The differentiation of mammalian neurons during development is a highly complex process involving regulation and coordination of gene expression at multiple steps. The P19 mouse embryonal carcinoma cell line is a suitable model system with which to analyze regulation of neuronal differentiation. These multipotential cells can be maintained and propagated in tissue culture in an undifferentiated state. Exposure of aggregated P19 cells to retinoic acid results in the differentiation of cells with many fundamental phenotypes of mammalian neurons. Undifferentiated P19 cells (...) are amenable to genetic manipulations such as transfection and establishment of stable clonal cell lines expressing introduced genes. Proteins that play a key role in the neuronal differentiation of P19 cells are beginning to be identified. These include retinoic acid receptors, the epidermal growth factor receptor and the transcription factors Oct‐3 and Brn‐2. The biological and technical advantages of this system should facilitate deeper analysis of the activities of proteins that play a role in neuronal differentiation. (shrink)

Several lines of evidence have underscored the remarkable neuroplasticity of the primate sensorimotor cortex, characterizing these cortical areas as dynamic constructs that are modelled in a use-dependent manner by behaviourally significant experiences. Their plasticity likely provides a neural substrate that may contribute to the dynamic systems paradigm argued by Shanker & King (S&K) as crucial for development of communication skills.

OBJECTIVE: To report and analyse the pattern of end-of-life decision making for terminal Chinese cancer patients. DESIGN: Retrospective descriptive study. SETTING: A cancer clinical trials unit in a large teaching hospital. PATIENTS: From April 1992 to August 1997, 177 consecutive deaths of cancer clinical trial patients were studied. MAIN MEASUREMENT: Basic demographic data, patient status at the time of signing a DNR consent, or at the moment of returning home to die are documented, and circumstances surrounding these events evaluated. RESULTS: (...) DNR orders were written for 64.4% of patients. Patients in pain (odds ratio 0.45, 95% CI 0.22-0.89), especially if requiring opioid analgesia (odds ratio 0.40, 95% CI 0.21-0.77), were factors associated with a higher probability of such an order. Thirty-five patients were taken home to die, a more likely occurrence if the patient was over 75 years (odds ratio 0.12, 95% CI 0.04-0.34), had children (odds ratio 0.14, 95% CI 0.02-0.79), had Taiwanese as a first language (odds ratio 6.74, 95% CI 3.04-14.93), or was unable to intake orally (odds ratio 2.73, 95% CI 1.26-5.92). CPR was performed in 30 patients, none survived to discharge. CONCLUSIONS: DNR orders are instituted in a large proportion of dying Chinese cancer patients in a cancer centre, however, the order is seldom signed by the patient personally. This study also illustrates that as many as 20% of dying patients are taken home to die, in accordance with local custom. (shrink)

Differential equations of second order appear in physical applications such as fluid dynamics, electromagnetism, acoustic vibrations, and quantum mechanics. In this paper, necessary and sufficient conditions are established of the solutions to second-order half-linear delay differential equations of the form ς y u ′ y a ′ + ∑ j = 1 m p j y u c j ϑ j y = 0 for y ≥ y 0, under the assumption ∫ ∞ ς η − 1 / a d (...) η = ∞. We consider two cases when a c j, where a and c j are the quotient of two positive odd integers. Two examples are given to show effectiveness and applicability of the result. (shrink)

The main idea of S-curve diagram is to assign different angle values to different nucleotide acid residues or to different protein amino acids, and then according to cos α j and sin α j, the values are accumulated to construct an S-curve diagram, which is in strict one-to-one correspondence with the biological sequence. In addition, the S-curve diagram proves to be without the degeneracy phenomenon, so that both the degeneracy problem represented by diagrams and the problem of visualization for biological (...) sequence data are solved. Meanwhile, a new approach to differentiate the similarity of biological sequences—the degree of similarity—is put forward on the basis of the S-curve diagram. To put it in detail, the least square approach is first adopted to obtain a straight line equation according to the S-curve diagram, then according to the distance formula of the point to the straight line, the average ratio of square sum for the distance between the S-curve and the straight line is calculated, and finally, the similarity of the biological sequences is presented by the new standard—the degree of similarity. As is shown by the experimental results, the S-curve diagram can better represent biological sequences within Cartesian coordinate system, and the mutation point of biological sequence. Thus, it turns out that the new standard—the degree of similarity is of obviously great advantage. (shrink)

本书内容分为四编:第一编印度因明;第二编藏传因明;第三编汉传因明;第四编二十世纪的因明研究。.

