American Journal of Bioethics 11 (6):5 - 13 (2011)

Authors
Jeremy Snyder
Simon Fraser University
Abstract
The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa
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DOI 10.1080/15265161.2011.568576
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References found in this work BETA

Minimal Risk as an International Ethical Standard in Research.Loretta M. Kopelman - 2004 - Journal of Medicine and Philosophy 29 (3):351 – 378.
Children as Research Subjects: A Dilemma.Loretta M. Kopelman - 2000 - Journal of Medicine and Philosophy 25 (6):723-744.
Children as Research Subjects: A Dilemma.Loretta M. Kopelman - 2000 - Journal of Medicine and Philosophy 25 (6):745-764.

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Citations of this work BETA

Why the Debate Over Minimal Risk Needs to Be Reconsidered.Ariella Binik & Charles Weijer - 2014 - Journal of Medicine and Philosophy 39 (4):387-405.
The Dangers of Using a Relative Risk Standard for Minimal Risk.Seema Shah - 2011 - American Journal of Bioethics 11 (6):22 - 23.
Reopening Old Divisions.David B. Resnik - 2011 - American Journal of Bioethics 11 (6):19 - 21.

View all 15 citations / Add more citations

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