We propose a framework for analyzing the development, operation and failure to survive of all things, living, non-living or organized groupings. This framework is a sequence of developments that improve survival capability. Framework processes range from origination of any entity/system, to the development of increased survival capability and development of life-forms and organizations that use intelligence. This work deals with a series of developmental changes that arise from the uncovering of emergent properties. The framework is intended to be general, but (...) we see a potential to apply it to scientific topics such as the exploration of the origin of life or the search for life beyond Earth, and to understand some biological issues in evolution and symbiosis, and also to apply to social systems that do not seem to be operating well, to determine their problems and correct them. (shrink)

The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the (...) relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa. (shrink)

This Editorial reports an exchange in form of a comment and reply on the article “History and Nature of the Jeffreys–Lindley Paradox” (Arch Hist Exact Sci 77:25, 2023) by Eric-Jan Wagenmakers and Alexander Ly.

The American Journal of Bioethics, Volume 11, Issue 6, Page W1-W3, June 2011.

Scholars have grown concerned around the increasing carceral logics embedded in social media practices. In this essay, we explore the process of getting “zucked” as a trend within digital platforms that disproportionately punishes minoritized digital users. Specifically, Black women report that with the advent of increased safety measures and policies to secure users on digital platforms, they become subject to harms of the institutional practices. By extending the conversation on carcerality beyond the confines of prisons, jails, and other forms of (...) criminal justice supervision, we argue that structures and institutions expand the lines of surveillance and that those traditionally subject to such harm continue to be affected. Although the concept of getting “zucked” might seem like an innocent response to individuals who violate terms of service, Black women suggest that this practice disparately targets them for speaking about racist and sexist incidents on- and offline. Such surveillance is misogynoir in public spaces, as Black women are punished for organizing on social media. (shrink)

The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data (...) from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. (shrink)

Organizational sensemaking is crucial for resource planning and crisis management since facing complex strategic problems that exceed their capacity and ability, such as crises, forces organizations to engage in inter-organizational collaboration, which leads to obtaining individual and diverse perspectives to comprehend the issues and find solutions. This online qualitative survey study examines how Norwegian Sea Rescue Society employees perceived the concept of an organizational crisis and how they sensed their co-workers react to it. The scope was the ongoing COVID-19 pandemic, (...) a global event affecting all countries and organizations and responding similarly globally. Data were collected during the Fall of 2020. The instrument of choice was the Internal Crisis Management and Crisis Communication survey. The results showed that the overall sample strongly believed in their organization’s overall resilience level. However, a somewhat vague understanding of roles and responsibilities in a crisis where detected, together with some signs of informal communication, rumor spreading, misunderstanding, frustration, and insecurity. This study contributes to the academic field of organizational research, hence crisis management and sensemaking, and could be valuable to managers and decision-makers across sectors. Increased knowledge about how employees react to a crisis may help optimize internal crisis management planning and utilize robust mitigation and response strategies. (shrink)

This study discusses narcissism and problems of the self from the perspective of psychoanalysis. The contributors define the major differences between the interpersonal viewpoint and other schools of psychoanalysis in terms of both diagnosis and treatment.

What is the future of legal philosophy? No doubt it has many. But we are betting that jurisprudence will gravitate towards freedom. Freedom, the attribute of the human subject, has largely been absent from legal philosophy. This is a lack that psychoanalytic jurisprudence aims to correct. In this essay, drafted as chapter in "On Philosophy in American Law" (Francis Jay Mootz III, ed.) to be published by the Cambridge University Press, we set forth what we think are the primary differences (...) between a jurisprudence based in the Continental tradition of speculative philosophy, and the liberal jurisprudences that dominate in the American academy. Most importantly, all liberal theories start with some intuition of the free, autonomous individual. In contrast, psychoanalysis views the subject's definition as the problem of philosophy. For psychoanalysis, as reformulated by Jacques Lacan, personality and freedom cannot exist in any empirical or hypothetical state of nature because nature is unfree - bound by iron-clad laws of cause and effect. Personality and freedom are artificial creations - hard-won achievements. Subjectivity - the capacity to bear duties and rights - is a stage in this struggle. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