According to an attractive conception of love as attention, discussed by Iris Murdoch, one strives to see one’s beloved accurately and justly. A puzzle for understanding how to love another in this way emerges in cases where more accurate and just perception of the beloved only reveals his flaws and vices, and where the beloved, in awareness of this, strives to escape the gaze of others - including, or perhaps especially, of his loved ones. Though less attentive forms of love (...) may be able to render one’s continued love coherent and justifiable in these cases, they risk further alienating the beloved precisely because they are less attentive and because of the operations of the beloved’s shame. I argue that attentive love is well-suited to alleviate this problem of alienation, but that in order to do so, it must be supplemented with grace. I propose a conception of gracious love as an affectionate love for the qualities of human nature, distinguishing this from a love of humanity, and show how this complex emotion, in being responsive to the complexities of shame, is able to alleviate the problem of alienation. (shrink)

Les questions d’éthique reviennent aujourd’hui avec force dans les sciences sociales en général et en sociologie en particulier. Cet article met en évidence les écueils que doivent éviter les comités d’éthique de la recherche universitaire dans le domaine des sciences sociales. L’auteur soutient que les écueils en question ne peuvent aisément être évités que par le dialogue entre les principaux acteurs concernés. En dernière analyse, dit l’auteur, le rôle des comités d’éthique de la recherche universitaire doit être d’assurer l’éducation à (...) l’éthique à travers un débat démocratique au sein de la communauté universitaire. (shrink)

The underlying idea presented in this book is that there are similarities as well as differences between Confucianism as Humanistic tradition and Christianity ...

姚伯茂(1937~ ),浙江诸暨人,上海工业大学人文学院院长、教授,中国辩证唯物主义研究会理事,上海市哲学学会常务理事.

This study explored the relationship among the emotional labor, psychological capital, and mental health of preschool teachers. A questionnaire survey was conducted on 411 preschool teachers in China. The results revealed the following: One emotional labor strategy had a significant negative effect on mental health, whereas two emotional labor strategies had significant positive effects. The psychological capital of preschool teachers had a complete mediation on the relationship between expression of naturally felt emotions and mental health and between the deep acting (...) and mental health. (shrink)

Richard Rorty's philosophy has two basic commitments: one to postmodernism and the other to liberalism. However, these commitments generate tension. As a postmodernist, he sharply criticizes the Enlightenment; as a liberal, he forcefully defends it. His postmodernist liberalism actually explains liberalism using irrationalism. /// 罗蒂哲学有两个基本承诺，一个是对后现代主义的承诺，一个是对自由主义 的承诺。但是这两种承诺之间存在着紧张关系: 作为后现代主义者，罗蒂对启蒙提 出了强烈的批评; 作为自由主义者，他又在极力地维护启蒙。罗蒂的后现代自由主 义实质上是以非理性主义来解释自由主义。.

TikTok has one of the most advanced algorithm systems and is the most addictive as compared to other social media platforms. While research on social media addiction is abundant, we know much less about how the TikTok information system environment affects users’ internal states of enjoyment, concentration, and time distortion, which in turn influences their addiction behavior. To fill this gap, this study collects responses from 659 adolescents in China aged between 10 and 19 years old, and the data is (...) then analyzed using Partial Least Square. We find that the system quality has a stronger influence than information quality in determining adolescents’ experience with TikTok and that the flow experience has significant direct and indirect effects on TikTok addiction behavior. Notably, this study finds that TikTok addiction is determined by users’ mental concentration on the medium and its content. Several theoretical insights from the stimulus–organism–response model and the flow theory are used to explain the findings. (shrink)

