Over a 20-year period, the United States has developed a consensus of legal opinion concerning living wills and other advance directives. At the heart of this consensus are two interconnected principles. First, the state should minimally interfere with the wishes of patients and surrogates and the decisions of physicians about foregoing life-sustaining treatments. Second, state interference is permissible for the sake of protecting a compelling state interest. The overwhelming majority of states with advance directive laws have attained this balance of (...) minimal interference and compelling state interest in developing their laws. (shrink)

Evolutionary fitness threats and rewards are associated with subjectively unpleasant and pleasant sensations, respectively. Initially, these correlations appear explainable via adaptation by natural selection. But here I analyse the major metaphysical perspectives on consciousness – physicalism, dualism, and panpsychism – and conclude that none help to understand the adaptive-seeming correlations via adaptation. I also argue that a recently proposed explanation, the phenomenal powers view, has major problems that mean it cannot explain the adaptive-seeming correlations via adaptation either. So the mystery (...) – call it the evolutionary paradox of consciousness – remains. Some have used this mystery to argue for non-naturalistic (e.g. theistic) explanations. But I propose a naturalistic, non-adaptive explanation of the adaptive-seeming correlations: namely, ‘sensational associative learning’ during development. In this perspective, pairing of particular sensations with unconditioned stimuli – fitness rewards or threats – cause the sensations themselves to come to be interpreted as good or bad, respectively. Sensations, like colours, that are not reliably paired with either fitness rewards or threats remain largely unvalenced. Sensational associative learning also provides explanations for adaptive-seeming structural aspects of sensations, such as the observation that sounds of different pitch are experienced as ordinal in correspondence to their wavelengths while the same is not true of colours of different hue. The sensational associative learning perspective appears compatible with physicalism, panpsychism, and dualism (though not epiphenomenalism). (shrink)

Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, previously identified by behavioural geneticists including ourselves, do not negate the value of PGSs, let alone genetics in general, for social science.

This essay explores some concerns about the quality of informed consent in patients whose autonomy is diminished by fatal illness. It argues that patients with diminished autonomy cannot give free and voluntary consent, and that recruitment of such patients as subjects in human experimentation exploits their vulnerability in a morally objectionable way. Two options are given to overcome this objection: (i) recruit only those patients who desire to contribute to medical knowledge, rather than gain access to experimental treatment, or (ii) (...) provide prospective subjects the choice to participate in standard doubleblind study or receive the experimental treatment. Either option would guarantee that patients in desperate conditions are given a more meaningful choice and a richer freedom, and thus a higher quality of informed consent, than under standard randomized trials. (shrink)

This paper discusses the connection between the actual history of mathematics and Lakatos's philosophy of mathematics, in three parts. The first points to studies by Lakatos and others which support his conception of mathematics and its history. In the second I suggest that the apparent poverty of Lakatosian examples may be due to the way in which the history of mathematics is usually written. The third part argues that Lakatos is right to hold philosophy accountable to history, even if Lakatos's (...) own view of mathematics fails that test. (shrink)

Ender Wiggin spends much of Ender's Game playing games of one sort or another. These range from simple role‐playing games with his siblings (“buggers and astronauts”), to battleroom contests, to the strange free play Giant's Drink video game in which he must kill a giant and confront his deepest fears. This chapter examines the role that games play in Ender's development as both a military commander and as a human being. It considers a number of interrelated questions: What is a (...) game? Is it really appropriate to call Battle School activities “games,” given how serious they are? What is the relationship between a good game and the development of a good person?. (shrink)

Tracing Walter Benjamin's convergences with, and divergences from, influential German theorist Carl Schmitt, this edited collection places his thinking in the context of broader 20th century political philosophy of his time, and examines the question of whether Benjamin presents the possibility for a distinctive political theology, mapping the coordinates of this question without collapsing the tensions internal to Benjamin's thought. This volume brings together a host of multifaceted contributions that explore why Benjamin has been a fertile source for thinking about (...) political theology and the possibilities that this new perspective brings to light. (shrink)

The UK Arts and Humanities Research Council has agreed to fund a series of three meetings with associated publications on mathematical cultures. This note describes the project.