The purpose of this essay is to explore the patterns of antiblackness within contemporary gaming. Video games are sites of necropolitical logics that use Black death to propel narratives. But even more concerning, is that these games might make sense of larger desires of white colonial supremacy, attempting to remove and destroy its troubled racialized past. Ethnographic observations also engage gaming as a carceral logic that seeks to surveil, police, and criminal Blackness. Under these conditions, it is imperative to explore (...) how the continuation of the institution of slavery within policing is actively embedded into technical and digital practices, leading to carceral conditions for those subject to its power and gaming provides a pathway to engage this trend. (shrink)

Protection of human participants is a fundamental facet of biomedical research. We report the activities of a health service research study in which there were three institutional review boards (IRBs), three legal departments and one research administration department providing recommendations and mandating changes in the study methods. Complying with IRB requirements can be challenging, but can also adversely affect study outcomes. Multiple protocol changes mandated from multiple IRBs created a research method that was not reflective of how substance use screening (...) would be performed in a clinical setting. There was direct conflict between the IRBs' perceptions of participants' protection with the researchers' need to use research methodology that assures the clinical relevancy of results. (shrink)

This study examines the use of an explicit, reflective method for teaching the difference and relationship between scientific theories and laws to ninth-grade students. Students reflected individually and then as a whole class on theories and laws using a Venn diagram, both before and after reading short articles describing features of theories and laws that provided an explicit challenge to their naïve prior conceptions. In small groups, they chose a theory or law, researched it, constructed a poster, and did a (...) gallery walk. Examination of students’ Venn diagrams and answers to a single question from VNOS-C given as both a pre- and post-test showed that prior to the lesson, all students except for one held more naïve views of both the difference between theories and laws and the nature of scientific theories. After the lesson, more than a third of them had improved their conceptions to more informed, and nearly a quarter understood that there is not a hierarchical relationship between scientific theories and laws. (shrink)

This article examines the response of minority gamers as they adopt new innovations in Xbox Live. Using diffusion of innovation theory, specific attention is given to gamers’ rate of adoption of the new Xbox Live environment, which was a recent update to the Xbox Live interface. By employing virtual ethnography, observations, and interviews reveal that gaming duration and gender are significant factors in identifying a gamer’s successful rate of adoption of the new innovation. Female participants reveal that Xbox Live intentionally (...) targets males as the default gamer and enact changes based on their needs. The research concludes with a plea to Xbox Live to acknowledge minority gamers such as women to incorporate their needs within the decision-making process of new innovations. (shrink)

The ratio of index- and ring-finger lengths is thought to be related to prenatal androgen exposure, and in many, though not all, populations, men have a lower average digit ratio than do women. In many studies an inverse relationship has been observed, among both men and women, between 2D:4D ratio and measures of athletic ability. It has been further suggested that, in hunter-gatherer populations, 2D:4D ratio might also be negatively correlated with hunting ability, itself assumed to be contingent on athleticism. (...) This hypothesis has been tested using endurance running performance among runners from a Western, educated, and industrialized population as a proximate measure of hunting ability. However, it has not previously been tested among actual hunter-gatherers using more ecologically valid measures of hunting ability and success. The current study addresses this question among Tanzanian Hadza hunter-gatherers. I employ a novel method of assessing hunting reputation that, unlike previous methods, allows granular distinctions to be made between hunters at all levels of perceived ability. I find no statistically significant relationship between digit ratio and either hunting reputation or two important hunting skills. I confirm that Hadza men have higher mean 2D:4D ratios than men in many Western populations. I discuss the notion that 2D:4D ratio may be the consequence of an allometric scaling relationship between relative and absolute finger lengths. Although it is difficult to draw clear conclusions from these results, the current study provides no support for the theorized relationship between 2D:4D ratio and hunting skill. (shrink)

For years a debate has raged within the various literatures of philosophy, psychiatry, and psychology over whether, and to what degree, the concepts that characterize psychopathology are social constructions that reflect cultural values. While the majority position among philosophers has been normativist, i.e., that the conception of a mental disorder is value-laden, a vocal and cogent minority have argued that psychopathology results from malfunctions that can be described by terminology that is objective and scientific. Scientists and clinicians have tended to (...) endorse the objectivist position, with some notable exceptions. (shrink)