Remanufactured Product, as one of the low-carbon products, is turned out to be more valuable and an increasing number of countries attach much importance to it. However, the low willingness of Chinese consumers to pay for the remanufactured products makes things go harder in the Chinese market. Our research, based on the form of questionnaire, attempts to explore the factors that affect the willingness of consumers to pay for the remanufactured products though Hierarchical regression analysis. The results show that population (...) variables (age, education, occupation and income), individual subjective variables (environmental awareness, old-product preference and reliance on Made in China) and product perception variables (perceived quality risk of MP4, face issue and environmental effect of product) have marked influences on the willingness to pay for the remanufactured products. (shrink)

Buddhist teachings and practices can be viewed as a journey of soteriological transformation, where language, as a tool for the analysis of views, occupies a place of special significance and importance. This article examines how the concept of non-duality, from the Madhyamaka perspective, has served as a powerful rhetorical device with the explicit aim of fostering soteriological transformation. Among the various expressions representative of the Madhyamaka perspective, two are particularly explored in this article for their facilitation of soteriological transformation: the (...) expression of ‘neither a dharma nor a not-dharma’ and the teaching that ‘one should let go even of dharmas, still more so not-dharmas’ . I argue that the Madhyamaka expression of ‘neither A nor not-A’ is hardly ever just about conforming to any linguistic conventions. It is about gaining liberation from linguistic conventions and unexamined remarks. (shrink)

The philosophy of historical sciences investigates their distinct objects of study, epistemic challenges, and methodological solutions. Rethinking astronomy in this light offers a contribution. First, the methodology of historical sciences adds to a more adequate description of how astronomers study and utilize token events. Second, astronomy faces a typical difficulty in identifying traces of some past events and has developed a delicate solution. This enriches the idea of trace and suggests a methodology that relies on iterations between data-driven approaches and (...) theory-driven approaches, together with the cross-validation between multiple relevant historical events or datasets. (shrink)

This article aims to summarize the current ethical issues in the field of clinical and counseling psychology and the process of developing professional ethical standards in China. First, through a review of the history of counseling and psychotherapy in China, general background information is provided. Important ethical issues are then discussed based on the results from several empirical studies. Finally, the process of developing the new edition of the Chinese Psychological Society Code of Ethics for Clinical and Counseling Psychology, the (...) main contents as well as the considerations taken into account in the development of this code are presented. (shrink)

In his article "Marxism and Revisionism," Lenin pointed out that Marxist theory "had to fight at every step in its journey of life." The history of the development of Marxism is one of the struggle against streams of various socialist ideas. Marxism developed in the struggle. In the 1840s Germany was on the eve of a bourgeois democratic revolution. In order to mobilize the proletariat and the broad masses of the people to participate in the impending democratic revolution, the bourgeoisie (...) had first of all to bring the theory of revolution into the workers' movement, combine the theory of revolution with the workers' movement, and found a proletarian revolutionary party on the basis of this combination. However, at that time, not only in France and Britain but also in Germany there were various socialist schools and ideas and "genuine socialism" was one of the influential socialist schools. Up to 1864 the "genuine socialists" vigorously disseminated their philistine viewpoint in the Union of Justice Advocates and hindered the founding of a proletarian revolutionary party. In order to arm the proletariat with the theory of revolution, win over the Union of Justice Advocates to their side, and turn the union into a real proletarian revolutionary party which would be armed with scientific socialism, Marx and Engels put up a firm struggle against various socialist schools which were hostile to scientific socialism, particularly against "genuine socialism," which had great influence in the Union of Justice Advocates, and theoretically smashed the "genuine socialist" school. In this struggle, Marx and Engels exposed the real class nature of the philistine theory, thoroughly refuted its erroneous viewpoints, particularly the "genuine socialist" flapdoodle about "love," smashed this school, and eliminated this school's evil effects on the workers' movement. Today it is still highly pertinent for us to study the writings and letters of Marx and Engels during the struggle. (shrink)

