar y juzgar cursos de acción no parecen ser suficientes si fijamos la atención en la fragilidad y la precariedad ontológica que caracteriza a la subjetividad. Indicar la naturaleza relacional (...) de la dignidad, y solventar la perjudicial adherencia entre lo jurídico y lo moral como consecuencia de su empleo, serán objetivos perseguidos en el artículo, al desembarazarse de enfoques realistas o naturalistas y rechazar cualquier atisbo romanticista que no considere las disonancias requeridas para la dignidad o exponga a los menos aventajados ante situaciones injustificadas de poder y dominación. (shrink)

Cet article se propose d’étudier quelques chapitres du Centheologicon d’Heymeric de Campo consacrés aux doctrines de Nicolas de Cues. La relation d’amitié entre les deux philosophes rend compte de leur mutuelle influence doctrinale et de la convergence de leurs perspectives philosophiques. L’analyse de cinq chapitres du Centheologicon, dont la source est Nicolas de Cues, permettra d’évaluer la correspondance théorique réelle entre ces chapitres et les ouvrages cusaniens. L’étude met en avant la consonance doctrinale des deux auteurs qui partagent la même (...) conception unitaire et universelle du savoir humain. (shrink)

In silico medicine is still forging a road for itself in the current biomedical landscape. Discursively and rhetorically, it is using a three-way positioning, first, deploying discourses of personalised medicine, second, extending the 3Rs from animal to clinical research, and third, aligning its methods with experimental methods. The discursive and rhetorical positioning in promotions and statements of the programme gives us insight into the sociability of the scientific labour of advancing the programme. Its progress depends on complex social, institutional and (...) technological conditions which are not external to its epistemology, but intricately interwoven with it. This article sets out to show that this is the case through an analysis of the process of computational modelling that is at the core of its epistemology. In this paper I show that the very notion of ‘model’ needs to be re-thought for in silico medicine, and propose a replacement, in the form of the ‘Model-Simulation-Experiment-System’ or MSE-system, which is simultaneously an epistemological, social and technological system. I argue that the MSE-system is radically mediated by social relations, technologies and symbolic systems. We need now to understand how such mediations operate effectively in the construction of robust MSE-systems. (shrink)

Name der Zeitschrift: Archiv für Geschichte der Philosophie Jahrgang: 99 Heft: 2 Seiten: 129-155.

The borders between the physical and the virtual are ever-more porous in the daily lives of those of us who live in Internet enabled societies. An increasing number of our daily interactions and transactions take place on the Internet. Social, economic, educational, medical, scientific and other activities are all permeated by the digital in one or other kind of virtual environment. Hand in hand with the ever-increasing reach of the Internet, the digital and the virtual, go concerns about trust. In (...) the increasing numbers of cross-disciplinary attempts to understand the way that the Internet is changing our societies, ‘trust’ is a truly cross-boundary word, used just as frequently by computer scientists as it is by economists, sociologists and philosophers. Concerns in the name of trust are articulated about the objects and artefacts found, accessed or bought on the Internet, about the people with whom we interact on the interact, and about the technological systems and infrastructures that enable us to carry out activities of different types. -/- This paper reflects on the implications for trust of the way we shape our technologies and they in turn shape us, for example, in the way we trust and the extent to which we can trust ourselves as trusters. The account I am working towards is an ecological and co-evolutionary view of trust and technologies, which attempts to hold in view the complex inter-relationships between the agents and other entities within and across environments. First, I consider the ways in which problems of justifying trust are analogous to problems of justifying knowledge, and claim that trust, like knowledge, cannot be justified from an external position. Second, I outline an account of internal relations drawn from phenomenology. This is followed by a discussion of three aspects of trust which are internally related to it: value, reason and morality. (shrink)