Experiential evidence shows that pain is associated with common meanings. These include a meaning of threat or danger, which is experienced as immediately distressing or unpleasant; cognitive meanings, which are focused on the long-term consequences of having chronic pain; and existential meanings such as hopelessness, which are more about the person with chronic pain than the pain itself. This interdisciplinary book - the second in the three-volume Meanings of Pain series edited by Dr Simon van Rysewyk - aims to better (...) understand pain by describing experiences of pain and the meanings these experiences hold for the people living through them. The lived experiences of pain described here involve various types of chronic pain, including spinal pain, labour pain, rheumatic pain, diabetic peripheral neuropathic pain, fibromyalgia, complex regional pain syndrome, endometriosis-associated pain, and cancer-related pain. Two chapters provide narrative descriptions of pain, recounted and interpreted by people with pain. Language is important to understanding the meaning of pain since it is the primary tool human beings use to manipulate meaning. As discussed in the book, linguistic meaning may hold clues to understanding some pain-related experiences, including the stigmatisation of people with pain, the dynamics of patient-clinician communication, and other issues, such as relationships between pain, public policy and the law, and attempts to develop a taxonomy of pain that is meaningful for patients. Clinical implications are described in each chapter. This book is intended for people with pain, their family members or caregivers, clinicians, researchers, advocates, and policy makers. (shrink)

This volume is the product of an important recent conference, convened by His Holiness the Dalai Lama, focusing on the intellectual legacy of the Tibetan philosopher, yogi, and saint Tsongkhapa (1357-1419). Entitled "Jé Tsongkhapa: Life, Thought, and Legacy," the conference commemorated the sixth hundredth anniversary of Tsongkhapa's passing and was held on December 21-23, 2019, at Ganden Monastery in Mundgod, India. Part 1 concerns Madhyamaka, a natural reflection of the very important and well-known contributions Tsongkhapa made to the study of (...) Indian philosophical thought. The first essay, Guy Newland's "Start Making Sense: Finding Tsongkhapa's Middle Way," provides a straightforward and clear introduction to Tsongkhapa's interpretation of Madhyamaka philosophy, showing how Tsongkhapa played an essential role in clarifying Candrakīrti's contributions to Madhyamaka thought. The second essay, "Celebrating Jé Tsongkhapa: The Twofold Object of the Identity View" by Dr. Dechen Rochard explores Tsongkhapa's understanding of Candrakīrti's negation of individual identity. The essay neatly demonstrates the centrality of the practitioner's view of self to the path to spiritual awakening. In the third chapter, "Thinking Beyond Thought: Tsongkhapa and Mipham on the Conceptualized Ultimate," Jay L. Garfield explores Tsongkhapa's views on the nature of ultimate reality, specifically Tsongkhapa's argument that this entails a movement from inferential to direct awareness of emptiness. The essay explores the need for accurate philosophical analysis in the context of meditation practice so as to directly realize the truths about the nature of self and reality that are the objects of the practice. It thus nicely points to the integration of Buddhist theory and practice. The second section of this volume is dedicated to Tsongkhapa's writings on the tantras. In the first chapter in this section, "Tsongkhapa's Masterful Exegesis of Cakrasaṃvara Tantra," I elucidate Tsongkhapa's approach to the study of tantric literature with a focus on his commentary on the Cakrasaṃvara Tantra. Chapter 6 is Gavin Kilty's contribution, "A Lamp to Illuminate the Five Stages: Tsongkhapa's Reformatory Work on Guhyasamāja Tantra." Kilty first surveys the Guhyasamāja tradition and its transmission to Tibet and the two main Indian exegetical traditions, the Ārya and J.ānapāda schools. Outlining Tsongkhapa's approach to the Guhyasamāja Tantra, he then focuses on how the tradition conceptualizes the generation-stage and completion-stage practices. Chapter 7, "The Shadow of Heshang: Tsongkhapa on Chan, Dzokchen, and Mahāmudrā" by Roger R. Jackson. Jackson explores the claim that Tsongkhapa received and secretly transmitted esoteric instructions on advanced meditation practices to realize the nature of mind and awakening. The volume concludes with a section entitled "Moving Minds," which explores Tsongkhapa's legacy and impact both in Tibet and beyond. It opens with "Jé Tsongkhapa's Contribution to Buddhist Hermeneutics" by Geshé Ngawang Samten. Buddhist hermeneutics, as understood here, is a response to the challenge posed by scriptures that appear to contradict one another. Chapter 9, "Tsongkhapa's Hermeneutics and the Perfection of Wisdom," contributed by Gareth Sparham, takes a more focused look at the interpretation of the Perfection of Wisdom literature in both India and Tibet. The tenth chapter is "Jé Tsongkhapa's Teachings and Translations in Mongolian" by Bataa Mishig-Ish, who surveys the dissemination of Tsongkhapa's oeuvre to Mongolia. The final chapter is BhikṣuṇīThubten Chodron's "Learning, Living, and Teaching Bodhicitta: Jé Tsongkhapa's Contribution to Spreading Compassion in the World." Venerable Chodron argues that Tsongkhapa's approach to teaching compassion is particularly suited for the modern, Western context. While this volume does not come close to exhausting the limits of what might be said concerning the impact of Tsongkhapa's work in Tibet and beyond, it does reunite contributions to this study that briefly converged in Preface xi Mundgod, India, just before the global pandemic ushered in a new awareness of our profound human interdependence. Hopefully these essays will advance the appreciation of Tsongkhapa's intellectual legacy in the wider English-speaking world, where he remains a little understood figure of Asian religious history, unlike in the Tibetan-speaking world, where his impact is justly celebrated. (shrink)