Objectives: Athlete burnout is a crucial concern affecting the development and athletic performance of young weightlifters. To reduce or relieve the prevalence of athlete burnout, this study examined the relationship across social support, sports motivation, mental toughness, and athlete burnout in weightlifters.Methods: A total of 315 weightlifters aged 17–28 years old from Sichuan, Chongqing, and Shanxi in China participated in this survey. The Perceived Available Support in Sport Questionnaire, Sports Motivation Questionnaire, Sports Mental Toughness Questionnaire, and Athlete Burnout Questionnaire were (...) used in this study. SPSS Statistics 19.0, AMOS 21.0, and PROCESS 3.0 macro were used to analyze the collected data.Results: The results indicated that weightlifters’ social support could negatively significantly affect athlete burnout [beta = −0.398; 95% confidence interval : −0.3699, −0.2184; P < 0.05) via mental toughness and sports motivation. The mediation analysis revealed that they had partial mediating effect, including three paths: First, social support had a direct effect on athlete burnout ; second, sport mental toughness had a mediating effect on athlete burnout ; and finally, sports motivation had a mediating effect on athlete burnout.Conclusion: The findings revealed that social support could inhibit or prevent athlete burnout via mental toughness and sports motivation; thus, to decrease or relieve the prevalence of burnout in weightlifters, it is an important solution to enhance their social support. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

Taking as the background the discourses on friendship initiated by ancient Confucian and Greek philosophers, this article is focused on Xunzi’s perspective on friends by examining where and how he engages effectively ethical justifications of friendship. It will be argued that although Xunzi shows a kind of consistency with Confucius and Mencius, he comes to justify friendship through his own deliberations on human nature, on learning and education, and on the nature and function of human community. We will then proceed (...) to examine the three perspectives Xunzi takes to highlight the ethical value of friends: friendship can be justified as it is needed in overcoming the inborn tendencies towards competition and strife; friendship can be justified because it is taken as supplementary to learning and education where friends are made equivalent to teachers in terms of moral influence and exemplary models; friendship can be justified because it is necessary for communities to function well and for individuals to lead a good life. We will finally come to the conclusion that these justifications constitute a unique ethics of friendship, which is not only significantly divergent from Greek propositions on friends but also differentiable, one way or another, from those proposed or presumed by Confucius and Mencius, and that the Xunzian philosophy of friendship is still an invaluable resource for us to draw on in the age of globalisation and de-globalisation. (shrink)

Artificial neural networks and supervised learning have become an essential part of science. Beyond using them for accurate input-output mapping, there is growing attention to a new feature-oriented approach. Under the assumption that networks optimised for a task may have learned to represent and utilise important features of the target system for that task, scientists examine how those networks manipulate inputs and employ the features networks capture for scientific discovery. We analyse this approach, show its hidden caveats, and suggest its (...) legitimate use. We distinguish three things that scientists call a ‘feature’: parametric, diagnostic, and real-world features. The feature-oriented approach aims for real-world features by interpreting the former two, which also partially rely on the network. We argue that this approach faces a problem of non-uniqueness: there are numerous discordant parametric and diagnostic features and ways to interpret them. When the approach aims at novel discovery, scientists often need to choose between those options, but they lack the background knowledge to justify their choices. Consequentially, features thus identified are not promised to be real. We argue that they should not be used as evidence but only used instrumentally. We also suggest transparency in feature selection and the plurality of choices. (shrink)

Research on multinational inter-organizational relationships has demonstrated that the capabilities of small and medium sized enterprises can be developed via partnerships, but at present, we lack studies that relate the development of such capabilities to the management of business governance structure. This study provides a new perspective on internationalized SME marketing strategies in the global context. Using a dynamic capability view of firms, the study develops hierarchical regression models linking global dynamic capabilities and governance structure. This study empirically verifies the (...) research framework from 206 internationalized SME Taiwanese firms. The results confirm previous studies that indicate positive correlations between market orientation, learning orientation, and global dynamic capabilities. The results also indicate that the development of global dynamic capabilities impacts the choice of governance structure in firms. Our study suggests that internationalized SMEs strategically manage their autonomy and strategic options by choosing combinations of different relationship types while they decide to develop global marketing capabilities and global design capability, or both. The study also found that market orientation and learning orientation act as enabling mechanisms for building global dynamic capabilities. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.