This is a review of What is a Mathematical Concept? edited by Elizabeth de Freitas, Nathalie Sinclair, and Alf Coles. In this collection of sixteen chapters, philosophers, educationalists, historians of mathematics, a cognitive scientist, and a mathematician consider, problematise, historicise, contextualise, and destabilise the terms ‘mathematical’ and ‘concept’. The contributors come from many disciplines, but the editors are all in mathematics education, which gives the whole volume a disciplinary centre of gravity. The editors set out to explore and reclaim the (...) canonical question ‘what is a mathematical concept?’ from the philosophy of mathematics. This review comments on each paper in the collection. (shrink)

BackgroundThe evolution of the female orgasm in humans and its role in romantic relationships is poorly understood. Whereas the male orgasm is inherently linked to reproduction, the female orgasm is not linked to obvious reproductive or survival benefits. It also occurs less consistently during penetrative sex than does the male orgasm. Mate-choice hypotheses posit that the wide variation in female orgasm frequency reflects a discriminatory mechanism designed to select high-quality mates.ObjectiveWe aimed to determine whether women report that their orgasm frequency (...) varies between partners, whether this variation reflects mates' personal characteristics, and whether this variation reflects own and partner sexual behaviour during intercourse.DesignWe collected survey data from 103 women who rated the extent to which their orgasm frequency varied between partners, the characteristics of previous sexual partners who induced high-orgasm frequency and those who induced low-orgasm frequency,... (shrink)

In the svārthānumāna chapter of his Pramāṇavārttika, the Buddhist philosopher Dharmakīrti presented a defense of his claim that legitimate inference must rest on a metaphysical basis if it is to be immune from the risks ordinarily involved in inducing general principles from a finite number of observations. Even if one repeatedly observes that x occurs with y and never observes y in the absence of x, there is no guarantee, on the basis of observation alone, that one will never observe (...) y in the absence of x at some point in the future. To provide such a guarantee, claims Dharmakīrti, one must know that there is a causal connection between x and y such that there is no possibility of y occurring in the absence of x. In the course of defending this central claim, Dharmakīrti ponders how one can know that there is a causal relationship of the kind necessary to guarantee a proposition of the form “Every y occurs with an x.” He also dismisses an interpretation of his predecessor Dignāga whereby Dignāga would be claiming non-observation of y in the absence of x is sufficient to warrant to the claim that no y occurs without x. The present article consists of a translation of kārikās 11–38 of Pramānavārttikam, svārthānumānaparicchedaḥ along with Dharmakīrti’s own prose commentary. The translators have also provided an English commentary, which includes a detailed introduction to the central issues in the translated text and their history in the literature before Dharmakīrti. (shrink)

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

BackgroundAn increasing number of studies utilize intracranial electrophysiology in human subjects to advance basic neuroscience knowledge. However, the use of neurosurgical patients as human research subjects raises important ethical considerations, particularly regarding informed consent and undue influence, as well as subjects’ motivations for participation. Yet a thorough empirical examination of these issues in a participant population has been lacking. The present study therefore aimed to empirically investigate ethical concerns regarding informed consent and voluntariness in Parkinson’s disease patients undergoing deep brain (...) stimulator (DBS) placement who participated in an intraoperative neuroscience study.MethodsTwo semi-structured 30-minute interviews were conducted preoperatively and postoperatively via telephone. Interviews assessed participants’ motivations for participation in the parent intraoperative study, recall of information presented during the informed consent process, and participants’ postoperative reflections on the research study.ResultsTwenty-two participants (mean age = 60.9) completed preoperative interviews at a mean of 7.8 days following informed consent and a mean of 5.2 days prior to DBS surgery. Twenty participants completed postoperative interviews at a mean of 5 weeks following surgery. All participants cited altruism or advancing medical science as “very important” or “important” in their decision to participate in the study. Only 22.7% (n = 5) correctly recalled one of the two risks of the study. Correct recall of other aspects of the informed consent was poor (36.4% for study purpose; 50.0% for study protocol; 36.4% for study benefits). All correctly understood that the study would not confer a direct therapeutic benefit to them.ConclusionEven though research coordinators were properly trained and the informed consent was administered according to protocol, participants demonstrated poor retention of study information. While intraoperative studies that aim to advance neuroscience knowledge represent a unique opportunity to gain fundamental scientific knowledge, improved standards for the informed consent process can help facilitate their ethical implementation. (shrink)

The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.