The aim of the SI is to bring to the fore the places in which cross-sector partnerships (CSPs) are formed; how place shapes the dynamics of CSPs, and how CSPs shape the specific settings in which they develop. The papers demonstrate that partnerships and place are intrinsically reciprocal: the morality and materiality inherent in places repeatedly reset the reference points for partners, trigger epiphanies, shift identities, and redistribute capacities to act. Place thus becomes generative of partnerships in the most profound (...) sense: by developing an awareness of their emplacement, CSPs commit to place, and through their place-based commitments produce three intertwined modalities of place-specific ethics that bind CSPs and place: ethic of recognition, an ethic of care, and an ethic of resilience. Our authors have found vivid examples of how emplaced CSPs embody these ethics, signaling hope for the sustainability of our (always hyper-local) life-worlds. (shrink)

The aim of UK-REACH (“The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers”) is to understand if, how, and why healthcare workers (HCWs) in the United Kingdom (UK) from ethnic minority groups are at increased risk of poor outcomes from COVID-19. In this article, we present findings from the ethical and legal stream of the study, which undertook qualitative research seeking to understand and address legal, ethical, and social acceptability issues around data protection, privacy, and information (...) governance associated with the linkage of HCWs’ registration data and healthcare data. We interviewed 22 key opinion leaders in healthcare and health research from across the UK in two-to-one semi-structured interviews. Transcripts were coded using qualitative thematic analysis. Participants told us that a significant aspect of Big Data research in public health is varying drivers of mistrust—of the research itself, research staff and funders, and broader concerns of mistrust within participant communities, particularly in the context of COVID-19 and those situated in more marginalised community settings. However, despite the challenges, participants also identified ways in which legally compliant and ethically informed approaches to research can be crafted to mitigate or overcome mistrust and establish greater confidence in Big Data public health research. Overall, our research indicates that a “Big Data Ethics by Design” approach to research in this area can help assure (1) that meaningful community and participant engagement is taking place and that extant challenges are addressed, and (2) that any new challenges or hitherto unknown unknowns can be rapidly and properly considered to ensure potential (but material) harms are identified and minimised where necessary. Our findings indicate such an approach, in turn, will help drive better scientific breakthroughs that translate into medical innovations and effective public health interventions, which benefit the publics studied, including those who are often marginalised in research. (shrink)