What accounts for the capacity of ordinary speakers to comprehend utterances of their language? The phenomenology of hearing speech in one’s own language makes it tempting to many epistemologists to look to perception for an answer to this question. That is, just as a visual experience as of a red square is often taken to give the perceiver immediate justification for believing that there is a red square in front of her, perhaps an auditory experience as of the speaker asserting (...) that p gives the competent hearer immediate justification for believing that the speaker has asserted that p. My aim here is to offer reasons for resisting this temptation. I argue that the perceptual model cannot adequately account for the hearer’s justification in many cases. The arguments here also allow us to draw certain further morals about the role of phenomenology in the epistemology of perception. (shrink)

This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

Introducing Applied Ethics Edited by Brenda Almond, Blackwell, 1995. Pp. 375. ISBN 0-631-19389-8. 45.00 (hbk), 14.99 (pbk). Environmental Ethics Edited by Robert Elliot, Oxford University Press, 1995. Pp. 255. ISBN 9-19-875144-3. 9.95 (pbk) Medicine and Moral Reasoning Edited by K.W.M. Fulford, Grant Gillett and Janet Martin Soskice Cambridge University Press, 1994. Pp. 207. ISBN 0-521-45325-9 37.50 (hbk), 12.95 (pbk). Enlightenment and Religion. Rational Dissent in Eighteenth-century Britain Edited by Knud Haakonssen, Cambridge University Press, 1996. Pp. xii + 348. ISBN 0-521-56060-8. (...) 40.00. Dialettica, Arte e Societ : Saggio su Theodor W. Adorno By Giacomo Rinaldi, Quattroventi, Urbino, 1994. Pp. 205. L. 30,000. Relevance: Communication and Cognition, new revised edition, By Dan Sperber and Deirdre Wilson, Blackwell, 1995. Pp. 326. ISBN 0-631-19878-4. 15.99. Autobiographical Reflections By Eric Voegelin (Edited, with Introduction, by Ellis Sandoz), Louisiana State University Press, 1996. Pp. 131. ISBN 0807120766 $10.95. (shrink)

The term “ideology” can cover almost any set of ideas, but its power to bewitch political activists results from its strange logic. It is part philosophy, part science, and part spiritual revelation, all tied together in leading to a remarkable paradox—that the modern Western world, beneath its liberal appearance, is actually the most systematically oppressive system of despotism the world has ever seen. In Alien Powers, Kenneth Minogue takes this complex intellectual construction apart, analyzing its logical, rhetorical, and psychological devices, (...) and thus opening it up to critical analysis. This new, ISI Books’ Background edition of Alien Powers includes a new introduction to the text by Martyn P. Thompson and critical essays on the text by political theorist Paul Gottfried and philosopher Stephen A. Erickson. (shrink)

The schism between analytic and continental philosophy resists repair because it is not confined to philosophers. It is a local manifestation of a far more profound and pervasive division. In 1959 C.P. Snow lamented the partition of intellectual life in to `two cultures': that of the scientist and that of the literary intellectual. If we follow the practice of most universities and bundle historical and literary studies together in the faculty of humanities on the one hand, and count pure mathematics (...) among the sciences on the other, then it is fair to say that the mutual ignorance and occasional hostility between scientists and humanists decried by Snow is still with us. And it runs through the middle of philosophy. Philosophy aspires to say something about everything, so it is unsurprising that philosophers have reproduced in miniature the division between the arts and the sciences. What is worrying is that we have failed to overcome it. (shrink)

Terence Tao New York, Oxford University Press, 2006xii + 103 pp., ISBN 9780199205615, £37.50 (hardback), ISBN 9780199205608, £12.99 (paperback)This is a book of mathematical problems and their solu...

The leading philosophers of science of the first half of the twentieth century had little use for the history of science. There are several possible explanations for this. One is that philosophers of science sometimes (knowingly or not) mimic the methodological habits and values of scientists. Many philosophers of science are motivated by admiration for the perceived rigor and intellectual hygiene of the exact sciences. Historical sense is not normally a cardinal virtue among physicists. Hence, those philosophers who take their (...) methodological cues from their scientific heroes are unlikely to think of philosophy as a historical discipline. Indeed, the idea of a close relationship between history and philosophy may have fallen into disrepute as a consequence of its association with idealist philosophers, of whom Hegel is the most notorious. Then there is Feyerabend's explanation, which is that the philosophy of science was transformed by the spectacular advances in formal logic which took place in the late nineteenth century. The development of modern formal logic made possible a range of hitherto inconceivable projects in the philosophy of science. The most radical of these was the positivist attempt to replace philosophy with the logical analysis of scientific language. Equally dependent on the new logic was Popper's attempt to explain the workings of empirical science using only deductive patterns of inference. According to Feyerabend, the philosophical projects engendered by the advances in formal logic came to dominate so thoroughly that everything else was marginalized (see feyerabend). It was not necessary for philosophers to know anything about the history of science, but they did have to be competent logicians: “As always maturity in a narrow domain means illiteracy elsewhere” (Feyerabend 1981, p. 20). (shrink)